KR920000940A - 종양 세포 성장 억제 인자 - Google Patents

종양 세포 성장 억제 인자 Download PDF

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Publication number
KR920000940A
KR920000940A KR1019910009292A KR910009292A KR920000940A KR 920000940 A KR920000940 A KR 920000940A KR 1019910009292 A KR1019910009292 A KR 1019910009292A KR 910009292 A KR910009292 A KR 910009292A KR 920000940 A KR920000940 A KR 920000940A
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KR
South Korea
Prior art keywords
cys
gly
tyr
glu
lys
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KR1019910009292A
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English (en)
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KR100187732B1 (ko
Inventor
도시 고무라사끼
히또시 도요다
다이스께 우찌다
가즈노리 하나다
Original Assignee
우에하라 아끼라
다이쇼 세이야꾸 가부시끼가이샤
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Publication of KR920000940A publication Critical patent/KR920000940A/ko
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Publication of KR100187732B1 publication Critical patent/KR100187732B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

종양 세포 성장 억제 인자
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 본 발명에 따른 종양 세포 성장 억제 인자에 대한 CM-3SW양이온 교환 크로마토그램의 용출 형태를 나타내는 그래프,
제2도는 본 발명에 따른 종양 세포 성장 억제 인자에 대한 페닐 5PW-RP 역상 HPLC의 용출형태를 나타내는 그래프,
제3도는 본 발명에 따른 종양 세포 성장 억제 인자에 대한 페닐 5WP-RP 역상 HPLC의 용출형태를 나타내는 그래프.

Claims (2)

  1. 3T3세포 유래 세포주의 배양 상징액으로부터 얻어지는 단백질로서, 다음의 특성르 갖는 종양 세포 성장 억제 인자.
    a) 분자량 환원 및 비환원 조건 하에서 SDS 폴리아크릴아미드 겔 전기영동에 의해 측정했을 때, 3.700±370달톤임 ; b) 컬럼 특성 약 7.4의 pH에서 음이온 교환 수지 컬럼 상에는 실질적으로 흡착되지 않고, 약 5.0의 pH에서 양이온 교환 수지 컬럼 상에는 실질적으로 흡착됨 ; c) 생리작용 적어도 인체의 전골수 백혈병 세포 및 인체의 자궁경부 종양 유래 세포에 대하여 억제 작용을 가짐.
  2. 제1항에 있어서, 다음의 두 아미노산 서열[(P-1) 및 (P-2)]중 어느 하나를 갖는 종양 세포 성장 억제인자.
    (P-1) :
    1 2 3 4 5 6 7 8 9
    Val-Gln-Ile-Thr-Lys-Cys-Ser-Ser-Asp-
    10 11 12 13 14 15 16 17 18
    Met-Asp-Gly-Tyr-Cys-Leu-His-Gly-Gln-
    19 20 21 22 23 24 25 26 27
    Cys-Ile-Tyr-Leu-Val-Asp-Met-Arg-Glu-
    28 29 30 31 32 33 34 35 36
    Lys-Phe-Cys-Arg-Cys-Glu-Val-Gly-Tyr-
    37 38 39 40 41 42 43 44 45
    Thr-Gly-Lys-Arg-Cys-Glu-His-Phe-Phe-
    46
    Leu-
    (P-1) :
    1 2 3 4 5 6 7 8 9
    Val-Gln-Ile-Thr-Lys-Cys-Ser-Ser-Asp-
    10 11 12 13 14 15 16 17 18
    Met-Asp-Gly-Tyr-Cys-Leu-His-Gly-Gln-
    19 20 21 22 23 24 25 26 27
    Cys-Ile-Tyr-Leu-Val-Asp-Met-Arg-Glu-
    28 29 30 31 32 33 34 35 36
    Lys-Phe-Cys-Arg-Cys-Glu-Val-Gly-Tyr-
    37 38 39 40 41 42 43 44
    Thr-Gly-Lys-Arg-Cys-Glu-His-Phe-
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910009292A 1990-06-06 1991-06-05 종양 세포 성장 억제 인자 KR100187732B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP03-011950 1990-02-01
JP14614390 1990-06-06
JP90-146143 1990-06-06
JP3011950A JP2784272B2 (ja) 1990-06-06 1991-02-01 腫瘍細胞増殖阻害因子

Publications (2)

Publication Number Publication Date
KR920000940A true KR920000940A (ko) 1992-01-29
KR100187732B1 KR100187732B1 (ko) 1999-06-01

Family

ID=26347473

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019910009292A KR100187732B1 (ko) 1990-06-06 1991-06-05 종양 세포 성장 억제 인자

Country Status (6)

Country Link
US (1) US5384394A (ko)
EP (1) EP0460910A3 (ko)
JP (1) JP2784272B2 (ko)
KR (1) KR100187732B1 (ko)
CA (1) CA2043536C (ko)
TW (1) TW201755B (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100239335B1 (ko) * 1991-12-05 2000-01-15 우에하라 아끼라 종양세포 증식 저해인자를 코드하는 dna 단편
CA2164295A1 (en) * 1993-06-04 1994-12-22 Toshi Komurasaki Human-derived tumor cell growth inhibitors
DE60312566T2 (de) * 2002-09-19 2008-01-10 National Research Council Of Canada, Ottawa Verfahren zur diagnose von kolorektaladenomen und -krebs mit protonenmagnetresonanzspektroskopie

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4708948A (en) * 1984-04-20 1987-11-24 The United States Of America As Represented By The Department Of Health And Human Services Substantially purified tumor growth inhibitory factor
US5155217A (en) * 1987-05-29 1992-10-13 The Trustees Of Columbia University In The City Of New York Ongogene encoding polypeptide having growth factor activity
JPH01148197A (ja) * 1987-12-04 1989-06-09 Green Cross Corp:The 腫瘍細胞障害因子

Also Published As

Publication number Publication date
TW201755B (ko) 1993-03-11
KR100187732B1 (ko) 1999-06-01
US5384394A (en) 1995-01-24
JPH04211698A (ja) 1992-08-03
CA2043536A1 (en) 1991-12-07
JP2784272B2 (ja) 1998-08-06
EP0460910A3 (en) 1992-10-28
CA2043536C (en) 2001-02-20
EP0460910A2 (en) 1991-12-11

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