NO844139L - Nye 1-substituerte-5-hydroksymetyl-2-merkapto-imidazol-derivater og fremgangsmaate for fremstilling derav - Google Patents
Nye 1-substituerte-5-hydroksymetyl-2-merkapto-imidazol-derivater og fremgangsmaate for fremstilling deravInfo
- Publication number
- NO844139L NO844139L NO844139A NO844139A NO844139L NO 844139 L NO844139 L NO 844139L NO 844139 A NO844139 A NO 844139A NO 844139 A NO844139 A NO 844139A NO 844139 L NO844139 L NO 844139L
- Authority
- NO
- Norway
- Prior art keywords
- mercapto
- hydroxymethyl
- substituted
- formula
- imidazole derivatives
- Prior art date
Links
- -1 1-SUBSTITUTED-5-HYDROXYMETHYL-2-MERCAPTO-IMIDAZOLE Chemical class 0.000 title abstract 3
- 229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- KEQUNHIAUQQPAC-UHFFFAOYSA-N Dihydroxyacetone (dimer) Chemical compound OCC1(O)COC(O)(CO)CO1 KEQUNHIAUQQPAC-UHFFFAOYSA-N 0.000 abstract 1
- 125000003158 alcohol group Chemical group 0.000 abstract 1
- 125000003172 aldehyde group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract 1
- 229910052736 halogen Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 150000002460 imidazoles Chemical class 0.000 abstract 1
- 239000011777 magnesium Substances 0.000 abstract 1
- 229910052749 magnesium Inorganic materials 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- ZNNZYHKDIALBAK-UHFFFAOYSA-M potassium thiocyanate Chemical compound [K+].[S-]C#N ZNNZYHKDIALBAK-UHFFFAOYSA-M 0.000 abstract 1
- 229940116357 potassium thiocyanate Drugs 0.000 abstract 1
- 125000005344 pyridylmethyl group Chemical group [H]C1=C([H])C([H])=C([H])C(=N1)C([H])([H])* 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Epoxy Resins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI833794A FI833794A0 (fi) | 1983-10-18 | 1983-10-18 | Substituerade 2-merkapto-imidazoler |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO844139L true NO844139L (no) | 1985-04-19 |
| NO159167B NO159167B (no) | 1988-08-29 |
| NO159167C NO159167C (no) | 1988-12-07 |
Family
ID=8517935
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO844139A NO159167C (no) | 1983-10-18 | 1984-10-17 | Nye 1-substituerte-5-hydroksymetyl-2-merkapto-imidazol-derivater og fremgangsmaate for fremstilling derav. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4584383A (no) |
| EP (1) | EP0146228B1 (no) |
| JP (1) | JPS60149568A (no) |
| AT (1) | ATE32064T1 (no) |
| AU (1) | AU566437B2 (no) |
| DD (1) | DD236730A1 (no) |
| DE (1) | DE3468869D1 (no) |
| DK (1) | DK174201B1 (no) |
| ES (1) | ES536186A0 (no) |
| FI (1) | FI833794A0 (no) |
| HU (1) | HU191960B (no) |
| IE (1) | IE57591B1 (no) |
| IL (1) | IL73255A (no) |
| NO (1) | NO159167C (no) |
| NZ (1) | NZ209896A (no) |
| SU (1) | SU1301313A3 (no) |
| UA (1) | UA5972A1 (no) |
| ZA (1) | ZA848112B (no) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4634711A (en) * | 1985-08-02 | 1987-01-06 | Smithkline Beckman Corporation | Pyridylalkyl imidazole-2-thiols |
| US5138069A (en) * | 1986-07-11 | 1992-08-11 | E. I. Du Pont De Nemours And Company | Angiotensin II receptor blocking imidazoles |
| FI91754C (fi) * | 1986-12-02 | 1994-08-10 | Tanabe Seiyaku Co | Analogiamenetelmä lääkeaineena käyttökelpoisen imidatsolijohdannaisen valmistamiseksi |
| US4882348A (en) * | 1987-12-29 | 1989-11-21 | Smithkline Beckman Corporation | 2-(aminoalkylthio)imidazoles as dopamine-β-hydroxylase inhibitors |
| US5210079A (en) * | 1988-01-07 | 1993-05-11 | E. I. Du Pont De Nemours And Company | Treatment of chronic renal failure with imidazole angiotensin-II receptor antagonists |
| CA1338238C (en) | 1988-01-07 | 1996-04-09 | David John Carini | Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids |
| US4880804A (en) * | 1988-01-07 | 1989-11-14 | E. I. Du Pont De Nemours And Company | Angiotensin II receptor blocking benzimidazoles |
| US5354867A (en) * | 1988-12-06 | 1994-10-11 | E. I. Du Pont De Nemours And Company | Angiotensin II receptor blocking imidazoles |
| CA2059000C (en) * | 1989-06-30 | 1998-01-20 | Robert John Ardecky | Fused-ring aryl substituted imidazoles |
| US5073566A (en) * | 1989-11-30 | 1991-12-17 | Eli Lilly And Company | Angiotensin ii antagonist 1,3-imidazoles and use thereas |
| US5332820A (en) * | 1991-05-20 | 1994-07-26 | E. I. Du Pont De Nemours And Company | Dibenzobicyclo(2.2.2) octane angiotensin II antagonists |
| US5401851A (en) * | 1992-06-03 | 1995-03-28 | Eli Lilly And Company | Angiotensin II antagonists |
| US5612360A (en) * | 1992-06-03 | 1997-03-18 | Eli Lilly And Company | Angiotensin II antagonists |
| IT1295405B1 (it) | 1997-09-30 | 1999-05-12 | Merck Sharp & Dohme Italia S P | Uso di un antagonista recettoriale di angiotensina ii per la preparazione di farmaci per aumentare il tasso di sopravvivenza di |
| KR100567183B1 (ko) * | 1997-11-14 | 2006-06-13 | 론자 아게 | 포르밀이미다졸의제조방법 |
| CN1372551A (zh) | 1999-09-06 | 2002-10-02 | 株式会社Lgci | 制备1－取代的5－羟甲基咪唑的方法 |
| KR100388788B1 (ko) * | 1999-09-06 | 2003-06-25 | 주식회사 엘지생명과학 | 1-치환된-5-하이드록시메틸 이미다졸의 신규 제조방법 |
| US6620939B2 (en) * | 2001-09-18 | 2003-09-16 | General Electric Company | Method for producing bisphenol catalysts and bisphenols |
| US7112702B2 (en) * | 2002-12-12 | 2006-09-26 | General Electric Company | Process for the synthesis of bisphenol |
| FI116292B (fi) * | 2003-01-08 | 2005-10-31 | Juvantia Pharma Ltd Oy | Menetelmä substituoitujen imidatsolijohdannaisten valmistamiseksi ja menetelmässä käytettäviä välituotteita |
| US7132575B2 (en) * | 2003-07-01 | 2006-11-07 | General Electric Company | Process for the synthesis of bisphenol |
| FI20050391A0 (fi) * | 2005-04-15 | 2005-04-15 | Orion Corp | Detomidiinihydrokloridin kiteytysmenetelmä |
| CN101747280B (zh) * | 2008-11-28 | 2011-11-09 | 上海迪赛诺医药发展有限公司 | 制备地托咪定及其中间体的方法 |
| US20210323929A1 (en) | 2018-07-18 | 2021-10-21 | Clexio Biosciences Ltd. | Purified Detomidine, Process of Preparing and Methods of Use |
| EP3782989A1 (en) | 2019-08-23 | 2021-02-24 | Andreas Sachse | Detomidine hydrochloride monohydrate |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2541924A (en) * | 1948-09-17 | 1951-02-13 | Lilly Co Eli | Synthesis of substituted imidazoles |
| AU518569B2 (en) * | 1979-08-07 | 1981-10-08 | Farmos-Yhtyma Oy | 4-benzyl- and 4-benzoyl imidazole derivatives |
| GB2092569B (en) * | 1981-02-05 | 1984-09-19 | Farmos Oy | Substituted imidazole derivatives and their preparation and use |
-
1983
- 1983-10-18 FI FI833794A patent/FI833794A0/fi not_active Application Discontinuation
-
1984
- 1984-09-24 ES ES536186A patent/ES536186A0/es active Granted
- 1984-10-02 DK DK198404713A patent/DK174201B1/da not_active IP Right Cessation
- 1984-10-16 IL IL73255A patent/IL73255A/xx not_active IP Right Cessation
- 1984-10-16 AU AU34263/84A patent/AU566437B2/en not_active Expired
- 1984-10-16 EP EP84307095A patent/EP0146228B1/en not_active Expired
- 1984-10-16 AT AT84307095T patent/ATE32064T1/de not_active IP Right Cessation
- 1984-10-16 IE IE2652/84A patent/IE57591B1/en not_active IP Right Cessation
- 1984-10-16 DD DD84268430A patent/DD236730A1/de not_active IP Right Cessation
- 1984-10-16 NZ NZ209896A patent/NZ209896A/en unknown
- 1984-10-16 DE DE8484307095T patent/DE3468869D1/de not_active Expired
- 1984-10-16 JP JP59218160A patent/JPS60149568A/ja not_active Expired - Lifetime
- 1984-10-16 US US06/661,487 patent/US4584383A/en not_active Expired - Lifetime
- 1984-10-17 UA UA3801008A patent/UA5972A1/uk unknown
- 1984-10-17 HU HU843890A patent/HU191960B/hu unknown
- 1984-10-17 ZA ZA848112A patent/ZA848112B/xx unknown
- 1984-10-17 NO NO844139A patent/NO159167C/no not_active IP Right Cessation
- 1984-10-17 SU SU843801008A patent/SU1301313A3/ru active
Also Published As
| Publication number | Publication date |
|---|---|
| NO159167B (no) | 1988-08-29 |
| SU1301313A3 (ru) | 1987-03-30 |
| NO159167C (no) | 1988-12-07 |
| IE842652L (en) | 1985-04-18 |
| UA5972A1 (uk) | 1994-12-29 |
| DK471384D0 (da) | 1984-10-02 |
| ATE32064T1 (de) | 1988-02-15 |
| ES8507507A1 (es) | 1985-09-01 |
| EP0146228A1 (en) | 1985-06-26 |
| ZA848112B (en) | 1985-06-26 |
| AU3426384A (en) | 1985-04-26 |
| ES536186A0 (es) | 1985-09-01 |
| HU191960B (en) | 1987-04-28 |
| US4584383A (en) | 1986-04-22 |
| JPS60149568A (ja) | 1985-08-07 |
| AU566437B2 (en) | 1987-10-22 |
| DK174201B1 (da) | 2002-09-16 |
| NZ209896A (en) | 1987-02-20 |
| DK471384A (da) | 1985-04-19 |
| DD236730A1 (de) | 1986-06-18 |
| DE3468869D1 (en) | 1988-02-25 |
| EP0146228B1 (en) | 1988-01-20 |
| HUT35649A (en) | 1985-07-29 |
| IE57591B1 (en) | 1993-01-13 |
| IL73255A (en) | 1988-11-30 |
| IL73255A0 (en) | 1985-01-31 |
| FI833794A0 (fi) | 1983-10-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |