FI833794A0 - SUBSTITUERADE 2-MERKAPTO-IMIDAZOLER - Google Patents

SUBSTITUERADE 2-MERKAPTO-IMIDAZOLER

Info

Publication number
FI833794A0
FI833794A0 FI833794A FI833794A FI833794A0 FI 833794 A0 FI833794 A0 FI 833794A0 FI 833794 A FI833794 A FI 833794A FI 833794 A FI833794 A FI 833794A FI 833794 A0 FI833794 A0 FI 833794A0
Authority
FI
Finland
Prior art keywords
formula
group
compounds
image
aldehyde
Prior art date
Application number
FI833794A
Other languages
Finnish (fi)
Inventor
Seppo S L Parhi
Original Assignee
Farmos Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmos Oy filed Critical Farmos Oy
Priority to FI833794A priority Critical patent/FI833794A0/en
Publication of FI833794A0 publication Critical patent/FI833794A0/en
Priority to ES536186A priority patent/ES536186A0/en
Priority to DK198404713A priority patent/DK174201B1/en
Priority to DE8484307095T priority patent/DE3468869D1/en
Priority to AT84307095T priority patent/ATE32064T1/en
Priority to NZ209896A priority patent/NZ209896A/en
Priority to JP59218160A priority patent/JPS60149568A/en
Priority to DD84268430A priority patent/DD236730A1/en
Priority to EP84307095A priority patent/EP0146228B1/en
Priority to US06/661,487 priority patent/US4584383A/en
Priority to AU34263/84A priority patent/AU566437B2/en
Priority to IE2652/84A priority patent/IE57591B1/en
Priority to IL73255A priority patent/IL73255A/en
Priority to UA3801008A priority patent/UA5972A1/en
Priority to ZA848112A priority patent/ZA848112B/en
Priority to HU843890A priority patent/HU191960B/en
Priority to NO844139A priority patent/NO159167C/en
Priority to SU843801008A priority patent/SU1301313A3/en
Priority to FI844079A priority patent/FI69302C/en
Priority to LV920317A priority patent/LV5065A3/en
Priority to LTRP767A priority patent/LT2219B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms

Abstract

The invention provides novel 1-substituted-5-hydroxymethyl-2-mercapto-imidazoles of the formula <IMAGE> (I) wherein R is pyridylmethyl, alkyl of 1 to 4 carbon atoms, or a radical of formula: <IMAGE> in which R1 is hydrogen or halogen and n is 1-3. These compounds are prepared by reacting together dihydroxyacetone dimer, the amine R-NH2, and potassium thiocyanate. The compounds of formula (I) are useful as starting materials in the preparation of known therapeutically valuable imidazole derivatives, by removing the mercapto group, oxidizing the alcohol group to an aldehyde group and condensing the aldehyde with an appropriate phenyl or phenylalkyl magnesium halide.
FI833794A 1983-10-18 1983-10-18 SUBSTITUERADE 2-MERKAPTO-IMIDAZOLER FI833794A0 (en)

Priority Applications (21)

Application Number Priority Date Filing Date Title
FI833794A FI833794A0 (en) 1983-10-18 1983-10-18 SUBSTITUERADE 2-MERKAPTO-IMIDAZOLER
ES536186A ES536186A0 (en) 1983-10-18 1984-09-24 A PROCEDURE TO PREPARE SUBSTITUTED 5-HYDROXIMETIL-2-MERCAPTO-IMIDAZOLES IN POSITION 1
DK198404713A DK174201B1 (en) 1983-10-18 1984-10-02 Substituted 2-mercoptoimidazoles or acid addition salts thereof and process for the preparation of these compounds
AT84307095T ATE32064T1 (en) 1983-10-18 1984-10-16 SUBSTITUTED 2-MERCAPTO-IMIDAZOLE AND THEIR PREPARATION AND APPLICATION.
EP84307095A EP0146228B1 (en) 1983-10-18 1984-10-16 Substituted 2-mercapto-imidazoles and their preparation and use
IL73255A IL73255A (en) 1983-10-18 1984-10-16 2-mercapto-5-hydroxymethyl-imidazole derivatives and their preparation
NZ209896A NZ209896A (en) 1983-10-18 1984-10-16 5-hydroxymethyl-2-mercapto-imidazoles preparation of 5-formyl-imidazoles
JP59218160A JPS60149568A (en) 1983-10-18 1984-10-16 1-substituted-5-hydroxymethyl-2-mercapto-imidazoles and manufacture
DD84268430A DD236730A1 (en) 1983-10-18 1984-10-16 PROCESS FOR PREPARING 1-SUBSTITUTED 5-HYDROXYMETHYL-2-MERKAPTO-IMIDAZOLENE
DE8484307095T DE3468869D1 (en) 1983-10-18 1984-10-16 Substituted 2-mercapto-imidazoles and their preparation and use
US06/661,487 US4584383A (en) 1983-10-18 1984-10-16 Substituted 2-mercapto-imidazoles and their preparation
AU34263/84A AU566437B2 (en) 1983-10-18 1984-10-16 Substituted-2-mercapto-imidazoles
IE2652/84A IE57591B1 (en) 1983-10-18 1984-10-16 Substituted 2-mercapto-imidazoles and their preparation and use
UA3801008A UA5972A1 (en) 1983-10-18 1984-10-17 Process for the preparation of substituted 2-mercaptoimidazoles
FI844079A FI69302C (en) 1983-10-18 1984-10-17 1-SUBSTITUTE 5-HYDROXIMETHYL-2-MERKAPTO-IMIDAZOLER
ZA848112A ZA848112B (en) 1983-10-18 1984-10-17 Substituted 2-mercapto-imidazoles and their perparation and use
HU843890A HU191960B (en) 1983-10-18 1984-10-17 Process for preparing substituted 2-mercapto-imidazoles
NO844139A NO159167C (en) 1983-10-18 1984-10-17 NEW 1-SUBSTITUTED-5-HYDROXYMETHYL-2-MERCAPTO IMIDAZOLE DERIVATIVES AND PROCEDURES FOR PREPARING THEREOF.
SU843801008A SU1301313A3 (en) 1983-10-18 1984-10-17 Method for producing substituted 2-mercapto-imidazoles
LV920317A LV5065A3 (en) 1983-10-18 1992-12-17 Method of obtaining substituted 2-mercapto-imidazoles
LTRP767A LT2219B (en) 1983-10-18 1993-07-07 THE DRAFT RECEIPT OF THE 2-MERKAPTO-IMIDAZOLU

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FI833794A FI833794A0 (en) 1983-10-18 1983-10-18 SUBSTITUERADE 2-MERKAPTO-IMIDAZOLER

Publications (1)

Publication Number Publication Date
FI833794A0 true FI833794A0 (en) 1983-10-18

Family

ID=8517935

Family Applications (1)

Application Number Title Priority Date Filing Date
FI833794A FI833794A0 (en) 1983-10-18 1983-10-18 SUBSTITUERADE 2-MERKAPTO-IMIDAZOLER

Country Status (18)

Country Link
US (1) US4584383A (en)
EP (1) EP0146228B1 (en)
JP (1) JPS60149568A (en)
AT (1) ATE32064T1 (en)
AU (1) AU566437B2 (en)
DD (1) DD236730A1 (en)
DE (1) DE3468869D1 (en)
DK (1) DK174201B1 (en)
ES (1) ES536186A0 (en)
FI (1) FI833794A0 (en)
HU (1) HU191960B (en)
IE (1) IE57591B1 (en)
IL (1) IL73255A (en)
NO (1) NO159167C (en)
NZ (1) NZ209896A (en)
SU (1) SU1301313A3 (en)
UA (1) UA5972A1 (en)
ZA (1) ZA848112B (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4634711A (en) * 1985-08-02 1987-01-06 Smithkline Beckman Corporation Pyridylalkyl imidazole-2-thiols
US5138069A (en) * 1986-07-11 1992-08-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
FI91754C (en) * 1986-12-02 1994-08-10 Tanabe Seiyaku Co An analogous method for preparing an imidazole derivative useful as a medicament
US4882348A (en) * 1987-12-29 1989-11-21 Smithkline Beckman Corporation 2-(aminoalkylthio)imidazoles as dopamine-β-hydroxylase inhibitors
US4880804A (en) * 1988-01-07 1989-11-14 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking benzimidazoles
CA1338238C (en) 1988-01-07 1996-04-09 David John Carini Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids
US5210079A (en) * 1988-01-07 1993-05-11 E. I. Du Pont De Nemours And Company Treatment of chronic renal failure with imidazole angiotensin-II receptor antagonists
US5354867A (en) * 1988-12-06 1994-10-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
EP0479892A1 (en) * 1989-06-30 1992-04-15 E.I. Du Pont De Nemours And Company Fused-ring aryl substituted imidazoles
US5073566A (en) * 1989-11-30 1991-12-17 Eli Lilly And Company Angiotensin ii antagonist 1,3-imidazoles and use thereas
US5332820A (en) * 1991-05-20 1994-07-26 E. I. Du Pont De Nemours And Company Dibenzobicyclo(2.2.2) octane angiotensin II antagonists
US5612360A (en) * 1992-06-03 1997-03-18 Eli Lilly And Company Angiotensin II antagonists
US5401851A (en) * 1992-06-03 1995-03-28 Eli Lilly And Company Angiotensin II antagonists
IT1295405B1 (en) 1997-09-30 1999-05-12 Merck Sharp & Dohme Italia S P USE OF AN ANGIOTENSIN II RECEPTORAL ANTAGONIST FOR DRUG PREPARATION TO INCREASE THE SURVIVAL RATE OF
KR100567183B1 (en) * 1997-11-14 2006-06-13 론자 아게 How to prepare formyl imidazole
KR100388788B1 (en) * 1999-09-06 2003-06-25 주식회사 엘지생명과학 A novel process for preparing 1-substituted-5-hydroxymethyl imidazole
AU7040500A (en) 1999-09-06 2001-04-10 Lg Chem Investment Ltd. Process for preparing a 1-substituted 5-hydroxymethyl imidazole
US6620939B2 (en) * 2001-09-18 2003-09-16 General Electric Company Method for producing bisphenol catalysts and bisphenols
US7112702B2 (en) * 2002-12-12 2006-09-26 General Electric Company Process for the synthesis of bisphenol
FI116292B (en) * 2003-01-08 2005-10-31 Juvantia Pharma Ltd Oy Process for the preparation of substituted imidazole derivatives and in the process useful intermediates
US7132575B2 (en) * 2003-07-01 2006-11-07 General Electric Company Process for the synthesis of bisphenol
FI20050391A0 (en) * 2005-04-15 2005-04-15 Orion Corp Crystallization method for detomidine hydrochloride
CN101747280B (en) * 2008-11-28 2011-11-09 上海迪赛诺医药发展有限公司 Method for preparing detomidine and the intermediate thereof
US20210323929A1 (en) 2018-07-18 2021-10-21 Clexio Biosciences Ltd. Purified Detomidine, Process of Preparing and Methods of Use
EP3782989A1 (en) 2019-08-23 2021-02-24 Andreas Sachse Detomidine hydrochloride monohydrate

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2541924A (en) * 1948-09-17 1951-02-13 Lilly Co Eli Synthesis of substituted imidazoles
AU518569B2 (en) * 1979-08-07 1981-10-08 Farmos-Yhtyma Oy 4-benzyl- and 4-benzoyl imidazole derivatives
GB2092569B (en) * 1981-02-05 1984-09-19 Farmos Oy Substituted imidazole derivatives and their preparation and use

Also Published As

Publication number Publication date
NO159167B (en) 1988-08-29
EP0146228A1 (en) 1985-06-26
ZA848112B (en) 1985-06-26
DE3468869D1 (en) 1988-02-25
IL73255A (en) 1988-11-30
IL73255A0 (en) 1985-01-31
DK471384A (en) 1985-04-19
US4584383A (en) 1986-04-22
AU3426384A (en) 1985-04-26
ES8507507A1 (en) 1985-09-01
EP0146228B1 (en) 1988-01-20
DD236730A1 (en) 1986-06-18
SU1301313A3 (en) 1987-03-30
NZ209896A (en) 1987-02-20
NO844139L (en) 1985-04-19
ATE32064T1 (en) 1988-02-15
UA5972A1 (en) 1994-12-29
JPS60149568A (en) 1985-08-07
HUT35649A (en) 1985-07-29
AU566437B2 (en) 1987-10-22
IE842652L (en) 1985-04-18
HU191960B (en) 1987-04-28
DK471384D0 (en) 1984-10-02
DK174201B1 (en) 2002-09-16
NO159167C (en) 1988-12-07
ES536186A0 (en) 1985-09-01
IE57591B1 (en) 1993-01-13

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Legal Events

Date Code Title Description
FD Application lapsed

Owner name: FARMOS-YHTYMAE OY