KR900700613A - 인간의 파라인플루엔자 바이러스 타입 3의 면역원성 단편을 함유하는 키메라 당단백질 - Google Patents
인간의 파라인플루엔자 바이러스 타입 3의 면역원성 단편을 함유하는 키메라 당단백질Info
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- KR900700613A KR900700613A KR1019890702416A KR890702416A KR900700613A KR 900700613 A KR900700613 A KR 900700613A KR 1019890702416 A KR1019890702416 A KR 1019890702416A KR 890702416 A KR890702416 A KR 890702416A KR 900700613 A KR900700613 A KR 900700613A
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- Prior art keywords
- glycoprotein
- polypeptide
- immunogenic fragment
- expression system
- human
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- 239000012634 fragment Substances 0.000 title claims 11
- 230000002163 immunogen Effects 0.000 title claims 11
- 108090000288 Glycoproteins Proteins 0.000 title claims 5
- 102000003886 Glycoproteins Human genes 0.000 title claims 5
- 241000712003 Human respirovirus 3 Species 0.000 title claims 3
- 229920001184 polypeptide Polymers 0.000 claims 12
- 108090000765 processed proteins & peptides Proteins 0.000 claims 12
- 102000004196 processed proteins & peptides Human genes 0.000 claims 12
- 101000926057 Human herpesvirus 2 (strain G) Envelope glycoprotein C Proteins 0.000 claims 8
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 5
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 5
- 229960005486 vaccine Drugs 0.000 claims 5
- 241000700605 Viruses Species 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 239000013612 plasmid Substances 0.000 claims 3
- 241000588724 Escherichia coli Species 0.000 claims 2
- 208000002606 Paramyxoviridae Infections Diseases 0.000 claims 2
- 238000002255 vaccination Methods 0.000 claims 2
- 241000201370 Autographa californica nucleopolyhedrovirus Species 0.000 claims 1
- 241000701822 Bovine papillomavirus Species 0.000 claims 1
- 241000701022 Cytomegalovirus Species 0.000 claims 1
- 241000238631 Hexapoda Species 0.000 claims 1
- 241001529936 Murinae Species 0.000 claims 1
- 241000256251 Spodoptera frugiperda Species 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 1
- 210000003527 eukaryotic cell Anatomy 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000010076 replication Effects 0.000 claims 1
- 241000701447 unidentified baculovirus Species 0.000 claims 1
- 210000005253 yeast cell Anatomy 0.000 claims 1
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- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- C12N2710/00011—Details
- C12N2710/14011—Baculoviridae
- C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
- C12N2710/14141—Use of virus, viral particle or viral elements as a vector
- C12N2710/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18611—Respirovirus, e.g. Bovine, human parainfluenza 1,3
- C12N2760/18622—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
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- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
- C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
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- Preparation Of Compounds By Using Micro-Organisms (AREA)
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Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (19)
- 신호 서열 및 인간의 파라인플루엔자 바이러스 타입 3당단백질 F 및 HN으로부터의 적어도 하나의 면역원성 단편을 포함하는 폴리펩타이드.
- 제1항에 있어서, 상기 폴리펩타이드가, N말단으로 시작하여, 당단백질 F로부터의 신호 서열, 당단백질F의 면역원성 단편 및 당단백질 HN의 면역원성 단편인 폴리펩타이드.
- 제1항의 폴리펩타이드를 포함하는 인간용 백신.
- 제3항에 있어서, 상기 폴리펩타이드가, N말단으로 시작하여, 당단백질 F로부터의 신호 서열, 당단백질 F의 면역원성 단편 및 당단백질 HN의 면역원성 단편인 백신.
- 예방접종에 의해 인간의 파라인플루엔자 바이러스 타입3으로부터 인간을 보호하는 백신을 제조하기 위한 제1항의 폴리펩타이드의 용도.
- 제5항에 있어서, 상기 폴리펩타이드가, N말단으로 시작하여, 당단백질 F로부터의 신호 서열, 당단백질 F의 면역원성 단편 및 당단백질 HN의 면역원성 단편인 용도.
- 제1항의 폴리펩타이드를 발현시킬 수 있는 DNA 서열을 함유한 적절한 숙주를 포함하는 발현시스템.
- 제7항에 있어서, 상기 DNA 서열이 N말단으로 시작하여, 당단백질 F로부터의 신호 서열, 당단백질 F의 면역원성 단편 및 당단백질 HN의 면역원성 단편인 폴리펩타이드를 제조하는 발현시스템.
- 제7항에 있어서, 상기 적절한 숙주가 박테리아 세포, 효모세포, 포유동물 세포 및 곤충세포로 구성되는 그룹으로부터의 선택된 발현시스템.
- 제9항에 있어서, 상기 적절한 숙주가 이. 콜라이 박테리아, 차이니즈 햄스터 난소 세포, 뮤린(murine, 쥐과의 일종) C127 세포 및 에스. 프러지페르다(S. Frugiperda) 세포로 구성되는 그룹으로부터 선택된 발현시스템.
- 제7항에 있어서, 상기 적절한 숙주가 상기 폴리펩타이드를 분비하는 발현시스템.
- 제7항에 있어서, 상기 DNA 서열이 플라스미드안에 함유된 발현시스템.
- 제12항에 있어서, 상기 플라스미드가 시토메갈로바이러스(Cytomegalovirus) 프로모터의 조절하에 있는 발현시스템.
- 제12항에 있어서, 적절한 진핵 세포중에서 상기 플라스미드의 복제가 소 유두종 바이러스 DNA 서열의 조절하에 있는 발현시스템.
- 제7항에 있어서, 상기 DNA 서열이 바큘로바이러스과의 재조합 바이러스안에 함유된 발현시스템.
- 제15항에 있어서, 상기 바이러스가 오토그라파 캘리포니카 뉴클리어 폴리헤드로시스 바이러스(Autogra pha Californica nuclear polyhedrosis virus)의 발현시스템.
- 인간의 파라인플루엔자 바이러스 타입 3당단백질 F 및 HN으로부터의 적어도 하나의 면역원성 단편을 포함하는 폴리펩티드.
- 제17항의 폴리펩타이드를 포함하는 인간용 백신.
- 예방접종에 의해 인간의 파라인플루엔자 바이러스 타입3으로부터 인간을 보호하는 백신을 제조하기 위한 제17항의 폴리펩타이드의 용도.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18464888A | 1988-04-22 | 1988-04-22 | |
US07/184,648 | 1988-04-22 | ||
PCT/US1989/000814 WO1989010405A1 (en) | 1988-04-22 | 1989-03-03 | Chimeric glycoproteins containig immunogenic segments of human parainfluenza virus type 3 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR900700613A true KR900700613A (ko) | 1990-08-16 |
KR970009347B1 KR970009347B1 (en) | 1997-06-10 |
Family
ID=22677770
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR89702416A KR970009347B1 (en) | 1988-04-22 | 1989-12-21 | Chimeric glycoproteins containing immunogenic segments of human parainfluenza virus type 3 |
Country Status (12)
Country | Link |
---|---|
US (2) | US5169628A (ko) |
EP (1) | EP0413695B1 (ko) |
KR (1) | KR970009347B1 (ko) |
AT (1) | ATE105334T1 (ko) |
AU (1) | AU611784B2 (ko) |
CA (1) | CA1306709C (ko) |
DE (1) | DE68915165T2 (ko) |
DK (1) | DK172635B1 (ko) |
FI (1) | FI102616B (ko) |
HK (1) | HK37397A (ko) |
NO (1) | NO303499B1 (ko) |
WO (1) | WO1989010405A1 (ko) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5486599A (en) * | 1989-03-29 | 1996-01-23 | The Board Of Trustees Of The Leland Stanford Junior University | Construction and use of synthetic constructs encoding syndecan |
GB8914968D0 (en) * | 1989-06-29 | 1989-08-23 | Connaught Lab | Production of virus and purification of viral envelope proteins for vaccine use |
JP2649285B2 (ja) * | 1990-11-29 | 1997-09-03 | 藤倉化成株式会社 | ヒトパラインフルエンザ4a型ウイルスフュージョンプロテイン遺伝子及び該遺伝子を含む物質 |
GB9120221D0 (en) * | 1991-09-23 | 1991-11-06 | Smithkline Beecham Biolog | Novel compounds |
GB9200117D0 (en) * | 1992-01-06 | 1992-02-26 | Connaught Lab | Production of recombinant chimeric proteins for vaccine use |
US6479055B1 (en) * | 1993-06-07 | 2002-11-12 | Trimeris, Inc. | Methods for inhibition of membrane fusion-associated events, including respiratory syncytial virus transmission |
US5550017A (en) * | 1993-10-12 | 1996-08-27 | Emory University | Anti-paramyxovirus screening method and vaccine |
US7300918B2 (en) | 1994-01-14 | 2007-11-27 | Matthias Rath | Method of producing vaccines from protein signal oligopeptides |
EP0744027B1 (en) * | 1994-01-14 | 2005-03-16 | Rath, Matthias, Dr. med. | Use of methods for identifying hydrophilic signal oligopeptides |
US5869036A (en) * | 1995-12-08 | 1999-02-09 | St. Louis University | Live attenuated vaccines based on CP45 HPIV-3 strain and method to ensure attenuation in such vaccine |
AU724621B2 (en) * | 1996-01-29 | 2000-09-28 | Georgetown University | Amplification of response from expressed recombinant protein |
FR2751229B1 (fr) * | 1996-07-19 | 1998-11-27 | Rhone Merieux | Formule de vaccin polynucleotidique notamment contre la pathologie respiratoire des bovins |
US6060308A (en) | 1997-09-04 | 2000-05-09 | Connaught Laboratories Limited | RNA respiratory syncytial virus vaccines |
JP2002512003A (ja) | 1997-11-14 | 2002-04-23 | コノート ラボラトリーズ リミテッド | パラミキソウイルスワクチンのためのアルファウイルスベクター |
BR0010322A (pt) | 1999-05-06 | 2002-04-09 | Univ Wake Forest | Vetor de expressão, vacina e seu método de uso para eliciar uma resposta imune dirigida contra um antìgeno em um mamìfero |
US6764685B1 (en) | 2000-03-21 | 2004-07-20 | Medimmune Vaccines, Inc. | Recombinant parainfluenza virus expression systems and vaccines |
CN101921732A (zh) | 2001-01-19 | 2010-12-22 | 维洛诺瓦蒂夫公司 | 在易感哺乳动物中引起呼吸道疾病的病毒 |
US8715922B2 (en) | 2001-01-19 | 2014-05-06 | ViroNovative | Virus causing respiratory tract illness in susceptible mammals |
IL163646A0 (en) | 2002-02-21 | 2005-12-18 | Vironovative Bv | Recombinant parainfluenza virus expression systemsand vaccines comprising heterologous antigens derived from metapneumovirus |
US7704720B2 (en) | 2003-04-25 | 2010-04-27 | Medimmune, Llc | Metapneumovirus strains and their use in vaccine formulations and as vectors for expression of antigenic sequences and methods for propagating virus |
BRPI0411099A (pt) * | 2003-06-05 | 2006-07-18 | Wyeth Corp | composições imunogênicas que compreendem os vetores de replicon do vìrus da encefalite eqüina venezuelana e antìgenos de proteìnas de paramixovìrus |
MD3718565T2 (ro) | 2015-10-22 | 2022-09-30 | Modernatx Inc | Vaccinuri împotriva virusului respirator |
MA50335A (fr) | 2016-12-08 | 2020-08-19 | Modernatx Inc | Vaccins à acide nucléique contre des virus respiratoires |
US11351242B1 (en) | 2019-02-12 | 2022-06-07 | Modernatx, Inc. | HMPV/hPIV3 mRNA vaccine composition |
WO2021119293A2 (en) * | 2019-12-10 | 2021-06-17 | Children's National Medical Center | T-cell epitopes of human parainfluenza virus 3 for adoptive t-cell immunotherapy |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4743553A (en) * | 1984-07-18 | 1988-05-10 | W. R. Grace & Co. | Synthetic genes for bovine parainfluenza virus |
JP2564268B2 (ja) * | 1985-08-28 | 1996-12-18 | 協和醗酵工業株式会社 | 融合抗原ポリペプチド |
US4790987A (en) * | 1985-11-15 | 1988-12-13 | Research Corporation | Viral glycoprotein subunit vaccine |
NZ230425A (en) * | 1988-09-02 | 1992-07-28 | Molecular Eng Ass | Production of paramyxovirus fusion (f) protein using recombinant baculovirus expression vector |
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1989
- 1989-03-03 AT AT8989903005T patent/ATE105334T1/de not_active IP Right Cessation
- 1989-03-03 US US07/582,891 patent/US5169628A/en not_active Expired - Lifetime
- 1989-03-03 WO PCT/US1989/000814 patent/WO1989010405A1/en active IP Right Grant
- 1989-03-03 DE DE68915165T patent/DE68915165T2/de not_active Expired - Lifetime
- 1989-03-03 AU AU31975/89A patent/AU611784B2/en not_active Expired
- 1989-03-03 EP EP89903005A patent/EP0413695B1/en not_active Expired - Lifetime
- 1989-03-13 CA CA000593516A patent/CA1306709C/en not_active Expired - Lifetime
- 1989-12-21 KR KR89702416A patent/KR970009347B1/ko not_active IP Right Cessation
-
1990
- 1990-10-18 DK DK199002518A patent/DK172635B1/da not_active IP Right Cessation
- 1990-10-19 NO NO904538A patent/NO303499B1/no not_active IP Right Cessation
- 1990-10-19 FI FI905184A patent/FI102616B/fi not_active IP Right Cessation
-
1992
- 1992-09-04 US US07/941,027 patent/US5284764A/en not_active Expired - Lifetime
-
1997
- 1997-03-27 HK HK37397A patent/HK37397A/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DK251890A (da) | 1990-10-18 |
NO904538L (no) | 1990-12-27 |
JPH03503760A (ja) | 1991-08-22 |
FI102616B1 (fi) | 1999-01-15 |
CA1306709C (en) | 1992-08-25 |
KR970009347B1 (en) | 1997-06-10 |
NO904538D0 (no) | 1990-10-19 |
FI905184A0 (fi) | 1990-10-19 |
WO1989010405A1 (en) | 1989-11-02 |
DE68915165D1 (de) | 1994-06-09 |
US5284764A (en) | 1994-02-08 |
US5169628A (en) | 1992-12-08 |
FI102616B (fi) | 1999-01-15 |
HK37397A (en) | 1997-04-04 |
DK251890D0 (da) | 1990-10-18 |
NO303499B1 (no) | 1998-07-20 |
AU3197589A (en) | 1989-11-24 |
EP0413695B1 (en) | 1994-05-04 |
DK172635B1 (da) | 1999-03-22 |
EP0413695A1 (en) | 1991-02-27 |
ATE105334T1 (de) | 1994-05-15 |
AU611784B2 (en) | 1991-06-20 |
DE68915165T2 (de) | 1994-09-08 |
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