KR920009404A - 위 체류 시간 지연성 제산제 - Google Patents
위 체류 시간 지연성 제산제 Download PDFInfo
- Publication number
- KR920009404A KR920009404A KR1019910020421A KR910020421A KR920009404A KR 920009404 A KR920009404 A KR 920009404A KR 1019910020421 A KR1019910020421 A KR 1019910020421A KR 910020421 A KR910020421 A KR 910020421A KR 920009404 A KR920009404 A KR 920009404A
- Authority
- KR
- South Korea
- Prior art keywords
- antacid
- anionic polymer
- water
- weight
- insoluble anionic
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
- A61K31/78—Polymers containing oxygen of acrylic acid or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/08—Oxides; Hydroxides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 실시예 1에 따른 정제의 제산 활성 시험 결과를 나타낸 도면.
Claims (9)
- 결합제로서 수불용 음이온성 폴리머를 사용하여 폴리카르보필의 칼슘염과 함께 응집된 제산 유효화합물을 함유하고, 위 점막에 고접착성(생물학적 접착성)을 갖고 있어서 결과적으로 위 통과가 지연되는 것이 특징은 위 체류시간 지연성 제산 제제.
- 제1항에 있어서, 제산 유효화합물 1중량부, 칼슘 폴리카르보필 0.1 내지 5중량부, 수불용 음이온성 폴리머 0.01 내지 1중량부 및 적합한 경우에 추가로 다른 종류의 통상적인 보조제 및 첨가제를 함유하는 것이 특징인 제산 제제.
- 제1항 또는 항에 있어서, 0.1 내지 0.5 중량부의 수불용 음이온성 폴리머를 함유하는 것이 특징인 제산 제제.
- 제1항 내지 3항중 어느 한 항에 있어서, 알루미늄 및/또는 마그네슘을 함유하고, 층격자 구조를 갖는 제산 유효 화합물을 함유하는 것이 특징인 제산 제제.
- 제1항 내지 4항중 어느 한 항에 있어서, 유효 화합물로서 히드로탈사이트, 마갈드레이트 또는 알마게이트를 함유하는 것이 특징인 제산제제.
- 15㎛ 이하의 평균입도를 갖는 칼슘 폴리카르보필을 함유하는 제산 제제.
- 수불용 음이온성 폴리머로서, 폴리아크릴산/메타크릴레이트코폴리머, 셀룰로오스 아세테이트 프탈레이트, 히드록시프로필 메틸셀룰로오스 프탈레이트, 셀룰로오스 아세테이트 석시네이트, 셀룰로오스 아세테이트 아디페이트 및/또는 셸락(shellac)으로 이루어진 군으로부터 선택된 화합물을 함유하는 제산 제제.
- 제1항 내지 7항중 어느 한 항에서, 제산 응집물이 25 내지 2000㎛의 평균 입도를 갖는 것이 특징인 제산 제제.
- a) 제산유효물질, b)칼슘 폴리카르보닐 및 c)수불용 음이온성 폴리머의 3가지 성분들으 혼합기 또는 유동상 장치 중의 습윤성 과립화, 건조 과립와, 압출, 구형화 및 펠렛화 등의 통상적인 응집 기법을 사용하여 응집시키고, 생성된 응집물을 통상적인 보조제 및 부형제를 사용하여 적합한 투여 형태로 전환시킬수 있는 것이 특징인 제1항에 의한 제산 제제의 제조방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEP4036757.6 | 1990-11-17 | ||
DE4036757A DE4036757A1 (de) | 1990-11-17 | 1990-11-17 | Antazida-zubereitung mit verlaengerter magenverweilzeit |
Publications (1)
Publication Number | Publication Date |
---|---|
KR920009404A true KR920009404A (ko) | 1992-06-25 |
Family
ID=6418502
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019910020421A KR920009404A (ko) | 1990-11-17 | 1991-11-16 | 위 체류 시간 지연성 제산제 |
Country Status (10)
Country | Link |
---|---|
US (1) | US5213794A (ko) |
EP (1) | EP0486863B1 (ko) |
JP (1) | JPH04290816A (ko) |
KR (1) | KR920009404A (ko) |
AT (1) | ATE127019T1 (ko) |
CA (1) | CA2055536A1 (ko) |
DE (2) | DE4036757A1 (ko) |
DK (1) | DK0486863T3 (ko) |
ES (1) | ES2077766T3 (ko) |
GR (1) | GR3017267T3 (ko) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20230067207A (ko) * | 2021-11-09 | 2023-05-16 | 오미경 | 식물의 저온 피해 예방을 위한 나노화공법을 이용한 냉해예방제 및 그 제조방법 |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5286489A (en) * | 1985-08-26 | 1994-02-15 | The Procter & Gamble Company | Taste masking compositions |
DE9212938U1 (de) * | 1992-09-25 | 1992-11-26 | Boehringer Ingelheim Gmbh, 6507 Ingelheim | Calciumpolycarbophil-Zubereitung zur Einnahme hoher Wirkstoffdosen |
US6224911B1 (en) * | 1993-03-16 | 2001-05-01 | Syntex (U.S.A.) Llc | Process for the preparation of enteric coated pharmaceutical dosage forms |
US5622980A (en) * | 1993-08-17 | 1997-04-22 | Applied Analytical Industries, Inc. | Oral compositions of H2-antagonists |
CA2191066A1 (en) * | 1994-06-06 | 1995-12-14 | Hiroyoshi Shiozawa | Solid antacid and process for producing the same |
GB9505032D0 (en) | 1995-03-13 | 1995-05-03 | Westminster Lab Ltd | Improvements in or relating to organic compositions |
ES2112747B1 (es) * | 1995-01-13 | 1999-09-16 | Almirall Prodesfarma Sa | Formulaciones farmaceuticas solidas orales para un carbonato basico de aluminio y magnesio con una disponibilidad palatabilidad mejorada. |
US6063398A (en) * | 1995-09-20 | 2000-05-16 | L'oreal | Cosmetic or dermopharmaceutical patch containing, in an anhydrous polymeric matrix, at least one active compound which is, in particular, unstable in oxidizing mediums, and at least one water-absorbing agent |
GB9720061D0 (en) | 1997-09-19 | 1997-11-19 | Crosfield Joseph & Sons | Metal compounds as phosphate binders |
PL342971A1 (en) * | 1998-03-20 | 2001-07-16 | Kowa Co | Medicinal compositions adhering to stomach/duodenum |
JPH11269064A (ja) * | 1998-03-20 | 1999-10-05 | Kowa Co | 胃・十二指腸付着性医薬組成物 |
FR2781152B1 (fr) * | 1998-07-20 | 2001-07-06 | Permatec Tech Ag | Utilisation d'un polymere de type acrylique en tant qu'agent de desagregation |
NZ518739A (en) * | 1999-11-02 | 2004-12-24 | Depomed Inc | Pharmacological inducement of the fed mode for enhanced drug administration to the stomach |
AU2141202A (en) * | 2000-12-05 | 2002-06-18 | Alexander Macgregor | Hydrostatic delivery system for controlled delivery of agent |
EP1245227A1 (en) * | 2001-03-31 | 2002-10-02 | Jagotec Ag | A pharmaceutical tablet system that floats in the stomach for programmed release of active substance and process of producing buoyant material contained in same |
FR2873113B1 (fr) * | 2004-07-19 | 2007-06-15 | Eurotab Sa | Produit solide compacte bicouche de purification d'eau |
FR2874325B1 (fr) * | 2004-08-19 | 2006-10-20 | Sanofi Synthelabo | Composition pharmaceutique sous forme de comprime a residence gastrique contenant de l'alfuzosine |
MY157620A (en) | 2006-01-31 | 2016-06-30 | Cytochroma Dev Inc | A granular material of a solid water-soluble mixed metal compound capable of binding phosphate |
CN101516780B (zh) * | 2006-07-31 | 2012-11-28 | 日本国土开发株式会社 | 类水滑石颗粒物及其制造方法 |
FR2906801B1 (fr) * | 2006-10-05 | 2008-12-12 | Eurotab Sa | Produit solide compacte bicouche de potabilisaton d'eau et procede de preparation. |
GB0714670D0 (en) * | 2007-07-27 | 2007-09-05 | Ineos Healthcare Ltd | Use |
GB0720220D0 (en) * | 2007-10-16 | 2007-11-28 | Ineos Healthcare Ltd | Compound |
TW201010743A (en) * | 2008-09-05 | 2010-03-16 | Otsuka Pharma Co Ltd | Pharmaceutical solid preparation |
EP2368544A4 (en) * | 2008-11-25 | 2012-08-15 | Mitsubishi Tanabe Pharma Corp | RAPID ORAL DELETING TABLET, AND PROCESS FOR PRODUCING THE SAME |
JP5249105B2 (ja) * | 2009-03-27 | 2013-07-31 | 協和化学工業株式会社 | 新規合成ハイドロタルサイト粒子 |
GB0913525D0 (en) | 2009-08-03 | 2009-09-16 | Ineos Healthcare Ltd | Method |
US9708415B2 (en) * | 2009-09-21 | 2017-07-18 | Virginia Tech Intellectual Properties, Inc. | Esters of cellulosic materials and diacids and method of making thereof |
GB201001779D0 (en) | 2010-02-04 | 2010-03-24 | Ineos Healthcare Ltd | Composition |
US20110195130A1 (en) * | 2010-02-09 | 2011-08-11 | Sanford Siegal | Edible compositions |
HU230560B1 (hu) * | 2010-07-30 | 2016-12-28 | Péter Hajnal | pH-függő szakaszos és nyújtott hatóanyagleadású gyógyszerkészítmény |
CN115777783A (zh) * | 2022-07-04 | 2023-03-14 | 浙江上方生物科技有限公司 | 一种防止胃食管倒流的健康饮料及其制备方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3555151A (en) * | 1966-12-21 | 1971-01-12 | Richardson Merrell Inc | Long acting solid antacid |
US4514389A (en) * | 1981-05-06 | 1985-04-30 | Kyowa Chemical Industry Co. Ltd. | Gastric antacid and method for controlling pH of gastric juice |
US4542019A (en) * | 1983-03-11 | 1985-09-17 | John Lezdey | Antacid compositions |
EP0163696B1 (en) * | 1983-11-14 | 1992-11-25 | Columbia Laboratories, Inc. | Use of a bioadhesive |
GB2201594B (en) * | 1986-06-24 | 1991-02-13 | Istvan Racz | Production of acid binding pharmaceutical preparations |
US4980175A (en) * | 1989-01-03 | 1990-12-25 | Leonard Chavkin | Liquid orally administrable compositions based on edible oils |
US4988679A (en) * | 1989-01-03 | 1991-01-29 | Leonard Chavkin | Liquid sustained release composition |
-
1990
- 1990-11-17 DE DE4036757A patent/DE4036757A1/de not_active Withdrawn
-
1991
- 1991-11-04 ES ES91118732T patent/ES2077766T3/es not_active Expired - Lifetime
- 1991-11-04 AT AT91118732T patent/ATE127019T1/de not_active IP Right Cessation
- 1991-11-04 DK DK91118732.6T patent/DK0486863T3/da active
- 1991-11-04 EP EP91118732A patent/EP0486863B1/de not_active Expired - Lifetime
- 1991-11-04 DE DE59106367T patent/DE59106367D1/de not_active Expired - Fee Related
- 1991-11-13 US US07/791,944 patent/US5213794A/en not_active Expired - Fee Related
- 1991-11-13 JP JP3324022A patent/JPH04290816A/ja active Pending
- 1991-11-14 CA CA002055536A patent/CA2055536A1/en not_active Abandoned
- 1991-11-16 KR KR1019910020421A patent/KR920009404A/ko active IP Right Grant
-
1995
- 1995-08-31 GR GR950402255T patent/GR3017267T3/el unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20230067207A (ko) * | 2021-11-09 | 2023-05-16 | 오미경 | 식물의 저온 피해 예방을 위한 나노화공법을 이용한 냉해예방제 및 그 제조방법 |
Also Published As
Publication number | Publication date |
---|---|
DE59106367D1 (de) | 1995-10-05 |
JPH04290816A (ja) | 1992-10-15 |
GR3017267T3 (en) | 1995-11-30 |
EP0486863A1 (de) | 1992-05-27 |
DK0486863T3 (da) | 1995-12-27 |
CA2055536A1 (en) | 1992-05-18 |
EP0486863B1 (de) | 1995-08-30 |
US5213794A (en) | 1993-05-25 |
DE4036757A1 (de) | 1992-05-21 |
ES2077766T3 (es) | 1995-12-01 |
ATE127019T1 (de) | 1995-09-15 |
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Legal Events
Date | Code | Title | Description |
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A201 | Request for examination | ||
E701 | Decision to grant or registration of patent right | ||
NORF | Unpaid initial registration fee |