KR910000705A - 신규한 벤즈이소퀴놀린 유도체 및 그의 제조 방법 - Google Patents

신규한 벤즈이소퀴놀린 유도체 및 그의 제조 방법 Download PDF

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Publication number
KR910000705A
KR910000705A KR1019900008764A KR900008764A KR910000705A KR 910000705 A KR910000705 A KR 910000705A KR 1019900008764 A KR1019900008764 A KR 1019900008764A KR 900008764 A KR900008764 A KR 900008764A KR 910000705 A KR910000705 A KR 910000705A
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South Korea
Prior art keywords
dihydrobenz
isoquinolin
ylmethyl
methylimidazol
hydrogen
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KR1019900008764A
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English (en)
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타다오 오케가와
마사노리 카와무라
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원본미기재
오노 화아마슈티칼 캄파니 리미팃드
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Publication of KR910000705A publication Critical patent/KR910000705A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

내용 없음

Description

신규한 벤즈이소퀴놀린 유도체 및 그의 제조 방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (6)

  1. 하기 일반식(Ⅰ)의 벤즈이소퀴놀린 유도체 또는 그의 비독성 산 부가염 또는 수화물.
    상기식에서, R1은 수소, C1-4알킬, C1-4알콕시, 히드록시 또는 할로겐이고; R3는 수소 또는 C1-4알킬이고; R4는 수소 또는 C1-6알킬이고; 1은 1-6이고; m은 1 또는 2이고; n은 1-3이다.
  2. 제1항에 있어서, 같거나 다를 수 있는 R1, R3및 R4가 수소 또는 메틸인 화합물.
  3. 제1항에 있어서, 2-(5-메틸이미다졸-4-일메틸)-1.2-디히드로벤즈[1,2-h]이소퀴놀린-1-온, 2-(5-메틸이미다졸-4-일메틸)-5-메톡시-1,2-디히드로벤즈[1,2-h]이소퀴놀린-1-온, 2-(5-메틸이미다졸-4-일메틸)-5.7-디메톡시-1,2-디히드로벤즈[1,2-h]이소퀴놀린-1-온, 2-(5-메틸이미다졸-4-일메틸)-8-메톡시-1,2-디히드로벤즈[1,2-h]이소퀴놀린-1-온, 2-(5-메틸이미다졸-4-일메틸)-6-메틸-1,2-디히드로벤즈[1,2-h]이소퀴놀린-1-온, 2-(5-메틸이미다졸-4-일메틸)-5-메틸-1,2-디히드로벤즈[1,2-h]이소퀴놀린-1-온, 2-(5-메틸이미다졸-4-일메틸)-5-히드록시-1,2-디히드로벤즈[1,2-h]이소퀴놀린-1-온, 및 2-(5-메틸이미다졸-4-일메틸)-6-브로모-1,2-디히드로벤즈[1,2-h]이소퀴놀린-1-온 또는 그의 비독성 산부가염인 화합물.
  4. 일반식(Ⅱ)의 화합물의 일반식(Ⅲ)의 화합물과의 N-알킬화, 필요하다면, 산성 조건하에서 가수분해 하기위해 결과 생성물을 처리하여 보호된 히드록시기를 히드록시로 전환시키는 것으로 구성된 일반식(Ⅰ)의 화합물의 제조 방법.
    상기식에서, R11은 수소, C1-4알킬, C1-4알콕시, 할로겐 또는 보호된 히드록시기이고 X는 할로겐이고 기타 부호는 제1항에서 정의된 바와 같다.
  5. 제약학적으로 허용가능한 담체 또는 피복물과 일반식(Ⅰ)의 벤즈이소퀴놀린 유도체, 그의 비도성 산부가염 또는 수화물로 구성된 제약학상의 조성물.
  6. 약제용의 제1항에 따른 벤즈이소퀴놀린 유도체 또는 그의 제약학적으로 허용가능한 염 또는 수화물.
    ※ 참고사항 : 최초출원 내용에 의해 공개하는 것임.
KR1019900008764A 1989-06-13 1990-06-12 신규한 벤즈이소퀴놀린 유도체 및 그의 제조 방법 KR910000705A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP14848089 1989-06-13
JP1-148480 1989-06-13

Publications (1)

Publication Number Publication Date
KR910000705A true KR910000705A (ko) 1991-01-30

Family

ID=15453699

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Application Number Title Priority Date Filing Date
KR1019900008764A KR910000705A (ko) 1989-06-13 1990-06-12 신규한 벤즈이소퀴놀린 유도체 및 그의 제조 방법

Country Status (5)

Country Link
US (1) US5059607A (ko)
EP (1) EP0405784A1 (ko)
JP (1) JPH0386876A (ko)
KR (1) KR910000705A (ko)
CA (1) CA2018956A1 (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR920008026A (ko) * 1990-10-24 1992-05-27 오노 화아마슈티칼 캄파니 리미팃드 이소퀴놀리논 유도체 또는 이의 무독성 산부가염 또는 이의 수화물, 이의 제조방법 및 이를 포함하는 약제 조성물
WO1995004723A1 (fr) * 1993-08-04 1995-02-16 Yamanouchi Pharmaceutical Co., Ltd. Derive d'imidazolylalkylamine et composition pharmaceutique contenant ledit derive
EP1904449A4 (en) * 2005-07-08 2010-07-28 Merck Sharp & Dohme CHECKPOINT KINASE INHIBITORS
KR101072814B1 (ko) 2009-03-27 2011-10-14 덕산하이메탈(주) 벤조 이소퀴놀린 화합물 및 이를 이용한 유기전기소자, 그 단말

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8612796D0 (en) * 1986-05-27 1986-07-02 Fbc Ltd Fungicides
US5116984A (en) * 1988-04-07 1992-05-26 Glaxo Group Limited Imidazole derivatives

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US5059607A (en) 1991-10-22
EP0405784A1 (en) 1991-01-02
CA2018956A1 (en) 1990-12-13
JPH0386876A (ja) 1991-04-11

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