KR920021563A - 니자티딘의 제조방법 및 그에 대한 중간체 - Google Patents

니자티딘의 제조방법 및 그에 대한 중간체 Download PDF

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Publication number
KR920021563A
KR920021563A KR1019920008444A KR920008444A KR920021563A KR 920021563 A KR920021563 A KR 920021563A KR 1019920008444 A KR1019920008444 A KR 1019920008444A KR 920008444 A KR920008444 A KR 920008444A KR 920021563 A KR920021563 A KR 920021563A
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KR
South Korea
Prior art keywords
methyl
hydrogen
ethyl
preparing
intermediates
Prior art date
Application number
KR1019920008444A
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English (en)
Other versions
KR100214184B1 (ko
Inventor
필립 모더 케네쓰
Original Assignee
원본 미기재
일라이 릴리 앤드 캄파니
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 원본 미기재, 일라이 릴리 앤드 캄파니 filed Critical 원본 미기재
Publication of KR920021563A publication Critical patent/KR920021563A/ko
Application granted granted Critical
Publication of KR100214184B1 publication Critical patent/KR100214184B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Saccharide Compounds (AREA)

Abstract

내용 없음

Description

니자티딘의 제조방법 및 그에 대한 중간체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. 하기 일반식의 화합물 또는 그의 염:
    상기식에서, R1은 수소, 메틸, 에틸, 벤질 또는 벤조일을 나타내고, R2는 메틸 또는 에틸을 나타내거나, 또는 R1및 R2는 이들이 결합된 질소 원자와 함께 피롤리딘, 피페리딘 또는 모르폴린 고리를 형성하며, R3는 수소 또는 메틸을 나타낸다.
  2. 제1항에 있어서, R1및 R2가 모두 메틸이고, R3가 수소인 화합물.
  3. 하기 일반식(II)의 4-하이드록시-4-클로로메틸-2-(아미노메틸) 티아졸린을 불활성 용매중에서 알칼리 금속 염기와 반응시킴을 포함하는 하기 일반식(I)의 2-(아미노메틸)-4-티아졸메탄올의 제조방법:
    상기식에서, R1은 수소, 메틸, 에틸, 벤질 또는 벤조일이고, R2는 메틸 또는 에틸이거나, 또는 R1및 R2는 이들이 결합된 질소원자와 함께 피롤리딘, 피페리딘 또는 모르폴린 고리를 형성하며, R3는 수소 또는 메틸이다.
    ※ 참고사항:최초출원 내용에 의하여 공개하는 것임.
KR1019920008444A 1991-05-21 1992-05-19 니자티딘의 제조방법 및 그에 대한 중간체 KR100214184B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70352691A 1991-05-21 1991-05-21
US703,526 1991-05-21

Publications (2)

Publication Number Publication Date
KR920021563A true KR920021563A (ko) 1992-12-18
KR100214184B1 KR100214184B1 (ko) 1999-08-02

Family

ID=24825733

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920008444A KR100214184B1 (ko) 1991-05-21 1992-05-19 니자티딘의 제조방법 및 그에 대한 중간체

Country Status (15)

Country Link
EP (2) EP0515121B1 (ko)
JP (2) JP3504280B2 (ko)
KR (1) KR100214184B1 (ko)
AT (1) ATE197296T1 (ko)
BR (1) BR9201895A (ko)
CA (3) CA2069055C (ko)
DE (1) DE69231541T2 (ko)
DK (1) DK0515121T3 (ko)
ES (1) ES2151480T3 (ko)
GR (1) GR3035263T3 (ko)
HU (1) HU219459B (ko)
IE (1) IE921623A1 (ko)
IL (1) IL101915A (ko)
MX (1) MX9202347A (ko)
PT (1) PT515121E (ko)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL189197C (nl) * 1979-09-04 1993-02-01 Bristol Myers Squibb Co 3,4-digesubstitueerde-1,2,5-thiadiazool-1-oxiden en 1,1-dioxiden, bereiding daarvan alsmede farmaceutische preparaten.
US4375547A (en) * 1980-10-02 1983-03-01 Eli Lilly And Company N-Methyl-N'-2-([(2-dimethylaminomethyl)-4-thiazolyl]methylthio)ethyl 2-nitro-1,1-ethenediamine

Also Published As

Publication number Publication date
DK0515121T3 (da) 2000-11-27
IL101915A (en) 1996-12-05
GR3035263T3 (en) 2001-04-30
PT515121E (pt) 2001-04-30
EP0515121B1 (en) 2000-11-02
MX9202347A (es) 1994-06-30
JPH05155889A (ja) 1993-06-22
BR9201895A (pt) 1993-01-05
JP2003040876A (ja) 2003-02-13
EP0515121A1 (en) 1992-11-25
HU9201664D0 (en) 1992-08-28
ATE197296T1 (de) 2000-11-15
JP3504280B2 (ja) 2004-03-08
HU219459B (hu) 2001-04-28
DE69231541T2 (de) 2001-06-07
CA2069055A1 (en) 1992-11-22
CA2069055C (en) 2001-08-07
CA2343336C (en) 2004-10-19
HUT62870A (en) 1993-06-28
ES2151480T3 (es) 2001-01-01
CA2343336A1 (en) 1992-11-22
IE921623A1 (en) 1992-12-02
CA2343023C (en) 2002-02-05
DE69231541D1 (de) 2000-12-07
IL101915A0 (en) 1992-12-30
KR100214184B1 (ko) 1999-08-02
EP0960880A1 (en) 1999-12-01

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