GB1500039A - Alkenylxanthines and their conversion to hydroxyalkylxanthines - Google Patents

Alkenylxanthines and their conversion to hydroxyalkylxanthines

Info

Publication number
GB1500039A
GB1500039A GB28341/75A GB2834175A GB1500039A GB 1500039 A GB1500039 A GB 1500039A GB 28341/75 A GB28341/75 A GB 28341/75A GB 2834175 A GB2834175 A GB 2834175A GB 1500039 A GB1500039 A GB 1500039A
Authority
GB
United Kingdom
Prior art keywords
atoms
prepared
radicals
alkenylxanthines
monoalkenyldialkylxanthines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB28341/75A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/485,869 external-priority patent/US4108995A/en
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of GB1500039A publication Critical patent/GB1500039A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/10—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 3 and 7, e.g. theobromine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline

Abstract

In the process there are prepared novel monoalkenyldialkylxanthines of the general formula I <IMAGE> One of the radicals R<1>, R<2> and R<3> is ( omega -1)-alken-1-yl having 4 to 8 C atoms, which does not have a branch in the ( omega -1)-position. The two other radicals are alkyl having 1 to 12 C atoms. According to the invention, a 1-halo-C4-C8-alkene having a terminal double bond, but not one containing a tertiary C atom, is reacted with an appropriate alkali metal salt of a dialkylxanthine. Haloalkenes having an unbranched carbon chain are preferably employed. Monoalkenyldialkylxanthines of the formula I may expediently be prepared in which one of the two alkyl radicals has 2 to 12 C atoms. The alkenylxanthines prepared are useful as starting substances for the preparation of therapeutically utilisable hydroxyalkylxanthine compounds, of which e.g. 1-(5'-hydroxyhexyl)theobromine is distinguished by promotion of the circulation.
GB28341/75A 1974-07-05 1975-07-04 Alkenylxanthines and their conversion to hydroxyalkylxanthines Expired GB1500039A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48587074A 1974-07-05 1974-07-05
US05/485,869 US4108995A (en) 1973-07-11 1974-07-05 Hydroxyhexyl-alkylxanthines and pharmaceutical compositions containing hydroxyhexyl-alkylxanthines

Publications (1)

Publication Number Publication Date
GB1500039A true GB1500039A (en) 1978-02-08

Family

ID=27048497

Family Applications (1)

Application Number Title Priority Date Filing Date
GB28341/75A Expired GB1500039A (en) 1974-07-05 1975-07-04 Alkenylxanthines and their conversion to hydroxyalkylxanthines

Country Status (14)

Country Link
JP (1) JPS5250800B2 (en)
AR (1) AR210330A1 (en)
AT (1) AT339917B (en)
CA (1) CA1062710A (en)
CH (2) CH622519A5 (en)
DK (1) DK140214B (en)
ES (1) ES439141A1 (en)
FI (1) FI59249C (en)
FR (1) FR2277089A1 (en)
GB (1) GB1500039A (en)
LU (1) LU72897A1 (en)
NL (1) NL166476C (en)
NO (1) NO143224C (en)
SE (2) SE420097B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH664568A5 (en) * 1984-01-12 1988-03-15 Sandoz Ag 8-ALPHA ACYLAMINE OERGOLINE.
DE3525801A1 (en) * 1985-07-19 1987-01-22 Hoechst Ag TERTIA HYDROXYALKYLXANTHINE, METHOD FOR THE PRODUCTION THEREOF, THE MEDICINAL PRODUCT CONTAINING IT AND THEIR USE
EP0570831A2 (en) * 1992-05-20 1993-11-24 Hoechst Aktiengesellschaft Use of Xanthinderivatives for treatment of cerebral nerve dammages after disruption of the blood circulation

Also Published As

Publication number Publication date
DK140214B (en) 1979-07-09
DK301775A (en) 1976-01-06
NL7507976A (en) 1976-01-07
NL166476C (en) 1981-08-17
ATA517275A (en) 1977-03-15
AT339917B (en) 1977-11-10
FR2277089B1 (en) 1978-03-17
AU8275575A (en) 1977-01-06
DK140214C (en) 1979-12-03
JPS5134194A (en) 1976-03-23
NO752423L (en) 1976-01-06
SE427183B (en) 1983-03-14
SE7807853L (en) 1978-07-14
NO143224B (en) 1980-09-22
CA1062710A (en) 1979-09-18
AR210330A1 (en) 1977-07-29
CH622519A5 (en) 1981-04-15
CH622018A5 (en) 1981-03-13
FR2277089A1 (en) 1976-01-30
LU72897A1 (en) 1976-05-31
FI751958A (en) 1976-01-06
SE7507726L (en) 1976-01-06
FI59249B (en) 1981-03-31
FI59249C (en) 1981-07-10
NO143224C (en) 1981-01-02
ES439141A1 (en) 1977-02-16
NL166476B (en) 1981-03-16
JPS5250800B2 (en) 1977-12-27
SE420097B (en) 1981-09-14

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19930704