KR880009038A - 트립토판의 정제방법 - Google Patents
트립토판의 정제방법 Download PDFInfo
- Publication number
- KR880009038A KR880009038A KR1019880000167A KR880000167A KR880009038A KR 880009038 A KR880009038 A KR 880009038A KR 1019880000167 A KR1019880000167 A KR 1019880000167A KR 880000167 A KR880000167 A KR 880000167A KR 880009038 A KR880009038 A KR 880009038A
- Authority
- KR
- South Korea
- Prior art keywords
- tryptophan
- purification method
- solution
- tryptophan purification
- crystallized
- Prior art date
Links
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 title claims 3
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 title claims 3
- 238000000034 method Methods 0.000 title claims 2
- 238000000746 purification Methods 0.000 title 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- 239000000243 solution Substances 0.000 claims 2
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 238000000855 fermentation Methods 0.000 claims 1
- 230000004151 fermentation Effects 0.000 claims 1
- 230000000813 microbial effect Effects 0.000 claims 1
- 238000006386 neutralization reaction Methods 0.000 claims 1
- 239000011347 resin Substances 0.000 claims 1
- 229920005989 resin Polymers 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
Abstract
내용 없음.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (1)
- (1) 발효 또는 효소를 사용하는 방법에 의해 제조된 트립토판을 함유하는 수용액으로부터 미생물 세포를 제거하고 : (2) PH값 1 내지 4범위의 용액을 활성탄 및 고다공성인 비극성 수지로 처리한 다음 : (3) 이 용액을 저급 지방족 알코올의 존재하에 중화반응하에서 결정화 시킴을 특징으로하여, 트립토판을 정제하는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62007003A JPH0648990B2 (ja) | 1987-01-14 | 1987-01-14 | トリプトフアンの精製方法 |
| JP7003 | 1987-01-14 | ||
| JP62-7003 | 1987-01-14 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR880009038A true KR880009038A (ko) | 1988-09-13 |
| KR930004052B1 KR930004052B1 (ko) | 1993-05-19 |
Family
ID=11653900
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019880000167A KR930004052B1 (ko) | 1987-01-14 | 1988-01-13 | 트립토판의 정제방법 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US4820825A (ko) |
| EP (1) | EP0274728B1 (ko) |
| JP (1) | JPH0648990B2 (ko) |
| KR (1) | KR930004052B1 (ko) |
| DE (1) | DE3779287D1 (ko) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2893813B2 (ja) * | 1990-03-15 | 1999-05-24 | 味の素株式会社 | 光学活性トリプトファンの晶析法 |
| JPH0489479A (ja) * | 1990-08-01 | 1992-03-23 | Ajinomoto Co Inc | 光学活性トリプトファンの回収方法 |
| JP2001199957A (ja) * | 2000-01-13 | 2001-07-24 | Ajinomoto Co Inc | トリプトファンの晶析法 |
| CN102249980B (zh) * | 2011-05-10 | 2013-09-25 | 中国人民解放军第四军医大学 | 一种控制色氨酸中4，5-色氨酸-二酮产生的工艺 |
| CN102304077A (zh) * | 2011-06-24 | 2012-01-04 | 南通诚信氨基酸有限公司 | 一种色氨酸的提纯方法 |
| EP2682168A1 (en) * | 2012-07-02 | 2014-01-08 | Millipore Corporation | Purification of biological molecules |
| KR101372811B1 (ko) * | 2012-09-27 | 2014-03-11 | 주식회사 라미나 | 트립토판 정제장치 및 방법 |
| US20150165340A1 (en) * | 2012-09-03 | 2015-06-18 | Laminar Co., Ltd. | Purification System Comprising Continuous Reactor and Purification Method Using Continuous Reactor |
| WO2015104464A1 (fr) | 2014-01-07 | 2015-07-16 | Novasep Process | Procédé de purification d'acides aminés aromatiques |
| WO2016083455A1 (en) * | 2014-11-25 | 2016-06-02 | Wageningen Universiteit | Process for the precipitation of amino and/or organic acids from a complex feed and amino and/or organic acid particles obtainable thereby |
| DE102018100810A1 (de) | 2018-01-16 | 2019-07-18 | Technische Universität Dortmund | Verfahren zur Aufarbeitung von L-Tryptophan |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2416956A (en) * | 1943-04-06 | 1947-03-04 | Sterling Drug Inc | Separation of tryptophane from mixed amino acids |
| US3385762A (en) * | 1964-06-29 | 1968-05-28 | Chugai Pharmaceutical Co Ltd | Process for the production of l-tryptophan by fermentation |
| GB1145512A (en) * | 1965-09-21 | 1969-03-19 | Kyowa Hakko Kogyo Company Ltd | Method for isolating tryptophan |
| FR2000641A1 (ko) * | 1968-01-24 | 1969-09-12 | Kyowa Hakko Kogyo Kk | |
| GB1222904A (en) * | 1968-10-03 | 1971-02-17 | Kyowa Hakko Kogyo Company Ltd | Process for producing l-tryptophan |
| JPS5335152B1 (ko) * | 1971-03-09 | 1978-09-26 | ||
| JPS58895A (ja) * | 1981-06-26 | 1983-01-06 | Mitsui Toatsu Chem Inc | Ｌ−トリプトフアンの製造方法 |
| JPS5939857A (ja) * | 1982-08-28 | 1984-03-05 | Ajinomoto Co Inc | アミノ酸の晶析方法 |
| AU566747B2 (en) * | 1984-01-10 | 1987-10-29 | Mitsui Chemicals, Inc. | Method of separating l-tryptophan |
| JPS61126070A (ja) * | 1984-11-21 | 1986-06-13 | Mitsui Toatsu Chem Inc | Ｌ−トリプトフアンの脱色精製方法 |
| US4769474A (en) * | 1985-04-10 | 1988-09-06 | Mitsui Toatsu Chemicals, Inc. | Process for purifying tryptophane |
-
1987
- 1987-01-14 JP JP62007003A patent/JPH0648990B2/ja not_active Expired - Lifetime
- 1987-12-22 EP EP87119045A patent/EP0274728B1/en not_active Expired - Lifetime
- 1987-12-22 DE DE8787119045T patent/DE3779287D1/de not_active Expired - Lifetime
-
1988
- 1988-01-13 KR KR1019880000167A patent/KR930004052B1/ko not_active IP Right Cessation
- 1988-01-14 US US07/143,847 patent/US4820825A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0274728A1 (en) | 1988-07-20 |
| US4820825A (en) | 1989-04-11 |
| KR930004052B1 (ko) | 1993-05-19 |
| JPS63177796A (ja) | 1988-07-21 |
| JPH0648990B2 (ja) | 1994-06-29 |
| DE3779287D1 (de) | 1992-06-25 |
| EP0274728B1 (en) | 1992-05-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A201 | Request for examination | ||
| G160 | Decision to publish patent application | ||
| E701 | Decision to grant or registration of patent right | ||
| GRNT | Written decision to grant | ||
| FPAY | Annual fee payment |
Payment date: 20070511 Year of fee payment: 15 |
|
| EXPY | Expiration of term |