KR920003973A - 서방제제 - Google Patents
서방제제 Download PDFInfo
- Publication number
- KR920003973A KR920003973A KR1019910015156A KR910015156A KR920003973A KR 920003973 A KR920003973 A KR 920003973A KR 1019910015156 A KR1019910015156 A KR 1019910015156A KR 910015156 A KR910015156 A KR 910015156A KR 920003973 A KR920003973 A KR 920003973A
- Authority
- KR
- South Korea
- Prior art keywords
- composition
- high molecular
- compound
- molecular compound
- water
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
- A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7007—Drug-containing films, membranes or sheets
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 세로축은 용해도를 나타내고 가로축은 시간(분)을 나타내는 히드로 코르티손 아세테이트-폴리비닐피롤리돈 조성물의 용해도를 나타내는 도해이다,
제2도는 세로축은 용해도를 나타내고 가로축은 시간(분)을 나타내는 히드로코르티손 아세테이트-폴리비닐 피롤리돈-폴리락트산 조성물의 용해도를 나타내는 도해이도,
제3도는 세로축은 용해도를 나타내고 가로축은 시간(분)을 나타내는 히드로코르티손/덱사메타손/또는 플루오로메톨론-폴리비닐피롤리돈-폴리락트산 조성물의 용해도를 나타내는 도해이다.
Claims (5)
- 난용성 약제, 수용성 고분자 화합물 및 생분해성 고분자 화합물을 함유하는 조성물.
- 제1항에 있어서, 난용성 약제가 스테로이드성 화합물인 조성물.
- 제1항 또는 제2항에 있어서, 수용성 고분자 화합물이 폴리비닐피롤리돈, 폴리에틸렌 글리콜 및 히드록시프로필 셀룰로오스로 구성된 군에서 선택된 적어도 1종인 조성물.
- 제1항 내지 제3항중 어느 한 항에 있어서, 생분해성 고분자 화합물이 폴리락트산 및 폴리글리콜산 및 상응하는 공중합체로 구성된 군에서 선택된 적어도 1종인 조성물.
- 제1항 내지 제4항중 어느 한 항에 있어서, 막대, 시트, 필름, 디스크 또는 미소캡슐의 조제형태인 조성물.※ 참고사항 : 최초출원 내용에 의하여 공개되는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP90-229887 | 1990-08-30 | ||
JP22988790 | 1990-08-30 | ||
JP229887/1990 | 1990-08-30 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR920003973A true KR920003973A (ko) | 1992-03-27 |
KR970009579B1 KR970009579B1 (ko) | 1997-06-14 |
Family
ID=16899272
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019910015156A KR970009579B1 (ko) | 1990-08-30 | 1991-08-30 | 서방제제 |
Country Status (10)
Country | Link |
---|---|
US (1) | US5183662A (ko) |
EP (1) | EP0474098B1 (ko) |
JP (1) | JP3934684B2 (ko) |
KR (1) | KR970009579B1 (ko) |
AT (1) | ATE102022T1 (ko) |
CA (1) | CA2050067C (ko) |
DE (1) | DE69101291T2 (ko) |
DK (1) | DK0474098T3 (ko) |
ES (1) | ES2062634T3 (ko) |
RU (1) | RU2053769C1 (ko) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU3941493A (en) * | 1992-03-30 | 1993-11-08 | Alza Corporation | Viscous suspensions of controlled-release drug particles |
US5626862A (en) | 1994-08-02 | 1997-05-06 | Massachusetts Institute Of Technology | Controlled local delivery of chemotherapeutic agents for treating solid tumors |
US5869079A (en) * | 1995-06-02 | 1999-02-09 | Oculex Pharmaceuticals, Inc. | Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents |
FR2748205A1 (fr) | 1996-05-06 | 1997-11-07 | Debio Rech Pharma Sa | Compositions pharmaceutiques pour la liberation controlee de principes actifs insolubles |
PT839525E (pt) | 1996-10-31 | 2004-10-29 | Takeda Chemical Industries Ltd | Preparacao de libertacao prolongada |
KR100244164B1 (ko) * | 1997-07-15 | 2000-03-02 | 김용옥 | 수용성 고분자-타크로리무스 접합체 화합물 및 그의 제조 방법 |
US6498153B1 (en) | 1998-12-31 | 2002-12-24 | Akzo Nobel N.V. | Extended release growth promoting two component composition |
JP2000281561A (ja) * | 1999-03-26 | 2000-10-10 | Ajinomoto Co Inc | 新規溶媒法固体分散体製剤 |
US6726918B1 (en) | 2000-07-05 | 2004-04-27 | Oculex Pharmaceuticals, Inc. | Methods for treating inflammation-mediated conditions of the eye |
DE10058772A1 (de) * | 2000-11-27 | 2002-06-06 | Falk Pharma Gmbh | Verfahren zur Herstellung leicht löslicher Arzneimittelformulierungen und entsprechende Formulierungen |
DK1339438T3 (da) | 2000-11-29 | 2006-02-13 | Allergan Inc | Forebyggelse af transplantatafvisning i ojet |
KR100446101B1 (ko) * | 2000-12-07 | 2004-08-30 | 주식회사 삼양사 | 수난용성 약물의 서방성 제형 조성물 |
EP1408876A4 (en) * | 2001-06-22 | 2004-09-22 | Durect Corp | ZERO ORDER COAXIAL IMPLANTS WITH EXTENDED RELEASE |
WO2003075892A1 (en) * | 2002-03-13 | 2003-09-18 | Novartis Ag | Pharmaceutical microparticles |
AU2003208245A1 (en) * | 2002-03-15 | 2003-09-29 | Kuyus, Stiftung | Composition and utilization thereof for forming a protective film on nasal mucous membranes |
US20050048099A1 (en) | 2003-01-09 | 2005-03-03 | Allergan, Inc. | Ocular implant made by a double extrusion process |
CL2004000983A1 (es) * | 2003-05-08 | 2005-03-04 | Altana Pharma Ag | Composicion farmaceutica oral en forma de tableta que comprende a pantoprazol magnetico dihidratado, en donde la forma de tableta esta compuesto por un nucleo, una capa intermedia y una capa exterior; y uso de la composicion farmaceutica en ulceras y |
PE20050150A1 (es) * | 2003-05-08 | 2005-03-22 | Altana Pharma Ag | Una forma de dosificacion que contiene (s)-pantoprazol como ingrediente activo |
MY142989A (en) | 2004-03-10 | 2011-02-14 | Bayer Schering Pharma Ag | Stabilised supersaturated solids of lipophilic drugs |
US20050244469A1 (en) | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Extended therapeutic effect ocular implant treatments |
KR20070121754A (ko) * | 2005-03-21 | 2007-12-27 | 마커사이트, 인코포레이티드 | 질환 또는 상태의 치료를 위한 약물 송달 시스템 |
US20070106271A1 (en) * | 2005-11-09 | 2007-05-10 | Searete Llc, A Limited Liability Corporation | Remote control of substance delivery system |
US8802128B2 (en) | 2006-06-23 | 2014-08-12 | Allergan, Inc. | Steroid-containing sustained release intraocular implants and related methods |
KR100816065B1 (ko) * | 2006-11-27 | 2008-03-24 | 동국제약 주식회사 | 초기 방출억제 특성이 우수한 서방출성 마이크로캡슐의제조방법 및 이에 의해 제조되는 마이크로캡슐 |
KR100871988B1 (ko) | 2007-06-25 | 2008-12-05 | 한국과학기술원 | 수용성 용매 없이 수용성 거대분자 약물이 봉입된 생분해성미립구 담체의 제조방법 및 생분해성 미립구 담체 |
US10064819B2 (en) | 2008-05-12 | 2018-09-04 | University Of Utah Research Foundation | Intraocular drug delivery device and associated methods |
US9877973B2 (en) | 2008-05-12 | 2018-01-30 | University Of Utah Research Foundation | Intraocular drug delivery device and associated methods |
JP5591226B2 (ja) | 2008-05-12 | 2014-09-17 | ユニバーシティ・オブ・ユタ・リサーチ・ファウンデイション | 眼内薬物送達装置および関連する方法 |
US9095404B2 (en) | 2008-05-12 | 2015-08-04 | University Of Utah Research Foundation | Intraocular drug delivery device and associated methods |
GB201119985D0 (en) | 2011-11-19 | 2012-01-04 | Diurnal Ltd | Treatment of adrenal insufficiency |
US10806703B2 (en) * | 2012-01-20 | 2020-10-20 | Lts Lohmann Therapie-System Ag | Transmucosal administration system for a pharmaceutical drug |
GB201308933D0 (en) | 2013-05-17 | 2013-07-03 | Diurnal Ltd | Paediatric composition |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1391554A (en) * | 1972-08-03 | 1975-04-23 | Beecham Group Ltd | Pharmaceutical compositions and process for their preparation |
US4048256A (en) * | 1976-06-01 | 1977-09-13 | American Cyanamid Company | Normally-solid, bioabsorbable, hydrolyzable, polymeric reaction product |
DE2856901D2 (de) * | 1977-06-07 | 1980-11-13 | Garching Instrumente | Form of implant medicament and preparation process |
GB2091554B (en) * | 1981-01-13 | 1984-09-12 | Mitsui Toatsu Chemicals | Rod like moulded drug |
US4432964A (en) * | 1981-08-24 | 1984-02-21 | Alza Corporation | Topical composition containing steroid in two forms released independently from polymeric carrier |
US4666704A (en) * | 1985-05-24 | 1987-05-19 | International Minerals & Chemical Corp. | Controlled release delivery system for macromolecules |
US4741872A (en) * | 1986-05-16 | 1988-05-03 | The University Of Kentucky Research Foundation | Preparation of biodegradable microspheres useful as carriers for macromolecules |
-
1991
- 1991-08-27 CA CA002050067A patent/CA2050067C/en not_active Expired - Fee Related
- 1991-08-27 DK DK91114374.1T patent/DK0474098T3/da active
- 1991-08-27 AT AT91114374T patent/ATE102022T1/de not_active IP Right Cessation
- 1991-08-27 US US07/750,482 patent/US5183662A/en not_active Expired - Lifetime
- 1991-08-27 ES ES91114374T patent/ES2062634T3/es not_active Expired - Lifetime
- 1991-08-27 DE DE69101291T patent/DE69101291T2/de not_active Expired - Fee Related
- 1991-08-27 EP EP91114374A patent/EP0474098B1/en not_active Expired - Lifetime
- 1991-08-29 JP JP29999291A patent/JP3934684B2/ja not_active Expired - Fee Related
- 1991-08-29 RU SU915001402A patent/RU2053769C1/ru active
- 1991-08-30 KR KR1019910015156A patent/KR970009579B1/ko not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0474098A1 (en) | 1992-03-11 |
ATE102022T1 (de) | 1994-03-15 |
ES2062634T3 (es) | 1994-12-16 |
CA2050067C (en) | 2000-05-30 |
CA2050067A1 (en) | 1992-03-01 |
US5183662A (en) | 1993-02-02 |
JP3934684B2 (ja) | 2007-06-20 |
RU2053769C1 (ru) | 1996-02-10 |
DK0474098T3 (da) | 1994-05-02 |
DE69101291T2 (de) | 1994-07-07 |
EP0474098B1 (en) | 1994-03-02 |
JPH054924A (ja) | 1993-01-14 |
DE69101291D1 (de) | 1994-04-07 |
KR970009579B1 (ko) | 1997-06-14 |
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