KR920021562A - 3-피라진 유도체 치환된 세팔로스포린 화합물 - Google Patents

3-피라진 유도체 치환된 세팔로스포린 화합물 Download PDF

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Publication number
KR920021562A
KR920021562A KR1019910007082A KR910007082A KR920021562A KR 920021562 A KR920021562 A KR 920021562A KR 1019910007082 A KR1019910007082 A KR 1019910007082A KR 910007082 A KR910007082 A KR 910007082A KR 920021562 A KR920021562 A KR 920021562A
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South Korea
Prior art keywords
triazolo
pyrazin
methyl
thiomethyl
oxo
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KR1019910007082A
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English (en)
Inventor
서정진
채정석
임성택
이영남
강희일
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연만희
주식회사 유한양행
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Priority to KR1019910007082A priority Critical patent/KR920021562A/ko
Publication of KR920021562A publication Critical patent/KR920021562A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/48—Methylene radicals, substituted by hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

3-피라진 유도체 치환된 세팔로스포린 화합물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (7)

  1. 광범위 항균력을 갖는 하기 일반식의 화합물들과 이들의 약제학으로 허용가능한 무독성염.
    상기 일반식에서,
    R1은 H, -CH3, -CH2COOH,
    R2는 (8-옥소-7,8-디히드로-1,2,4-트리아졸로[4,3-a]피리진-7-일)메틸, 8-옥소-7,8-디히드로-3-메틸-1,2,4-트리아졸로[4,3-a] 피라진-7-일)메틸, (8-옥소-7,8-디히드로-3-트리플루오로메틸-1,2,4-트리아졸로[4,3-a]피라진-7-일)메틸, (1,2,4-트리아졸로[4,3-a]피라진-8-일)티오메틸, 4-옥소-1,2,4-트리아졸로[4,3-a]퀴녹살린-5-일)메틸, (1,2,4-트리아졸로[4,3-a]퀴녹살린-4-일)티오메틸, s-테트라졸로[1,5-a]피라진-8-일) 티오메틸이다.
  2. (6R,7R)-7-[(Z)-2-(2-아미노티아졸-4-일)-2-메톡시이미노아세트아미도-3-[8-옥소-7,8-디히드로-1,2,4-트리아졸로[4,3-a]피라진-7-일)메틸]-3-세펨-4-카르복실산 및 그의 약제학적으로 허용가능한 무독성염.
  3. (6R,7R)-7-[(Z)-2-(2-아미노티아졸-4-일)-2-메톡시이미노아세트아미도-3-[1,2,4-트리아졸로[4,3-a]피라진-8-일)티오메틸]-3-세펨-4-카르복실산 및 그의 약제학적으로 허용가능한 무독성염.
  4. (6R,7R)-7-[(Z)-2-(2-아미노티아졸-4-일)-2-(1,5-디히드록시-4-피리돈-2-일)메톡시이미노아세트아미도]-3-[(1,2,4-트리아졸로[4,3-a]피라진-8-일)티오메틸]-3-세펨-4-카르복실산 및 그의 약제학적으로 허용가능한 무독성염.
  5. (6R,7R)-7-[(Z)-2-(2-아미노티아졸-4-일)-2-메톡시이미노아세트아미도]-3-[(s-테트라졸로[1,5-a]피라진-8-일)티오메틸]-3-세펨-4-카르복실산 및 그의 약제학적으로 허용가능한 무독성염.
  6. (6R,7R)-7-[(Z)-2-(2-아미노티아졸-4-일)-2-(1,5-디히드록시-4-피리돈-2-일)메톡시이미노아세트아미도]-3-[(s-테트라졸로[1,5-a]피라진-8-일)티오메틸]-3-세펨-4-카르복실산 및 그의 약제학적으로 허용가능한 무독성염.
  7. 일반식(II)의 7-아미노세팔로스포란산과 일반식(IIIa,IIIb,IIIc, 및 IIId)의 피라진유도체를 반응시켜 중간체인 일반식(IV)의 화합물을 합성한 후 일반식(V)나 일반식(VI)의 화합물을 반응시켜 일반식(I)의 화합물을 제조하는 방법.
    상기 일반식에서,
    R1은 H, -CH3, -CH2COOH,또는기이고,
    R2는 (8-옥소-7,8-디히드로-1,2,4-트리아졸로[4,3-a]피리진-7-일)메틸, 8-옥소-7,8-디히드록시-3-메틸-1,2,4-트리아졸로[4,3-a]피라진-7-일)메틸, (8-옥소-7,8-디히드로-3-트리플루오로메틸-1,2,4-트리아졸로[4,3-a]피라진-7-일)메틸, (1,2,4-트리아졸로[4,3-a]피라진-8-일)티오메틸, (4-옥소-1,2,4-트리아졸로[4,3-a]퀴녹살린-5-일)메틸, (1,2,4-트리아졸로[4,3-a]퀴녹살린-4-일)티오메틸 또는 (s-테트라졸로[1,5-a]피라진-8-일)티오메틸이며, R3는 H, CF3또는 CH3를 나타내고, X 및 Y는 각각 N 또는 CH를 표시한다.
    ※ 참고사항:최초출원 내용에 의하여 공개하는 것임.
KR1019910007082A 1991-05-02 1991-05-02 3-피라진 유도체 치환된 세팔로스포린 화합물 KR920021562A (ko)

Priority Applications (1)

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KR1019910007082A KR920021562A (ko) 1991-05-02 1991-05-02 3-피라진 유도체 치환된 세팔로스포린 화합물

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KR1019910007082A KR920021562A (ko) 1991-05-02 1991-05-02 3-피라진 유도체 치환된 세팔로스포린 화합물

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KR920021562A true KR920021562A (ko) 1992-12-18

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114715287A (zh) * 2022-03-01 2022-07-08 浙江零跑科技股份有限公司 一种平齐车门c柱结构

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114715287A (zh) * 2022-03-01 2022-07-08 浙江零跑科技股份有限公司 一种平齐车门c柱结构

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