SE7507726L - PROCEDURE FOR THE PREPARATION OF HYDROXIALKYLXANTINES. - Google Patents
PROCEDURE FOR THE PREPARATION OF HYDROXIALKYLXANTINES.Info
- Publication number
- SE7507726L SE7507726L SE7507726A SE7507726A SE7507726L SE 7507726 L SE7507726 L SE 7507726L SE 7507726 A SE7507726 A SE 7507726A SE 7507726 A SE7507726 A SE 7507726A SE 7507726 L SE7507726 L SE 7507726L
- Authority
- SE
- Sweden
- Prior art keywords
- atoms
- prepared
- radicals
- preparation
- monoalkenyldialkylxanthines
- Prior art date
Links
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- NSMXQKNUPPXBRG-UHFFFAOYSA-N 1-(5-hydroxyhexyl)-3,7-dimethyl-3,7-dihydro-1H-purine-2,6-dione Chemical compound O=C1N(CCCCC(O)C)C(=O)N(C)C2=C1N(C)C=N2 NSMXQKNUPPXBRG-UHFFFAOYSA-N 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- -1 alkali metal salt Chemical class 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/10—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 3 and 7, e.g. theobromine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
In the process there are prepared novel monoalkenyldialkylxanthines of the general formula I <IMAGE> One of the radicals R<1>, R<2> and R<3> is ( omega -1)-alken-1-yl having 4 to 8 C atoms, which does not have a branch in the ( omega -1)-position. The two other radicals are alkyl having 1 to 12 C atoms. According to the invention, a 1-halo-C4-C8-alkene having a terminal double bond, but not one containing a tertiary C atom, is reacted with an appropriate alkali metal salt of a dialkylxanthine. Haloalkenes having an unbranched carbon chain are preferably employed. Monoalkenyldialkylxanthines of the formula I may expediently be prepared in which one of the two alkyl radicals has 2 to 12 C atoms. The alkenylxanthines prepared are useful as starting substances for the preparation of therapeutically utilisable hydroxyalkylxanthine compounds, of which e.g. 1-(5'-hydroxyhexyl)theobromine is distinguished by promotion of the circulation.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48587074A | 1974-07-05 | 1974-07-05 | |
| US05/485,869 US4108995A (en) | 1973-07-11 | 1974-07-05 | Hydroxyhexyl-alkylxanthines and pharmaceutical compositions containing hydroxyhexyl-alkylxanthines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE7507726L true SE7507726L (en) | 1976-01-07 |
| SE420097B SE420097B (en) | 1981-09-14 |
Family
ID=27048497
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7507726A SE420097B (en) | 1974-07-05 | 1975-07-04 | PROCEDURE FOR THE PREPARATION OF HYDROXIAL CHYLXANTINES |
| SE7807853A SE427183B (en) | 1974-07-05 | 1978-07-14 | MONO- (ALKEN-1-YL) -XANTINES FOR USE AS INTERMEDIATES IN THE PREPARATION OF THERAPEUTIC VALUABLE HYDROXIAL COOLXANTIN COMPOUNDS |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7807853A SE427183B (en) | 1974-07-05 | 1978-07-14 | MONO- (ALKEN-1-YL) -XANTINES FOR USE AS INTERMEDIATES IN THE PREPARATION OF THERAPEUTIC VALUABLE HYDROXIAL COOLXANTIN COMPOUNDS |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JPS5250800B2 (en) |
| AR (1) | AR210330A1 (en) |
| AT (1) | AT339917B (en) |
| CA (1) | CA1062710A (en) |
| CH (2) | CH622519A5 (en) |
| DK (1) | DK140214B (en) |
| ES (1) | ES439141A1 (en) |
| FI (1) | FI59249C (en) |
| FR (1) | FR2277089A1 (en) |
| GB (1) | GB1500039A (en) |
| LU (1) | LU72897A1 (en) |
| NL (1) | NL166476C (en) |
| NO (1) | NO143224C (en) |
| SE (2) | SE420097B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL193541C (en) * | 1984-01-12 | 2000-01-04 | Novartis Ag | Alpha-acylaminoergolines, methods for their preparation, and preparations containing them. |
| DE3525801A1 (en) * | 1985-07-19 | 1987-01-22 | Hoechst Ag | TERTIA HYDROXYALKYLXANTHINE, METHOD FOR THE PRODUCTION THEREOF, THE MEDICINAL PRODUCT CONTAINING IT AND THEIR USE |
| EP0570831A2 (en) * | 1992-05-20 | 1993-11-24 | Hoechst Aktiengesellschaft | Use of Xanthinderivatives for treatment of cerebral nerve dammages after disruption of the blood circulation |
-
1975
- 1975-07-02 CH CH859275A patent/CH622519A5/en not_active IP Right Cessation
- 1975-07-03 JP JP50081475A patent/JPS5250800B2/ja not_active Expired
- 1975-07-03 LU LU72897A patent/LU72897A1/xx unknown
- 1975-07-03 DK DK301775AA patent/DK140214B/en not_active IP Right Cessation
- 1975-07-04 NO NO752423A patent/NO143224C/en unknown
- 1975-07-04 AT AT517275A patent/AT339917B/en not_active IP Right Cessation
- 1975-07-04 GB GB28341/75A patent/GB1500039A/en not_active Expired
- 1975-07-04 ES ES439141A patent/ES439141A1/en not_active Expired
- 1975-07-04 FI FI751958A patent/FI59249C/en not_active IP Right Cessation
- 1975-07-04 AR AR258487A patent/AR210330A1/en active
- 1975-07-04 NL NL7507976.A patent/NL166476C/en not_active IP Right Cessation
- 1975-07-04 SE SE7507726A patent/SE420097B/en not_active IP Right Cessation
- 1975-07-04 FR FR7521043A patent/FR2277089A1/en active Granted
- 1975-07-04 CA CA230,790A patent/CA1062710A/en not_active Expired
-
1978
- 1978-07-14 SE SE7807853A patent/SE427183B/en not_active IP Right Cessation
-
1980
- 1980-04-29 CH CH331680A patent/CH622018A5/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DK140214C (en) | 1979-12-03 |
| NO143224C (en) | 1981-01-02 |
| SE427183B (en) | 1983-03-14 |
| FI59249B (en) | 1981-03-31 |
| NL7507976A (en) | 1976-01-07 |
| NO752423L (en) | 1976-01-06 |
| CA1062710A (en) | 1979-09-18 |
| FI751958A (en) | 1976-01-06 |
| ATA517275A (en) | 1977-03-15 |
| DK140214B (en) | 1979-07-09 |
| GB1500039A (en) | 1978-02-08 |
| NL166476C (en) | 1981-08-17 |
| CH622018A5 (en) | 1981-03-13 |
| FR2277089A1 (en) | 1976-01-30 |
| FR2277089B1 (en) | 1978-03-17 |
| NL166476B (en) | 1981-03-16 |
| DK301775A (en) | 1976-01-06 |
| AU8275575A (en) | 1977-01-06 |
| AR210330A1 (en) | 1977-07-29 |
| JPS5250800B2 (en) | 1977-12-27 |
| CH622519A5 (en) | 1981-04-15 |
| NO143224B (en) | 1980-09-22 |
| LU72897A1 (en) | 1976-05-31 |
| ES439141A1 (en) | 1977-02-16 |
| JPS5134194A (en) | 1976-03-23 |
| SE420097B (en) | 1981-09-14 |
| AT339917B (en) | 1977-11-10 |
| FI59249C (en) | 1981-07-10 |
| SE7807853L (en) | 1978-07-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE3468869D1 (en) | Substituted 2-mercapto-imidazoles and their preparation and use | |
| KR870006039A (en) | Novel thiazole compound, preparation method thereof and pharmaceutical composition containing the compound | |
| UA7228A1 (en) | Method for synthesizing derivatives of n-(4-indolylpiperidine alkyl) benzimidazolon or their salts | |
| ES437997A1 (en) | X-ray contrast media | |
| NO165921C (en) | PROCEDURE FOR THE PREPARATION OF DISUBSTITUTED PROLINE DERIVATIVES. | |
| CH614448A5 (en) | Process for the preparation of novel tertiary amines and their acid addition salts, and compounds thus prepared | |
| SE7507726L (en) | PROCEDURE FOR THE PREPARATION OF HYDROXIALKYLXANTINES. | |
| FR2358141A1 (en) | NEW LOCAL ANESTHESICS | |
| ATE25666T1 (en) | PROCESS FOR THE PRODUCTION OF DIAMINOALCOHOLS. | |
| ES378824A1 (en) | Procedure for the preparation of hydroxyrotonic acid lactons. (Machine-translation by Google Translate, not legally binding) | |
| FR2359832A1 (en) | 1,3,5-TRIS- (2-CHLOROFORMYL-OXYETHYL) -ISOCYANURATE | |
| SE7714656L (en) | SULFAMOYLBENZOIC ACIDS | |
| ATE35261T1 (en) | 4-ETHYL-2-HYDROXY-3-METHYL-2-PHENYLMORPHOLINE AND ITS ADDITION SALTS. | |
| ES399003A1 (en) | 2-aryl-amino-imidazoline-2 compounds | |
| GB845486A (en) | Improvements in or relating to 2-diarylalkyl-3,4,5,6-tetrahydropyrimidines | |
| ES365218A1 (en) | Beta-alkoxy-acrylic acid amides | |
| GB1325944A (en) | Bisoxalic acid diamides | |
| GB1522537A (en) | 2,4-diamino-5-benzylpyrimidines | |
| GB1540049A (en) | 9,11-bridged prostaglandins | |
| ATE29253T1 (en) | PROCESS FOR THE PREPARATION OF 4-QUINOLINONES. | |
| ES428968A1 (en) | Procedure for the preparation of 1, 2, 2, 2-tetrafluoraltil-eteres. (Machine-translation by Google Translate, not legally binding) | |
| ATE24899T1 (en) | PROCESS FOR THE PREPARATION OF 4-QUINOLINONES. | |
| ES398232A1 (en) | A procedure for the preparation of replaced indenilactic acid esters. (Machine-translation by Google Translate, not legally binding) | |
| ES428624A1 (en) | Procedure for the preparation of pyrimidine derivatives. (Machine-translation by Google Translate, not legally binding) | |
| CH623443GA3 (en) | Process for the preparation of stilbene compounds and their use as optical brighteners |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NUG | Patent has lapsed |
Ref document number: 7507726-3 Effective date: 19940210 Format of ref document f/p: F |