KR910016674A - 신규한 레티노이드 - Google Patents
신규한 레티노이드 Download PDFInfo
- Publication number
- KR910016674A KR910016674A KR1019910004702A KR910004702A KR910016674A KR 910016674 A KR910016674 A KR 910016674A KR 1019910004702 A KR1019910004702 A KR 1019910004702A KR 910004702 A KR910004702 A KR 910004702A KR 910016674 A KR910016674 A KR 910016674A
- Authority
- KR
- South Korea
- Prior art keywords
- compound
- formula
- alkyl
- och
- cis
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
- C07C403/06—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms
- C07C403/12—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms by esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
- C07C403/20—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by carboxyl groups or halides, anhydrides, or (thio)esters thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/09—Geometrical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Dermatology (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Physical Vapour Deposition (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (10)
- 하기 일반식(I)의 화합물;R1-OCH(R2)OC(O)R3(I)상기식에서, R1은 13-시스-레티노일을 의미하고; R2는 수소 또는 저급-알킬을 의미하며; R3는 직쇄 저급-알킬을 의미한다.
- 제1항에 있어서, R3가 메틸인 화합물.
- 메틸렌 아세테이트 3,7-디메틸-9-(2,6,6-트리메틸-1-사이클로헥센-1-일)-2(Z),4,6,8(E)-노나테트라에노에이트.
- 에틸리덴 아세테이트 3,7-디메틸-9-(2,6,6-트리메틸-1-사이클로헥센-1-일)-2(Z),5,7,8(E)-노나테트라에노에이트.
- 약제를 사용하기 위한 제1항 내지 제4항의 화합물의 용도.
- 13-시스-레티노산 또는 그의 열과 하기 일반식(Ⅱ)의 화합물을 반응시키거나 또는 일반식 R3COOH산의 염과 하기 일반식(Ⅲ)의 화합물을 반응시킴을 포함하는, 제1항의 일반식(I)의 화합물의 제조방법:XCH(R2)OC(O)R3(Ⅱ)R1-OCH(R2)X (Ⅲ)상기식에서, X는 할로겐이고, R1,R2및 R3는 제1항에 나타낸 의미를 갖는다.
- 제1항 내지 제4항의 화합물 및 약학적 또는 화장품용 담체를 함유하는 약학 또는 화장품제제.
- 피부 질환의 국소 치료용 약제의 제조 및 노화 피부 치료용 화장제에 있어서의 활성 물질로의 제1항 내지 제4항의 화합물의 용도.
- 제6항의 방법 또는 그와 화학적으로 명백히 동등한 방법에 의해 제조된 하기 일반식(I)의 화합물:R1-OCH(R2)OC(O)R3(I)상기식에서, R1은 13-시스-레타노일을 의미하고; R2는 수소 또는 저급-알킬을 의미하며; R3는 직쇄 저급-알칼을 의미한다.
- 실질적으로 본 명세서, 특히 실시예와 관련하여 개시한 바와 같은 신규한 화합물, 제조 방법 및 제제.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH100890 | 1990-03-27 | ||
CH1008/90 | 1990-03-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR910016674A true KR910016674A (ko) | 1991-11-05 |
KR960008666B1 KR960008666B1 (en) | 1996-06-28 |
Family
ID=4200298
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR91004702A KR960008666B1 (en) | 1990-03-27 | 1991-03-25 | Novel retinoid |
Country Status (23)
Country | Link |
---|---|
US (1) | US5158773A (ko) |
EP (1) | EP0449099B1 (ko) |
JP (1) | JPH0798797B2 (ko) |
KR (1) | KR960008666B1 (ko) |
AT (1) | ATE130848T1 (ko) |
AU (1) | AU646439B2 (ko) |
CA (1) | CA2037150C (ko) |
DE (1) | DE59106962D1 (ko) |
DK (1) | DK0449099T3 (ko) |
ES (1) | ES2080848T3 (ko) |
FI (1) | FI96201C (ko) |
GR (1) | GR3019014T3 (ko) |
HR (1) | HRP930344B1 (ko) |
HU (1) | HU207980B (ko) |
IE (1) | IE71178B1 (ko) |
IL (1) | IL97607A (ko) |
MC (1) | MC2222A1 (ko) |
NO (1) | NO174801B (ko) |
NZ (1) | NZ237513A (ko) |
PT (1) | PT97148B (ko) |
SA (1) | SA91110302B1 (ko) |
YU (1) | YU48480B (ko) |
ZA (1) | ZA912075B (ko) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6071923A (en) * | 1994-09-16 | 2000-06-06 | Bar-Ilan University | Retinoyloxy aryl-substituted alkylene butyrates useful for the treatment of cancer and other proliferative diseases |
US5710176A (en) * | 1994-09-16 | 1998-01-20 | Bar-Ilan University | Retinoyloxy (substituted) methyl butyrates useful for the treatment of cancer and other proliferative diseases |
US6040342A (en) * | 1994-09-16 | 2000-03-21 | Bar-Ilan University | Retinoyloxy (alkyl-substituted) methyl butyrates useful for the treatment of cancer and other proliferative diseases |
US5534261A (en) * | 1995-01-17 | 1996-07-09 | University Of Southern California | Retinoid-based compositions and method for preventing adhesion formation using the same |
CA2258593A1 (en) * | 1996-07-02 | 1998-01-08 | Abraham Nudelman | Retinoyloxy(substituted)alkylene butyrates useful for the treatment of cancer and other proliferative diseases |
US6130248A (en) * | 1996-12-30 | 2000-10-10 | Bar-Ilan University | Tricarboxylic acid-containing oxyalkyl esters and uses thereof |
US6110970A (en) * | 1997-03-11 | 2000-08-29 | Beacon Laboratories, Inc. | Nitrogen-containing oxyalkylene esters and uses thereof |
US6124495A (en) | 1997-03-11 | 2000-09-26 | Beacon Laboratories, Inc. | Unsaturated oxyalkylene esters and uses thereof |
US6030961A (en) * | 1997-03-11 | 2000-02-29 | Bar-Ilan Research & Development Co., Ltd. | Oxyalkylene phosphate compounds and uses thereof |
US5939455A (en) * | 1997-03-11 | 1999-08-17 | Beacon Laboratories, Inc. | Therapeutic augmentation of oxyalkylene diesters and butyric acid derivatives |
US6043389A (en) * | 1997-03-11 | 2000-03-28 | Mor Research Applications, Ltd. | Hydroxy and ether-containing oxyalkylene esters and uses thereof |
US6110955A (en) * | 1997-03-11 | 2000-08-29 | Beacon Laboratories, Inc. | Metabolically stabilized oxyalkylene esters and uses thereof |
US6720445B2 (en) * | 2000-12-21 | 2004-04-13 | Beacon Laboratories, Inc. | Acetyloxymethyl esters and methods for using the same |
WO2017074982A1 (en) | 2015-10-30 | 2017-05-04 | Patagonia Pharmaceuticals, Llc | Isotretinoin formulations and uses and methods thereof |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4476056A (en) * | 1982-11-05 | 1984-10-09 | Hoffmann-La Roche Inc. | Trifluoromethoxy analogs of aromatic retinoids |
US4677120A (en) * | 1985-07-31 | 1987-06-30 | Molecular Design International | Topical prodrugs for treatment of acne and skin diseases |
JP2622955B2 (ja) * | 1986-07-29 | 1997-06-25 | エイボン プロダクツ インコ−ポレイテツド | 無水化粧品 |
ZA877325B (en) * | 1986-10-06 | 1988-04-07 | F. Hoffmann-La Roche & Co. Aktiengesellschaft | Novel retinoids |
DK498487A (da) * | 1986-10-06 | 1988-04-07 | Hoffmann La Roche | Hidtil ukendte retinoider |
-
1991
- 1991-02-26 CA CA002037150A patent/CA2037150C/en not_active Expired - Lifetime
- 1991-03-04 US US07/663,356 patent/US5158773A/en not_active Expired - Lifetime
- 1991-03-12 FI FI911207A patent/FI96201C/fi not_active IP Right Cessation
- 1991-03-14 YU YU45591A patent/YU48480B/sh unknown
- 1991-03-20 DE DE59106962T patent/DE59106962D1/de not_active Expired - Fee Related
- 1991-03-20 AT AT91104375T patent/ATE130848T1/de not_active IP Right Cessation
- 1991-03-20 EP EP91104375A patent/EP0449099B1/de not_active Expired - Lifetime
- 1991-03-20 ES ES91104375T patent/ES2080848T3/es not_active Expired - Lifetime
- 1991-03-20 DK DK91104375.0T patent/DK0449099T3/da active
- 1991-03-20 IL IL9760791A patent/IL97607A/en not_active IP Right Cessation
- 1991-03-20 ZA ZA912075A patent/ZA912075B/xx unknown
- 1991-03-20 NZ NZ237513A patent/NZ237513A/xx unknown
- 1991-03-21 MC MC912176A patent/MC2222A1/xx unknown
- 1991-03-22 JP JP3081208A patent/JPH0798797B2/ja not_active Expired - Fee Related
- 1991-03-22 HU HU91968A patent/HU207980B/hu not_active IP Right Cessation
- 1991-03-25 KR KR91004702A patent/KR960008666B1/ko not_active IP Right Cessation
- 1991-03-26 PT PT97148A patent/PT97148B/pt not_active IP Right Cessation
- 1991-03-26 NO NO911233A patent/NO174801B/no not_active IP Right Cessation
- 1991-03-26 AU AU73831/91A patent/AU646439B2/en not_active Ceased
- 1991-03-26 IE IE100591A patent/IE71178B1/en not_active IP Right Cessation
- 1991-04-09 SA SA91110302A patent/SA91110302B1/ar unknown
-
1993
- 1993-03-12 HR HRP-455/91A patent/HRP930344B1/xx not_active IP Right Cessation
-
1996
- 1996-02-19 GR GR960400415T patent/GR3019014T3/el unknown
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