KR920003973A - 서방제제 - Google Patents

서방제제 Download PDF

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Publication number
KR920003973A
KR920003973A KR1019910015156A KR910015156A KR920003973A KR 920003973 A KR920003973 A KR 920003973A KR 1019910015156 A KR1019910015156 A KR 1019910015156A KR 910015156 A KR910015156 A KR 910015156A KR 920003973 A KR920003973 A KR 920003973A
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South Korea
Prior art keywords
composition
high molecular
compound
molecular compound
water
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KR1019910015156A
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English (en)
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KR970009579B1 (ko
Inventor
야스시 모리따
아끼라 오오또리
마사꼬 안도오
Original Assignee
요시다 쇼우지
센쥬세이야꾸 가부시기가이샤
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Publication of KR920003973A publication Critical patent/KR920003973A/ko
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Publication of KR970009579B1 publication Critical patent/KR970009579B1/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

내용 없음

Description

서방제제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 세로축은 용해도를 나타내고 가로축은 시간(분)을 나타내는 히드로 코르티손 아세테이트-폴리비닐피롤리돈 조성물의 용해도를 나타내는 도해이다,
제2도는 세로축은 용해도를 나타내고 가로축은 시간(분)을 나타내는 히드로코르티손 아세테이트-폴리비닐 피롤리돈-폴리락트산 조성물의 용해도를 나타내는 도해이도,
제3도는 세로축은 용해도를 나타내고 가로축은 시간(분)을 나타내는 히드로코르티손/덱사메타손/또는 플루오로메톨론-폴리비닐피롤리돈-폴리락트산 조성물의 용해도를 나타내는 도해이다.

Claims (5)

  1. 난용성 약제, 수용성 고분자 화합물 및 생분해성 고분자 화합물을 함유하는 조성물.
  2. 제1항에 있어서, 난용성 약제가 스테로이드성 화합물인 조성물.
  3. 제1항 또는 제2항에 있어서, 수용성 고분자 화합물이 폴리비닐피롤리돈, 폴리에틸렌 글리콜 및 히드록시프로필 셀룰로오스로 구성된 군에서 선택된 적어도 1종인 조성물.
  4. 제1항 내지 제3항중 어느 한 항에 있어서, 생분해성 고분자 화합물이 폴리락트산 및 폴리글리콜산 및 상응하는 공중합체로 구성된 군에서 선택된 적어도 1종인 조성물.
  5. 제1항 내지 제4항중 어느 한 항에 있어서, 막대, 시트, 필름, 디스크 또는 미소캡슐의 조제형태인 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개되는 것임.
KR1019910015156A 1990-08-30 1991-08-30 서방제제 KR970009579B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP90-229887 1990-08-30
JP22988790 1990-08-30
JP229887/1990 1990-08-30

Publications (2)

Publication Number Publication Date
KR920003973A true KR920003973A (ko) 1992-03-27
KR970009579B1 KR970009579B1 (ko) 1997-06-14

Family

ID=16899272

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019910015156A KR970009579B1 (ko) 1990-08-30 1991-08-30 서방제제

Country Status (10)

Country Link
US (1) US5183662A (ko)
EP (1) EP0474098B1 (ko)
JP (1) JP3934684B2 (ko)
KR (1) KR970009579B1 (ko)
AT (1) ATE102022T1 (ko)
CA (1) CA2050067C (ko)
DE (1) DE69101291T2 (ko)
DK (1) DK0474098T3 (ko)
ES (1) ES2062634T3 (ko)
RU (1) RU2053769C1 (ko)

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KR100871988B1 (ko) 2007-06-25 2008-12-05 한국과학기술원 수용성 용매 없이 수용성 거대분자 약물이 봉입된 생분해성미립구 담체의 제조방법 및 생분해성 미립구 담체
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Also Published As

Publication number Publication date
EP0474098A1 (en) 1992-03-11
ATE102022T1 (de) 1994-03-15
ES2062634T3 (es) 1994-12-16
CA2050067C (en) 2000-05-30
CA2050067A1 (en) 1992-03-01
US5183662A (en) 1993-02-02
JP3934684B2 (ja) 2007-06-20
RU2053769C1 (ru) 1996-02-10
DK0474098T3 (da) 1994-05-02
DE69101291T2 (de) 1994-07-07
EP0474098B1 (en) 1994-03-02
JPH054924A (ja) 1993-01-14
DE69101291D1 (de) 1994-04-07
KR970009579B1 (ko) 1997-06-14

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