KR910003114A - 세팔로스포린 c를 글루타릴-7-아미노세팔로스포란산으로 효소 산화시키는 개선된 방법 - Google Patents

세팔로스포린 c를 글루타릴-7-아미노세팔로스포란산으로 효소 산화시키는 개선된 방법 Download PDF

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Publication number
KR910003114A
KR910003114A KR1019900010913A KR900010913A KR910003114A KR 910003114 A KR910003114 A KR 910003114A KR 1019900010913 A KR1019900010913 A KR 1019900010913A KR 900010913 A KR900010913 A KR 900010913A KR 910003114 A KR910003114 A KR 910003114A
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Prior art keywords
cell
glutaryl
cephalosporin
triginopsis
variabilis
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KR1019900010913A
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KR0163175B1 (ko
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토마스 비센지 제프리
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리로이 휘테커
일라이 릴리 앤드 캄파니
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
    • C12N9/0022—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3)
    • C12N9/0024—D-Amino acid oxidase (1.4.3.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/99—Enzyme inactivation by chemical treatment
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cephalosporin Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

내용 없음.

Description

세팔로스포린 C를 글루타릴-7-아미노세팔로스포란산으로 효소 산화시키는 개선된 방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (5)

  1. pH 약 11 내지 약 12에서 효소들을 염기성 수용액과 접촉시킴을 포함하는, D-아미노산 옥시다제 효소의 존재하에서 카탈라제 효소를 불활성시키는 방법.
  2. 제1항에 있어서, 상기 옥시다제와 카탈라제가 트리기놉시스 배리아빌리스(Triginopsis variablilis)의 투과 가능한 완전 세포에 존재하는 방법.
  3. 제1항에 있어서, 상기 옥시다제와 카탈라제가 수성 무세포 추출물에 존재하는 방법.
  4. 세팔로스포린 C를 글루타릴-7-ACA로 효소 산화시킬 때 트리기놉시스 배리아빌리스의 투과가능한 완전세포 또는 무세포 추출물을 사용하기 전에 트리기놉시스 배리아빌리스의 상기 투과가능한 완전 세포 또는 상기 무세포 추출물을 염기로 처리하여 pH 약 11 내지 약 12가 되게 함을 포함하는 세팔로스포린 C를 글루타릴-7-ACA로 효소 전환시키는 방법.
  5. 트리기놉시스 배리아빌리스의 완전 세포 또는 무세포 추출물을 아세톤/물로 처리함을 포함하는 에스테라제효소의 불활성화 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900010913A 1989-07-19 1990-07-18 세팔로스포린 c를 글루타릴-7-아미노 세팔로스포란산으로 효소 산화시키는 개선된 방법 KR0163175B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38250589A 1989-07-19 1989-07-19
US7/382,505 1989-07-19
US07/382505 1989-07-19

Publications (2)

Publication Number Publication Date
KR910003114A true KR910003114A (ko) 1991-02-26
KR0163175B1 KR0163175B1 (ko) 1998-11-16

Family

ID=23509253

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019900010913A KR0163175B1 (ko) 1989-07-19 1990-07-18 세팔로스포린 c를 글루타릴-7-아미노 세팔로스포란산으로 효소 산화시키는 개선된 방법

Country Status (13)

Country Link
US (2) US5424203A (ko)
EP (2) EP0409521B1 (ko)
JP (1) JP2883173B2 (ko)
KR (1) KR0163175B1 (ko)
AT (1) ATE129012T1 (ko)
CA (2) CA2268710C (ko)
DE (1) DE69022909T2 (ko)
DK (1) DK0409521T3 (ko)
ES (1) ES2079442T3 (ko)
GR (1) GR3017731T3 (ko)
HU (1) HU212587B (ko)
IE (1) IE71523B1 (ko)
IL (1) IL95090A (ko)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE129012T1 (de) * 1989-07-19 1995-10-15 Lilly Co Eli Enzymatische oxidation von ceph c zu glutaryl-7- aminocephalosporansäure.
DE4028119C1 (ko) * 1990-09-05 1991-12-05 Hoechst Ag, 6230 Frankfurt, De
CA2100987C (en) * 1992-07-27 1999-06-15 Kaoru Furuya A transformant capable of producing d-amino acid oxidase
EP0600247A3 (de) * 1992-11-05 1995-05-10 Hoechst Ag Verfahren zur selektiven Desaktivierung von unerwünschten Proteinen in einem Proteingemisch mittels Mikrowelleneinstrahlung.
ES2097080B1 (es) * 1993-03-08 1997-11-16 Asahi Chemical Ind Procedimiento para la conversion de cefalosporina c en acido glutaril-7-aminocefalosporanico.
WO1997020921A1 (en) * 1995-12-07 1997-06-12 Novo Nordisk A/S Selective inactivation of enzyme activities
WO1999013058A2 (en) * 1997-09-09 1999-03-18 Biochemie Gesellschaft Mbh Esterase free enzymes
AU2002227889A1 (en) * 2001-01-31 2002-08-12 Novozymes A/S Oxidase free of catalase side activities
KR100512774B1 (ko) * 2001-10-06 2005-09-07 종근당바이오 주식회사 7-아미노세팔로스포란산의 제조를 위한 세팔로스포린ｃ배양액의 전처리방법
US20090208543A1 (en) * 2008-01-22 2009-08-20 Oral Health Clinical Services Method and apparatus for applying a protective oral care composition
EP3473715B1 (en) * 2016-06-21 2021-08-04 PHC Holdings Corporation Catalase inhibitor and method for measuring analyte using catalase inhibitor

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1272769A (en) * 1968-08-02 1972-05-03 Glaxo Lab Ltd Improvements in or relating to cephalosporin derivatives
GB1385685A (en) * 1971-04-21 1975-02-26 Glaxo Lab Ltd Cephalosporin derivatives
GB1474519A (ko) * 1973-05-14 1977-05-25
US3976546A (en) * 1974-11-08 1976-08-24 Glaxo Laboratories Limited Cephalosporins
US4079180A (en) * 1975-01-22 1978-03-14 Asahi Kasei Kogyo Kabushiki Kaisha Process for preparing 7-aminocephalosporanic acid derivatives
US4394450A (en) * 1982-03-01 1983-07-19 Miles Laboratories, Inc. Method for purification of uricase
DE3447023A1 (de) * 1984-12-22 1986-06-26 Hoechst Ag, 6230 Frankfurt Neue d-aminosaeure-transaminase und ihre verwendung
ATE129012T1 (de) * 1989-07-19 1995-10-15 Lilly Co Eli Enzymatische oxidation von ceph c zu glutaryl-7- aminocephalosporansäure.

Also Published As

Publication number Publication date
HU212587B (en) 1996-08-29
IL95090A (en) 1995-08-31
IE902623A1 (en) 1991-02-27
IE71523B1 (en) 1997-02-12
EP0409521B1 (en) 1995-10-11
IL95090A0 (en) 1991-06-10
JPH0353879A (ja) 1991-03-07
US5559006A (en) 1996-09-24
DE69022909D1 (de) 1995-11-16
CA2268710C (en) 2000-09-26
HUT59727A (en) 1992-06-29
DE69022909T2 (de) 1996-04-11
US5424203A (en) 1995-06-13
HU904539D0 (en) 1990-12-28
GR3017731T3 (en) 1996-01-31
ATE129012T1 (de) 1995-10-15
KR0163175B1 (ko) 1998-11-16
EP0601996A1 (en) 1994-06-15
EP0409521A2 (en) 1991-01-23
ES2079442T3 (es) 1996-01-16
DK0409521T3 (da) 1996-02-05
JP2883173B2 (ja) 1999-04-19
CA2021299A1 (en) 1991-01-20
CA2021299C (en) 1999-08-17
EP0409521A3 (en) 1991-09-11

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