KR890701736A - 과산화물 분자변위보효소의 포합체 - Google Patents
과산화물 분자변위보효소의 포합체Info
- Publication number
- KR890701736A KR890701736A KR1019890700575A KR890700575A KR890701736A KR 890701736 A KR890701736 A KR 890701736A KR 1019890700575 A KR1019890700575 A KR 1019890700575A KR 890700575 A KR890700575 A KR 890700575A KR 890701736 A KR890701736 A KR 890701736A
- Authority
- KR
- South Korea
- Prior art keywords
- conjugate
- polyethylene glycol
- glycol
- peroxide
- pharmaceutical composition
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/44—Oxidoreductases (1)
- A61K38/446—Superoxide dismutase (1.15)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
- C12N11/089—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0089—Oxidoreductases (1.) acting on superoxide as acceptor (1.15)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Toxicology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (11)
- 폴리에틸렌글리콜이나 폴리에틸렌 폴리프로필렌 글리콜 공중합체 잔기같은 그중에 상술된 글리콜이 표준물질을 PEG로하여 HPLC로 측정하였을 때 평균 분자량이 대략 40,000-1,000,000인 것으로 말단이 C1∼4-알킬이나 C1∼4-알콕시기로 치환된 것이나 미치환된 것인 폴리알킬렌 글리콜에 연결시약으로 연결된 과산화물 분자변위 보효소의 수용성인, 실제적으로는 비 면역적인 포합체.
- 제1항에 있어서, HPLC에 의해 측정된 평균 분자량이 대략 40,000-200,000인 폴리에틸렌 글리콜인 폴리알킬렌 글리콜로 된 포합체.
- 제2항에 있어서, 평균 분자량이 대략 50,000-150,000인 폴리에틸렌 글리콜인 폴리 알킬렌 글리콜로된 포합체.
- 제3항에 있어서, 2개에서 8개의 폴리에틸렌글리콜기가 과산화물 분자변위 보효소 분자를 함유하는 구리와 아연에 각각 연결되어 있는 포합체.
- 제4항에 있어서, 2개 내지 6개의 폴리에틸렌글리콜기가 각각의 과산화물 분자변위 보효소 분자에 연결되어 있는 포합체.
- 제5항에 있어서, 폴리에틸렌글리콜이 이소프로폭시 폴리에틸렌 글리콜인 포합체.
- 제1항에 있어서, 폴리에틸렌 글리콜의 말단기가 과산화물 분자변위 보효소 리신의 말단 아미노기에 Co결합으로 부착되어 있는 포합체.
- 과산화물 분자변위 보효소의 치료효과에 유효한 제1항의 포합체를 함유하고 있는 약제학적 구성.
- 항염효과에 유효한 양의 포합체를 함유하고 있는 제8항에 따른 약제학적 구성.
- 산소독성을 경감시키는데 효과적인 양의 포합체를 함유하는 제8항에 따른 약제학적 구성.
- 재관류 상처를 방지하는데 효과적인 양의 포합체를 함유하는 제8항에 따른 약제학적 구성.※ 참고사항:최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US81009 | 1979-10-01 | ||
US8100987A | 1987-08-03 | 1987-08-03 | |
US081.009 | 1987-08-03 | ||
PCT/US1988/002530 WO1989001033A1 (en) | 1987-08-03 | 1988-07-29 | Conjugates of superoxide dismutase |
Publications (2)
Publication Number | Publication Date |
---|---|
KR890701736A true KR890701736A (ko) | 1989-12-21 |
KR920001426B1 KR920001426B1 (ko) | 1992-02-13 |
Family
ID=22161332
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019890700575A KR920001426B1 (ko) | 1987-08-03 | 1988-07-29 | 과산화물 분자변위 보효소의 포합체 |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP0377613B1 (ko) |
JP (1) | JP2515389B2 (ko) |
KR (1) | KR920001426B1 (ko) |
CN (1) | CN1020458C (ko) |
AU (1) | AU608901B2 (ko) |
CA (1) | CA1309046C (ko) |
DE (1) | DE3876997T2 (ko) |
DK (1) | DK160842C (ko) |
ES (1) | ES2007536A6 (ko) |
HU (1) | HU203783B (ko) |
IE (1) | IE64284B1 (ko) |
IL (1) | IL87177A (ko) |
NZ (1) | NZ225481A (ko) |
PH (1) | PH27225A (ko) |
RU (1) | RU1776275C (ko) |
WO (1) | WO1989001033A1 (ko) |
ZA (1) | ZA885249B (ko) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0470128B2 (en) † | 1989-04-19 | 2003-08-13 | Enzon, Inc. | Active carbonates of polyalkylene oxides for modification of polypeptides |
US5109118A (en) * | 1989-07-06 | 1992-04-28 | Yutaka Mizushima | Modified biologically active proteins |
GB8919661D0 (en) * | 1989-08-31 | 1989-10-11 | Univ Alberta | Superoxide dismutase-catalase conjugates |
US5772996A (en) * | 1990-08-03 | 1998-06-30 | Public Health Laboratory Service Board | Pharmaceutical compositions containing superoxide dismutase from Bacillus Stearothermophilus and Bacillus Caldotenax |
EP0598037A1 (en) * | 1991-08-05 | 1994-05-25 | Sanofi | Buffered formulation of peg-sod |
FR2687681B1 (fr) * | 1992-02-20 | 1995-10-13 | Transgene Sa | Conjugues polyethyleneglycol-hirudine, leur procede de preparation et leur emploi pour le traitement des thromboses. |
US5349001A (en) * | 1993-01-19 | 1994-09-20 | Enzon, Inc. | Cyclic imide thione activated polyalkylene oxides |
US5516703A (en) * | 1993-08-20 | 1996-05-14 | The University Of Utah | Coating of hydrophobic surfaces to render them protein resistant while permitting covalent attachment of specific ligands |
US6284503B1 (en) | 1993-08-20 | 2001-09-04 | University Of Utah Research Foundation | Composition and method for regulating the adhesion of cells and biomolecules to hydrophobic surfaces |
AU768765B2 (en) * | 1998-06-23 | 2004-01-08 | Novozymes A/S | A polypeptide-polymer conjugate |
US6638526B1 (en) | 1998-06-23 | 2003-10-28 | Novozymes A/S | Polypeptides conjugated to copolymers of ethylene oxide and propylene oxide to reduce allergenicity |
WO2000004138A1 (en) * | 1998-07-17 | 2000-01-27 | Novozymes A/S | A polypeptide-polymer conjugate with improved wash performance |
US20040062748A1 (en) | 2002-09-30 | 2004-04-01 | Mountain View Pharmaceuticals, Inc. | Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof |
US8129330B2 (en) | 2002-09-30 | 2012-03-06 | Mountain View Pharmaceuticals, Inc. | Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof |
EA008866B1 (ru) | 2002-12-26 | 2007-08-31 | Маунтин Вью Фамэсьютикэлс, Инк. | ПОЛИМЕРНЫЙ КОНЪЮГАТ МОДИФИКАЦИЙ ИНТЕРФЕРОНА-β, ФАРМАЦЕВТИЧЕСКИЕ ПРОДУКТЫ НА ЕГО ОСНОВЕ И СПОСОБ ИХ ПОЛУЧЕНИЯ |
BRPI0411160A (pt) * | 2003-05-12 | 2006-07-11 | Affymax Inc | novos compostos modificados com poli(glicol etilênico) e usos dos mesmos |
CN108445106A (zh) * | 2018-04-11 | 2018-08-24 | 南京明捷生物医药检测有限公司 | 一种药物中消泡剂聚丙二醇残留的检测方法 |
CN108864309B (zh) * | 2018-07-26 | 2021-07-13 | 广州暨南大学医药生物技术研究开发中心有限公司 | 重组人sod-生长因子融合蛋白、其制备方法及其应用 |
CN109112119B (zh) * | 2018-08-28 | 2022-04-26 | 佛山科学技术学院 | 经化学修饰的鸭血sod制剂的制备方法 |
CN117551625B (zh) * | 2024-01-12 | 2024-03-08 | 山东爱维德生物科技有限公司 | 一种用于木立芦荟sod胶的聚乙二醇二胺-海藻酸改性sod酶及其应用 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL74177A (en) * | 1984-02-03 | 1989-09-10 | Abbott Lab | Stabilized enzyme conjugate composition containing a calcium salt and a polyethylene glycol |
GB8430253D0 (en) * | 1984-11-30 | 1985-01-09 | Beecham Group Plc | Compounds |
GB8430252D0 (en) * | 1984-11-30 | 1985-01-09 | Beecham Group Plc | Compounds |
JPH084504B2 (ja) * | 1985-04-26 | 1996-01-24 | 味の素株式会社 | 安定化ス−パ−オキサイドジスムタ−ゼ |
-
1988
- 1988-07-19 IE IE220688A patent/IE64284B1/en not_active IP Right Cessation
- 1988-07-20 ZA ZA885249A patent/ZA885249B/xx unknown
- 1988-07-20 NZ NZ225481A patent/NZ225481A/en unknown
- 1988-07-21 IL IL87177A patent/IL87177A/xx not_active IP Right Cessation
- 1988-07-21 ES ES8802307A patent/ES2007536A6/es not_active Expired
- 1988-07-29 AU AU23268/88A patent/AU608901B2/en not_active Ceased
- 1988-07-29 KR KR1019890700575A patent/KR920001426B1/ko not_active IP Right Cessation
- 1988-07-29 DE DE8888907489T patent/DE3876997T2/de not_active Expired - Fee Related
- 1988-07-29 EP EP88907489A patent/EP0377613B1/en not_active Expired - Lifetime
- 1988-07-29 HU HU885380A patent/HU203783B/hu not_active IP Right Cessation
- 1988-07-29 PH PH37315A patent/PH27225A/en unknown
- 1988-07-29 WO PCT/US1988/002530 patent/WO1989001033A1/en active IP Right Grant
- 1988-07-29 JP JP63506483A patent/JP2515389B2/ja not_active Expired - Fee Related
- 1988-08-02 CN CN88104857A patent/CN1020458C/zh not_active Expired - Fee Related
- 1988-08-03 CA CA000573740A patent/CA1309046C/en not_active Expired - Lifetime
-
1989
- 1989-08-10 DK DK392789A patent/DK160842C/da not_active IP Right Cessation
-
1990
- 1990-02-02 RU SU904742978A patent/RU1776275C/ru active
Also Published As
Publication number | Publication date |
---|---|
EP0377613A1 (en) | 1990-07-18 |
NZ225481A (en) | 1990-11-27 |
JP2515389B2 (ja) | 1996-07-10 |
HU203783B (en) | 1991-09-30 |
PH27225A (en) | 1993-05-04 |
DE3876997D1 (de) | 1993-02-04 |
IL87177A0 (en) | 1988-12-30 |
ES2007536A6 (es) | 1989-06-16 |
HUT52816A (en) | 1990-08-28 |
DK160842B (da) | 1991-04-22 |
DE3876997T2 (de) | 1993-04-29 |
JPH02504341A (ja) | 1990-12-13 |
WO1989001033A1 (en) | 1989-02-09 |
CA1309046C (en) | 1992-10-20 |
AU2326888A (en) | 1989-03-01 |
DK160842C (da) | 1991-10-14 |
CN1020458C (zh) | 1993-05-05 |
RU1776275C (ru) | 1992-11-15 |
ZA885249B (en) | 1989-04-26 |
EP0377613B1 (en) | 1992-12-23 |
IE64284B1 (en) | 1995-07-26 |
IL87177A (en) | 1992-08-18 |
CN1031088A (zh) | 1989-02-15 |
KR920001426B1 (ko) | 1992-02-13 |
IE882206L (en) | 1989-02-03 |
DK392789D0 (da) | 1989-08-10 |
AU608901B2 (en) | 1991-04-18 |
DK392789A (da) | 1989-08-10 |
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GRNT | Written decision to grant | ||
FPAY | Annual fee payment |
Payment date: 20070208 Year of fee payment: 16 |
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