KR900007412A - 약제학적 조성물 - Google Patents

약제학적 조성물 Download PDF

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KR900007412A
KR900007412A KR1019890016872A KR890016872A KR900007412A KR 900007412 A KR900007412 A KR 900007412A KR 1019890016872 A KR1019890016872 A KR 1019890016872A KR 890016872 A KR890016872 A KR 890016872A KR 900007412 A KR900007412 A KR 900007412A
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component
pharmaceutical composition
polyoxyethylene glycol
group
ether
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KR1019890016872A
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옥산나 바신스키 마리아
하워드 인펠드 미틴
샤 나프니트
우노우스키 죠엘
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쟝-자끄 오가이, 롤란드 보러
에프.호프만-라 롯슈 에이지
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Publication of KR900007412A publication Critical patent/KR900007412A/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/25—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids with polyoxyalkylated alcohols, e.g. esters of polyethylene glycol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

내용 없음

Description

약제학적 조성물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (14)

  1. 약제학적으로 불활성인 담체의 존재 또는 부재하에 (a) 항균성 화합물 (b) 흡수 중진량의 2-성분 흡수 중진계를 함유하며, 여기서, 2-성분 흡수 증진계 (b)는 (1)(C6-C18)알콜과 폴리옥시에틸렌 글리콜의 에테르인 제1성분, 및 (2)(ⅰ)폴리옥시에틸렌 글리콜-(C6-C18)카복실산 글리세라이드 에스테르, (ⅱ)(C6-C18)카복실산 또는 약제학적으로 허용되는 이의 염, 및 (ⅲ)2개 이상의 (C6-C18)카복실산, 글리세롤 및 폴리옥시에틸렌 글리콜의 에스테르 중에서 선택된 제2성분으로 이루어짐을 특징으로 하는 약제학적 조성물.
  2. 제1항에 있어서, 흡수 중진계가 성분 (b)는 (1)(C6-C18)알콜과 폴리옥시에틸렌 글리콜의 에테르, 및 성분(b) (2)(ⅰ)폴리옥시에틸렌 글리콜-(C6-C18)카복실산 글리세라이드 에스테르로 이루어지는 약제학적 조성물.
  3. 제2항에 있어서, 성분(b)(1)이 라우릴 알콜과 폴리옥시에틸렌 글리콜의 에테르이고, 성분(b)(2)(ⅰ)이 폴리옥시에틸렌글리콜-8 카프릴레이트/카프레이트 글리세라이드 에스테르인 약제학적 조성물.
  4. 제1항에 있어서, 흡수 중진계가 성분(b)(1)인 (C6-C18) 알콜과 폴리옥시에틸렌 글리콜의 에테르, 및 성분(b)(2)(ⅱ)인 (C6-C18)카복실산 또는 약제학적으로 허용되는 이의 염으로 이루어지는 약제학적 조성물.
  5. 제4항에 있어서, 성분(b)(1)이 라우릴 알콜과 폴리옥시에틸렌 글리콜의 에테르이고, 성분(b)(2)(ⅱ)가 카프릴산 나트륨이 약제학적 조성물.
  6. 제1항에 있어서, 흡수 중진계가 성분(b)(1)인 (C6-C18) 알콜과 폴리옥시에틸렌 글리콜의 에테르, 및 성분(b)(2)(ⅱ)인 2개 이상의 (C6-C18)카복실산, 글리세롤 및 폴리옥시에틸렌 글리콜의 에스테르로 이루어지는 약재학적 조성물.
  7. 제6항에 있어서, 성분(b)(1)이 라우릴 알콜과 폴리옥시에틸렌 글리콜의 에테르이고, 성분(b)(2)(ⅱ)폴리옥시에틸렌 글리콜 글리세롤 코코에이트인 약재학적 조성물.
  8. 제7항에 있어서, 항균성 화합물이 β-락탐인약제학적 조성물.
  9. 제8항에 있어서, β-락탐이 하기 일반식의 화합물인 약제학적 조성물.
    상기식에서, R1은 수소 또는 임의로 치환된 알킬이고, R2는 일반식 SO- 3M+의 그룹이거나, R1과 R2는 이들이 결합된 β-락탐(아제티디논)과 환과 함께 일반식의 화합물을 나타내며,
    M+는 양성자 또는 양이온이고, R3은 아실아미노 그룹 또는 하이드록시알킬 그룹이며, X는 -S-, -O-, -SO-, -SO2-, -CH2또는 -CH(CH3)이고,
    Y는 일반식
    R4는 치환된 티오 그룹(이는 에틸티오, -SCH2CH2NH2,및
    중에서 선택된다. 임의로 치환된 저급 알킬 그룹(이는 아미노메틸, 아실아미노메틸 및중에서 선택된다) 도는 카바모일옥시
    O
    ∥
    (-OCVH2)와 같은 치환된 옥시그룹이고, -COOE그룹과 연결되어있는 탄소원자는 β-락탐환의 질소 원자에 결합되어 있으며, Z는 수소, 할로겐, 알콕시 또는 일반식(CH2T의 그룹이고, T는 수소, 알킬-CO-O-,피리디늄, 카복스아미도 피리디늄, 아미노피리디늄, 카바모일옥시, 아지도, 시아노, 하이드록실, 치환 가능한 -S-페닐 그룹 또는 -S-het그룹(여기서, "het"는 임의로 치환된 5- 또는 6-원 헤테로사이클릭환이다)이며, E는 수소, 약제학적으로 허용되는 에스테르 그룹 또는 염-형성 양이온이다.
  10. 제8항에있어서, 항균성 화합물이(E)-2-(이소부톡시카보닐)-2-펜테닐(6R,7R)-7-[(Z)-2(2-아미노-4-티아졸린)-2-(메톡시이미노)아세트아미도]-3-(아지도메틸)-8-옥소-5-티아-1-아자비사이클로[4,2,0]옥트-2-엔-2-카복실레이트인 약제학적 조성물.
  11. 제10항에 있어서, 항균성 화합물이 세프트리악손 또는 약제학적으로 허용되는 이의 염, 에스테르 또는 수화물인 약제학적 조성물.
  12. 제1항 내지 11항중 어느 한 항에 있어서, 피복된 장용 경구 투여 형태로 존재하는 약제학적 조성물.
  13. 제1항 내지 11항중 어느 한 항에 있어서, 직장투여 형태로 존재하는 약제학적 조성물.
  14. 전술된 바와 같은 약제학적 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890016872A 1988-11-22 1989-11-21 약제학적 조성물 KR900007412A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27459088A 1988-11-22 1988-11-22
US274,590 1988-11-22

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KR900007412A true KR900007412A (ko) 1990-06-01

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EP (1) EP0370481B1 (ko)
JP (1) JPH0774165B2 (ko)
KR (1) KR900007412A (ko)
AT (1) ATE94765T1 (ko)
AU (1) AU625276B2 (ko)
CA (1) CA2003340A1 (ko)
DE (1) DE58905681D1 (ko)
DK (1) DK585889A (ko)
HU (1) HU205713B (ko)
IE (1) IE63119B1 (ko)
IL (1) IL92357A (ko)
NZ (1) NZ231447A (ko)
PH (1) PH26390A (ko)
YU (1) YU221889A (ko)
ZA (1) ZA898331B (ko)

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Publication number Priority date Publication date Assignee Title
DE4115849A1 (de) * 1991-05-15 1992-11-19 Lohmann Therapie Syst Lts Penetrationsfoerdernde substanz
GB9405304D0 (en) * 1994-03-16 1994-04-27 Scherer Ltd R P Delivery systems for hydrophobic drugs
SI9400338A (en) * 1994-08-31 1996-04-30 Lek D D Vancomycin hydrochloride suspensions for peroral use and for filling into soft ,gelatine capsules.
JPH08208510A (ja) * 1994-11-03 1996-08-13 F Hoffmann La Roche Ag インターフェロン組成物
FR2775188B1 (fr) * 1998-02-23 2001-03-09 Lipha Forme galenique a liberation immediate ou liberation prolongee administrable par voie orale comprenant un agent promoteur d'absorption et utilisation de cet agent promoteur d'absorption
IL125244A (en) * 1998-07-07 2002-12-01 Yissum Res Dev Co Pharmaceutical compositions containing low-melting waxes
US7658938B2 (en) 1999-02-22 2010-02-09 Merrion Reasearch III Limited Solid oral dosage form containing an enhancer
JP2002537321A (ja) * 1999-02-22 2002-11-05 エラン コーポレイション ピーエルスィー 促進剤を含む固体経口剤形
US8119159B2 (en) 1999-02-22 2012-02-21 Merrion Research Iii Limited Solid oral dosage form containing an enhancer
EP1392272B1 (en) 2001-05-11 2014-08-06 Merrion Research III Limited Permeation enhancers
AU2007235251B2 (en) 2006-04-07 2013-02-07 Merrion Research Iii Limited Solid oral dosage form containing an enhancer
WO2009137078A1 (en) 2008-05-07 2009-11-12 Merrion Research Iii Limited Compositions of peptides and processes of preparation thereof
HUE033611T2 (en) 2008-09-17 2017-12-28 Chiasma Inc Pharmaceutical preparations and associated dosing procedures
US9089484B2 (en) 2010-03-26 2015-07-28 Merrion Research Iii Limited Pharmaceutical compositions of selective factor Xa inhibitors for oral administration
US8802114B2 (en) 2011-01-07 2014-08-12 Merrion Research Iii Limited Pharmaceutical compositions of iron for oral administration
US10265384B2 (en) 2015-01-29 2019-04-23 Novo Nordisk A/S Tablets comprising GLP-1 agonist and enteric coating
MA41462A (fr) 2015-02-03 2021-05-12 Chiasma Inc Méthode de traitement de maladies
US11141457B1 (en) 2020-12-28 2021-10-12 Amryt Endo, Inc. Oral octreotide therapy and contraceptive methods

Family Cites Families (6)

* Cited by examiner, † Cited by third party
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CA1168949A (en) * 1979-08-13 1984-06-12 William G. Gorman Cleansing compositions
US4525339A (en) * 1982-10-15 1985-06-25 Hoffmann-La Roche Inc. Enteric coated oral dosage form
EP0126348A2 (en) * 1983-05-19 1984-11-28 Kyoto Pharmaceutical Industries, Ltd. Composition for rectal administration and method of promoting rectal drug absorption
JPS59212427A (ja) * 1983-05-19 1984-12-01 Kyoto Yakuhin Kogyo Kk 直腸投与用組成物
CA1256799A (en) * 1984-02-22 1989-07-04 Walter Fuller Suppositories
EP0179583A1 (en) * 1984-10-04 1986-04-30 Merck & Co. Inc. A system for enhancing the water dissolution rate and solubility of poorly soluble drugs

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ATE94765T1 (de) 1993-10-15
JPH02180837A (ja) 1990-07-13
DK585889A (da) 1990-05-23
PH26390A (en) 1992-07-02
IE63119B1 (en) 1995-03-22
IE893718L (en) 1990-05-22
AU625276B2 (en) 1992-07-09
EP0370481A3 (de) 1991-01-16
HU205713B (en) 1992-06-29
JPH0774165B2 (ja) 1995-08-09
ZA898331B (en) 1990-07-25
CA2003340A1 (en) 1990-05-22
YU221889A (en) 1992-05-28
DE58905681D1 (de) 1993-10-28
HUT52374A (en) 1990-07-28
EP0370481B1 (de) 1993-09-22
AU4538489A (en) 1990-05-31
NZ231447A (en) 1992-09-25
IL92357A0 (en) 1990-07-26
EP0370481A2 (de) 1990-05-30
DK585889D0 (da) 1989-11-21
HU896123D0 (en) 1990-02-28
IL92357A (en) 1994-10-07

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