KR960700213A - 항-안드로겐성 일고리-및 이고리-알켄(Anti-androgenic cyclo and bicyclo alkenes) - Google Patents

항-안드로겐성 일고리-및 이고리-알켄(Anti-androgenic cyclo and bicyclo alkenes)

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KR960700213A
KR960700213A KR1019950702903A KR19950702903A KR960700213A KR 960700213 A KR960700213 A KR 960700213A KR 1019950702903 A KR1019950702903 A KR 1019950702903A KR 19950702903 A KR19950702903 A KR 19950702903A KR 960700213 A KR960700213 A KR 960700213A
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래리 씨. 포드
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패트릭 라일러
코스모스 파마 슈티칼 코오포레이숀
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Abstract

본 발명은 제2안드로겐 수용체 부위에 대해 항-안드로겐 활성을 갖는 하기 일반식(ⅰ), (ⅱ) 및 (ⅲ)의 화합물에 관한 것으로서, 상기 화합물은 좌창, 남성 탈모증, 유착증 및 켈로이드를 앓고 있는 사람을 비롯한 포유동물을 치료하는데 유용하고, 여성의 유방 확대 수술후 비바람직한 유방 캡슐의 형성, 골관절염 및 알쯔하이머질병 증후군과 같은, 안드로겐 수용체와 관련이 있는 기타 질병 또는 질환을 치료하는데 효과적이며, 또한 항-안드로겐 화합물에 의해 조절되는 것으로 공지된, 특정 유기물과 군류의 물질 대사에 대해 억제 효과를 나타낸다:

Description

항-안드로겐성 일고리-및 이고리-알켄(Anti-androgenic cyclo and bicyclo alkenes)
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (38)

  1. 하기 일반식 (ⅰ), (ⅱ) 및 (ⅲ)의 화합물로 구성되는 군에서 선택되는 화합물:
    (ⅰ) (ⅱ) (ⅲ)
    상기 식중에서, R은 H, C1-6알킬 또는 CO-R2(식중, R2는 C1-6알킬임)이고; R1은 H, CH3또는 (CH2)m-CH3이며; n은 2 내지 10의 정수이고; m은 1 내지 6의 정수이다.
  2. 제1항에 있어서, 일반식(ⅰ)을 갖는 화합물.
  3. 제2항에 있어서, n이 3이고, R1이 H인 화합물.
  4. 제3항에 있어서, R이 H인 화합물.
  5. 제3항에 있어서, R이 OCH3인 화합물.
  6. 제2항에 있어서, n이 3이고, R1이 CH2CH3인 화합물.
  7. 제6항에 있어서, R이 H인 화합물.
  8. 제6항에 있어서, R이 OCH3인 화합물.
  9. 제2항에 있어서, R이 CO-R2인 화합물.
  10. 제1항에 있어서, 일반식(ⅱ)을 갖는 화합물.
  11. 제10항에 있어서, n이 3이고, R1이 H인 화합물.
  12. 제11항에 있어서, R이 H인 화합물.
  13. 제11항에 있어서, R이 OCH3인 화합물.
  14. 제10항에 있어서, n이 3이고, R1이 CH2CH3인 화합물.
  15. 제14항에 있어서, R이 H인 화합물.
  16. 제14항에 있어서, R이 OCH3인 화합물.
  17. 제10항에 있어서, R이 CO-R2인 화합물.
  18. 제1항에 있어서, 일반식(ⅲ)을 갖는 화합물.
  19. 제18항에 있어서, n이 3이고, R1이 H인 화합물.
  20. 제19항에 있어서, R이 H인 화합물.
  21. 제19항에 있어서, R이 OCH3인 화합물.
  22. 제18항에 있어서, n이 3이고, R1이 CH2CH3인 화합물.
  23. 제22항에 있어서, R이 H인 화합물.
  24. 제22항에 있어서, R이 OCH3인 화합물.
  25. 제18항에 있어서, R이 CO-R2인 화합물.
  26. 하기 일반식 (ⅰ),(ⅱ) 및(ⅲ)의 화합물로 구성되는 군에서 선택되는 화합물을 효과적인 투여량으로 함유하는 약학적 조성물을 포유 동물에 투여하는 것을 포함하여, 상기 포유 동물의 안드로겐 수용체 부위를 차단시키는 방법:
    (ⅰ) (ⅱ) (ⅲ)
    상기 식중에서, R은 H, C1-6알킬 또는 CO-R2(식중, R2는 C1-6알킬임)이고; R1은 H, CH3또는 (CH2)m-CH3이며; n은 2 내지 10의 정수이고; m은 1 내지 6의 정수이다.
  27. 제26항에 있어서, 상기 약학적 조성물은 국소 투여에 적합하도록 조제하여 국소 투여하는 방법.
  28. 제26항에 있어서, 상기 약학적 조성물은 체내 투여에 적합하도록 조제하여 체내 투여하는 방법.
  29. 제26항에 있어서, 상기 약학적 조성물은 좌창을 앓고 있는 포유 동물에 투여하는 방법.
  30. 제26항에 있어서, 상기 약학적 조성물은 남성 탈모증을 앓고 있는 사람에게 투여하는 방법.
  31. 제26항에 있어서, 상기 약학적 조성물은 켈로이드를 앓고 있는 포유 동물에 투여하는 방법.
  32. 제26항에 있어서, 상기 약학적 조성물은 엘라스틴의 합성을 촉진시킬 목적으로 포유 동물에 투여하는 방법.
  33. 제26항에 있어서, 상기 약학적 조성물은 삽입물 주위에 형성된 섬유 아세포 캡슐을 감소시킬 목적으로, 이질제 유방 삽입물을 지닌 여성에게 투여하는 방법.
  34. 제26항에 있어서, 상기 약학적 조성물은 사람의 주름진 피부를 치료할 목적으로, 국소 투여하는 방법.
  35. 제26항에 있어서, 상기 약학적 조성물은 알쯔하이머 질병을 앓고 있는 사람에게 투여하는 방법.
  36. 제26항에 있어서, 상기 약학적 조성물은 이스트균 감염된 사람에게 투여하는 방법.
  37. 제26항에 있어서, 상기 약학적 조성물은 골관절염을 앓고 있는 사람에게 투여하는 방법.
  38. 안드로겐 수용체 부위를 차단시킴으로써, 상기 부위를 지닌 미생물 또는 균류의 성장을 조절하는 방법으로서, 상기 방법은 하기 일반식 (ⅰ), (ⅱ) 및 (ⅲ)의 화합물을 효과적인 투여량으로 함유하는 약학적 조성물을 상기 미생물 또는 균류에 투여하는 단계를 포함하는 것을 특징으로 하는 방법:
    (ⅰ) (ⅱ) (ⅲ)
    상기 식중에서, R은 H, C1-6알킬 또는 CO-R2(식중, R2는 C1-6알킬임)이고; R1은 H, CH3또는 (CH2)m-CH3이며; n은 2 내지 10의 정수이고; m은 1 내지 6의 정수이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019950702903A 1993-01-15 1993-10-14 항-안드로겐성 일고리-및 이고리-알켄(Anti-androgenic cyclo and bicyclo alkenes) KR960700213A (ko)

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US08004972 US5264619B1 (en) 1993-01-15 1993-01-15 Anti-androgenic cyclo and bicyclo alkenes
US08/004,972 1993-01-15
PCT/US1993/009844 WO1994015900A1 (en) 1993-01-15 1993-10-14 Anti-androgenic cyclo and bicyclo alkenes

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US5264619A (en) 1993-11-23
DK0679152T3 (da) 1998-02-23
GR3025092T3 (en) 1998-01-30
ZA938767B (en) 1994-06-30
JPH08505851A (ja) 1996-06-25
AU5584794A (en) 1994-08-15
EP0679152B1 (en) 1997-08-27
TW294656B (ko) 1997-01-01
AU672265B2 (en) 1996-09-26
CN1091733A (zh) 1994-09-07
NO952787D0 (no) 1995-07-13
MX9307235A (es) 1994-07-29
BR9307758A (pt) 1995-10-24
US5264619B1 (en) 1996-05-14
EP0679152A1 (en) 1995-11-02
PH30285A (en) 1997-02-20
ATE157342T1 (de) 1997-09-15
NO952787L (no) 1995-09-01
CA2152588A1 (en) 1994-07-21
CA2152588C (en) 1998-05-05
IL107699A0 (en) 1994-02-27
DE69313466D1 (en) 1997-10-02
WO1994015900A1 (en) 1994-07-21
MY109679A (en) 1997-04-30
CN1051758C (zh) 2000-04-26
ES2107793T3 (es) 1997-12-01
DE69313466T2 (de) 1998-04-02

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