KR920021579A - 펩티드 화합물 및 이의 제조 방법 - Google Patents

펩티드 화합물 및 이의 제조 방법 Download PDF

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Publication number
KR920021579A
KR920021579A KR1019920007969A KR920007969A KR920021579A KR 920021579 A KR920021579 A KR 920021579A KR 1019920007969 A KR1019920007969 A KR 1019920007969A KR 920007969 A KR920007969 A KR 920007969A KR 920021579 A KR920021579 A KR 920021579A
Authority
KR
South Korea
Prior art keywords
alkyl
compound
carboxy
salt
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1019920007969A
Other languages
English (en)
Korean (ko)
Inventor
히사시 다카스기
아키로 다나카
히로요시 사카이
다카토시 이시카와
Original Assignee
후지사와 도모키치로
후지사와야쿠힝 고교 가부시키가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB919110298A external-priority patent/GB9110298D0/en
Priority claimed from GB929202260A external-priority patent/GB9202260D0/en
Application filed by 후지사와 도모키치로, 후지사와야쿠힝 고교 가부시키가이샤 filed Critical 후지사와 도모키치로
Publication of KR920021579A publication Critical patent/KR920021579A/ko
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1019—Tetrapeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1019920007969A 1991-05-13 1992-05-12 펩티드 화합물 및 이의 제조 방법 Ceased KR920021579A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP9110298.8 1991-05-13
GB919110298A GB9110298D0 (en) 1991-05-13 1991-05-13 New peptide compound and a process for the preparation thereof
JP9202260.7 1992-02-03
GB929202260A GB9202260D0 (en) 1992-02-03 1992-02-03 New peptide compound and a process for the preparation thereof

Publications (1)

Publication Number Publication Date
KR920021579A true KR920021579A (ko) 1992-12-18

Family

ID=26298895

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920007969A Ceased KR920021579A (ko) 1991-05-13 1992-05-12 펩티드 화합물 및 이의 제조 방법

Country Status (15)

Country Link
US (1) US5574016A (enExample)
EP (1) EP0513675B1 (enExample)
JP (1) JP2606528B2 (enExample)
KR (1) KR920021579A (enExample)
CN (2) CN1043647C (enExample)
AT (1) ATE142641T1 (enExample)
AU (1) AU662522B2 (enExample)
CA (1) CA2068478A1 (enExample)
DE (1) DE69213546T2 (enExample)
DK (1) DK0513675T3 (enExample)
ES (1) ES2091359T3 (enExample)
GR (1) GR3021182T3 (enExample)
HU (2) HUT61780A (enExample)
IL (1) IL101839A (enExample)
TW (1) TW203057B (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5272162A (en) * 1992-07-02 1993-12-21 G. D. Searle & Co. Platelet aggregation inhibitors
US5354738A (en) * 1992-09-04 1994-10-11 G. D. Searle & Co. Platelet aggregation inhibitors
US5314902A (en) * 1993-01-27 1994-05-24 Monsanto Company Urea derivatives useful as platelet aggregation inhibitors
DE4309867A1 (de) * 1993-03-26 1994-09-29 Cassella Ag Neue Harnstoffderivate, ihre Herstellung und Verwendung
GB9406144D0 (en) * 1993-03-29 1994-05-18 Zeneca Ltd Heterocyclic compounds
NZ262941A (en) * 1993-03-29 1997-07-27 Zeneca Ltd Pyridine derivatives and medicaments
US5652242A (en) * 1993-03-29 1997-07-29 Zeneca Limited Heterocyclic derivatives
US5750754A (en) * 1993-03-29 1998-05-12 Zeneca Limited Heterocyclic compounds
US5753659A (en) * 1993-03-29 1998-05-19 Zeneca Limited Heterocyclic compouds
GB9313268D0 (en) * 1993-06-28 1993-08-11 Zeneca Ltd Chemical compounds
GB9313285D0 (en) * 1993-06-28 1993-08-11 Zeneca Ltd Acid derivatives
US5463011A (en) * 1993-06-28 1995-10-31 Zeneca Limited Acid derivatives
US5780590A (en) * 1993-10-15 1998-07-14 Rhone-Poulenc Rorer Pharmaceuticals Inc. Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides
PT729362E (pt) * 1993-11-19 2000-06-30 Searle & Co Composicao transdermica de n-¬n-¬5-¬4-(aminoiminometil)fenil|-1oxopentil|-l-alfa-aspartil|-l-fenillalanina ou esteres e seus sais farmaceuticamente aceitaveis
US6387880B1 (en) 1994-10-24 2002-05-14 G.D. Searle & Co. Transdermal N-[N-[5-[4-(aminoiminomethly)phenyl]-1-oxopentyl]-L-α-aspartyl]-L-phenylalainine or its esters and their pharmaceutically acceptable salts
CA2204006A1 (en) * 1994-11-01 1996-05-09 Youko Terajima Tetrahydroisoquinoline derivative and medical preparation containing the same
US5766932A (en) * 1995-12-20 1998-06-16 Hoechst Marion Roussel, Inc. Process for preparing N-acetyl(L)-4-cyanophenylalanine from a mixture of the corresponding D,L ethyl esters using subtilisin
ES2179957T3 (es) * 1995-12-20 2003-02-01 Aventis Pharma Inc Procedimiento para preparar n-acetil(l)-4-cianofenilalanina ac-(l)-phe(4-cn)-oh y n-acetil-(l)-p-amidinofenilalanina-ciclohexilglicina-beta-(3-n-metilpiridinio)-alanina ac-(l)-paph-chg-palme(3)-nh2.
JP2001131078A (ja) * 1999-11-09 2001-05-15 Iatron Lab Inc 新規活性固定化血小板及びその製造方法
DE10005631A1 (de) * 2000-02-09 2001-08-23 Max Planck Gesellschaft Arginin-Mimetika als Faktor X¶a¶-Inhibitoren
CN1313441C (zh) * 2000-09-06 2007-05-02 艾米斯菲尔技术有限公司 用于递送活性剂的氰基苯氧基羧酸化合物及其组合物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4857508A (en) * 1987-12-03 1989-08-15 Monsanto Company Novel platelet-aggregation inhibitor peptide derivatives
US5039805A (en) * 1988-12-08 1991-08-13 Hoffmann-La Roche Inc. Novel benzoic and phenylacetic acid derivatives
CA2008116C (en) * 1989-02-23 2001-11-20 Thomas Weller Glycine derivatives
AU646838B2 (en) * 1990-03-09 1994-03-10 F. Hoffmann-La Roche Ag Acetic acid derivatives
CA2037153A1 (en) * 1990-03-09 1991-09-10 Leo Alig Acetic acid derivatives
CA2099994C (en) * 1991-03-06 2003-05-20 Robert B. Garland Phenyl amidines derivatives useful as platelet aggregation inhibitors
DE4212304A1 (de) * 1992-04-13 1993-10-14 Cassella Ag Asparaginsäurederivate, ihre Herstellung und Verwendung

Also Published As

Publication number Publication date
HUT61780A (en) 1993-03-01
IL101839A0 (en) 1992-12-30
AU662522B2 (en) 1995-09-07
CN1120047A (zh) 1996-04-10
CN1043647C (zh) 1999-06-16
ATE142641T1 (de) 1996-09-15
AU1614492A (en) 1992-11-19
TW203057B (enExample) 1993-04-01
JP2606528B2 (ja) 1997-05-07
CN1066660A (zh) 1992-12-02
JPH05148207A (ja) 1993-06-15
EP0513675B1 (en) 1996-09-11
DE69213546T2 (de) 1997-02-27
HU211266A9 (en) 1995-11-28
CA2068478A1 (en) 1992-11-14
EP0513675A1 (en) 1992-11-19
IL101839A (en) 1996-12-05
ES2091359T3 (es) 1996-11-01
HU9201578D0 (en) 1992-08-28
US5574016A (en) 1996-11-12
GR3021182T3 (en) 1996-12-31
DE69213546D1 (de) 1996-10-17
DK0513675T3 (da) 1996-09-30

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Legal Events

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PA0109 Patent application

Patent event code: PA01091R01D

Comment text: Patent Application

Patent event date: 19920512

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 19970509

Comment text: Request for Examination of Application

Patent event code: PA02011R01I

Patent event date: 19920512

Comment text: Patent Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 19990317

Patent event code: PE09021S01D

E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 19990611

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

Patent event date: 19990317

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I