KR860003211A - 16-펜옥시 및 16-치환된 펜옥시-프로스타트리에노산 유도체의 제조용 중간체를 제조하는 방법 - Google Patents
16-펜옥시 및 16-치환된 펜옥시-프로스타트리에노산 유도체의 제조용 중간체를 제조하는 방법 Download PDFInfo
- Publication number
- KR860003211A KR860003211A KR1019850007405A KR850007405A KR860003211A KR 860003211 A KR860003211 A KR 860003211A KR 1019850007405 A KR1019850007405 A KR 1019850007405A KR 850007405 A KR850007405 A KR 850007405A KR 860003211 A KR860003211 A KR 860003211A
- Authority
- KR
- South Korea
- Prior art keywords
- compound
- phenoxy
- formula
- hydrogen
- yloxy
- Prior art date
Links
- -1 16-substituted phenoxy-prostatrienoic acid Chemical class 0.000 title claims 5
- 238000004519 manufacturing process Methods 0.000 title claims 3
- 239000000543 intermediate Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 claims abstract 11
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 6
- 239000001257 hydrogen Substances 0.000 claims abstract 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract 3
- 125000003545 alkoxy group Chemical group 0.000 claims abstract 2
- 125000000217 alkyl group Chemical group 0.000 claims abstract 2
- 125000001475 halogen functional group Chemical group 0.000 claims abstract 2
- 150000002431 hydrogen Chemical group 0.000 claims abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims abstract 2
- 238000000034 method Methods 0.000 claims 4
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 239000003638 chemical reducing agent Substances 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- ARNWQMJQALNBBV-UHFFFAOYSA-N lithium carbide Chemical compound [Li+].[Li+].[C-]#[C-] ARNWQMJQALNBBV-UHFFFAOYSA-N 0.000 claims 2
- 125000006239 protecting group Chemical group 0.000 claims 2
- LZXRUWUWOLCKTF-UHFFFAOYSA-N C(C)(C)(C)C=1C(=[Si](C=CC1)C)C Chemical compound C(C)(C)(C)C=1C(=[Si](C=CC1)C)C LZXRUWUWOLCKTF-UHFFFAOYSA-N 0.000 claims 1
- CDXNICWECYJOCE-UHFFFAOYSA-L [C-]#[C-].Cl[Ce+2]Cl Chemical compound [C-]#[C-].Cl[Ce+2]Cl CDXNICWECYJOCE-UHFFFAOYSA-L 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0025—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing keto groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (9)
- 구조식(B)의 화합물을, 카르보닐그룹을 입체 특이적으로 환원시킬 수 있는 화합물의 그룹으로부터 선택된 환원제와 반응시킴을 특징으로하는 구조식(A)의 화합물의 제조방법
- 제1항에 있어서, 환원제(R)-알핀보란인 방법.
- (a) 일반식 (Ⅱ)의 화합물을 리튬아세틸라이드 또는 디클로로세륨아세틸라이드 시약과 반응시키며, 또한 임의로 (b) R1및 R2가 에테르형성그룹인 일반식(Ⅰ)의 화합물을 얻기 위하여 1-하이드록시그룹을 보호시키며, 또한 더욱 임의로 (c) R1및 R2가 모두 수소인 일반식(Ⅰ)의 화합물을 얻기 위하여 보호그룹들을 제거함을 특징으로 하여, 일반식(Ⅰ)의 화합물을 제조하는 방법.상기식에서, R1및 R2는 수소 또는 에테르형성 그룹이고, X는 수소, 할로, 트리플루오로메틸, 저급알킬 또는 저급알콕시이다.
- 제3(a)항에 있어서, 일반식(Ⅱ)의 화합물이 감온에서 THF중의 리튬아세틸라이드 또는 디클로로-세륨아세틸라이드시약과 반응되는 방법.
- 제3(b)항에 있어서, 하이드록시보호그룹이 3급-부틸디메틸실린인 방법.
- 제3항에 있어서, X가 수소인 방법.
- 제6항에 있어서, (1α,4α-디하이드록시-3β-(3α-하이드록시-4-펜옥시-1-(E)-부텐-1-일)-시클로펜트-2α-일)-1-부트-3-인-2-온이 제조되는 방법.
- 제6항에 있어서, (1α-(3급-부틸디메틸실릴옥시)-4α-(테트라하이드로피란-2-일옥시)-εβ-(3α-(테트라하이드로피란-2-일옥시)-4-펜옥시-1-(E)-부텐-1-일)-시클로펜트-2α-일)-1-부트-3-인-2-온이제조되는 방법.
- 제6항에 있어서, (1α-하이드록시-4α-(테트라하이드로피란-2-일옥시)-3β-(3α-테트라하이드로-피란-2-일옥시)-4-펜옥시-1-(E)-부텐-1-시클로펜트-2α-일)-1-부트-3-인-2-온이 제조되는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65895084A | 1984-10-09 | 1984-10-09 | |
| US658.950 | 1984-10-09 | ||
| US658,950 | 1984-10-09 | ||
| US77481485A | 1985-09-13 | 1985-09-13 | |
| US774,814 | 1985-09-13 | ||
| US37.814 | 1985-09-13 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR860003211A true KR860003211A (ko) | 1986-05-21 |
| KR890003941B1 KR890003941B1 (ko) | 1989-10-13 |
Family
ID=27097724
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019850007405A KR890003941B1 (ko) | 1984-10-09 | 1985-10-08 | 16-펜옥시 및 16-치환된 펜옥시-프로스타트리에노산 유도체의 제조용 중간체를 제조하는 방법 |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0177933B1 (ko) |
| KR (1) | KR890003941B1 (ko) |
| AT (1) | ATE42947T1 (ko) |
| AU (1) | AU589911B2 (ko) |
| CA (1) | CA1246560A (ko) |
| DE (1) | DE3570073D1 (ko) |
| DK (2) | DK460585A (ko) |
| ES (1) | ES8609233A1 (ko) |
| FI (1) | FI853907L (ko) |
| HU (1) | HU197290B (ko) |
| IL (1) | IL76612A (ko) |
| NO (1) | NO163485C (ko) |
| NZ (1) | NZ213749A (ko) |
| PL (1) | PL146525B1 (ko) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4804787A (en) * | 1983-12-22 | 1989-02-14 | Syntex (U.S.A.) Inc. | Processes and intermediates for making 16-phenoxy and 16-substituted phenoxy-prostatrienoic acid derivatives |
| US4600785A (en) * | 1983-12-22 | 1986-07-15 | Syntex (U.S.A.) Inc. | Processes and intermediates for making 16-phenoxy and 16-substituted phenoxy-prostatrienoic acid derivatives |
| US4912235A (en) * | 1983-12-22 | 1990-03-27 | Syntex (U.S.A.) Inc. | Processes and intermediates for making 16-phenoxy- and 16-substituted phenoxy-prostatrienoic acid derivatives and their stereoisomers |
| DE102014018512A1 (de) | 2014-12-12 | 2016-06-16 | Giesecke & Devrient Gmbh | Optisch variables Sicherheitselement |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES449162A1 (es) * | 1975-06-23 | 1977-12-16 | Syntex Inc | Un procedimiento para la preparacion de un compuesto racemi-co u 8r-antimerico. |
| DE3107100A1 (de) * | 1981-02-20 | 1982-09-09 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Azaprostacycline, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung |
| US4600785A (en) * | 1983-12-22 | 1986-07-15 | Syntex (U.S.A.) Inc. | Processes and intermediates for making 16-phenoxy and 16-substituted phenoxy-prostatrienoic acid derivatives |
| ZA855740B (en) * | 1984-07-31 | 1987-03-25 | Syntex Inc | 11-substituted-16-phenoxy and 16-substituted phenoxy-prostatrienoic acid derivatives |
-
1985
- 1985-10-08 FI FI853907A patent/FI853907L/fi not_active IP Right Cessation
- 1985-10-08 DE DE8585112738T patent/DE3570073D1/de not_active Expired
- 1985-10-08 KR KR1019850007405A patent/KR890003941B1/ko not_active IP Right Cessation
- 1985-10-08 HU HU853905A patent/HU197290B/hu not_active IP Right Cessation
- 1985-10-08 DK DK460585A patent/DK460585A/da not_active Application Discontinuation
- 1985-10-08 EP EP85112738A patent/EP0177933B1/en not_active Expired
- 1985-10-08 IL IL76612A patent/IL76612A/xx unknown
- 1985-10-08 AT AT85112738T patent/ATE42947T1/de not_active IP Right Cessation
- 1985-10-08 NO NO853968A patent/NO163485C/no unknown
- 1985-10-08 NZ NZ213749A patent/NZ213749A/xx unknown
- 1985-10-08 AU AU48405/85A patent/AU589911B2/en not_active Ceased
- 1985-10-08 ES ES547691A patent/ES8609233A1/es not_active Expired
- 1985-10-08 CA CA000492518A patent/CA1246560A/en not_active Expired
- 1985-10-09 PL PL1985255694A patent/PL146525B1/pl unknown
-
1991
- 1991-04-05 DK DK91611A patent/DK61191D0/da not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| HU197290B (en) | 1989-03-28 |
| DK61191A (da) | 1991-04-05 |
| CA1246560A (en) | 1988-12-13 |
| DE3570073D1 (en) | 1989-06-15 |
| PL146525B1 (en) | 1989-02-28 |
| NO163485C (no) | 1990-06-06 |
| AU4840585A (en) | 1986-04-17 |
| NO853968L (no) | 1986-04-10 |
| PL255694A1 (en) | 1986-12-02 |
| FI853907L (fi) | 1986-04-10 |
| IL76612A (en) | 1990-01-18 |
| AU589911B2 (en) | 1989-10-26 |
| ES547691A0 (es) | 1986-09-01 |
| NZ213749A (en) | 1989-01-06 |
| EP0177933B1 (en) | 1989-05-10 |
| IL76612A0 (en) | 1986-02-28 |
| DK61191D0 (da) | 1991-04-05 |
| EP0177933A3 (en) | 1986-09-10 |
| DK460585A (da) | 1986-04-10 |
| ES8609233A1 (es) | 1986-09-01 |
| ATE42947T1 (de) | 1989-05-15 |
| HUT38612A (en) | 1986-06-30 |
| EP0177933A2 (en) | 1986-04-16 |
| KR890003941B1 (ko) | 1989-10-13 |
| NO163485B (no) | 1990-02-26 |
| FI853907A0 (fi) | 1985-10-08 |
| DK460585D0 (da) | 1985-10-08 |
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| LAPS | Lapse due to unpaid annual fee |