KR910018398A - 3당류 유니트(unit)를 함유하는 탄수화물 유도체 - Google Patents

3당류 유니트(unit)를 함유하는 탄수화물 유도체 Download PDF

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Publication number
KR910018398A
KR910018398A KR1019910006403A KR910006403A KR910018398A KR 910018398 A KR910018398 A KR 910018398A KR 1019910006403 A KR1019910006403 A KR 1019910006403A KR 910006403 A KR910006403 A KR 910006403A KR 910018398 A KR910018398 A KR 910018398A
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KR
South Korea
Prior art keywords
carbohydrate derivative
aryl
alkyl
aralkyl
carbohydrate
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KR1019910006403A
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English (en)
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KR0185991B1 (ko
Inventor
아드리안 안톤 반 보오켈 콘스탄트
뻬띠뚜 마우리스
Original Assignee
에프. 지. 엠. 헤르만스 에이. 지. 제이. 베르미렌
악조. 엔. 브이
아. 세. 세와르
사노피 에스. 아
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Application filed by 에프. 지. 엠. 헤르만스 에이. 지. 제이. 베르미렌, 악조. 엔. 브이, 아. 세. 세와르, 사노피 에스. 아 filed Critical 에프. 지. 엠. 헤르만스 에이. 지. 제이. 베르미렌
Publication of KR910018398A publication Critical patent/KR910018398A/ko
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Publication of KR0185991B1 publication Critical patent/KR0185991B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof

Abstract

내용 없음

Description

3당류 유니트(unit)를 함유하는 탄수화물 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (8)

  1. 하기 일반식(Ⅰ)의 3당류 유니트를 함유하는 탄수화물 유도체.
    상기식에서 R 은 알킬, 아릴 또는 아르알킬이며; Q 는 알킬, 아릴, 아르알킬 또는 SO- 3이며; A 와 B는 각각 따로 수소, 알킬, 아릴, 아르아킬, 또는 탄수화물기로부터 선택되며; 하전부위는 반대이온에 의해 상보된다.
  2. 제1항에 있어서, R 은 메틸이고, Q는 메틸인것을 특징으로 하는 탄수화물 유도체.
  3. 제1항에 있어서, R 은 메틸이고, Q 는 SO- 3인것을 특징으로 하는 탄수화물 유도체.
  4. 제2항 또는 제3항에 있어서, A는 하기 일반식 (Ⅱ)로 표시되고, B는 하기 일반식 (Ⅲ)으로 표시되는 것을 특징으로 하는 탄수화물유도체.
    상기 식에서, R1, R2, R3, R4, 와 R5는 각각 따로 수소, 알킬, 아릴, 아르알킬, 또는 SO- 3로부터 선택된다.
  5. 제4항에 있어서, R1, R2와 R3는 메틸이고, R4와 R5는 SO- 3이고 OR3는α-배열을 갖는 것을 특징으로 하는 탄수화물 유도체.
  6. 하기 일반식 (Ⅳ)의 3당류유니트를 함유하는 보호된 탄수화물 유도체를 본 기술분야에 공지된 방법으로 탈보호시키고, 황산화 시키는 것을 특징으로 하는 제1항의 탄수화물 유도체를 제조하는 방법.
    상기식에서 R은 알킬, 아릴 또는 아르알킬이며; P1은 산보호기이며, P2는 히드록시보호기이며; P3는 히드록시보호기 또는 알킬,아릴 또는 아르알킬기이며; A′과 B′은 각각 A 및 B이거나, 그들의 보호된 유도체이다.
  7. 제1항의 탄수화물 유도체를 약학적 허용 보조제와 혼합된 상태로 함유하는 약학적 조성물.
  8. 혈전증의 치료 또는 근육세포 증식의 억제를 위한 약제의 제조에 제1항의 탄수화물 유도체를 사용하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910006403A 1990-04-23 1991-04-22 3당류 유니트를 함유하는 탄수화물 유도체 KR0185991B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP90.201006.5 1990-04-23
EP90201006 1990-04-23

Publications (2)

Publication Number Publication Date
KR910018398A true KR910018398A (ko) 1991-11-30
KR0185991B1 KR0185991B1 (ko) 1999-04-01

Family

ID=8205000

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019910006403A KR0185991B1 (ko) 1990-04-23 1991-04-22 3당류 유니트를 함유하는 탄수화물 유도체

Country Status (16)

Country Link
EP (1) EP0454220B1 (ko)
KR (1) KR0185991B1 (ko)
AU (1) AU644429B2 (ko)
BR (1) BR1100979A (ko)
CA (1) CA2040905C (ko)
DE (1) DE69100275T2 (ko)
DK (1) DK0454220T3 (ko)
ES (1) ES2060284T3 (ko)
FI (1) FI101541B (ko)
HK (1) HK1002319A1 (ko)
HU (2) HU215152B (ko)
IE (1) IE64378B1 (ko)
IL (1) IL97904A (ko)
NZ (1) NZ237909A (ko)
PT (1) PT97437B (ko)
ZA (1) ZA912951B (ko)

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IL102758A (en) * 1991-08-23 1997-03-18 Akzo Nv Glycosaminoglycanoid derivatives, their preparation and pharmaceutical compositions comprising them
US5696100A (en) * 1992-12-22 1997-12-09 Glycomed Incorporated Method for controlling O-desulfation of heparin and compositions produced thereby
WO1994020512A2 (en) * 1993-03-01 1994-09-15 Glycan Pharmaceuticals, Inc. Analogs for specific oligosaccharide-protein interactions and uses therefor
FR2704226B1 (fr) * 1993-04-22 1995-07-21 Sanofi Elf 3-desoxy oligosaccharides, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
EP0649854B1 (en) * 1993-09-01 2000-03-15 Akzo Nobel N.V. Bisconjugates comprising two saccharides and a spacer
IL115745A (en) * 1994-11-07 2000-11-21 American Home Prod Acylated benzylglycosides and pharmaceutical compositions containing them
US5565432A (en) * 1994-11-07 1996-10-15 American Home Products Corporation Smooth muscle cell proliferation inhibitors
US5498775A (en) * 1994-11-07 1996-03-12 American Home Products Corporation Polyanionic benzylglycosides as inhibitors of smooth muscle cell proliferation
IL120722A (en) * 1996-05-08 1999-07-14 Akzo Nobel Nv Polysulfated tetrasaccharide derivatives and pharmaceutical compositions containing them
IL126893A (en) * 1997-11-19 2003-05-29 Akzo Nobel Nv Sulfated pentasaccharide derivatives and pharmaceutical compositions containing them
US6258784B1 (en) 1998-11-24 2001-07-10 American Home Products Corp. Acetal benzylmaltosides as inhibitors of smooth muscle cell proliferation
US6339064B1 (en) 1998-11-24 2002-01-15 American Home Products Corporation Benzylglycosylamides as inhibitors of smooth muscle cell proliferation
US6451767B1 (en) 1998-11-24 2002-09-17 Wyeth Benzylmaltotriosides as inhibitors of smooth muscle cell proliferation
US6664243B1 (en) 1998-11-24 2003-12-16 Wyeth Benzyllactobionamides as inhibitors of smooth muscle cell proliferation
US6340670B1 (en) 1998-11-24 2002-01-22 American Home Products Corporation Acetal benzylmaltosides as inhibitors of smooth muscle cell proliferation
US6362170B1 (en) 1998-11-24 2002-03-26 American Home Products Corporation Benzylglycosylamides as inhibitors of smooth muscle cell proliferation
US7132402B2 (en) 1998-11-24 2006-11-07 Wyeth Acylated benzylmaltosides as inhibitors of smooth muscle cell proliferation
US6187755B1 (en) 1998-11-24 2001-02-13 American Home Products Corporation Benzylmaltosides as inhibitors of smooth muscle cell proliferation
US7081448B2 (en) 1998-11-24 2006-07-25 Wyeth Benzyllactobionamides as inhibitors of smooth muscle cell proliferation
US6291434B1 (en) 1998-11-24 2001-09-18 American Home Products Corp. Benzylmaltotriosides as inhibitors of smooth muscle cell proliferation
SE9904483D0 (sv) * 1999-12-08 1999-12-08 Astra Ab New use
TWI403334B (zh) 2004-12-23 2013-08-01 Merck Sharp & Dohme 包含生物素殘基之抗血栓雙重抑制劑
TWI376234B (en) 2005-02-01 2012-11-11 Msd Oss Bv Conjugates of a polypeptide and an oligosaccharide
EP2279249A4 (en) 2008-05-30 2014-03-05 Momenta Pharmaceuticals Inc Saccharide structures and process for their preparation and use
US9873712B2 (en) * 2014-10-03 2018-01-23 Amphastar Pharmaceuticals, Inc. Method of purifying idraparinux sodium

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0300099A1 (en) * 1987-07-20 1989-01-25 Akzo N.V. New pentasaccharides
DE3734815A1 (de) * 1987-10-14 1989-04-27 Luitpold Werk Chem Pharm Polyschwefelsaeureester von bis-aldonsaeureamiden und deren derivaten, verfahren zu ihrer herstellung und arzneimittel
EP0333243A3 (en) * 1988-03-10 1989-09-27 Akzo N.V. Sulphated k5 antigen and sulphated k5 antigen fragments
JPH0296588A (ja) * 1988-09-29 1990-04-09 Rikagaku Kenkyusho 硫酸化オリゴ糖及びその関連物質

Also Published As

Publication number Publication date
FI101541B1 (fi) 1998-07-15
FI911942A0 (fi) 1991-04-22
EP0454220A1 (en) 1991-10-30
IL97904A (en) 1995-07-31
IE911277A1 (en) 1991-10-23
HU215152B (hu) 2000-11-28
IE64378B1 (en) 1995-07-26
AU7525591A (en) 1991-10-24
BR1100979A (pt) 1999-12-07
IL97904A0 (en) 1992-06-21
AU644429B2 (en) 1993-12-09
PT97437B (pt) 1998-08-31
CA2040905A1 (en) 1991-10-24
DK0454220T3 (da) 1993-11-22
FI101541B (fi) 1998-07-15
ZA912951B (en) 1992-01-29
NZ237909A (en) 1993-03-26
HK1002319A1 (en) 1998-08-14
PT97437A (pt) 1992-01-31
ES2060284T3 (es) 1994-11-16
FI911942A (fi) 1991-10-24
CA2040905C (en) 2001-11-20
HUT57223A (en) 1991-11-28
KR0185991B1 (ko) 1999-04-01
EP0454220B1 (en) 1993-08-18
HU911346D0 (en) 1991-10-28
DE69100275D1 (de) 1993-09-23
HU211506A9 (en) 1995-11-28
DE69100275T2 (de) 1993-12-02

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