KR900007804A - 치환된 2-클로로피리딘의 제조방법 - Google Patents

치환된 2-클로로피리딘의 제조방법 Download PDF

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KR900007804A
KR900007804A KR1019890016795A KR890016795A KR900007804A KR 900007804 A KR900007804 A KR 900007804A KR 1019890016795 A KR1019890016795 A KR 1019890016795A KR 890016795 A KR890016795 A KR 890016795A KR 900007804 A KR900007804 A KR 900007804A
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alkyl
chlorophosphoramide
chlorine
chlorophosphate
reaction
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KR1019890016795A
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KR0139639B1 (ko
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카우프만 디이터
갈렌캄프 베른트
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루디 마이어, 클라우스 대너
바이엘 아크티엔 게젤샤프트
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음

Description

치환된 2-클로로피리딘의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 일반식(Ⅱ)의 피리딘 1-옥사이드를 -20℃ 내지 200℃의 온도에서 불활성 유기용매 및 산 수용체의 존재하에서 클로로포스포릭 에스테르 및 클로로포스포르아미드중에서 선택된 염소-함유 인산 유도체와 반응시키고, 필요할 경우 그 생성물을 추가로 분리시킴을 특징으로 하여, 일반식(Ⅰ)의 치환된 2-클로로피리딘 유도체를 제조하는 방법.
    상기식에서, R1은 수소, 염소, 시아노, 카브알콕시(C1-C4) 또는(여기에서, R5및 R6는 동일하거나 상이하며 수소 또는 알킬(C1-C4)을 나타낸다)를 나타내며, R2는 수소, 염소, 알킬(C1-C4), 할로게노알킬(C1-C4), 시아노알킬(C1-C4), 알콕시(C1-C4), 알킬(C1-C4), 디알킬아미노(C1-C4), 알킬(C1-C4), 카브알콕시(C1-C4) 또는(여기에서, R5및 R6는 동일하거나 상이하며 수소 또는 알킬(C1-C4)을 나타낸다)를 나타내거나, R1및 R2는 함께 이가 그룹 -CH=CH-CH=CH-를 나타내고, R3는 수소, 염소, 카브알콕시(C1-C4) 또는(여기에서, R5및 R6는 동일하거나 상이하며 수소 또는 알킬(C1-C4)을 나타내며, R4는 수소, 염소, 또는 시아노를 나타내거나, R3및 R4는 함께 이가 그룹 -CH=CH-CH=CH-를 나타낸다.
  2. 제1항에 있어서, 반응에 염소-함유 인산유도체로서 모노알킬 클로로포스페이트, 디알킬 클로로포스페이트, 사이클로알킬 클로로포스페이트, 아릴 클로로포스페이트, 디아릴 클로로포스페이트, N-모노알킬-클로로포스포르아미드, N,N-디알킬-클로로포스포르아미드, N,N,N',N'-테트르알킬 클로로포르포릭 디아미드, N-사이클로알킬-클로로 포스포르아미드, N-아릴-클로로포스포르아미드 또는 N,N-디아릴-클로로포스포르아미드를 사용함을 특징으로 하는 방법.
  3. 제1항 또는 2항에 있어서, 산 수용체로서 디알킬아민, 트리알킬아민, 디알킬사이클로알킬아민, 디알킬아르알킬아민, 디알킬아릴아민 및 디알킬피리딘중에서 선택된 염기성 유기 질소 화합물을 사용함을 특징으로 하는 방법.
  4. 제1항 내지 3항중 어느 한 항에 있어서, 산수용체로서 디이소프로필아민을 사용함을 특징으로 하는 방법.
  5. 제1항 내지 4항중 어느 한 항에 있어서, 불활성 유기 용매로서 메틸렌 클로라이드, 클로로포름 또는 클로로벤젠을 사용함을 특징으로 하는 방법.
  6. 제1항 내지 5항중 어느 한 항에 있어서, 반응을 0℃ 내지 150℃의 온도에서 수행함을 특징으로 하는 방법.
  7. 제1항 내지 6항중 어느 한 항에 있어서, 각각의 경우에 클로로포스포릭 에스테르 또는 클로로포스포르 아미드와 아민 1 내지 10몰의 등몰랑 혼합물을 희석제 중의 일반식(Ⅲ)의 치환된 피리딘-N-옥사이드 1몰의 용액에 적가하고, 반응 혼합물을 수시간 동안 교반시킴을 특징으로 하는 방법.
  8. 제1항 내지 7항중 어느 한 항에 있어서, 반응으로 생성된 반응 혼합물을 수증기 증류, 증류 또는 추출시킴을 특징으로 하는 방법.
  9. 제1항 내지 8항중 어느 한 항에 있어서, 3-메틸-피리딘-1-옥사이드를 산 수용체로서 디이소프로필아민을 가하면서 메틸렌 클로라이드 또는 클로로벤젠 중의 N,N-디알킬-디클로로포스포르아미드 또는 알킬 디클로포스페이트와 반응시켜 2-클로로-5-메틸-피리딘을 제조함을 특징으로 하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890016795A 1988-11-22 1989-11-20 치환된 2-클로로피리딘의 제조방법 KR0139639B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3839332A DE3839332A1 (de) 1988-11-22 1988-11-22 Verfahren zur herstellung von substituierten 2-chlorpyridinen
DEP3839332.8 1988-11-22

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KR900007804A true KR900007804A (ko) 1990-06-02
KR0139639B1 KR0139639B1 (ko) 1998-06-01

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US (1) US5010201A (ko)
EP (1) EP0370317B1 (ko)
JP (1) JP2806998B2 (ko)
KR (1) KR0139639B1 (ko)
DE (2) DE3839332A1 (ko)

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DE4020055A1 (de) * 1990-01-18 1991-07-25 Bayer Ag Verfahren zur herstellung von substituierten 2-chlor-pyridinen
DE4020052A1 (de) * 1990-06-23 1992-01-02 Bayer Ag Verfahren zur herstellung von 2-chlor-5-methyl-pyridin
DE4111215A1 (de) * 1991-04-06 1992-10-08 Bayer Ag Verfahren zur herstellung von 2-chlorpyridinen
DE4217021A1 (de) * 1991-12-13 1993-06-17 Bayer Ag Verfahren zur herstellung von 5-substituierten 2-chlor-pyridinen
KR930023342A (ko) * 1992-05-12 1993-12-18 비트 라우버, 토마스 케플러 2-클로로-5-클로로메틸- 피리딘의 제조방법
DE4234637A1 (de) * 1992-10-14 1994-04-21 Bayer Ag Verfahren zur Herstellung von 2-substituierten 5-Alkyl-pyridinen
DE4301110A1 (de) * 1993-01-18 1994-07-21 Bayer Ag Verfahren zur Herstellung von 2-Amino-5-aminomethyl-pyridin
KR100543694B1 (ko) * 1999-01-19 2006-01-23 주식회사 코오롱 2-클로로피리딘의 제조방법
KR100371590B1 (ko) * 2000-02-18 2003-02-11 주식회사 유니온 케미칼 2-클로로피리딘의 제조방법
CN101260076B (zh) * 2007-03-08 2012-04-11 南京红太阳生物化学有限责任公司 2-氯-5-甲基吡啶的制备方法
CN102532007B (zh) * 2010-12-13 2013-10-09 中国中化股份有限公司 一种制备2-氯-5-取代吡啶的方法
CN102219732B (zh) * 2011-04-22 2013-04-17 安徽国星生物化学有限公司 一种2-氯-5-甲基吡啶化合物的制备方法
EP3099666B1 (en) * 2014-01-27 2018-12-12 Vertellus Holdings LLC Process for making 2-chloro-5-methylpyridine
IT201900022209A1 (it) 2019-11-26 2021-05-26 Osram Gmbh Lampada e procedimento corrispondente
WO2022099692A1 (zh) * 2020-11-16 2022-05-19 单县欣润化工有限公司 一种2-氯-5-三氟甲基吡啶合成方法及系统

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CH628892A5 (it) * 1977-06-22 1982-03-31 Simes Procedimento per la preparazione di acidi chinolinici ad attivita antiinfiammatoria.
US4211873A (en) * 1978-07-25 1980-07-08 The Dow Chemical Company Preparation of chloromethylpyridines
ATE7295T1 (de) * 1980-01-16 1984-05-15 Lacer, S.A. 2-halo-pyridine, ihre herstellung und pharmazeutische zusammensetzungen.
DE3572982D1 (en) * 1984-03-06 1989-10-19 Takeda Chemical Industries Ltd Chemically modified lymphokine and production thereof
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DE3800179A1 (de) * 1988-01-07 1989-07-20 Bayer Ag Verfahren zur herstellung von 2-chlor-5-methyl-pyridin

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JP2806998B2 (ja) 1998-09-30
DE58904566D1 (de) 1993-07-08
US5010201A (en) 1991-04-23
EP0370317A1 (de) 1990-05-30
EP0370317B1 (de) 1993-06-02
DE3839332A1 (de) 1990-05-23
KR0139639B1 (ko) 1998-06-01
JPH02184671A (ja) 1990-07-19

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