KR910006243A - 안트라닐산 유도체, 그의 제법 및 용도 - Google Patents

안트라닐산 유도체, 그의 제법 및 용도 Download PDF

Info

Publication number
KR910006243A
KR910006243A KR1019900015418A KR900015418A KR910006243A KR 910006243 A KR910006243 A KR 910006243A KR 1019900015418 A KR1019900015418 A KR 1019900015418A KR 900015418 A KR900015418 A KR 900015418A KR 910006243 A KR910006243 A KR 910006243A
Authority
KR
South Korea
Prior art keywords
hydrogen
halogen
alkyl
compound
formula
Prior art date
Application number
KR1019900015418A
Other languages
English (en)
Inventor
마이엔피슈 페터
힐덴브란트 크리스토프
제레 쟝-끌로드
Original Assignee
베르너 발데크
시바-가이기 아게
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 베르너 발데크, 시바-가이기 아게 filed Critical 베르너 발데크
Publication of KR910006243A publication Critical patent/KR910006243A/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C07D213/643—2-Phenoxypyridines; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C07D213/85—Nitriles in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/38—One sulfur atom

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Fodder In General (AREA)

Abstract

내용 없음

Description

안트라닐산 유도체, 그의 제법 및 용도
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (14)

  1. 하기 일반식(I)의 화합물 또는 생리학적으로 허용되는 그의 산부가염;
    상기식에서, R₁은 할로겐, C₁-C2알킬, C₁-C2티오알킬, C₁-C₂-할로알킬, 니트로, C₁-C₂-알콕시 또는 SOnR기이고, 여기서 R은 C₁-C2알킬 또는 페닐, n은 0,1 또는 2이며; R₂는 수소, 할로겐, C₁-C₂알킬, C₁-C₂할로알킬, C₁-C₂할로알콕시 또는 C₁-C₂알콕시이고; R3은 수소 또는 C₁-C2알킬이고; R4는 수소 또는 C₁-C₂알킬이고; R5는 수소, 할로겐 또는 C₁-C₂알킬이고;R7은 수소, 할로겐,또는 C₁-C5알킬이고; R7은 수소, 할로겐, C₁-C2알킬, 니트로, C₁-C₂할로알킬, C₁-C2할로알콕시 또는C ₁-C₂알콕시이고; R8은 수소, 할로겐, C₁-C₂알킬, C₁-C2할로알킬, C₁-C₂할로알콕시 또는 C₁-C2알콕시이고; R9는 수소, 할로겐, C₁-C₂알킬, ₁-C₂할로알킬, C₁-C₂할로알콕시 또는 C₁-C2알콕시이고; R9는 수소, 할로겐, C₁-C₂알킬, C₁-C₂할로알킬 C₁-C₂알킬티오, C3-C6시클로알킬 또는 시아노이고; R11은 수소, 할로겐, C₁-C6알킬, C₁-C₂할로알킬, ₁-C₂알킬티오 또는 C3-C6시클로알킬;R12는 수소 또는 할로겐이며; Y는 =CH-또는 =N- 이다.
  2. 제1항에 있어서, R1이 수소, 할로겐, C1-C₂알킬, C1-₂할로알킬, 니트로, C1-C₂-알콕시, 또는 SOnR기, 여기서 R은 C1-C2알킬 또는 페닐이고, n은 0,1 또는 2이고, R2내지 R12및 Y가 제1항에서 정의한 바와 같은 일반식(I)의 화합물.
  3. 제1항에 있어서, R₁,R₂,R₃,R₄,R7,R8,R9,R12및 Y가 일반식(I)에 대한 정의와 같고; R5가 수소, 할로겐 또는 C₁-C3알킬이고;R6이 수소, 할로겐 또는 C₁-C3알킬이고; R10이 수소, 할로겐, C₁-C4알킬, C₁-C₂할로알킬, C1-C2알킬티오, 시클로프로필 또는 시아노이며;R11이 수소, 할로겐, C₁-C4알킬, C₁-C₂할로알킬, C₁-C₂알킬티오 또는 시클로프로필인 일반식(I)의 화합물 또는 생리학적으로 허용되는 그의 산부가염.
  4. 제2항에 있어서, R1이 수소, 할로겐, 메틸, 메톡시 또는 에틸이고; R5가 수소, 메틸 또는 할로겐이고; R3이 수소, 메틸 또는 에틸이고;R4가 수소, 메틸 또는 에틸이고; R5가 수소, 할로겐 또는 C1-C4알킬이고;R6이 수소, 할로겐 또는 C1-C4알킬이고;R7이 수소, 할로겐, 메틸, 메톡시, CF3또는 니트로이고;R8이 수소 또는 할로겐이며;R9가 수소, 할로겐, C₁-C₂알킬, C₁-C₂할로알킬, C₁-C₂할로알콕시 또는 C1-C₂알콕시이고;R10과 R11이 서로 독립적으로 각기 수소, 할로겐, C1-C4알킬, 메틸티오, 트리플루오로메틸, CF2CCl2F, 시클로프로필 또는 시아노이고;R12가 수소 또는 할로겐이며;Y가 =CH-또는 =N- 이고, 피리딘옥시 또는 피리미딘옥시치환기가 페닐 고리의 3- 또는 4- 위치를 통하여 결합되어 있는 일반식(I)의 화합물.
  5. 제1항에 있어서, R1이 5-할로겐 또는 4-할로겐이고;R2가 수소이며;R3은 수소 또는 C1-C2알킬이고; R4는 수소 또는 C₁-C2알킬이고;R5는 수소, 할로겐 또는 C₁-C5알킬이고;R6은 수소, 할로겐 또는 C₁-C5알킬이고;R7은 수소, 할로겐, C₁-C6알킬, C₁-C2할로알킬, C₁-C2할로알콕시 또는 C₁-C2알콕시이고;R10은 수소, 할로겐, C₁-C6알킬, C₁-C₂할로알킬, C₁-C₂알킬티오, C3-C6시클로알킬 또는 시아노이고;R11은 수소, 할로겐, C₁-C6알킬, C₁-C₂할로알킬, C₁-C₂알킬티오, C3-C6시클로알킬이고;R12는 수소 또는 할로겐이며; Y는 =CH-또는 =N- 인 화합물 또는 생리학적으로 허용되는 그의 산부가염.
  6. 제5항에 있어서, R1이 5-염소 또는 4-염소이고; R2가 수소이며;R3은 수소, 메틸 또는 에틸이고;R4가 수소, 메틸 또는 에틸이고;R5가 수소, 할로겐 또는 C1-C4알킬이고;R6이 수소, 할로겐 또는 C1-C4알킬이고;R7이 수소, 할로겐, 메틸, 메톡시, CF3또는 니트로이고;R8이 수소 또는 할로겐이며;R9가 수소, 할로겐, C1-C₂알킬, C1-C₂할로알킬, C1-C₂할로알콕시 또는 C1-C₂알콕시이고;R10과 R11이 서로 독립적으로 각기 수소, 할로겐, C1-C4알킬, 메틸티오, 트리플루오로메틸, CF2CCl2F, 시클로프로필 또는 시아노이고;R12가 수소 또는 할로겐이며;Y가=CH-또는 =N- 이고, 피리딘옥시 또는 피리딘옥시 치환기가 페닐 고리의 3- 또는 4- 위치를 통하여 결합되어 있는 일반식(I)의 화합물.
  7. 제1항에 있어서, 5-클로로-2-[(4-클로로페닐술포닐)-아미노]-벤조산[4-(4-트리풀루오로-메틸-6-시클로프로필리미딘-2-일옥시)아닐리드]; 5-클로로-2-[(4-클로로페닐술포닐)-아미노]-벤조산[4-(3-클로로-5-트리-플루오로메틸피리딘-2-일옥시)아닐리드] 5-클로로-2-[(4-클로로페닐술포닐)-아미노]-벤조산[4-(4-트리풀루오로-메틸피리딘-2-일옥시)아닐리드]; 5-클로로-2-[(4-클로로페닐술포닐)-아미노]-벤조산[4-(4-트리풀루오로-메틸-6-3차부틸피리미딘-2-일옥시)아닐리드];3,5-디클로-2-[4-클로로페닐술포닐)-아미노]-벤조산[4-(4-트리플루-오로메틸-6-시클로프로필피리미딘-2-일옥시)아닐리드];3,5-디클로로-2-[(4-클로로페닐술포닐)-아미노]벤조산[4-(5-트리플루-오로메틸피리딘-2-일옥시)아닐리드]로 부터 선택되는 화합물.
  8. 제1항에 있어서, 4-클로로-2-[(4-클로로페닐술포닐)-아미노]-벤조산[4-(3-클로로-5-트리플루오로메틸피리딘-2-일옥시)아닐리드]인 화합물.
  9. (A)하기 일반식(Ⅱ)의 화합물을 하기 일반식(Ⅲ)의 벤젠술폰산 할라이드와 반응시키거나;
    (B)하기 일반식(Ⅳ)의 화합물을 하기 일반식(Ⅴ)의 화합물과 반응시키는 것을 포함하는 제1항 내지 제8항중 어느 한항에 따른 일반식(I)화합물의 제조 방법;
    상기식(Ⅱ),(Ⅲ),Ⅳ) 및 (V)에서 치환기 R1내지 R12및 Y는 일반식(I)에 대한 정의와 같고, 일반식(Ⅲ)에서 X는 할로겐, 바람직하게는 염소 또는 브롬, 특히 염소이며, 일반식(Ⅳ)에서 A는 할로겐(바람직하게는 염소 또는 브롬), OH, 또는 아미노기와 반응할 수 있는 이탈기이고, 필요에 따라서는 R3과 R4가 수소이거나 그들 중 하나만이 수소인 일반식(Ⅱ)의 화합물을 알킬화시킨다.
  10. 제1항 내지 제8항 중 어느 한 항에 따른 일반식(I)의 화합물과 함께 생리학적으로 허용되는 배합 보조제를 함유하는 구충 조성물.
  11. 구충 효과량만큼의 제1항 내지 제8항중 어느 한 항에 따른 일반식(I)의 화합물을 온혈 동물에게 예방적으로 또는 치료목적으로 투여하는 것을 포함하는 온혈 동물내 기생충 박멸 방법.
  12. 온혈 동물내 기생충을 박멸하는 방법에서 사용하기 위한 제1항 내지 제8항중 어느 한 항에 따른 일반식(I)의 화합물.
  13. 구충제의 제조를 위한 제1항 내지 제8항 중 어느 한항에 따른 일반식(I)의 화합물의 용도.
  14. 하기 일반식의 화합물:
    상기식에서, R₁,R₂,R₃,R5,R6,R10,R11및 R12는 제1항에 정의된 바와 같고 R13은 -NO₂또는 -NHR₄이고 여기서 R4는 제1항에 정의된 바와 같다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900015418A 1989-09-26 1990-09-25 안트라닐산 유도체, 그의 제법 및 용도 KR910006243A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH3481/89-4 1989-09-26
CH348189 1989-09-26

Publications (1)

Publication Number Publication Date
KR910006243A true KR910006243A (ko) 1991-04-27

Family

ID=4256912

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019900015418A KR910006243A (ko) 1989-09-26 1990-09-25 안트라닐산 유도체, 그의 제법 및 용도

Country Status (11)

Country Link
US (2) US5081125A (ko)
EP (1) EP0420804A3 (ko)
JP (1) JPH03123773A (ko)
KR (1) KR910006243A (ko)
AU (1) AU627075B2 (ko)
CA (1) CA2026037A1 (ko)
DD (1) DD299179A5 (ko)
HU (1) HUT54986A (ko)
IE (1) IE903450A1 (ko)
IL (1) IL95750A0 (ko)
ZA (1) ZA907637B (ko)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19830431A1 (de) 1998-07-08 2000-01-13 Hoechst Marion Roussel De Gmbh Sulfonylamino-carbonsäure-N-arylamide als Guanylatcyclase-Aktivatoren
US7041691B1 (en) * 1999-06-30 2006-05-09 Amgen Inc. Compounds for the modulation of PPARγ activity
AU6118001A (en) 2000-05-03 2001-11-12 Tularik Inc Combination therapeutic compositions and methods of use
US20030171399A1 (en) * 2000-06-28 2003-09-11 Tularik Inc. Quinolinyl and benzothiazolyl modulators
JP4083422B2 (ja) * 2000-12-22 2008-04-30 石原産業株式会社 アニリン誘導体またはその塩ならびにそれらを含有するサイトカイン産生抑制剤
CA2432713C (en) * 2000-12-22 2009-10-27 Ishihara Sangyo Kaisha, Ltd. Aniline derivatives or salts thereof and cytokine production inhibitors containing the same
US7459562B2 (en) * 2004-04-23 2008-12-02 Bristol-Myers Squibb Company Monocyclic heterocycles as kinase inhibitors
TW200538453A (en) * 2004-04-26 2005-12-01 Bristol Myers Squibb Co Bicyclic heterocycles as kinase inhibitors
US7173031B2 (en) 2004-06-28 2007-02-06 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
US7439246B2 (en) * 2004-06-28 2008-10-21 Bristol-Myers Squibb Company Fused heterocyclic kinase inhibitors
US7432373B2 (en) * 2004-06-28 2008-10-07 Bristol-Meyers Squibb Company Processes and intermediates useful for preparing fused heterocyclic kinase inhibitors
US8754219B2 (en) * 2010-04-27 2014-06-17 Calcimedica, Inc. Compounds that modulate intracellular calcium
EP2990403A1 (en) * 2014-08-29 2016-03-02 Novartis Tiergesundheit AG Anthranilamides, sulfonamides and nitro analogues derived therefrom as anthelmintics

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB865735A (en) * 1957-12-24 1961-04-19 Geigy Ag J R Process for the production of new aminobenzoic acid derivatives and their use in pest control
GB876526A (en) * 1957-12-24 1961-09-06 Geigy Ag J R Process for the production of new aminobenzoic acid derivatives and their use in pest control
DE3523705A1 (de) * 1985-07-03 1987-01-08 Hoechst Ag Arzneimittel und deren verwendung
ATE116298T1 (de) * 1987-12-07 1995-01-15 Ciba Geigy Ag 3-aminobenzoylphenylharnstoffe.

Also Published As

Publication number Publication date
US5132314A (en) 1992-07-21
HUT54986A (en) 1991-04-29
HU906028D0 (en) 1991-03-28
AU6320190A (en) 1991-04-11
CA2026037A1 (en) 1991-03-27
EP0420804A2 (de) 1991-04-03
US5081125A (en) 1992-01-14
AU627075B2 (en) 1992-08-13
ZA907637B (en) 1991-05-29
IL95750A0 (en) 1991-06-30
IE903450A1 (en) 1991-04-10
JPH03123773A (ja) 1991-05-27
DD299179A5 (de) 1992-04-02
EP0420804A3 (en) 1991-11-27

Similar Documents

Publication Publication Date Title
KR910006243A (ko) 안트라닐산 유도체, 그의 제법 및 용도
KR910006277A (ko) N-치환된-4-피리미딘아민 및 피리미딘디아민, 이의 제조방법 및 약제로서의 이의 용도
KR880005071A (ko) 벤조일우레아 화합물, 그의 제법 및 그를 함유하는 살충제
KR880011130A (ko) 페닐트리아졸 유도체 및 살충제
PL141641B1 (en) Agent for fighting against and/or preventing paralyzing effects of microorganisms and method of obtaining new derivatives of n-/2-nitrophenylo/-4-aminopyrimidiines
ATE40684T1 (de) (benzoyl-4-piperidino)-2-phenyl-1alkanolderivate, ihre herstellung und ihre verwendung als heilmittel.
ATE196293T1 (de) Triazole enthaltende antifungizide mittel
KR830005152A (ko) N-페닐피라졸 유도체의 제조방법
KR910006257A (ko) 안트라닐산 유도체 및 이를 함유하는 구충제 조성물
FI925501A0 (fi) Imidazolfoereningar, deras framstaellning och anvaendning
DE69103968D1 (de) 2-(Aminoalkyl)-5-(arylalkyl)1,3-dioxanderivate, ihre Herstellung und ihre Anwendung in der Therapeutik.
FI945763A0 (fi) Herbisidiset yhdisteet
KR840007575A (ko) 벤조일 우레아 화합물의 제조방법
EP0337560A3 (de) 2-Phenylsulfinyl-nitro-pyridine, Verfahren zu ihrer Herstellung und ihre Verwendung
KR960016716A (ko) 테트라졸리논
NO910167D0 (no) Haarfargemiddel.
KR900018042A (ko) 부텐산 유도체
ATE200666T1 (de) Sulfonylharnstoffderivate, verfahren zu ihrer herstellung und ihre verwendung
ATE266026T1 (de) Benzofurancarboxamide und deren therapeutische verwendung
ES8104210A1 (es) Un procedimiento para la preparacion de un compuesto de biu-ret 1,1,3,5-sustituido.
KR880013881A (ko) 하이드라진 유도체, 그들의 제조방법 및 그들이 함유된 약제학적 조성물
PT950049E (pt) Difenil-alquil-tetra-hidropiridinas processo para a sua preparacao e composicoes farmaceuticas contendo-as
EA200000116A1 (ru) Противогрибковые соединения на основе 2,4,4-тризамещенных-1,3-диоксоланов
KR900700104A (ko) 항불안제
JPS53112845A (en) Urea derivative, its preparation and herbicide therefrom

Legal Events

Date Code Title Description
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid