KR910009686A - 키랄 3,4-에폭시 벤조피란의 신규 제조 방법 - Google Patents

키랄 3,4-에폭시 벤조피란의 신규 제조 방법 Download PDF

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Publication number
KR910009686A
KR910009686A KR1019900019429A KR900019429A KR910009686A KR 910009686 A KR910009686 A KR 910009686A KR 1019900019429 A KR1019900019429 A KR 1019900019429A KR 900019429 A KR900019429 A KR 900019429A KR 910009686 A KR910009686 A KR 910009686A
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KR
South Korea
Prior art keywords
benzopyran
epoxy
dihydro
cyano
dimethyl
Prior art date
Application number
KR1019900019429A
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English (en)
Inventor
스미스 폴
그하브쇼우 마이클
Original Assignee
데이빗 로버츠
비이참 그루우프 피이엘시이
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Priority claimed from GB898926993A external-priority patent/GB8926993D0/en
Priority claimed from GB909023300A external-priority patent/GB9023300D0/en
Application filed by 데이빗 로버츠, 비이참 그루우프 피이엘시이 filed Critical 데이빗 로버츠
Publication of KR910009686A publication Critical patent/KR910009686A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/04—Compounds containing oxirane rings containing only hydrogen and carbon atoms in addition to the ring oxygen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Epoxy Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음

Description

키랄 3,4-에폭시 벤조피란의 신규 제조 방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 하기 일반식(D) 화합물:
    (상기식에서, NH2및 OH 부분은 트랜스이고, 각각(R,S) 또는 (S,R)이다.)의 사차 암모늄염의 염기 처리로 구성되는, 하기 일반식(A)′또는 (A)″화합물의 제조방법:
  2. 제1항에 있어서, Z이 산소인 방법.
  3. 제1항 또는 제2항에 있어서, R1이 치환체이고, R2가 수소인 방법.
  4. 제1항, 제2항 또는 제3항에 있어서, R3및 R4가 모두 메틸기인 방법.
  5. 제1항 내지 제4항중 어느 한 항에 있어서, R1이 니트로, 시아노, 아세틸, CF3,C2F5,OCF3,에틸,이소프로필 또는 시클로펜틸인 방법.
  6. 제1항 내지 제5항중 어느 한 항에 있어서, 일반식(A′)의 화합물 즉, (S,S)-이성체의 제조방법.
  7. 제1항에 있어서, (3S,4S)-6-시아노-3,4-디히드로-3,4-에폭시-2,2-디메틸-2H-1-벤조피란, (3R,4R)-6-시아노-3,4-디히드로-3,4-에폭시-2,2-디메틸-2H-1-벤조피란, 또는 (3S, 4S)-6-에틸-3,4-디히드로-3,4-에폭시-2,2-디메틸-2H-1-벤조피란의 제조방법.
  8. 제1항에 있어서, 사차 암모늄 염이 RL(이때, R은 C1-4알킬이고, L은 수소이다)로 형성된 것인 방법.
  9. 제8항에 있어서, RL이 CH3I인 방법.
  10. 제1항에 따라 제조된 것과 같이, 각각 일반식(A′)또는(A″)의 (3S,4S) 또는 (3R,4R) 에폭시드로부터 제조되는 (3S,4R) 또는 (4R,4S) 칼륨 통로 활성제 벤조피란.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900019429A 1989-11-29 1990-11-28 키랄 3,4-에폭시 벤조피란의 신규 제조 방법 KR910009686A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB898926993A GB8926993D0 (en) 1989-11-29 1989-11-29 Process
GB89269930 1989-11-29
GB90233008 1990-10-25
GB909023300A GB9023300D0 (en) 1990-10-25 1990-10-25 Process

Publications (1)

Publication Number Publication Date
KR910009686A true KR910009686A (ko) 1991-06-28

Family

ID=26296278

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019900019429A KR910009686A (ko) 1989-11-29 1990-11-28 키랄 3,4-에폭시 벤조피란의 신규 제조 방법

Country Status (8)

Country Link
EP (1) EP0430621A3 (ko)
JP (1) JPH03190878A (ko)
KR (1) KR910009686A (ko)
AU (1) AU633383B2 (ko)
CA (1) CA2030969A1 (ko)
IE (1) IE904278A1 (ko)
NZ (1) NZ236228A (ko)
PT (1) PT96023B (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3936616A1 (de) * 1989-11-03 1991-05-08 Merck Patent Gmbh Verfahren zur enantiomerentrennung von benzopyranderivaten
US5573758A (en) * 1995-04-28 1996-11-12 Allergan Method for reducing intraocular pressure in the mammalian eye by administration of potassium channel blockers

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2107706A (en) * 1981-09-25 1983-05-05 Beecham Group Plc Benzopyrans
DE3811017A1 (de) * 1988-03-31 1989-10-19 Hoechst Ag Ungesaettigte n-benzopyranyllactame
EP0346724A1 (de) * 1988-06-16 1989-12-20 MERCK PATENT GmbH Chromanderivate
GB8924373D0 (en) * 1989-10-30 1989-12-20 Beecham Group Plc Novel compounds
DE3936616A1 (de) * 1989-11-03 1991-05-08 Merck Patent Gmbh Verfahren zur enantiomerentrennung von benzopyranderivaten

Also Published As

Publication number Publication date
JPH03190878A (ja) 1991-08-20
PT96023B (pt) 1997-08-29
AU6697890A (en) 1991-06-06
CA2030969A1 (en) 1991-05-30
NZ236228A (en) 1992-07-28
IE904278A1 (en) 1991-06-05
AU633383B2 (en) 1993-01-28
PT96023A (pt) 1991-09-13
EP0430621A2 (en) 1991-06-05
EP0430621A3 (en) 1992-03-04

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