KR900006311A - 5-치환된-3-푸르알데히드의 제조방법 - Google Patents

5-치환된-3-푸르알데히드의 제조방법 Download PDF

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Publication number
KR900006311A
KR900006311A KR1019890014842A KR890014842A KR900006311A KR 900006311 A KR900006311 A KR 900006311A KR 1019890014842 A KR1019890014842 A KR 1019890014842A KR 890014842 A KR890014842 A KR 890014842A KR 900006311 A KR900006311 A KR 900006311A
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KR
South Korea
Prior art keywords
alkyl
trimethylsilyl
hydroxy
electrophilic
compound
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KR1019890014842A
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English (en)
Inventor
씨.엠.리 가리
Original Assignee
마틴 에이.보우이트
알러간, 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 마틴 에이.보우이트, 알러간, 인코포레이티드 filed Critical 마틴 에이.보우이트
Publication of KR900006311A publication Critical patent/KR900006311A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C07D307/46—Doubly bound oxygen atoms, or two oxygen atoms singly bound to the same carbon atom
    • C07D307/48—Furfural
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C07D307/46—Doubly bound oxygen atoms, or two oxygen atoms singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/0825—Preparations of compounds not comprising Si-Si or Si-cyano linkages
    • C07F7/0827—Syntheses with formation of a Si-C bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/22—Tin compounds
    • C07F7/2208—Compounds having tin linked only to carbon, hydrogen and/or halogen

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

내용 없음

Description

5-치환된-3-푸르알데히드의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (8)

  1. 3-푸르알데히드를 (1) 리튬 모르폴라이드와 반응시키고, 이어서 (2) 2급-부틸리튬과 반응시킨 후, (3) 친전자성 물질과 반응시킴을 특징으로 하여, 다음 일반식(I)의 화합물을 제조하는 방법.
    상기식에서 E는 친전자성 그룹이다.
  2. 제 1 항에 있어서, E가 트리알킬실릴 ; 트리알킬스타닐 ; C1-20알킬 ; C1-20알케닐 또는 알키닐(여기에서 이중결합 또는 3중결합은 C2또는 그 이상의 탄소에 존재한다) ; 할로, 저급알킬 또는 저급알콕시에 의해 페닐환이 임의 치환된 벤질 ; N-알킬 카바모일 ; 알킬머캅토 ; 페닐머캅토 ; 또는 알카노일인 방법.
  3. 제 2 항에 있어서, E가 트리메틸실릴, 트리에틸실릴, 또는 t-부틸 디메틸실릴인 방법.
  4. 제 3 항에 있어서, E가 트리메틸실릴이고, 친전자성 물질이 트리메틸실릴 클로라이드인 방법.
  5. 제 2 항에 있어서, E가 트리부틸 스타닐인 방법.
  6. 제 2 항에 있어서, E가 옥틸, 1-하이드록시-1-메틸데실 또는 1-하이드록시 헥실인 방법.
  7. 제 2 항에 있어서, E가 (4-브로모페닐)-1-하이드록시 메틸인 방법.
  8. 제 1 항에 있어서, 친전자성 물질이 할라이드, 알데히드, 케톤, 이소시아네이트, 에폭사이드, 디설파이드 또는 에스테르인 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890014842A 1988-10-18 1989-10-16 5-치환된-3-푸르알데히드의 제조방법 KR900006311A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US259225 1988-10-18
US07/259,225 US4935530A (en) 1988-10-18 1988-10-18 Process for preparing 5-substituted-3-furaldehydes

Publications (1)

Publication Number Publication Date
KR900006311A true KR900006311A (ko) 1990-05-07

Family

ID=22984077

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890014842A KR900006311A (ko) 1988-10-18 1989-10-16 5-치환된-3-푸르알데히드의 제조방법

Country Status (19)

Country Link
US (1) US4935530A (ko)
EP (1) EP0365256B1 (ko)
JP (1) JPH02164876A (ko)
KR (1) KR900006311A (ko)
CN (1) CN1023802C (ko)
AT (1) ATE94552T1 (ko)
AU (1) AU614474B2 (ko)
CA (1) CA2000677A1 (ko)
DE (1) DE68909166T2 (ko)
DK (1) DK517889A (ko)
ES (1) ES2044137T3 (ko)
FI (1) FI894924A0 (ko)
HU (1) HU204806B (ko)
IE (1) IE63693B1 (ko)
IL (1) IL91981A0 (ko)
NO (1) NO172799C (ko)
NZ (1) NZ231026A (ko)
PT (1) PT92016B (ko)
ZA (1) ZA897768B (ko)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5134128A (en) * 1987-06-08 1992-07-28 Allergan, Inc. Anti-inflammatory furanones
US5043457A (en) * 1990-04-17 1991-08-27 Allergan, Inc. 2(5H)-furanones substituted in the 3 position, as Ca2+ channel antagonists and anti-inflammatory agents
US5171863A (en) * 1987-06-08 1992-12-15 Allergan, Inc. Intermediates for preparing 4-substituted 2-5(H)-furanones as anti-inflammatory agents
US5082954A (en) * 1987-06-08 1992-01-21 Allergan, Inc. Intermediates and processes for preparing 4-substituted 2-5(H)-furanones as anti-inflammatory agents
US5322953A (en) * 1987-06-08 1994-06-21 Allergan, Inc. 2-trialkylsilyl-3-furaldehydes
US5037811A (en) * 1990-04-17 1991-08-06 Allergan, Inc. 4-(oxygen, sulfur or nitrogen substituted)-methyl 5-hydroxy-2(5H)-furanones as anti-inflammatory agents
US5045564A (en) * 1988-12-07 1991-09-03 Allergan, Inc. Anti-inflammatory 2-furanones
US5112853A (en) * 1989-11-20 1992-05-12 Allergan, Inc. Anti-inflammatory furanone compounds
US5258400A (en) * 1989-11-20 1993-11-02 Allergan, Inc. Anti-inflammatory furanone compounds
US5225571A (en) * 1991-04-30 1993-07-06 Allergan, Inc. Substituted dihydroxy-bis-[5-hydroxy-2(5H)-furanone-4-yl]-alkanes as anti-inflammatory agents
US5183906A (en) * 1991-04-30 1993-02-02 Allergan, Inc. 2- and 5-alkyl and phenyl substituted 4-(1-hydroxy, 1-acyloxy or 1-carbamoyloxy)-5-hydroxy-2 (5h)-furanones as anti-inflammatory agents
US5169963A (en) * 1991-08-30 1992-12-08 Allergan, Inc. Di-(5-hydroxy-2(5H)2-oxo-4-furyl)alkylmethyl-alpha,omega alkanedioates and N,N-bis-(5-hydroxy-2(5H)2-oxo-4-furyl)alkylmethyl-alpha,omega-dialkanoic acid amides as anti-inflammatory agents
US5171864A (en) * 1991-08-30 1992-12-15 Allergan, Inc. Di-(5-hydroxy-2(5H)-2-oxo-4-furyl)methyl-alpha,omega alkane-dioates and N,N-bis-(5-hydroxy-2(5H)-2-oxo-4-furyl)methyl-alpha,omega-dialkanoic acid amides as anti-inflammatory agents
US5268387A (en) * 1992-04-24 1993-12-07 Allergan, Inc. Pharmaceutical compositions and method for administering 3 and 4-substituted 2(5H)-furanones to a mammal for inhibiting bone loss
US5451686A (en) * 1994-04-15 1995-09-19 Allergan, Inc. 3 and 5 alkyl and phenyl 4-(hydroxy or acyloxy)-alkyl substituted 2(5H)-furanones as anti-inflammatory agents
US5639468A (en) * 1995-06-07 1997-06-17 University Of Southern California Method for reducing or preventing post-surgical adhesion formation using manoalide and analogs thereof
US7317116B2 (en) * 2004-12-10 2008-01-08 Archer-Daniels-Midland-Company Processes for the preparation and purification of hydroxymethylfuraldehyde and derivatives
US7393963B2 (en) * 2004-12-10 2008-07-01 Archer-Daniels-Midland Company Conversion of 2,5-(hydroxymethyl)furaldehyde to industrial derivatives, purification of the derivatives, and industrial uses therefor
KR101463933B1 (ko) * 2012-08-14 2014-11-26 한국과학기술원 5-치환된 또는 2,5-치환된 3-푸르알데히드 유도체의 제조방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4221585A (en) * 1978-08-04 1980-09-09 E. I. Du Pont De Nemours And Company N-[(2,6-Dimethoxypyrimidin-4-yl)]aminocarbonyl benzene sulfonamides and their herbicidal compositions and methods of use
US4195026A (en) * 1978-12-04 1980-03-25 Iowa State University Research Foundation, Inc. Substituted furans from butenolides
US4500520A (en) * 1983-03-01 1985-02-19 E. I. Du Pont De Nemours And Company Antiinflammatory and/or analgesic silylfurans
WO1987006127A1 (en) * 1986-04-07 1987-10-22 The Upjohn Company Anthelmintic acylhydrazones, method of use and compositions
GB8609452D0 (en) * 1986-04-17 1986-05-21 Ici Plc Fungicides
CA1329390C (en) * 1987-06-08 1994-05-10 John N. Bonfiglio Anti-inflammatory furanones

Also Published As

Publication number Publication date
FI894924A0 (fi) 1989-10-17
NO172799B (no) 1993-06-01
NO894133L (no) 1990-04-19
AU4296889A (en) 1990-05-10
ATE94552T1 (de) 1993-10-15
ES2044137T3 (es) 1994-01-01
IE893335L (en) 1990-04-18
DE68909166T2 (de) 1994-02-10
US4935530A (en) 1990-06-19
DK517889D0 (da) 1989-10-18
HU204806B (en) 1992-02-28
EP0365256A1 (en) 1990-04-25
EP0365256B1 (en) 1993-09-15
CN1023802C (zh) 1994-02-16
HUT51266A (en) 1990-04-28
DE68909166D1 (de) 1993-10-21
PT92016B (pt) 1995-06-30
PT92016A (pt) 1990-04-30
JPH02164876A (ja) 1990-06-25
IE63693B1 (en) 1995-05-31
IL91981A0 (en) 1990-07-12
AU614474B2 (en) 1991-08-29
ZA897768B (en) 1990-07-25
DK517889A (da) 1990-04-19
CN1042154A (zh) 1990-05-16
NO894133D0 (no) 1989-10-17
CA2000677A1 (en) 1990-04-18
NO172799C (no) 1993-09-08
HU895337D0 (en) 1990-01-28
NZ231026A (en) 1991-05-28

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