KR910004617A - 치환된 피라진, 이의 제형 및 약제로서의 용도 - Google Patents
치환된 피라진, 이의 제형 및 약제로서의 용도 Download PDFInfo
- Publication number
- KR910004617A KR910004617A KR1019900012128A KR900012128A KR910004617A KR 910004617 A KR910004617 A KR 910004617A KR 1019900012128 A KR1019900012128 A KR 1019900012128A KR 900012128 A KR900012128 A KR 900012128A KR 910004617 A KR910004617 A KR 910004617A
- Authority
- KR
- South Korea
- Prior art keywords
- salt
- compound
- chloropyrazin
- azabicyclo
- octane
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
내용 없음.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (13)
- 화합물 (R)-3-[2-(6-클로로피라진)일]-1-아자비사이클로[2.2.2]옥탄 또는 이의 염.
- 제1항에 있어서, 하이드로클로라이드, 수소 말레에이트, 세스퀴옥살레이트 또는 수소 타르트레이트 염인 화합물.
- (a) 하기 일반식(VIII)의 화합물 또는 이의 염을 환화시키거나; (b) 3-[2-(6-클로로피라진)일]-1-아자비사이클로[2.2.2]옥탄의 에난티오머를 분할하고; 임의로는 상기와 같이 제조된 화합물과 산을 반응시킴으로써 이의 산 부가염을 제조함을 특징으로 하여, 제1항 또는 제2항에 따른 화합물 또는 이의 염을 제조하는 방법.상기식에서, R4는 불안정한 이탈 그룹이다.
- 제3(a)항에 있어서, R4가 메실레이트 또는 할로인 방법.
- 제3(a)항 또는 4항에 있어서, 일반식(VIII)의 염이 하이드로클로라이드인 방법.
- 제3(a)항에 있어서, 키랄산을 사용하여 분할하는 방법.
- (R)-3-[2-(6-클로로피라진)일]-1-아자비사이클로[2.2.2]옥탄 또는 약제학적으로 허용되는 이의 염 및 약제학적으로 허용되는 담체를 포함함을 특징으로 하는 제약학적 조성물.
- (R)-3-[2-(6-클로로피라진)일]-1-아자비사이클로[2.2.2]옥탄 또는 약제학적으로 허용되는 이의 염 및 약제학적으로 허용되는 담체 혼합시킴을 특징으로 하여, 제7항에 따른 조성물을 제조하는 방법.
- 환자에게 (R)-3-[2-(6-클로로피라진)일]-1-아자비사이클로[2.2.2]옥탄 또는 약제학적으로 허용되는 이의 염을 투여함을 특징으로 하여, 신경 질환 및 정신 질환을 치료 또는 예방하는 방법.
- 제9항에 있어서, 질환이 치매인 방법.
- 제3항 내지 제6항중 어느 한 항에 따른 방법에 의해 제조된 제1항 또는 제2항의 화합물.
- 제8항에 따른 방법에 의해 제조된 제7항의 제형.
- 실질적으로 본 발명의 상세한 설명 및 실시예와 관련하여 기술된 화합물, 제형 및 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8918060.8 | 1989-08-08 | ||
GB898918060A GB8918060D0 (en) | 1989-08-08 | 1989-08-08 | Therapeutic agents |
Publications (1)
Publication Number | Publication Date |
---|---|
KR910004617A true KR910004617A (ko) | 1991-03-29 |
Family
ID=10661305
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019900012128A KR910004617A (ko) | 1989-08-08 | 1990-08-08 | 치환된 피라진, 이의 제형 및 약제로서의 용도 |
Country Status (13)
Country | Link |
---|---|
US (1) | US5073557A (ko) |
EP (1) | EP0416754A3 (ko) |
JP (1) | JPH03135979A (ko) |
KR (1) | KR910004617A (ko) |
AU (1) | AU6083090A (ko) |
CA (1) | CA2022885A1 (ko) |
FI (1) | FI903919A0 (ko) |
GB (1) | GB8918060D0 (ko) |
IE (1) | IE902875A1 (ko) |
IL (1) | IL95312A0 (ko) |
NO (1) | NO903484L (ko) |
PT (1) | PT94921A (ko) |
ZA (1) | ZA906251B (ko) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK72790D0 (da) * | 1990-03-21 | 1990-03-21 | Ferrosan As | Heterocycliske forbindelser, deres fremstilling og anvendelse |
GB9017353D0 (en) * | 1990-08-08 | 1990-09-19 | Merck Sharp & Dohme | Chemical process |
CA2050264A1 (en) * | 1990-08-30 | 1992-03-01 | Raymond Baker | Substituted pyrazine and its salts, compositions containing them and their use in medicine |
GB9201749D0 (en) * | 1992-01-28 | 1992-03-11 | Smithkline Beecham Plc | Medicaments |
US5478939A (en) * | 1994-07-20 | 1995-12-26 | American Cyanamid Company | (R,R) and (S,S) 2,5-diazabicyclo [2,2,1]heptane derivatives |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4442096A (en) * | 1982-12-27 | 1984-04-10 | Merck & Co., Inc. | 2-(Substituted)amino-3-cyano-5-halo-6-(substituted)-pyrazine antimicrobial compounds, compositions and use |
DE3515709C1 (de) * | 1985-05-02 | 1986-12-18 | Union Rheinische Braunkohlen Kraftstoff AG, 5000 Köln | Verfahren zum Reinigen von fluessigem Schwefel |
NZ219646A (en) * | 1986-03-27 | 1990-10-26 | Merck Sharp & Dohme | Oxadiazole derivatives of azacyclics for treating cns disorders |
NZ227684A (en) * | 1988-01-30 | 1991-07-26 | Merck Sharp & Dohme | Pyrazine, pyridazine, and pyrimidine derivatives and pharmaceutical compositions |
DE58906678D1 (de) * | 1988-07-28 | 1994-02-24 | Ciba Geigy | Kupfer- und Nickeldihalogenidkomplexe, Verfahren zu deren Herstellung und deren Verwendung. |
-
1989
- 1989-08-08 GB GB898918060A patent/GB8918060D0/en active Pending
-
1990
- 1990-08-06 PT PT94921A patent/PT94921A/pt not_active Application Discontinuation
- 1990-08-08 IE IE287590A patent/IE902875A1/en unknown
- 1990-08-08 CA CA002022885A patent/CA2022885A1/en not_active Abandoned
- 1990-08-08 JP JP2210150A patent/JPH03135979A/ja active Pending
- 1990-08-08 IL IL95312A patent/IL95312A0/xx unknown
- 1990-08-08 ZA ZA906251A patent/ZA906251B/xx unknown
- 1990-08-08 FI FI903919A patent/FI903919A0/fi not_active Application Discontinuation
- 1990-08-08 US US07/564,490 patent/US5073557A/en not_active Expired - Fee Related
- 1990-08-08 EP EP19900308725 patent/EP0416754A3/en not_active Withdrawn
- 1990-08-08 NO NO90903484A patent/NO903484L/no unknown
- 1990-08-08 AU AU60830/90A patent/AU6083090A/en not_active Abandoned
- 1990-08-08 KR KR1019900012128A patent/KR910004617A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP0416754A3 (en) | 1991-11-27 |
GB8918060D0 (en) | 1989-09-20 |
FI903919A0 (fi) | 1990-08-08 |
US5073557A (en) | 1991-12-17 |
NO903484L (no) | 1991-02-11 |
CA2022885A1 (en) | 1991-02-09 |
ZA906251B (en) | 1991-07-31 |
EP0416754A2 (en) | 1991-03-13 |
IL95312A0 (en) | 1991-06-30 |
IE902875A1 (en) | 1991-02-27 |
JPH03135979A (ja) | 1991-06-10 |
NO903484D0 (no) | 1990-08-08 |
PT94921A (pt) | 1991-04-18 |
AU6083090A (en) | 1991-02-14 |
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Legal Events
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WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |