KR900004756A - 황산화 올리고당 및 그의 관련 물질 - Google Patents

황산화 올리고당 및 그의 관련 물질 Download PDF

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Publication number
KR900004756A
KR900004756A KR1019890014037A KR890014037A KR900004756A KR 900004756 A KR900004756 A KR 900004756A KR 1019890014037 A KR1019890014037 A KR 1019890014037A KR 890014037 A KR890014037 A KR 890014037A KR 900004756 A KR900004756 A KR 900004756A
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KR
South Korea
Prior art keywords
nphth
methanol
carried out
debenzylation reaction
nhac
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KR1019890014037A
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English (en)
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마사노리 고바야시
마모루 스기모도
겐끼찌 도미다
유끼시게 이또오
도모야 오가와
Original Assignee
오다 미노루
리가가꾸 겐뀨쇼오
곤도오 야스노리
메꾸또 가부시끼가이샤
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Application filed by 오다 미노루, 리가가꾸 겐뀨쇼오, 곤도오 야스노리, 메꾸또 가부시끼가이샤 filed Critical 오다 미노루
Publication of KR900004756A publication Critical patent/KR900004756A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/08—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to sulfur, selenium or tellurium
    • C07H5/10—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to sulfur, selenium or tellurium to sulfur
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

내용 없음

Description

황산화 올리고당 및 그의 관련물질
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 다음 일반식을 가지는 황산화 올리고당 또는 그의 관련물질 :
    상기식에서, ⓛ R1=R2=C6H5CH2(BN),
    및 R5=OH,
    (식중 X=할로겐원자) 또는
    ② R1=R2=Bn, R3=NHAc(Ac=아세틸기), R4=H, MP 또는 SO3M(식중 M=알칼리금속) 및 R5=
    ③ R1=
    (식중 R6=Ac, Bn 또는 H), R2=Bn, R3=NPhth, R4=MP 및 R5=
    ④
    R2=Bn, R3=NPhth, R4=MP 및 R5=OH,
    ⑤
    R2=Bn, R3=NPhth, R4=MP 및 R5=OAc, OH,
    (X는 할로겐원자) 또는
    ⑥
    (식중 R7=H 또는 t-Bu(C6H5)2Si-(TBDPS)), R2=Bn, R3=NPhth, R4=MP 및
    R5=
    ⑦
    R2=Bn, R3=NPhth 또는 NHAc, R4=MP 및
    R5=
    ⑧ R1=
    (식중 R8=H 또는 TBDPS), R2=Bn, R3=NHAc, R4=H 및
    R5=
    ⑨
    (식중 M=알칼리 금속), R2=Bn, R3=NHAc, R4=SO3M 및
    R5=그리고
    ⑩
    R2=Bn, R3=NPhth R4=MP 및
    R5=
  2. 다음 일반식(2):
    (상기식에서 Bn은 벤질기이고, M은 알칼리 금속이며 Ac는 아세틸기이다)를 가지는 화합물을 탈벤질화하는 것으로 이루어지는, 다음 일반식(1):
    (상기식에서 M 및 Ac는 상기에서 규정된 바와같다)을 가지는 황산화 올리고당의 제조방법.
  3. 제2항에 있어서, 탈벤질화 반응이 10%-Pd/C, 5%-Pd/C, PtO2및 Pd(OH)2로부터 선택된 촉매의 존재하에 수행되는 것을 특징으로 하는 방법.
  4. 제2항에 있어서, 탈벤질화 반응이 메탄올/물, 메탄올 및 메탄올/아세트산으로부터 선택된 용매중에서 수행되는 것을 특징으로 하는 방법.
  5. 제2항에 있어서, 탈벤질화반응이 0 내지 80℃에서 1시간 내지 1주동안 수행되는 것을 특징으로 하는 방법.
  6. 다음 일반식(4):
    (상기식에서 Bn은 벤질기이고, M은 알칼리 금속이며 Ac는 아세틸기이다)를 가지는 화합물을 탈벤질화하는 것으로 이루어지는, 다음 일반식(3):
    (상기식에서 M 및 Ac는 상기에서 규정된 바와같다)을 가지는 황산화 올리고당의 제조방법.
  7. 제6항에 있어서, 탈벤질화 반응이 10%-Pd/C, 5%-Pd/C, PtO2및 Pd(OH)2로부터 선택된 촉매의 존재하에 수행되는 것을 특징으로 하는 방법.
  8. 제6항에 있어서, 탈벤질화 반응이 메탄올/물, 메탄올 및 메탄올/아세트산으로부터 선택된 용매중에서 수행되는 것을 특징으로 하는 방법.
  9. 제6항에 있어서, 탈벤질화반응이 0 내지 80℃에서 1시간 내지 1주동안 수행되는 것을 특징으로 하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890014037A 1988-09-29 1989-09-29 황산화 올리고당 및 그의 관련 물질 KR900004756A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP88-245748 1988-09-29
JP63245748A JPH0296588A (ja) 1988-09-29 1988-09-29 硫酸化オリゴ糖及びその関連物質

Publications (1)

Publication Number Publication Date
KR900004756A true KR900004756A (ko) 1990-04-13

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KR1019890014037A KR900004756A (ko) 1988-09-29 1989-09-29 황산화 올리고당 및 그의 관련 물질

Country Status (10)

Country Link
US (1) US4992533A (ko)
EP (1) EP0361490A3 (ko)
JP (1) JPH0296588A (ko)
KR (1) KR900004756A (ko)
AU (1) AU610760B2 (ko)
CA (1) CA1328450C (ko)
DK (1) DK479889A (ko)
HU (1) HUT51281A (ko)
NO (1) NO893872L (ko)
NZ (1) NZ230800A (ko)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0454220T3 (da) * 1990-04-23 1993-11-22 Sanofi Elf Carbohydratderivater omfattende en trisaccharidenhed
JPH05213982A (ja) * 1991-03-26 1993-08-24 Dainippon Ink & Chem Inc オリゴ糖トコフェロール配糖体及び硫酸化オリゴ糖トコフェロール配糖体並びにこれを有効成分とする抗ウイルス剤
US5705178A (en) * 1991-05-31 1998-01-06 Gliatech, Inc. Methods and compositions based on inhibition of cell invasion and fibrosis by anionic polymers
US5605938A (en) * 1991-05-31 1997-02-25 Gliatech, Inc. Methods and compositions for inhibition of cell invasion and fibrosis using dextran sulfate
JP4429386B2 (ja) * 1994-12-01 2010-03-10 生化学工業株式会社 ケラタン硫酸オリゴ糖画分及びそれを含む薬剤
AUPN261895A0 (en) * 1995-04-28 1995-05-18 Australian National University, The Preparation and use of sulfated oligosaccharides
SE9502265D0 (sv) * 1995-06-21 1995-06-21 Ism Inst For Socio Medical Res Användning av substituerade pentos- eller hexosderivat, som fysiologiskt aktiva substanser samt komposition innehållande dessa
SE9502264D0 (sv) * 1995-06-21 1995-06-21 Ism Inst For Socio Medical Res Method for preparing sulphate esters
AU6557299A (en) 1999-01-07 2000-07-13 Seikagaku Corporation Method for producing oligosaccharide, and novel oligosaccharide and pharaceutical composition containing the same

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4415490A (en) * 1979-07-24 1983-11-15 Nippon Zeon Co., Ltd. Non-thrombogenic material
US4818816A (en) * 1981-04-28 1989-04-04 Choay, S.A. Process for the organic synthesis of oligosaccharides and derivatives thereof
FR2504535B1 (fr) * 1981-04-28 1987-08-14 Choay Sa Disaccharides derives d'un acide uronique et d'une glucosamine et compositions pharmaceutiques les contenant pour le controle de la coagulation sanguine
AU563351C (en) * 1982-01-15 2003-06-19 Glaxo Group Limited Synthesis of oligosaccharides
SE8203925D0 (sv) * 1982-06-23 1982-06-23 Svenska Sockerfabriks Ab New and novel glycosides, glycoconjugates and processes for their preparation

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NO893872L (no) 1990-03-30
EP0361490A2 (en) 1990-04-04
CA1328450C (en) 1994-04-12
NO893872D0 (no) 1989-09-28
JPH0296588A (ja) 1990-04-09
DK479889D0 (da) 1989-09-29
AU610760B2 (en) 1991-05-23
NZ230800A (en) 1991-06-25
DK479889A (da) 1990-03-30
US4992533A (en) 1991-02-12
AU4231689A (en) 1990-04-05
HUT51281A (en) 1990-04-28
EP0361490A3 (en) 1991-10-16

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