KR910004555A - 디아릴아세틸렌, 그의 제법 및 용도 - Google Patents

디아릴아세틸렌, 그의 제법 및 용도 Download PDF

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Publication number
KR910004555A
KR910004555A KR1019900012135A KR900012135A KR910004555A KR 910004555 A KR910004555 A KR 910004555A KR 1019900012135 A KR1019900012135 A KR 1019900012135A KR 900012135 A KR900012135 A KR 900012135A KR 910004555 A KR910004555 A KR 910004555A
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formula
alkyl
diarylacetylene
hydrogen
group
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KR1019900012135A
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English (en)
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얀센 베른트
뷔스트 한스-하이너
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방에르트, 바르츠
바스프 악티엔게젤샤프트
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Publication of KR910004555A publication Critical patent/KR910004555A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/004—Aftersun preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/14—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
    • C07C321/24—Thiols, sulfides, hydropolysulfides, or polysulfides having thio groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Birds (AREA)
  • Immunology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Seasonings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Cosmetics (AREA)
  • Steroid Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

내용 없음.

Description

디아릴아세틸렌, 그의 제법 및 용도
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (13)

  1. 하기 일반식(I)의 디아릴아세틸렌 :
    상기식에서 R1은 수소 또는 C1-C4-알킬이고, R2및 R3은 각각 수소 : R1인 수소인 경우 서로 함께 -C(CH3)2-B-C(CH3)2-그룹 (여기서, B는 -CH2CH2- 또는 -CH(CH3)-임) 또는 -OC(CH3)(Z)CH2CH2-그룹 (여기서, Z는 C1-C4-알킬임)을 형성하거나 R2는 C1-C3-알콕시이고, R3은 직쇄, 측쇄 또는 다환식일 수 있는 C1-C10-알킬 ; 또는 R2가 수소인 경우 R1및 R3는 각각 상기에서 언급한 바와 같은 알킬이고, R4는 C1-C6-알킬이며, n은 0, 1 또는 2이다.
  2. 제1항에 있어서, R2및 R3이 서로 함께 -C(CH3)2-B-C(CH3)2-그룹을 형성하는 일반식(I)의 디아릴아세틸렌.
  3. 제1항에 있어서, R1및 R3이 각각 C1-C4-알킬인 일반식(I)의 디아릴아세틸렌.
  4. 제2항에 있어서, n이 2인 일반식(I)의 디아릴아세틸렌.
  5. 제1항에 있어서, R2가 C1-C3-알콕시이며 R3이 아다만틸인 일반식(I)의 디아릴아세틸렌.
  6. a) 하기 일반식(II)의 스틸벤을 할로겐화 사킨다음 2몰의 할로겐화 수소를 제거하고 또는 b) 하기일반식(III)의 α-클로로벤질포스폰산염을 하기 일반식(IV)의 알데히드와 반응시키고, 또는 c) 하기 일반식(V)의 α-클로로포스폰산염을 하기 일반식(VI)의 알데히드와 반응시키고, 또는 d) 촉매 및 염기의 존재하에서 하기 일반식(VII)의 모노아릴아세틸렌을 하기 일반식(VIII)의 할로겐화 아릴과 반응시키고, 또는 e) 촉매 및 염기의 존재하에서 하기일반식(IX)의 할로겐화 아릴을 하기 일반식(X)의 모노아릴아세틸렌과 반응시키고, 적당한 경우 그 결과 수득한 화합물을 표준방법에 따라 일반식(I)의 다른 화합물로 전환시키는 것으로 이루어지는 제1 내지 5항중 어느 한 항에서 청구한 바와같은 일반식(I)의 디아릴아세틸렌의 제법 :
    상기식에서, R1은 수소 또는 C1-C4-알킬이고, R2및 R3은 각각 수소 : R1이 수소인 경우 서로 함께 -C(CH3)2-B-C(CH3)2-그룹 (여기서, B는 -CH2CH2- 또는 -CH(CH3)-임) 또는 -OC(CH3)(Z)CH2CH2-그룹 (여기서, Z는 C1-C2-알킬임)을 형성하거나 R2는 C1-C3-알콕시이고, R3은 직쇄, 측쇄 또는 다환식일 수 있는 C1-C10-알킬 ; 또는 R2가 수소인 경우 R1및 R3은 각각 상기에서 언급한 바와 같은 알킬이고, R4는 C1-C6-알킬이며, n은 0, 1 또는 2이며, Hal은 염소, 브롬 또는 요오드이다.
  7. 활성 화합물로서 제1 내지 5항중 어느 한 항에서 청구한 바와같은 일반식(I)의 디아릴아세틸렌 0.001 내지 1중량% 외에도 통상적인 약제 또는 미용제 보조제를 함유하는 국소용 약제 또는 미용제.
  8. 활성 화합물로서 제1 내지 5항중 어느 한 항에서 청구한 바와 같은 일반식(I)의 디아릴아세틸렌 0.1 내지 250mg/1회 투여량외에도 통상적인 약제 보조제를 함유하는 전신용 약제.
  9. 제7항에 있어서, 여드름 또는 전선 또는 병적 각질화와 관련된 다른 피부질환 및 습진, 사마귀 및 백반증을 치료하기 위한 약제.
  10. 제7항에 있어서, UV 선에 의해 야기되는 피부손상 또는 의인성 피부손상을 치료하기위한 약제.
  11. 제7 또는 8항에 있어서, 전암 또는 종양을 치료하기 위한 약제.
  12. 제7 또는 8항에 있어서, 류머티스성 및 관절염성 질환을 치료하기 위한 약제.
  13. 제7항에 있어서, 건성 안구 및 각화상 질환을 치료하기 위한 약제.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900012135A 1989-08-08 1990-08-08 디아릴아세틸렌, 그의 제법 및 용도 KR910004555A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP39261484 1989-08-08
DE3926148A DE3926148A1 (de) 1989-08-08 1989-08-08 Diarylacetylene, ihre herstellung und verwendung

Publications (1)

Publication Number Publication Date
KR910004555A true KR910004555A (ko) 1991-03-28

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Country Link
US (1) US5087637A (ko)
EP (1) EP0412387B1 (ko)
JP (1) JPH0377863A (ko)
KR (1) KR910004555A (ko)
AT (1) ATE97655T1 (ko)
AU (1) AU629669B2 (ko)
CA (1) CA2022570A1 (ko)
CZ (1) CZ278011B6 (ko)
DE (2) DE3926148A1 (ko)
DK (1) DK0412387T3 (ko)
HU (1) HU206313B (ko)
IL (1) IL95269A (ko)
NO (1) NO173092C (ko)
PL (1) PL164651B1 (ko)
ZA (1) ZA906201B (ko)

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PL286386A1 (en) 1991-09-23
JPH0377863A (ja) 1991-04-03
EP0412387B1 (de) 1993-11-24
AU629669B2 (en) 1992-10-08
DE3926148A1 (de) 1991-02-28
US5087637A (en) 1992-02-11
NO903460D0 (no) 1990-08-07
IL95269A0 (en) 1991-06-30
PL164651B1 (pl) 1994-08-31
HU904926D0 (en) 1991-01-28
EP0412387A3 (en) 1991-03-27
AU6022890A (en) 1991-02-14
NO173092C (no) 1993-10-27
DE59003587D1 (de) 1994-01-05
DK0412387T3 (da) 1993-12-20
NO173092B (no) 1993-07-19
NO903460L (no) 1991-02-11
CZ278011B6 (en) 1993-07-14
ATE97655T1 (de) 1993-12-15
IL95269A (en) 1994-10-07
HUT54975A (en) 1991-04-29
CA2022570A1 (en) 1991-02-09
CS9003897A2 (en) 1991-08-13
HU206313B (en) 1992-10-28
EP0412387A2 (de) 1991-02-13
ZA906201B (en) 1992-04-29

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