CA2068478A1 - Peptide compound and a process for the preparation thereof - Google Patents

Peptide compound and a process for the preparation thereof

Info

Publication number
CA2068478A1
CA2068478A1 CA002068478A CA2068478A CA2068478A1 CA 2068478 A1 CA2068478 A1 CA 2068478A1 CA 002068478 A CA002068478 A CA 002068478A CA 2068478 A CA2068478 A CA 2068478A CA 2068478 A1 CA2068478 A1 CA 2068478A1
Authority
CA
Canada
Prior art keywords
compound
alkyl
formula
salt
carboxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002068478A
Other languages
English (en)
French (fr)
Inventor
Hisashi Takasugi
Akito Tanaka
Hiroyoshi Sakai
Takatoshi Ishikawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Pharma Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB919110298A external-priority patent/GB9110298D0/en
Priority claimed from GB929202260A external-priority patent/GB9202260D0/en
Application filed by Individual filed Critical Individual
Publication of CA2068478A1 publication Critical patent/CA2068478A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1019—Tetrapeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA002068478A 1991-05-13 1992-05-12 Peptide compound and a process for the preparation thereof Abandoned CA2068478A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9110298.8 1991-05-13
GB919110298A GB9110298D0 (en) 1991-05-13 1991-05-13 New peptide compound and a process for the preparation thereof
GB9202260.7 1992-02-03
GB929202260A GB9202260D0 (en) 1992-02-03 1992-02-03 New peptide compound and a process for the preparation thereof

Publications (1)

Publication Number Publication Date
CA2068478A1 true CA2068478A1 (en) 1992-11-14

Family

ID=26298895

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002068478A Abandoned CA2068478A1 (en) 1991-05-13 1992-05-12 Peptide compound and a process for the preparation thereof

Country Status (15)

Country Link
US (1) US5574016A (enExample)
EP (1) EP0513675B1 (enExample)
JP (1) JP2606528B2 (enExample)
KR (1) KR920021579A (enExample)
CN (2) CN1043647C (enExample)
AT (1) ATE142641T1 (enExample)
AU (1) AU662522B2 (enExample)
CA (1) CA2068478A1 (enExample)
DE (1) DE69213546T2 (enExample)
DK (1) DK0513675T3 (enExample)
ES (1) ES2091359T3 (enExample)
GR (1) GR3021182T3 (enExample)
HU (2) HUT61780A (enExample)
IL (1) IL101839A (enExample)
TW (1) TW203057B (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5272162A (en) * 1992-07-02 1993-12-21 G. D. Searle & Co. Platelet aggregation inhibitors
US5354738A (en) * 1992-09-04 1994-10-11 G. D. Searle & Co. Platelet aggregation inhibitors
US5314902A (en) * 1993-01-27 1994-05-24 Monsanto Company Urea derivatives useful as platelet aggregation inhibitors
DE4309867A1 (de) * 1993-03-26 1994-09-29 Cassella Ag Neue Harnstoffderivate, ihre Herstellung und Verwendung
DK0691959T3 (da) * 1993-03-29 1999-04-26 Zeneca Ltd Heterocykliske derivater som blodpladeaggregations-inhibitorer
US5652242A (en) * 1993-03-29 1997-07-29 Zeneca Limited Heterocyclic derivatives
US5753659A (en) * 1993-03-29 1998-05-19 Zeneca Limited Heterocyclic compouds
US5750754A (en) * 1993-03-29 1998-05-12 Zeneca Limited Heterocyclic compounds
EP0690847A1 (en) * 1993-03-29 1996-01-10 Zeneca Limited Heterocyclic compounds as platelet aggregation inhibitors
US5463011A (en) * 1993-06-28 1995-10-31 Zeneca Limited Acid derivatives
GB9313268D0 (en) * 1993-06-28 1993-08-11 Zeneca Ltd Chemical compounds
GB9313285D0 (en) * 1993-06-28 1993-08-11 Zeneca Ltd Acid derivatives
US5780590A (en) * 1993-10-15 1998-07-14 Rhone-Poulenc Rorer Pharmaceuticals Inc. Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides
WO1995013825A1 (en) * 1993-11-19 1995-05-26 G.D. Searle & Co. TRANSDERMAL COMPOSITION OF N-[N-[5-[4-(AMINOIMINOMETHYL)PHENYL]-1-OXOPENTYL]-L-α-ASPARTYL]-L-PHENYLALANINE OR ITS ESTERS AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS
US6387880B1 (en) 1994-10-24 2002-05-14 G.D. Searle & Co. Transdermal N-[N-[5-[4-(aminoiminomethly)phenyl]-1-oxopentyl]-L-α-aspartyl]-L-phenylalainine or its esters and their pharmaceutically acceptable salts
WO1996013497A1 (en) * 1994-11-01 1996-05-09 Terumo Kabushiki Kaisha Tetrahydroisoquinoline derivative and medicinal preparation containing the same
SK281432B6 (sk) * 1995-12-20 2001-03-12 Hoechst Marion Roussel, Inc. Spôsob prípravy n-acetyl-(l)-4-kyanofenylalanínu ac-(l)-phe(4- -cn)-oh a n-acetyl-(l)-p-amidinofenylalanín-cyklohexylglycín- -beta-(3-n-metylpyridínium)-alanínu ac-(l)-paph-chg-palme(3)-nh2
US5766932A (en) * 1995-12-20 1998-06-16 Hoechst Marion Roussel, Inc. Process for preparing N-acetyl(L)-4-cyanophenylalanine from a mixture of the corresponding D,L ethyl esters using subtilisin
JP2001131078A (ja) * 1999-11-09 2001-05-15 Iatron Lab Inc 新規活性固定化血小板及びその製造方法
DE10005631A1 (de) * 2000-02-09 2001-08-23 Max Planck Gesellschaft Arginin-Mimetika als Faktor X¶a¶-Inhibitoren
JP5089845B2 (ja) * 2000-09-06 2012-12-05 エミスフェアー・テクノロジーズ・インク シアノフェノキシカルボン酸化合物および活性薬剤送達用組成物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4857508A (en) * 1987-12-03 1989-08-15 Monsanto Company Novel platelet-aggregation inhibitor peptide derivatives
US5039805A (en) * 1988-12-08 1991-08-13 Hoffmann-La Roche Inc. Novel benzoic and phenylacetic acid derivatives
CA2008116C (en) * 1989-02-23 2001-11-20 Thomas Weller Glycine derivatives
AU646838B2 (en) * 1990-03-09 1994-03-10 F. Hoffmann-La Roche Ag Acetic acid derivatives
CA2037153A1 (en) * 1990-03-09 1991-09-10 Leo Alig Acetic acid derivatives
US5481021A (en) * 1991-03-06 1996-01-02 G. D. Searle & Co. Phenyl amidines derivatives useful as platelet aggregation inhibitors
DE4212304A1 (de) * 1992-04-13 1993-10-14 Cassella Ag Asparaginsäurederivate, ihre Herstellung und Verwendung

Also Published As

Publication number Publication date
TW203057B (enExample) 1993-04-01
JP2606528B2 (ja) 1997-05-07
IL101839A0 (en) 1992-12-30
JPH05148207A (ja) 1993-06-15
DE69213546D1 (de) 1996-10-17
EP0513675A1 (en) 1992-11-19
AU1614492A (en) 1992-11-19
KR920021579A (ko) 1992-12-18
DE69213546T2 (de) 1997-02-27
DK0513675T3 (da) 1996-09-30
HU211266A9 (en) 1995-11-28
ES2091359T3 (es) 1996-11-01
HUT61780A (en) 1993-03-01
CN1066660A (zh) 1992-12-02
US5574016A (en) 1996-11-12
HU9201578D0 (en) 1992-08-28
IL101839A (en) 1996-12-05
CN1043647C (zh) 1999-06-16
CN1120047A (zh) 1996-04-10
ATE142641T1 (de) 1996-09-15
AU662522B2 (en) 1995-09-07
GR3021182T3 (en) 1996-12-31
EP0513675B1 (en) 1996-09-11

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Legal Events

Date Code Title Description
FZDE Discontinued