MX2015012020A - Procedimiento de sintesis. - Google Patents
Procedimiento de sintesis.Info
- Publication number
- MX2015012020A MX2015012020A MX2015012020A MX2015012020A MX2015012020A MX 2015012020 A MX2015012020 A MX 2015012020A MX 2015012020 A MX2015012020 A MX 2015012020A MX 2015012020 A MX2015012020 A MX 2015012020A MX 2015012020 A MX2015012020 A MX 2015012020A
- Authority
- MX
- Mexico
- Prior art keywords
- ethoxyhept
- bicyclo
- oxirane
- spiro
- heptane
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/65—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/69—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by addition to carbon-to-carbon double or triple bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/34—Separation; Purification; Stabilisation; Use of additives
- C07C41/46—Use of additives, e.g. for stabilisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
- C07C43/14—Unsaturated ethers
- C07C43/162—Unsaturated ethers containing rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
- C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
- C07C45/58—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in three-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/76—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton with the aid of ketenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/78—Separation; Purification; Stabilisation; Use of additives
- C07C45/86—Use of additives, e.g. for stabilisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/385—Saturated compounds containing a keto group being part of a ring
- C07C49/517—Saturated compounds containing a keto group being part of a ring containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/613—Unsaturated compounds containing a keto groups being part of a ring polycyclic
- C07C49/617—Unsaturated compounds containing a keto groups being part of a ring polycyclic a keto group being part of a condensed ring system
- C07C49/623—Unsaturated compounds containing a keto groups being part of a ring polycyclic a keto group being part of a condensed ring system having two rings
- C07C49/633—Unsaturated compounds containing a keto groups being part of a ring polycyclic a keto group being part of a condensed ring system having two rings the condensed ring system containing eight or nine carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D301/00—Preparation of oxiranes
- C07D301/02—Synthesis of the oxirane ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/20—All rings being cycloaliphatic the ring system containing seven carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/22—All rings being cycloaliphatic the ring system containing eight carbon atoms, e.g. pentalene
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Epoxy Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Se describe un procedimiento de sintetizar 6-(5-etoxi-hept-1- iI)biciclo[3.3.0octan-3-ona mediante la reacción de 3-(5-etoxihept-1 -il)ciclopenteno con dicloroceteno. Los productos de reacción resultantes se hacen reaccionar ácido acético y cinc para producir 4-(5-etoxi-hept-1-iI)biciclo[3.2.0]he ptan-6-ona (5-etoxihept-1-il)biciclo[3.2.0]heptan-7-ona, que se hacen reaccionar con yoduro trimetilsulfonIo para producir 2-(5-etoxi-hept-1 -iI)espiro[biciclo[3 .2.0]heptan-6,2'- oxirano] y 4-(5-etoxi-hept-1 -iI)espiro-[biciclo[3.2 .O]heptan-6,2'-oxirano ]. El yoduro litio se hace reaccionar con 2-(5-etoxi-hept-1 il)espiro[biciclo[3.2 .Ojheptan-6,2'- oxirano] y 4-(5-etoxi-hept-1 -iI)espiro[biciclo[3.2. O]heptan-6,2'-oxirano] para producir (5-etoxi-hept-1 -il)biciclo[3.3.0]octal-3-ona. También se describe un procedimiento sintetizar 6-(5-metoxihept-1 -il)biciclo[3. 3.0]octan-3-ona.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/IB2013/000360 WO2014140655A1 (en) | 2013-03-11 | 2013-03-11 | Method of synthesis |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2015012020A true MX2015012020A (es) | 2016-04-06 |
Family
ID=51535921
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015012020A MX2015012020A (es) | 2013-03-11 | 2013-03-11 | Procedimiento de sintesis. |
Country Status (18)
Country | Link |
---|---|
US (3) | US20160016874A1 (es) |
EP (2) | EP2970071B1 (es) |
JP (1) | JP6335936B2 (es) |
KR (2) | KR20180050764A (es) |
CN (2) | CN107266303B (es) |
AU (1) | AU2013382072B2 (es) |
BR (1) | BR112015021973B1 (es) |
CA (1) | CA2904558C (es) |
ES (1) | ES2853929T3 (es) |
HK (1) | HK1216419A1 (es) |
HU (1) | HUE053184T2 (es) |
IL (1) | IL241475A0 (es) |
MX (1) | MX2015012020A (es) |
NZ (1) | NZ711989A (es) |
PH (1) | PH12015502008A1 (es) |
RU (1) | RU2634698C2 (es) |
SG (1) | SG11201507157YA (es) |
WO (1) | WO2014140655A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112015021973B1 (pt) | 2013-03-11 | 2022-08-16 | Grey Pacific Labs, Llc | Método de síntese |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4689345A (en) | 1982-05-06 | 1987-08-25 | Cbd Corporation | Oxygenated alkyl substituted bicyclo alkanes |
WO1983004019A1 (en) * | 1982-05-06 | 1983-11-24 | Cbd Corporation | Cycloaliphatic pharmaceutical compounds |
US4689349A (en) | 1982-05-06 | 1987-08-25 | Cbd Corporation | Anti-tumor halo bicyclo alkanones |
ZA848741B (en) * | 1983-11-08 | 1985-07-31 | Walter J Kasha | Pharmaceutical composition for inhibition of tumours |
US4731458A (en) * | 1986-04-25 | 1988-03-15 | Cbd Corporation | Spiro[bicyclo[3.2.0]heptane-6,2'-oxirane] derivatives |
CN1062898A (zh) * | 1991-12-30 | 1992-07-22 | 中国科招高技术有限公司 | 2-(5-甲氧基-1-庚基)双环(3,3,o)辛烷-7-酮的合成方法 |
DE4204808A1 (de) * | 1992-02-18 | 1993-08-19 | Basf Ag | Verfahren zur herstellung von (omega)-formylalkancarbonsaeureestern |
US5264619B1 (en) * | 1993-01-15 | 1996-05-14 | Cosmos Pharm Corp | Anti-androgenic cyclo and bicyclo alkenes |
AU2001100223A4 (en) | 2001-08-01 | 2001-09-20 | Peter Michael Murphy | Parallel drive differential |
KR20160052812A (ko) * | 2008-04-14 | 2016-05-12 | 할로자임, 아이엔씨 | 히알루로난 관련 질환 및 상태 치료용 변형된 히알루로니다제 및 그 용도 |
US8410314B1 (en) * | 2010-06-21 | 2013-04-02 | Bcs Business Consulting Services Pte Ltd. | Method of synthesis |
CN102311440B (zh) * | 2010-07-02 | 2015-01-07 | 无锡药明康德生物技术有限公司 | 1-甲氧羰基-3-苄基-8-叔丁氧羰基-3,8-二氮杂双环[3.2.1]辛烷及制备方法 |
AU2011200223A1 (en) * | 2011-01-20 | 2012-08-09 | Norman Graham Haines | An Attachment for Mounting Wear Parts |
NZ591253A (en) * | 2011-02-18 | 2011-07-29 | Bcs Business Consulting Services Pte Ltd | Process for producing 6-(5-ethoxy-hept-1-yl)bicyclo[3.3.0]octane-3-one and product thereof |
BR112015021973B1 (pt) | 2013-03-11 | 2022-08-16 | Grey Pacific Labs, Llc | Método de síntese |
-
2013
- 2013-03-11 BR BR112015021973-0A patent/BR112015021973B1/pt active IP Right Grant
- 2013-03-11 JP JP2015562340A patent/JP6335936B2/ja active Active
- 2013-03-11 NZ NZ711989A patent/NZ711989A/en unknown
- 2013-03-11 CN CN201710186057.9A patent/CN107266303B/zh active Active
- 2013-03-11 AU AU2013382072A patent/AU2013382072B2/en active Active
- 2013-03-11 US US14/773,203 patent/US20160016874A1/en not_active Abandoned
- 2013-03-11 KR KR1020187012441A patent/KR20180050764A/ko not_active Application Discontinuation
- 2013-03-11 CA CA2904558A patent/CA2904558C/en active Active
- 2013-03-11 CN CN201380074479.7A patent/CN105143162B/zh active Active
- 2013-03-11 EP EP13877627.3A patent/EP2970071B1/en active Active
- 2013-03-11 WO PCT/IB2013/000360 patent/WO2014140655A1/en active Application Filing
- 2013-03-11 EP EP20207375.5A patent/EP3838881B1/en active Active
- 2013-03-11 MX MX2015012020A patent/MX2015012020A/es unknown
- 2013-03-11 RU RU2015138272A patent/RU2634698C2/ru active
- 2013-03-11 SG SG11201507157YA patent/SG11201507157YA/en unknown
- 2013-03-11 ES ES13877627T patent/ES2853929T3/es active Active
- 2013-03-11 KR KR1020157027748A patent/KR20150135338A/ko not_active Application Discontinuation
- 2013-03-11 HU HUE13877627A patent/HUE053184T2/hu unknown
-
2015
- 2015-09-08 PH PH12015502008A patent/PH12015502008A1/en unknown
- 2015-09-10 IL IL241475A patent/IL241475A0/en unknown
-
2016
- 2016-04-15 HK HK16104313.4A patent/HK1216419A1/zh unknown
-
2017
- 2017-01-30 US US15/419,928 patent/US10150724B2/en active Active
-
2018
- 2018-12-10 US US16/215,329 patent/US20190194107A1/en not_active Abandoned
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