FI833794A0 - Substituerade 2-merkapto-imidazoler - Google Patents
Substituerade 2-merkapto-imidazolerInfo
- Publication number
- FI833794A0 FI833794A0 FI833794A FI833794A FI833794A0 FI 833794 A0 FI833794 A0 FI 833794A0 FI 833794 A FI833794 A FI 833794A FI 833794 A FI833794 A FI 833794A FI 833794 A0 FI833794 A0 FI 833794A0
- Authority
- FI
- Finland
- Prior art keywords
- formula
- group
- compounds
- image
- aldehyde
- Prior art date
Links
- -1 1-substituted-5-hydroxymethyl-2-mercapto-imidazoles Chemical class 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- KEQUNHIAUQQPAC-UHFFFAOYSA-N Dihydroxyacetone (dimer) Chemical compound OCC1(O)COC(O)(CO)CO1 KEQUNHIAUQQPAC-UHFFFAOYSA-N 0.000 abstract 1
- 125000003158 alcohol group Chemical group 0.000 abstract 1
- 125000003172 aldehyde group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract 1
- 229910052736 halogen Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 150000002460 imidazoles Chemical class 0.000 abstract 1
- 229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 abstract 1
- 239000011777 magnesium Substances 0.000 abstract 1
- 229910052749 magnesium Inorganic materials 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- ZNNZYHKDIALBAK-UHFFFAOYSA-M potassium thiocyanate Chemical compound [K+].[S-]C#N ZNNZYHKDIALBAK-UHFFFAOYSA-M 0.000 abstract 1
- 229940116357 potassium thiocyanate Drugs 0.000 abstract 1
- 125000005344 pyridylmethyl group Chemical group [H]C1=C([H])C([H])=C([H])C(=N1)C([H])([H])* 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Epoxy Resins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Priority Applications (21)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI833794A FI833794A0 (fi) | 1983-10-18 | 1983-10-18 | Substituerade 2-merkapto-imidazoler |
| ES536186A ES8507507A1 (es) | 1983-10-18 | 1984-09-24 | Un procedimiento para preparar 5-hidroximetil-2-mercapto-imidazoles sustituidos en posicion 1 |
| DK198404713A DK174201B1 (da) | 1983-10-18 | 1984-10-02 | Substituerede 2-mercoptoimidazoler eller syreadditionssalte deraf samt fremgangsmåde til fremstilling af disse forbindelser |
| US06/661,487 US4584383A (en) | 1983-10-18 | 1984-10-16 | Substituted 2-mercapto-imidazoles and their preparation |
| AU34263/84A AU566437B2 (en) | 1983-10-18 | 1984-10-16 | Substituted-2-mercapto-imidazoles |
| NZ209896A NZ209896A (en) | 1983-10-18 | 1984-10-16 | 5-hydroxymethyl-2-mercapto-imidazoles preparation of 5-formyl-imidazoles |
| DD84268430A DD236730A1 (de) | 1983-10-18 | 1984-10-16 | Verfahren zur herstellung von 1-substituierten 5-hydroxymethyl-2-merkapto-imidazolen |
| IE2652/84A IE57591B1 (en) | 1983-10-18 | 1984-10-16 | Substituted 2-mercapto-imidazoles and their preparation and use |
| EP84307095A EP0146228B1 (en) | 1983-10-18 | 1984-10-16 | Substituted 2-mercapto-imidazoles and their preparation and use |
| JP59218160A JPS60149568A (ja) | 1983-10-18 | 1984-10-16 | １−置換−５−ヒドロキシメチル−２−メルカプト−イミダゾ−ル類およびその製法 |
| IL73255A IL73255A (en) | 1983-10-18 | 1984-10-16 | 2-mercapto-5-hydroxymethyl-imidazole derivatives and their preparation |
| AT84307095T ATE32064T1 (de) | 1983-10-18 | 1984-10-16 | Substituierte 2-mercapto-imidazole und deren herstellung und anwendung. |
| DE8484307095T DE3468869D1 (en) | 1983-10-18 | 1984-10-16 | Substituted 2-mercapto-imidazoles and their preparation and use |
| ZA848112A ZA848112B (en) | 1983-10-18 | 1984-10-17 | Substituted 2-mercapto-imidazoles and their perparation and use |
| UA3801008A UA5972A1 (uk) | 1983-10-18 | 1984-10-17 | Спосіб отримання заміщених 2-меркапто-імідазолів |
| FI844079A FI69302C (fi) | 1983-10-18 | 1984-10-17 | 1-substituerade 5-hydroximetyl-2-merkapto-imidazoler |
| HU843890A HU191960B (en) | 1983-10-18 | 1984-10-17 | Process for preparing substituted 2-mercapto-imidazoles |
| SU843801008A SU1301313A3 (ru) | 1983-10-18 | 1984-10-17 | Способ получени замещенных 2-меркапто-имидазолов |
| NO844139A NO159167C (no) | 1983-10-18 | 1984-10-17 | Nye 1-substituerte-5-hydroksymetyl-2-merkapto-imidazol-derivater og fremgangsmaate for fremstilling derav. |
| LV920317A LV5065A3 (lv) | 1983-10-18 | 1992-12-17 | Aizvietotu 2-merkapto-imidazolu iegusanas metode |
| LTRP767A LT2219B (lt) | 1983-10-18 | 1993-07-07 | Pavaduotu 2-merkapto-imidazolu gavimo budas |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI833794A FI833794A0 (fi) | 1983-10-18 | 1983-10-18 | Substituerade 2-merkapto-imidazoler |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FI833794A0 true FI833794A0 (fi) | 1983-10-18 |
Family
ID=8517935
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI833794A FI833794A0 (fi) | 1983-10-18 | 1983-10-18 | Substituerade 2-merkapto-imidazoler |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4584383A (no) |
| EP (1) | EP0146228B1 (no) |
| JP (1) | JPS60149568A (no) |
| AT (1) | ATE32064T1 (no) |
| AU (1) | AU566437B2 (no) |
| DD (1) | DD236730A1 (no) |
| DE (1) | DE3468869D1 (no) |
| DK (1) | DK174201B1 (no) |
| ES (1) | ES8507507A1 (no) |
| FI (1) | FI833794A0 (no) |
| HU (1) | HU191960B (no) |
| IE (1) | IE57591B1 (no) |
| IL (1) | IL73255A (no) |
| NO (1) | NO159167C (no) |
| NZ (1) | NZ209896A (no) |
| SU (1) | SU1301313A3 (no) |
| UA (1) | UA5972A1 (no) |
| ZA (1) | ZA848112B (no) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4634711A (en) * | 1985-08-02 | 1987-01-06 | Smithkline Beckman Corporation | Pyridylalkyl imidazole-2-thiols |
| US5138069A (en) * | 1986-07-11 | 1992-08-11 | E. I. Du Pont De Nemours And Company | Angiotensin II receptor blocking imidazoles |
| FI91754C (fi) * | 1986-12-02 | 1994-08-10 | Tanabe Seiyaku Co | Analogiamenetelmä lääkeaineena käyttökelpoisen imidatsolijohdannaisen valmistamiseksi |
| US4882348A (en) * | 1987-12-29 | 1989-11-21 | Smithkline Beckman Corporation | 2-(aminoalkylthio)imidazoles as dopamine-β-hydroxylase inhibitors |
| US5210079A (en) * | 1988-01-07 | 1993-05-11 | E. I. Du Pont De Nemours And Company | Treatment of chronic renal failure with imidazole angiotensin-II receptor antagonists |
| US4880804A (en) * | 1988-01-07 | 1989-11-14 | E. I. Du Pont De Nemours And Company | Angiotensin II receptor blocking benzimidazoles |
| CA1338238C (en) | 1988-01-07 | 1996-04-09 | David John Carini | Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids |
| US5354867A (en) * | 1988-12-06 | 1994-10-11 | E. I. Du Pont De Nemours And Company | Angiotensin II receptor blocking imidazoles |
| SG50669A1 (en) * | 1989-06-30 | 1998-07-20 | Du Pont | Fused-ring aryl subtituted imidazoles |
| US5073566A (en) * | 1989-11-30 | 1991-12-17 | Eli Lilly And Company | Angiotensin ii antagonist 1,3-imidazoles and use thereas |
| US5332820A (en) * | 1991-05-20 | 1994-07-26 | E. I. Du Pont De Nemours And Company | Dibenzobicyclo(2.2.2) octane angiotensin II antagonists |
| US5401851A (en) * | 1992-06-03 | 1995-03-28 | Eli Lilly And Company | Angiotensin II antagonists |
| US5612360A (en) * | 1992-06-03 | 1997-03-18 | Eli Lilly And Company | Angiotensin II antagonists |
| IT1295405B1 (it) | 1997-09-30 | 1999-05-12 | Merck Sharp & Dohme Italia S P | Uso di un antagonista recettoriale di angiotensina ii per la preparazione di farmaci per aumentare il tasso di sopravvivenza di |
| KR100567183B1 (ko) * | 1997-11-14 | 2006-06-13 | 론자 아게 | 포르밀이미다졸의제조방법 |
| KR100388788B1 (ko) * | 1999-09-06 | 2003-06-25 | 주식회사 엘지생명과학 | 1-치환된-5-하이드록시메틸 이미다졸의 신규 제조방법 |
| AU7040500A (en) | 1999-09-06 | 2001-04-10 | Lg Chem Investment Ltd. | Process for preparing a 1-substituted 5-hydroxymethyl imidazole |
| US6620939B2 (en) * | 2001-09-18 | 2003-09-16 | General Electric Company | Method for producing bisphenol catalysts and bisphenols |
| US7112702B2 (en) * | 2002-12-12 | 2006-09-26 | General Electric Company | Process for the synthesis of bisphenol |
| FI116292B (fi) * | 2003-01-08 | 2005-10-31 | Juvantia Pharma Ltd Oy | Menetelmä substituoitujen imidatsolijohdannaisten valmistamiseksi ja menetelmässä käytettäviä välituotteita |
| US7132575B2 (en) * | 2003-07-01 | 2006-11-07 | General Electric Company | Process for the synthesis of bisphenol |
| FI20050391A0 (fi) * | 2005-04-15 | 2005-04-15 | Orion Corp | Detomidiinihydrokloridin kiteytysmenetelmä |
| CN101747280B (zh) * | 2008-11-28 | 2011-11-09 | 上海迪赛诺医药发展有限公司 | 制备地托咪定及其中间体的方法 |
| US20210323929A1 (en) | 2018-07-18 | 2021-10-21 | Clexio Biosciences Ltd. | Purified Detomidine, Process of Preparing and Methods of Use |
| EP3782989A1 (en) | 2019-08-23 | 2021-02-24 | Andreas Sachse | Detomidine hydrochloride monohydrate |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2541924A (en) * | 1948-09-17 | 1951-02-13 | Lilly Co Eli | Synthesis of substituted imidazoles |
| AU518569B2 (en) * | 1979-08-07 | 1981-10-08 | Farmos-Yhtyma Oy | 4-benzyl- and 4-benzoyl imidazole derivatives |
| GB2092569B (en) * | 1981-02-05 | 1984-09-19 | Farmos Oy | Substituted imidazole derivatives and their preparation and use |
-
1983
- 1983-10-18 FI FI833794A patent/FI833794A0/fi not_active Application Discontinuation
-
1984
- 1984-09-24 ES ES536186A patent/ES8507507A1/es not_active Expired
- 1984-10-02 DK DK198404713A patent/DK174201B1/da not_active IP Right Cessation
- 1984-10-16 DE DE8484307095T patent/DE3468869D1/de not_active Expired
- 1984-10-16 NZ NZ209896A patent/NZ209896A/en unknown
- 1984-10-16 AT AT84307095T patent/ATE32064T1/de not_active IP Right Cessation
- 1984-10-16 AU AU34263/84A patent/AU566437B2/en not_active Expired
- 1984-10-16 DD DD84268430A patent/DD236730A1/de not_active IP Right Cessation
- 1984-10-16 IL IL73255A patent/IL73255A/xx not_active IP Right Cessation
- 1984-10-16 IE IE2652/84A patent/IE57591B1/en not_active IP Right Cessation
- 1984-10-16 EP EP84307095A patent/EP0146228B1/en not_active Expired
- 1984-10-16 US US06/661,487 patent/US4584383A/en not_active Expired - Lifetime
- 1984-10-16 JP JP59218160A patent/JPS60149568A/ja not_active Expired - Lifetime
- 1984-10-17 HU HU843890A patent/HU191960B/hu unknown
- 1984-10-17 ZA ZA848112A patent/ZA848112B/xx unknown
- 1984-10-17 NO NO844139A patent/NO159167C/no not_active IP Right Cessation
- 1984-10-17 SU SU843801008A patent/SU1301313A3/ru active
- 1984-10-17 UA UA3801008A patent/UA5972A1/uk unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HU191960B (en) | 1987-04-28 |
| HUT35649A (en) | 1985-07-29 |
| EP0146228A1 (en) | 1985-06-26 |
| ES536186A0 (es) | 1985-09-01 |
| DK471384D0 (da) | 1984-10-02 |
| DE3468869D1 (en) | 1988-02-25 |
| DD236730A1 (de) | 1986-06-18 |
| EP0146228B1 (en) | 1988-01-20 |
| JPS60149568A (ja) | 1985-08-07 |
| AU566437B2 (en) | 1987-10-22 |
| ATE32064T1 (de) | 1988-02-15 |
| US4584383A (en) | 1986-04-22 |
| ES8507507A1 (es) | 1985-09-01 |
| DK471384A (da) | 1985-04-19 |
| AU3426384A (en) | 1985-04-26 |
| NZ209896A (en) | 1987-02-20 |
| NO844139L (no) | 1985-04-19 |
| NO159167C (no) | 1988-12-07 |
| ZA848112B (en) | 1985-06-26 |
| IL73255A (en) | 1988-11-30 |
| DK174201B1 (da) | 2002-09-16 |
| UA5972A1 (uk) | 1994-12-29 |
| IE842652L (en) | 1985-04-18 |
| IE57591B1 (en) | 1993-01-13 |
| SU1301313A3 (ru) | 1987-03-30 |
| IL73255A0 (en) | 1985-01-31 |
| NO159167B (no) | 1988-08-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application lapsed |
Owner name: FARMOS-YHTYMAE OY |