KR920008068A - 치킨 아네미아 바이러스 왁찐 및 진단방법 - Google Patents
치킨 아네미아 바이러스 왁찐 및 진단방법 Download PDFInfo
- Publication number
- KR920008068A KR920008068A KR1019910019391A KR910019391A KR920008068A KR 920008068 A KR920008068 A KR 920008068A KR 1019910019391 A KR1019910019391 A KR 1019910019391A KR 910019391 A KR910019391 A KR 910019391A KR 920008068 A KR920008068 A KR 920008068A
- Authority
- KR
- South Korea
- Prior art keywords
- acid sequence
- cav
- sequence
- nucleic acid
- seq
- Prior art date
Links
- 241000725585 Chicken anemia virus Species 0.000 title description 2
- 238000003745 diagnosis Methods 0.000 title 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 9
- 108020004414 DNA Proteins 0.000 claims description 2
- 150000007523 nucleic acids Chemical group 0.000 claims 10
- 229920001184 polypeptide Polymers 0.000 claims 9
- 102000004196 processed proteins & peptides Human genes 0.000 claims 9
- 108090000765 processed proteins & peptides Proteins 0.000 claims 9
- 125000003275 alpha amino acid group Chemical group 0.000 claims 7
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical group CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims 7
- 241000700605 Viruses Species 0.000 claims 3
- 230000001900 immune effect Effects 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 101000787132 Acidithiobacillus ferridurans Uncharacterized 8.2 kDa protein in mobL 3'region Proteins 0.000 claims 2
- 101000827262 Acidithiobacillus ferrooxidans Uncharacterized 18.9 kDa protein in mobE 3'region Proteins 0.000 claims 2
- 101000811747 Antithamnion sp. UPF0051 protein in atpA 3'region Proteins 0.000 claims 2
- 101000666833 Autographa californica nuclear polyhedrosis virus Uncharacterized 20.8 kDa protein in FGF-VUBI intergenic region Proteins 0.000 claims 2
- 101000977023 Azospirillum brasilense Uncharacterized 17.8 kDa protein in nodG 5'region Proteins 0.000 claims 2
- 101000977027 Azospirillum brasilense Uncharacterized protein in nodG 5'region Proteins 0.000 claims 2
- 101000827607 Bacillus phage SPP1 Uncharacterized 8.5 kDa protein in GP2-GP6 intergenic region Proteins 0.000 claims 2
- 101000961975 Bacillus thuringiensis Uncharacterized 13.4 kDa protein Proteins 0.000 claims 2
- 101000962005 Bacillus thuringiensis Uncharacterized 23.6 kDa protein Proteins 0.000 claims 2
- 101000961984 Bacillus thuringiensis Uncharacterized 30.3 kDa protein Proteins 0.000 claims 2
- 101000964407 Caldicellulosiruptor saccharolyticus Uncharacterized 10.7 kDa protein in xynB 3'region Proteins 0.000 claims 2
- 101000644901 Drosophila melanogaster Putative 115 kDa protein in type-1 retrotransposable element R1DM Proteins 0.000 claims 2
- 101000785191 Drosophila melanogaster Uncharacterized 50 kDa protein in type I retrotransposable element R1DM Proteins 0.000 claims 2
- 101000747704 Enterobacteria phage N4 Uncharacterized protein Gp1 Proteins 0.000 claims 2
- 101000747702 Enterobacteria phage N4 Uncharacterized protein Gp2 Proteins 0.000 claims 2
- 101000861206 Enterococcus faecalis (strain ATCC 700802 / V583) Uncharacterized protein EF_A0048 Proteins 0.000 claims 2
- 101000769180 Escherichia coli Uncharacterized 11.1 kDa protein Proteins 0.000 claims 2
- 101000758599 Escherichia coli Uncharacterized 14.7 kDa protein Proteins 0.000 claims 2
- 101000768777 Haloferax lucentense (strain DSM 14919 / JCM 9276 / NCIMB 13854 / Aa 2.2) Uncharacterized 50.6 kDa protein in the 5'region of gyrA and gyrB Proteins 0.000 claims 2
- 101000607404 Infectious laryngotracheitis virus (strain Thorne V882) Protein UL24 homolog Proteins 0.000 claims 2
- 101000735632 Klebsiella pneumoniae Uncharacterized 8.8 kDa protein in aacA4 3'region Proteins 0.000 claims 2
- 101000768930 Lactococcus lactis subsp. cremoris Uncharacterized protein in pepC 5'region Proteins 0.000 claims 2
- 101000976301 Leptospira interrogans Uncharacterized 35 kDa protein in sph 3'region Proteins 0.000 claims 2
- 101000976302 Leptospira interrogans Uncharacterized protein in sph 3'region Proteins 0.000 claims 2
- 101000778886 Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601) Uncharacterized protein LA_2151 Proteins 0.000 claims 2
- 101000658690 Neisseria meningitidis serogroup B Transposase for insertion sequence element IS1106 Proteins 0.000 claims 2
- 101000748660 Pseudomonas savastanoi Uncharacterized 21 kDa protein in iaaL 5'region Proteins 0.000 claims 2
- 101000584469 Rice tungro bacilliform virus (isolate Philippines) Protein P1 Proteins 0.000 claims 2
- 101001121571 Rice tungro bacilliform virus (isolate Philippines) Protein P2 Proteins 0.000 claims 2
- 101000818100 Spirochaeta aurantia Uncharacterized 12.7 kDa protein in trpE 5'region Proteins 0.000 claims 2
- 101000818096 Spirochaeta aurantia Uncharacterized 15.5 kDa protein in trpE 3'region Proteins 0.000 claims 2
- 101000818098 Spirochaeta aurantia Uncharacterized protein in trpE 3'region Proteins 0.000 claims 2
- 101000766081 Streptomyces ambofaciens Uncharacterized HTH-type transcriptional regulator in unstable DNA locus Proteins 0.000 claims 2
- 101001026590 Streptomyces cinnamonensis Putative polyketide beta-ketoacyl synthase 2 Proteins 0.000 claims 2
- 101001037658 Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) Glucokinase Proteins 0.000 claims 2
- 101000804403 Synechococcus elongatus (strain PCC 7942 / FACHB-805) Uncharacterized HIT-like protein Synpcc7942_1390 Proteins 0.000 claims 2
- 101000750910 Synechococcus elongatus (strain PCC 7942 / FACHB-805) Uncharacterized HTH-type transcriptional regulator Synpcc7942_2319 Proteins 0.000 claims 2
- 101000750896 Synechococcus elongatus (strain PCC 7942 / FACHB-805) Uncharacterized protein Synpcc7942_2318 Proteins 0.000 claims 2
- 101000644897 Synechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) Uncharacterized protein SYNPCC7002_B0001 Proteins 0.000 claims 2
- 101000916321 Xenopus laevis Transposon TX1 uncharacterized 149 kDa protein Proteins 0.000 claims 2
- 101000916336 Xenopus laevis Transposon TX1 uncharacterized 82 kDa protein Proteins 0.000 claims 2
- 101001000760 Zea mays Putative Pol polyprotein from transposon element Bs1 Proteins 0.000 claims 2
- 101000760088 Zymomonas mobilis subsp. mobilis (strain ATCC 10988 / DSM 424 / LMG 404 / NCIMB 8938 / NRRL B-806 / ZM1) 20.9 kDa protein Proteins 0.000 claims 2
- 101000678262 Zymomonas mobilis subsp. mobilis (strain ATCC 10988 / DSM 424 / LMG 404 / NCIMB 8938 / NRRL B-806 / ZM1) 65 kDa protein Proteins 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 230000000984 immunochemical effect Effects 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000008177 pharmaceutical agent Substances 0.000 claims 2
- 244000144977 poultry Species 0.000 claims 2
- 238000004458 analytical method Methods 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 230000002238 attenuated effect Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 238000005516 engineering process Methods 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 108700026244 Open Reading Frames Proteins 0.000 description 2
- 241000721047 Danaus plexippus Species 0.000 description 1
- 108091033411 PCA3 Proteins 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 108091008146 restriction endonucleases Proteins 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/10011—Circoviridae
- C12N2750/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1A도 1B도는 각각 pCA1 및 pCA3의 엔도뉴클레아제 제한 효소 모형을 나타낸 것이다.
제2도는 CAV군주 26P4의 RF DNA서 열내에 존재하는 오픈리딩 프레임(ORF)을 나타낸 것이다.
제3도는 HVT게놈의 Us영역에 상응하는 DNA 단편의 제한 효소 지도를 나타내는 것이다.
Claims (20)
- CAV 관련 폴리펩티드를 암호하는 헥산 서열.
- 제1항에 있어서, 상기 서열이 a. SEQ ID NO:2에 제시된 아미노산 서열을 갖는 ORF 1;b. SEQ ID NO:3에 제시된 아미노산 서열을 갖는 ORF 2;c, SEQ ID NO:4에 제시된 아미노산 서열을 갖는 ORF 3;로 구성된 군으로부터 선택된 폴리펩티드의 적어도 일부 및 그것의 기능적 등가물을 암호하는 것을 특징으로 하는 헥산서열.
- CAV 게놈의 적어도 일부를 포함하는 헥산서열.
- 제3항에 있어서, 상기 서열이 SEQ ID NO:1에 제시된 데옥시리보헥산서열의 적어도 일부를 함유하는 것을 특징으로 하는 핵산서열.
- 제4항에 있어서, 상기 서열이 SEQ ID NO:1에 제시된 서열의 876 내지 2225, 101내지 502 또는 403내지 1053의 위치에 존재하는 DNA서열의 적어도 일부를 함유하는 것을 특징으로 하는 핵산서열.
- 제1항 내지 제5항중 어느 한 항의 핵산서열을 포함하는 재조합 헥산 분자.
- 제6항에 있어서, 상기 핵산 서열이 형질발현 조절서열에 자동적으로 연결되는 것을 특징으로 하는 재조합 핵산분자.
- 제1항 내지 제5항중 어느 한 항의 핵산 서열을 함유하는 벡터 바이러스.
- 제1항 내지 제5항중 어느 한 항의 핵산 서열 또는 제6항 내지 제7항중 어느 한 항의 재조합 핵산 분자로 형질전환되거나 또는 제8항의 벡터 바이러스를 함유하는 숙주 세포.
- CAV관련 항원의 면역학적 특성을 갖는 폴리펩티드.
- 제1항에 있어서, 상기 플라펩티드가 a.SEQ ID NO:2에 제시된 아미노산 서열을 갖는 ORF 1; b. SEQ ID NO:3에 제시된 아미노산 서열을 갖는 ORF 2; c, SEQ ID NO:4에 제시된 아미노산 서열을 갖는 ORF 3;로 구성된 군으로부터 선택된 아미노산 서열의 적어도 일부 및 그것의 기능적 등가물을 함유하는 것을 특징으로 하는 헥산서열.
- 제1항 내지 제5항중 어느 한항의 핵산서열에 의해 암호하는 CAV 관련 폴리펩티드.
- 제10항 내지 제12항중 어느 한항의 폴리펩티드와 면역학적으로 반응하는 항체 또는 항혈청.
- 제조합 DNA 기술에 의한 CAV게놈상의 돌연변이로 인해 산출되는 것을 특징으로 하며, 자연적으로는 발생하지 않는 감쇄된 CAV.
- 제7항에 의한 재조합 핵산분자, 제8항에 의한 벡터 바이러스, 제9항에 의한 숙주세포, 제10항 내지 제12항중 어느 한항에 의한 폴리펩티드 또는 제14항에 의한 CAV를 포함하는 것을 특징으로 하며, CAV감염에 대하여 가금류를 보호할 수 있는 왁찐.
- 제9항에 의한 숙주 세포를 배양한 후 CAV함유 물질을 수거하여 면역 활성을 갖는 약학적 제제로 가공하는 것을 특징으로 하는 CAV왁찐의 제조방법.
- 제10항 내지 제12항중 어느 한항에 의한 폴리펩티드를 면역 활성을 갖는 약학적 제제로 가공하는 것을 특징으로 하는 CAV왁찐의 제조방법.
- 제15항에 의한 왁찐의 유효량을 동물에 투여하는 것을 특징으로 하는 CAV감염에 대하여 가금류를 보호할 수 있는 방법.
- 제10항 내지 제12항중 어느 한항에 의한 폴리펩티드를 포함하는 면역화학적 시약.
- 제19항에 의한 면역화학적 시약을 포함하며 면역-분석을 실시할 수 있는 테스트 키트.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US60588190A | 1990-10-31 | 1990-10-31 | |
US7/605,881 | 1990-10-31 | ||
US07/605,881 | 1990-10-31 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR920008068A true KR920008068A (ko) | 1992-05-27 |
KR100204438B1 KR100204438B1 (ko) | 1999-06-15 |
Family
ID=24425583
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019910019391A KR100204438B1 (ko) | 1990-10-31 | 1991-10-30 | 치킨 아네미아 바이러스 백신 및 진단방법 |
Country Status (10)
Country | Link |
---|---|
US (1) | US5554525A (ko) |
EP (1) | EP0483911A3 (ko) |
JP (1) | JPH0586088A (ko) |
KR (1) | KR100204438B1 (ko) |
CN (1) | CN1041326C (ko) |
AU (1) | AU8688891A (ko) |
CA (1) | CA2054542A1 (ko) |
HU (1) | HUT62325A (ko) |
MX (1) | MX9101810A (ko) |
ZA (1) | ZA918426B (ko) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100801996B1 (ko) * | 2000-07-28 | 2008-02-12 | 후지츠 히다찌 플라즈마 디스플레이 리미티드 | 컬러 표시의 색재현 보정 회로 및 컬러 디스플레이 |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6071520A (en) * | 1990-09-12 | 2000-06-06 | Leadd Bv | Chicken anemia virus mutants and vaccines and uses based on the viral proteins VP1, VP2 and VP3 or sequences of that virus coding therefor |
NL9002008A (nl) * | 1990-09-12 | 1992-04-01 | Stichting Centr Diergeneeskund | Recombinant dna en rna en daarvan afgeleide produkten. |
US6162461A (en) * | 1990-09-12 | 2000-12-19 | Leadd B.V. | Chicken anemia virus mutants and vaccines and uses based on the viral proteins VP1, VP2 and VP3 or sequences of that virus coding therefor |
US20080234466A1 (en) * | 1990-09-12 | 2008-09-25 | Noteborn Mathieu H M | Delivery method for the tumor-specific apoptosis-inducing activity of apoptin |
US6217870B1 (en) | 1990-09-12 | 2001-04-17 | Leadd, Bv | Chicken anemia virus mutants and vaccines and uses based on the viral proteins VP1 VP2 and VP3 or sequences of that virus coding therefor |
NL9301272A (nl) * | 1993-07-20 | 1995-02-16 | Aesculaap Bv | Chicken Anemia Virus mutanten en vaccins en toepassingen gebaseerd op de virale eiwitten VP1, VP2 en VP3 of daarvoor coderende sequenties van dat virus. |
US20030138443A1 (en) * | 1993-03-08 | 2003-07-24 | Noteborn Mathews H.M. | Cloning of chicken anemia virus DNA |
US5981502A (en) * | 1990-09-12 | 1999-11-09 | Leadd B.V. | Methods and compositions for inducing apoptosis in tumor cells |
US5789567A (en) * | 1994-07-06 | 1998-08-04 | Cornell Research Foundation, Inc. | Chicken infectious anemia virus vaccine |
GB9414888D0 (en) * | 1994-07-23 | 1994-09-14 | Univ Belfast | Method and composition |
ES2167536T3 (es) | 1995-01-06 | 2002-05-16 | Akzo Nobel Nv | Vacuna dirigida contra el agente de la anemia infecciosa en pollos de engorde. |
WO1996040931A1 (en) * | 1995-06-07 | 1996-12-19 | Aesculaap B.V. | Neutralizing conformational epitopes of chicken anemia virus |
WO1997018329A1 (en) * | 1995-11-14 | 1997-05-22 | Ragland William L | Efficient method of detecting an infectious agent in blood |
US6593134B1 (en) | 2000-03-10 | 2003-07-15 | Cornell Research Foundation, Inc. | Method of propagating chicken infectious anemia virus |
AUPR567401A0 (en) * | 2001-06-14 | 2001-07-12 | University Of Melbourne, The | Circovirus vaccines |
BR0212279A (pt) * | 2001-09-05 | 2004-10-13 | Biomune | Vacina obtida de linhagem celular para vìrus causador de anemia em galinhas |
BRPI0611534A2 (pt) | 2005-05-12 | 2010-09-21 | Novartis Ag | genes e proteìnas da brachyspira hyodysenteriae e uso das mesmas para diagnose e terapia |
JP2007331603A (ja) | 2006-06-15 | 2007-12-27 | Kanzaki Kokyukoki Mfg Co Ltd | 船内外機のシフト装置 |
MX2010001381A (es) | 2007-08-03 | 2010-09-14 | Spirogene Pty Ltd | Genes y proteinas de brachyspira hyodysenteriae y usos de los mismos. |
GB0720250D0 (en) | 2007-10-17 | 2007-11-28 | Univ Edinburgh | Immunogenic compositions containing escherichia coli h7 flagella and methods of use thereof |
EP2363407A1 (en) | 2008-02-28 | 2011-09-07 | Murdoch University | Novel sequences of Brachyspira, immunogenic compositions, methods for preparation and use thereof |
AU2009227986C1 (en) | 2008-03-27 | 2014-06-19 | Murdoch University | Novel sequences of Brachyspira, immunogenic compositions, methods for preparation and use thereof |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU7966987A (en) * | 1986-09-08 | 1988-04-07 | Applied Biotechnology, Inc. | Empty viral capsid vaccines |
ES2070997T3 (es) * | 1989-12-04 | 1995-06-16 | Akzo Nobel Nv | Virus de herpes recombinante de pavos y vacunas vector vivas derivadas de los mismos. |
NL9002008A (nl) * | 1990-09-12 | 1992-04-01 | Stichting Centr Diergeneeskund | Recombinant dna en rna en daarvan afgeleide produkten. |
-
1991
- 1991-10-22 ZA ZA918426A patent/ZA918426B/xx unknown
- 1991-10-23 EP EP19910202737 patent/EP0483911A3/en not_active Withdrawn
- 1991-10-29 MX MX9101810A patent/MX9101810A/es unknown
- 1991-10-30 CA CA002054542A patent/CA2054542A1/en not_active Abandoned
- 1991-10-30 KR KR1019910019391A patent/KR100204438B1/ko not_active IP Right Cessation
- 1991-10-30 AU AU86888/91A patent/AU8688891A/en not_active Abandoned
- 1991-10-30 CN CN91111520A patent/CN1041326C/zh not_active Expired - Fee Related
- 1991-10-31 HU HU913433A patent/HUT62325A/hu unknown
- 1991-10-31 JP JP3286877A patent/JPH0586088A/ja active Pending
-
1992
- 1992-07-20 US US07/917,722 patent/US5554525A/en not_active Expired - Fee Related
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100801996B1 (ko) * | 2000-07-28 | 2008-02-12 | 후지츠 히다찌 플라즈마 디스플레이 리미티드 | 컬러 표시의 색재현 보정 회로 및 컬러 디스플레이 |
KR100802000B1 (ko) * | 2000-07-28 | 2008-02-12 | 후지츠 히다찌 플라즈마 디스플레이 리미티드 | 플라즈마 디스플레이의 표시 방법 |
Also Published As
Publication number | Publication date |
---|---|
HU913433D0 (en) | 1992-01-28 |
EP0483911A2 (en) | 1992-05-06 |
HUT62325A (en) | 1993-04-28 |
ZA918426B (en) | 1992-12-30 |
MX9101810A (es) | 1992-07-08 |
US5554525A (en) | 1996-09-10 |
JPH0586088A (ja) | 1993-04-06 |
CN1041326C (zh) | 1998-12-23 |
CA2054542A1 (en) | 1992-05-01 |
AU8688891A (en) | 1992-05-07 |
KR100204438B1 (ko) | 1999-06-15 |
EP0483911A3 (en) | 1993-02-24 |
CN1062168A (zh) | 1992-06-24 |
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