KR890017259A - 모액으로부터의 항생물질 회수방법 및 그의 약학적으로 허용할 수 있는 신규한 염 - Google Patents
모액으로부터의 항생물질 회수방법 및 그의 약학적으로 허용할 수 있는 신규한 염 Download PDFInfo
- Publication number
- KR890017259A KR890017259A KR1019890006240A KR890006240A KR890017259A KR 890017259 A KR890017259 A KR 890017259A KR 1019890006240 A KR1019890006240 A KR 1019890006240A KR 890006240 A KR890006240 A KR 890006240A KR 890017259 A KR890017259 A KR 890017259A
- Authority
- KR
- South Korea
- Prior art keywords
- chloro
- carboxylic acid
- dethia
- carba
- cepem
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D463/02—Preparation
- C07D463/06—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
- C07D463/16—Nitrogen atoms
- C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
- C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D463/22—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Cephalosporin Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (8)
- 안트라퀘논-1,5-디설폰산 또는 그의 알칼리 금속염을 일반식(Ⅱ) 화합물의 희석 수용액에 첨가하고 ; pH 를 약 1.0 내지 약 2.5로 조절함을 포함하는 일반식(Ⅰ)의 염의 제조방법.상기식에서, X는 황 또는 -CH2-이고 ; Y는 클로로이고 ; R은 수소, 하이드록시 또는 (C1내지 C4알킬)-S02NH-이다.
- 제 1 항에 있어서, R이 수소인 방법.
- 제 1 항에 있어서, R이 (C1내지 C4알킬)-SO2-NH-인 방법.
- 일반식(Ⅰ)의 화합물.상기식에서, X는 황 또는 -CH2-이고 ; Y는 클로로이고 , R은 수소, 하이드록시 또는 (C1내지 C4알킬)-S02NH-이다.
- 7β-(D-페닐글리실아미노)-3-클로로-1-카바(데티아)-3-세펨-4-카복실산, 7β-(D-페닐글리실아미노)-3-클로로-3-세펨-4-카복실산, 7β-(D-p-하이드록시페닐글리실아미노)-1-카바(1-데티아)-3-클로로-3-세펨-4-카복실산, 7β-(D-m-에틸설포닐아미노페닐글리실아미노)-1-카바(1-데티아)-3-클로로-3-세펨-4-카복실산, 및 7β-(D-m-메틸설포닐아미노페닐글리실아미노)-1-카바(1-데티아)-3-클로로-3-세펨-4-카복실산중 어느 한 화합물의 안트라퀴논-1,5-디설포네이트 염.
- 제 4 항에서 청구한 바와 같은 일반식(Ⅰ) 화합물의 항균제로의 용도.상기식에서, X는 황 또는 -CH2- 이고 ; Y는 클로로이고 ; R은 수소, 하이드록시 또는 (C1내지 C4알킬)-SO2NH-이다.
- 항균제로 사용하기 위한 7β-(D-페닐글리실아미노)-3-클로로-1-카바(데티아)-3-세펨-4-카복실산, 7β-(D-페닐글리실아미노)-3-클로로-3-세펨-4-카복실산, 7β-(D-p-하이드록시페닐글리실아미노)-1-카바(1-데티아)-3-세펨-4-카복실산, 7β-(D-m-에틸설포닐아미노페닐아미노페닐글리실아미노)-1-카바(1-데티아)-3-클로로-3-세펨-4-카복실산, 및 7β-(D-m-메틸실포닐아미노페닐글리실아미노)-1-카바(1-데티아)-3-클로로-세펨-4-카복실산중 어느 한 화합물의 안트라퀴논-1,5-디설포네이트 염.
- 활성 성분으로 제 4 항 또는 5항에서 청구한 바와 같은 일반식(Ⅰ) 화합물과 그의 약학적으로 허용할 수 있는 하나이상의 담체를 함께 포함하는 약학적 제제.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19347488A | 1988-05-13 | 1988-05-13 | |
US193474 | 1988-05-13 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR890017259A true KR890017259A (ko) | 1989-12-15 |
KR0135979B1 KR0135979B1 (ko) | 1998-04-25 |
Family
ID=22713792
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019890006240A KR0135979B1 (ko) | 1988-05-13 | 1989-05-10 | 모액으로부터의 항생물질 회수방법 및 그의 약학적으로 허용할 수 있는 신규한 염 |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0341991A3 (ko) |
JP (1) | JPH0215078A (ko) |
KR (1) | KR0135979B1 (ko) |
HU (1) | HU203761B (ko) |
IL (1) | IL90269A (ko) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5434259A (en) * | 1993-02-05 | 1995-07-18 | Eli Lilly And Company | Process for isolation of cefaclor after enzymatic acylation |
US5412094A (en) * | 1993-06-28 | 1995-05-02 | Eli Lilly And Company | Bicyclic beta-lactam/paraben complexes |
US6001996A (en) * | 1995-05-11 | 1999-12-14 | Eli Lilly And Company | Complexes of cephalosporins and carbacephalosporins with parabens |
US6362410B1 (en) | 1999-09-28 | 2002-03-26 | Kabushiki Kaisha Kawai Gakki Seisakusho | Electronic musical instrument |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3676434A (en) * | 1970-07-29 | 1972-07-11 | Lilly Co Eli | Cephalosporin salts |
US3925372A (en) * | 1973-02-23 | 1975-12-09 | Lilly Co Eli | Alpha-aminoacyl-3-halo cephalosporins |
JPS608296A (ja) * | 1983-06-29 | 1985-01-17 | ユング・ジン・フア−マシウテイカル・インダストリアル・カンパニイ・リミテツド | セフアロスポリン誘導体の製造方法 |
US4708956A (en) * | 1985-12-12 | 1987-11-24 | Kyowa Hakko Kogyo Co., Ltd. | 3-position halogenated cephalosporin analogs and pharmaceutical compositions |
-
1989
- 1989-05-10 EP EP19890304705 patent/EP0341991A3/en not_active Withdrawn
- 1989-05-10 KR KR1019890006240A patent/KR0135979B1/ko not_active IP Right Cessation
- 1989-05-11 IL IL9026989A patent/IL90269A/en not_active IP Right Cessation
- 1989-05-11 JP JP1118503A patent/JPH0215078A/ja active Pending
- 1989-05-12 HU HU892395A patent/HU203761B/hu not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
KR0135979B1 (ko) | 1998-04-25 |
IL90269A0 (en) | 1989-12-15 |
IL90269A (en) | 1994-02-27 |
JPH0215078A (ja) | 1990-01-18 |
EP0341991A3 (en) | 1991-08-28 |
HUT50350A (en) | 1990-01-29 |
HU203761B (en) | 1991-09-30 |
EP0341991A2 (en) | 1989-11-15 |
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