KR920000785A - 새로운 혈소판 응집 억제인자 - Google Patents

새로운 혈소판 응집 억제인자 Download PDF

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Publication number
KR920000785A
KR920000785A KR1019910010241A KR910010241A KR920000785A KR 920000785 A KR920000785 A KR 920000785A KR 1019910010241 A KR1019910010241 A KR 1019910010241A KR 910010241 A KR910010241 A KR 910010241A KR 920000785 A KR920000785 A KR 920000785A
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South Korea
Prior art keywords
platelet aggregation
mammal
compound
administering
pharmaceutically acceptable
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KR1019910010241A
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English (en)
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KR940000753B1 (ko
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시옹 청 포우
폴 아담스 스티븐
필립 페이건 레리
Original Assignee
제임스 클리프튼 보올딩
몬산토 캄파니
포올 디. 메투카이티스
지. 디. 써얼 앤드 캄파니
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Publication of KR920000785A publication Critical patent/KR920000785A/ko
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Publication of KR940000753B1 publication Critical patent/KR940000753B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

내용 없음

Description

새로운 혈소판 응집 억제인자
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 8-Go-Asp-phe-(□), 8-Go-Asp-MPE(■) 그리고 RGDS(×)같은 고려된 억제제에 의해 씻겨진 인체 혈소판의 섬유소원 결합의 억제를 나타낸다. 억제 인제들의 섬유소원 결합 비율을 대조구(억제 인자 없음)와 비교하여 억제제의 몰탈 농도에 대해 그렸다.
제2도는 인체 혈소판이 풍부한 혈장내에서 8-Go-Asp-phe-(□)와 8-Go-Asp-MPE(■)에 의한 ADP-유도 혈소판 응집의 억제를 대조구(억제제 없음)와 비교하여 혈소판 응집 비율을 억제제의 몰탈 농도에 대해 그렸다.
제3도는 개의 혈소판이 풍부한 혈장내에서 8-Go-Asp-phe-(□)와 8-Go-Asp-MPE(■)에 의한 콜라겐-유도 혈소판 응집의 억제를 제2도와 같은 방법으로 그렸다.

Claims (5)

  1. N-[8-[(아미노이미노메틸)아미노]-1-옥소옥틸]-N-L-α-아스파틸-L-페닐 알라닌.
  2. 약학적으로 허용되는 담체내의 제1항의 화합물을 혈소판 응집을 억제하기에 효과적인 양으로 포유동물에게 투여함으로써 온혈 포유동물에서 혈소판 응집을 억제하는 방법.
  3. 약학적으로 허용되는 담체내의 제1항의 화합물을 혈전형성의 억제에 효과적인 양으로 포유동물에게 투여함으로서 온혈 포유동물에서 혈전 형상을 억제하는 방법.
  4. 약학적으로 허용되는 담체내에 있는 제1항의 화합물.
  5. 재환류 시간을 단축하고 재폐쇄가 이루어지는 시간을 연장하기에 적합한 제1항의 화합물을 효과적인 양으로 공동투여함으로써 온혈 포유동물에 투여된 조직플라스미노겐 활성제의 혈전용해활성을 촉진하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910010241A 1990-06-20 1991-06-19 새로운 혈소판 응집 억제 인자 KR940000753B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/540,953 US5053393A (en) 1988-07-20 1990-06-20 Novel platelet-aggregation inhibitor
US540,953 1990-06-20

Publications (2)

Publication Number Publication Date
KR920000785A true KR920000785A (ko) 1992-01-29
KR940000753B1 KR940000753B1 (ko) 1994-01-29

Family

ID=24157584

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019910010241A KR940000753B1 (ko) 1990-06-20 1991-06-19 새로운 혈소판 응집 억제 인자

Country Status (17)

Country Link
US (1) US5053393A (ko)
EP (1) EP0462960B1 (ko)
JP (1) JPH0651719B2 (ko)
KR (1) KR940000753B1 (ko)
AT (1) ATE123293T1 (ko)
AU (1) AU631070B2 (ko)
CA (1) CA2044978C (ko)
DE (1) DE69110091T2 (ko)
DK (1) DK0462960T3 (ko)
ES (1) ES2075415T3 (ko)
FI (1) FI106380B (ko)
IE (1) IE72519B1 (ko)
IL (1) IL98557A (ko)
NO (1) NO301373B1 (ko)
NZ (1) NZ238611A (ko)
PT (1) PT98026B (ko)
ZA (1) ZA914728B (ko)

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US5332726A (en) * 1989-09-29 1994-07-26 Rhone-Poulenc Rorer Pharmaceuticals Inc. Antithrombotic peptides and pseudopeptides
TW201303B (ko) * 1990-07-05 1993-03-01 Hoffmann La Roche
US5260277A (en) * 1990-09-10 1993-11-09 Tanabe Seiyaku Co., Ltd. Guanidinyl and related cell adhesion modulation compounds
NZ239846A (en) * 1990-09-27 1994-11-25 Merck & Co Inc Sulphonamide derivatives and pharmaceutical compositions thereof
MX9201416A (es) * 1991-03-28 1992-10-01 Rhone Poulenc Rorer Int Peptidos y pseudopeptidos antitromboticos.
DE4126277A1 (de) * 1991-08-08 1993-02-11 Cassella Ag Hydantoinderivate
US5239113A (en) * 1991-10-15 1993-08-24 Monsanto Company Substituted β-amino acid derivatives useful as platelet aggregation inhibitors and intermediates thereof
US5625093A (en) * 1991-10-15 1997-04-29 G. D. Searle & Co. Substituted β-amino acid derivatives useful as platelet aggregation inhibitors
US5254573A (en) * 1991-10-15 1993-10-19 Monsanto Company Substituted heterocyclic derivatives useful as platelet aggregation inhibitors
WO1993008823A1 (en) * 1991-11-06 1993-05-13 Tanabe Seiyaku Co., Ltd. Guanidinyl and related cell adhesion modulation compounds
US5258398A (en) * 1991-12-16 1993-11-02 Rhone-Poulenc Rorer Pharmaceuticals Inc. Antithrombotic diaminoalkanoic acid derivatives
TW223629B (ko) * 1992-03-06 1994-05-11 Hoffmann La Roche
US5338725A (en) * 1992-06-30 1994-08-16 The Research Foundation Of The State University Of New York Anti-aggregatory agents for platelets
US6380163B1 (en) * 1992-12-22 2002-04-30 Baxter International Inc. Peritoneal dialysis solutions with polypeptides
DE4302485A1 (de) * 1993-01-29 1994-08-04 Merck Patent Gmbh Piperazinderivate
AU687790B2 (en) * 1993-02-09 1998-03-05 Biogen Idec Ma Inc. Treatment for insulin dependent diabetes
EP0623615B1 (de) * 1993-05-01 1999-06-30 MERCK PATENT GmbH Substituierte 1-Phenyl-oxazolidin-2-on Derivate, deren Herstellung und deren Verwendung als Adhäsionsrezeptor-Antagonisten
TW394760B (en) * 1993-09-07 2000-06-21 Hoffmann La Roche Novel Carboxamides, process for their preparation and pharmaceutical composition containing the same
DE4332384A1 (de) * 1993-09-23 1995-03-30 Merck Patent Gmbh Adhäsionsrezeptor-Antagonisten III
DE4405378A1 (de) * 1994-02-19 1995-08-24 Merck Patent Gmbh Adhäsionsrezeptor-Antagonisten
DE4429461A1 (de) * 1994-08-19 1996-02-22 Merck Patent Gmbh Adhäsionsrezeptor-Antagonisten
ES2123889T3 (es) 1994-11-02 1999-01-16 Merck Patent Gmbh Antagonistas de receptores de adhesion.
DE4439846A1 (de) * 1994-11-08 1996-05-09 Merck Patent Gmbh Adhäsionsrezeptor-Antagonisten
DE19504954A1 (de) * 1995-02-15 1996-08-22 Merck Patent Gmbh Adhäsionsrezeptor-Antagonisten
DE19516483A1 (de) * 1995-05-05 1996-11-07 Merck Patent Gmbh Adhäsionsrezeptor-Antagonisten
US5891418A (en) * 1995-06-07 1999-04-06 Rhomed Incorporated Peptide-metal ion pharmaceutical constructs and applications
US7018627B1 (en) 1995-06-07 2006-03-28 Icos Corporation Macrophage derived chemokine (MDC), MDC analogs, MDC inhibitor substances, and uses thereof
US5654334A (en) * 1995-06-23 1997-08-05 Oklahoma Medical Research Foundation Analgesic use of N-L-α-aspartyl-L-phenylalanine 1-methyl ester
US5872122A (en) * 1997-10-16 1999-02-16 Monsanto Company Pyrimidinylamidino β-amino acid derivatives useful as inhibitors of platelet aggregation

Family Cites Families (13)

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FR2215948B1 (ko) * 1973-02-01 1976-05-14 Centre Etd Ind Pharma
US4127580A (en) * 1975-02-07 1978-11-28 Parcor Process for the preparation of thieno-pyridine derivatives
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US4517686A (en) * 1982-08-04 1985-05-21 La Jolla Cancer Research Foundation Polypeptide
US4578079A (en) * 1982-08-04 1986-03-25 La Jolla Cancer Research Foundation Tetrapeptide
US4614517A (en) * 1982-08-04 1986-09-30 La Jolla Cancer Research Foundation Tetrapeptide
US4683291A (en) * 1985-10-28 1987-07-28 Scripps Clinic And Research Foundation Platelet binding inhibitors
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Also Published As

Publication number Publication date
NZ238611A (en) 1992-09-25
DK0462960T3 (da) 1995-10-02
US5053393A (en) 1991-10-01
FI913006A0 (fi) 1991-06-19
DE69110091D1 (de) 1995-07-06
NO912396L (no) 1991-12-23
IL98557A (en) 1996-01-31
DE69110091T2 (de) 1996-02-08
IL98557A0 (en) 1992-07-15
AU7912191A (en) 1992-01-02
AU631070B2 (en) 1992-11-12
IE72519B1 (en) 1997-04-23
NO301373B1 (no) 1997-10-20
ATE123293T1 (de) 1995-06-15
IE912100A1 (en) 1992-01-01
NO912396D0 (no) 1991-06-19
KR940000753B1 (ko) 1994-01-29
EP0462960A1 (en) 1991-12-27
PT98026B (pt) 1998-11-30
FI106380B (fi) 2001-01-31
PT98026A (pt) 1992-04-30
CA2044978C (en) 2001-06-12
JPH04230299A (ja) 1992-08-19
FI913006A (fi) 1991-12-21
JPH0651719B2 (ja) 1994-07-06
ES2075415T3 (es) 1995-10-01
ZA914728B (en) 1993-02-24
EP0462960B1 (en) 1995-05-31
CA2044978A1 (en) 1991-12-21

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