KR910011265A - 에스트로겐-함유 겔 제제 - Google Patents

에스트로겐-함유 겔 제제 Download PDF

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Publication number
KR910011265A
KR910011265A KR1019900021903A KR900021903A KR910011265A KR 910011265 A KR910011265 A KR 910011265A KR 1019900021903 A KR1019900021903 A KR 1019900021903A KR 900021903 A KR900021903 A KR 900021903A KR 910011265 A KR910011265 A KR 910011265A
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KR
South Korea
Prior art keywords
estrogen
component
gel formulation
containing gel
weight
Prior art date
Application number
KR1019900021903A
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English (en)
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KR0173309B1 (ko
Inventor
히로시 아케미
다카시 기노시타
사브로 오쓰카
요시후미 호사카
구니오 쓰카모토
요시히사 나카노
Original Assignee
야마구치 에이이치
데이코쿠조키세이야쿠 가부시키가이샤
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Publication of KR910011265A publication Critical patent/KR910011265A/ko
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Publication of KR0173309B1 publication Critical patent/KR0173309B1/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7076—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising ingredients of undetermined constitution or reaction products thereof, e.g. rosin or other plant resins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens

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  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dermatology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Botany (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)

Abstract

내용 없음

Description

에스트로겐-함유 겔 제제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 실시예에서 수득한 겔 제제에 대한 워터 테스트의 방출 결과 그래프도이다

Claims (11)

  1. 기질이 이의 한쪽 표면에 성분(a)에스트로겐, (b)아크릴레이트 중합체 및 (c) 성분 (b)와 혼화성인 액체 성분을 함유하고 성분(b) : 성분(c)의 중량비가 1.0/0.25 내지 1.0/2.0인 조성무를 가교결합시킴으로써 형성된 가교결합 겔 층을 함유함을 특징으로 하는 에스트로겐-함유겔 제제.
  2. 제1항에 있어서, 성분(b)가 알킬(메트)아크릴 레이트, 비닐 단량체의 측쇄상에 적어도 하나의 질소원자를 함유하는 포화 또는 불포화 헤테로사이클릭 환이 달린 비닐단량체 및 (메트) 아크릴산을 공중합시켜 수득한 아크릴 공중합체인 에스트로겐-함유 겔 제제.
  3. 제1항에 있어서, 성분(a)가 에스트라디올인 에스트로겐-함유 겔 제제.
  4. 제1항에 있어서, 성분(b) : 성분(c)의 중량비가 1.0/0.4 내지 1.0/2.0인 에스트로겐-함유 겔 제제.
  5. 제4항에 있어서, 성분(b) : 성분(c)의 중량비가 1.0/0.6 내지 1.0/1.8인 에스트로겐-함유 겔 제제.
  6. 제1항에 있어서, 에스트로겐의 함량이 가교결합된 겔 층의 총량을 기준으로 20중량%이하인 에스트로겐-함유겔 제제.
  7. 제6항에 있어서, 에스트로겐의 함량이 가교결합된 겔 층의 총량을 기준으로 1 내지 10중량%인 에스트로겐-함유겔 제제.
  8. 제7항에 있어서, 에스트로겐의 함량이 가교결합된 겔 층의 총량을 기준으로 1 내지 8중량%인 에스트로겐-함유 겔 제제.
  9. 제1항에 있어서, 조성물이 삼작용성 이소시아네이트, 금속 알콜레이트 및 티타늄 또는 알루미늄을 아크릴레이트 중합체 100중량부당 0.01 내지 2.0중량부의 양으로 함유하는 금속 킬레이트 화합물 중에서 선택된 가교결합제를 추가로 함유하는 에스트로겐-함유 겔 제제.
  10. 제1항에 있어서, 가교결합된 겔 층의 두께가 10 내지 300㎛인 에스트로겐-함유 겔 제제.
  11. 제10항에 있어서, 가교결합된 겔 층의 두께가 40 내지 160㎛인 인스트로겐-함유 겔 제제.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900021903A 1989-12-28 1990-12-27 에스트로겐 함유 겔 제제 KR0173309B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP344639/89 1989-12-28
JP34463989 1989-12-28
JP237383/90 1990-09-06
JP237383190 1990-09-06
JP23738390A JP3273430B2 (ja) 1989-12-28 1990-09-06 エストロゲン含有ゲル製剤

Publications (2)

Publication Number Publication Date
KR910011265A true KR910011265A (ko) 1991-08-07
KR0173309B1 KR0173309B1 (ko) 1999-02-01

Family

ID=26533184

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019900021903A KR0173309B1 (ko) 1989-12-28 1990-12-27 에스트로겐 함유 겔 제제

Country Status (10)

Country Link
US (1) US5242951A (ko)
EP (1) EP0435200B1 (ko)
JP (1) JP3273430B2 (ko)
KR (1) KR0173309B1 (ko)
AT (1) ATE124872T1 (ko)
CA (1) CA2033113C (ko)
DE (1) DE69020875T2 (ko)
DK (1) DK0435200T3 (ko)
ES (1) ES2075129T3 (ko)
GR (1) GR3017650T3 (ko)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5762952A (en) * 1993-04-27 1998-06-09 Hercon Laboratories Corporation Transdermal delivery of active drugs
JP2539330B2 (ja) * 1993-05-11 1996-10-02 日東電工株式会社 医療用粘着剤及びこれを用いて形成された医療用外用材
DE4336299A1 (de) * 1993-10-25 1995-05-11 Arbo Robotron Medizin Technolo Gelkörper zur percutanen Verabreichung, insbesondere von Medikamenten
JP3576608B2 (ja) * 1994-11-15 2004-10-13 日東電工株式会社 貼付剤および貼付製剤
AU6032696A (en) * 1995-06-07 1996-12-30 Cygnus Therapeutic Systems Pressure sensitive acrylate adhesive composition cross-linke d with aluminum acetylacetonate and containing a drug having a reactive aromatic hydroxyl group
US5861431A (en) * 1995-06-07 1999-01-19 Iotek, Inc. Incontinence treatment
JP2000515523A (ja) 1996-07-22 2000-11-21 ザ・ビクトリア・ユニバーシティ・オブ・マンチェスター 創傷および線維性障害の治療における性ステロイド機能モジュレーターの使用
EP0961794A1 (en) * 1997-02-21 1999-12-08 Adhesives Research, Inc. Transdermal pressure sensitive adhesive drug delivery system and pressure sensitive adhesive used therein
US6239228B1 (en) 1997-02-21 2001-05-29 Adhesives Research, Inc. Pressure sensitive adhesive containing macromer having repeat hydrophilic moieties
US5951999A (en) 1997-02-21 1999-09-14 Adhesives Research, Inc. Transdermal pressure sensitive adhesive drug delivery system
DE19834007C1 (de) * 1998-07-29 2000-02-24 Lohmann Therapie Syst Lts Estradiolhaltiges Pflaster zur transdermalen Applikation von Hormonen und seine Verwendung
AU1667701A (en) * 2000-02-10 2001-08-16 Rohm And Haas Company Bioadhesive composition
US6698162B2 (en) 2000-03-23 2004-03-02 Teikoku Pharma Usa, Inc. Methods of producing a terminally sterilized topical patch preparation
US7198801B2 (en) 2000-08-03 2007-04-03 Antares Pharma Ipl Ag Formulations for transdermal or transmucosal application
US8980290B2 (en) 2000-08-03 2015-03-17 Antares Pharma Ipl Ag Transdermal compositions for anticholinergic agents
JP5027373B2 (ja) * 2002-08-09 2012-09-19 帝國製薬株式会社 エストラジオール含有貼付剤
CA2494915C (en) * 2002-08-09 2012-07-10 Teikoku Seiyaku Co., Ltd. Female hormone-containing patch
PT1670433E (pt) 2003-10-10 2012-02-08 Ferring Bv Fórmula farmacológica transdérmica para a minimização de resíduos na pele
JP4745747B2 (ja) * 2004-08-12 2011-08-10 日東電工株式会社 フェンタニル含有貼付製剤
JP4824963B2 (ja) * 2004-08-12 2011-11-30 日東電工株式会社 貼付材及び貼付製剤
WO2006125642A1 (en) 2005-05-27 2006-11-30 Antares Pharma Ipl Ag Methods and apparatus for transdermal or transmucosal application of testosterone
CN101232869B (zh) * 2005-06-16 2016-03-02 沃纳奇尔科特有限责任公司 局部给药的凝胶组合物
WO2006138715A1 (en) * 2005-06-16 2006-12-28 Warner Chilcott Company, Inc. Estrogen compositions for vaginal administration
US10016442B2 (en) 2005-06-16 2018-07-10 Allergan Pharmaceuticals International Limited Estrogen compositions for vaginal administration
CA2646667C (en) 2006-04-21 2014-03-11 Antares Pharma Ipl Ag Methods of treating hot flashes with formulations for transdermal or transmucosal application
CN107362131A (zh) * 2017-08-31 2017-11-21 北京海霞润月更年期综合症医学研究院 一种雌激素凝胶及制备方法
CN114344700A (zh) * 2022-01-18 2022-04-15 兰州大学 一种载有雌二醇微乳的可溶性微针及其制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3267083A (en) * 1963-06-07 1966-08-16 Union Carbide Corp Reprocessable crosslinked polymeric compositions
JPS51107389A (ja) * 1975-03-18 1976-09-22 Kojin Kk Horiakurirusanaruminiumuenno seizohoho
US4078060A (en) * 1976-05-10 1978-03-07 Richardson-Merrell Inc. Method of inducing an estrogenic response
SU1243627A3 (ru) * 1979-12-05 1986-07-07 Дзе Кендалл Компани (Фирма) Гелеобразующа композици
JPS572303A (en) * 1980-06-04 1982-01-07 Wako Pure Chem Ind Ltd Preparation of crosslinked alkali salt of polyacrylic acid
CH655656B (ko) * 1982-10-07 1986-05-15
JPS60190723A (ja) * 1984-03-09 1985-09-28 Yamanouchi Pharmaceut Co Ltd 難溶性薬物の溶解速度向上方法
ATE59302T1 (de) * 1984-07-24 1991-01-15 Key Pharma Klebende schicht zur transdermalen freigabe.
JPS6160620A (ja) * 1984-09-03 1986-03-28 Teijin Ltd ピログルタミン酸エステル類を含有する医薬品組成物
EP0223524B1 (en) * 1985-11-08 1991-10-23 Nitto Denko Corporation Use of adhesive dermal bandages and dermal percutaneous preparations
CN1021196C (zh) * 1986-12-29 1993-06-16 新泽西州州立大学(鲁杰斯) 透皮雌激素/孕激素药剂单元、系统及方法
US4906475A (en) * 1988-02-16 1990-03-06 Paco Pharmaceutical Services Estradiol transdermal delivery system
WO1989007951A1 (en) * 1988-02-26 1989-09-08 Riker Laboratories, Incorporated Transdermal estradiol delivery system
US4994267A (en) * 1988-03-04 1991-02-19 Noven Pharmaceuticals, Inc. Transdermal acrylic multipolymer drug delivery system
CA2000401C (en) * 1988-10-11 1996-05-28 Masato Azuma Percutaneous pharmaceutical preparation
US5002986A (en) * 1989-02-28 1991-03-26 Hoechst Celanese Corporation Fluid absorbent compositions and process for their preparation

Also Published As

Publication number Publication date
EP0435200A2 (en) 1991-07-03
DE69020875D1 (de) 1995-08-17
EP0435200B1 (en) 1995-07-12
ATE124872T1 (de) 1995-07-15
KR0173309B1 (ko) 1999-02-01
JP3273430B2 (ja) 2002-04-08
DK0435200T3 (da) 1995-11-20
DE69020875T2 (de) 1995-12-14
CA2033113C (en) 1996-09-03
GR3017650T3 (en) 1996-01-31
CA2033113A1 (en) 1991-06-29
US5242951A (en) 1993-09-07
ES2075129T3 (es) 1995-10-01
JPH03220121A (ja) 1991-09-27
EP0435200A3 (en) 1991-09-11

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