KR890014566A - 알콕시- 및 알킬아미노-카보닐알킬포스포리피드, 이의 제조방법 및 약제로서의 이의 용도 - Google Patents
알콕시- 및 알킬아미노-카보닐알킬포스포리피드, 이의 제조방법 및 약제로서의 이의 용도 Download PDFInfo
- Publication number
- KR890014566A KR890014566A KR1019890002876A KR890002876A KR890014566A KR 890014566 A KR890014566 A KR 890014566A KR 1019890002876 A KR1019890002876 A KR 1019890002876A KR 890002876 A KR890002876 A KR 890002876A KR 890014566 A KR890014566 A KR 890014566A
- Authority
- KR
- South Korea
- Prior art keywords
- compound
- formula
- hydroxy
- carbon atoms
- oxo
- Prior art date
Links
- 239000003814 drug Substances 0.000 title claims 2
- 150000001875 compounds Chemical class 0.000 claims 18
- 125000004432 carbon atom Chemical group C* 0.000 claims 7
- -1 CH 2 Substances 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 claims 4
- 150000001412 amines Chemical class 0.000 claims 3
- NAJHYBRINFRREC-UHFFFAOYSA-N hexadecyl 4-[hydroxy-[2-(1-methylpyrrolidin-1-ium-1-yl)ethoxy]phosphanyl]oxybutanoate Chemical compound CCCCCCCCCCCCCCCCOC(=O)CCCOP(O)OCC[N+]1(C)CCCC1 NAJHYBRINFRREC-UHFFFAOYSA-N 0.000 claims 2
- 150000004679 hydroxides Chemical class 0.000 claims 2
- OQLMMTHBQURBDI-UHFFFAOYSA-O 2-(1-methylpyrrolidin-1-ium-1-yl)ethyl [4-oxo-4-(pentylamino)butyl] hydrogen phosphite Chemical compound CCCCCNC(=O)CCCOP(O)OCC[N+]1(C)CCCC1 OQLMMTHBQURBDI-UHFFFAOYSA-O 0.000 claims 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- RZQXITQMFZFBJR-UHFFFAOYSA-O [4-(decylamino)-4-oxobutyl] 2-(1-methylpyrrolidin-1-ium-1-yl)ethyl hydrogen phosphite Chemical compound CCCCCCCCCCNC(=O)CCCOP(O)OCC[N+]1(C)CCCC1 RZQXITQMFZFBJR-UHFFFAOYSA-O 0.000 claims 1
- QSMIZPONTSUESZ-UHFFFAOYSA-O [4-(hexadecylamino)-4-oxobutyl] 2-(1-methylpyrrolidin-1-ium-1-yl)ethyl hydrogen phosphite Chemical compound CCCCCCCCCCCCCCCCNC(=O)CCCOP(O)OCC[N+]1(C)CCCC1 QSMIZPONTSUESZ-UHFFFAOYSA-O 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 230000003110 anti-inflammatory effect Effects 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 210000001072 colon Anatomy 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 150000002431 hydrogen Chemical group 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 229910052740 iodine Inorganic materials 0.000 claims 1
- 239000011630 iodine Substances 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 230000003287 optical effect Effects 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
- C07F9/6544—Six-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/59—Hydrogenated pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/650952—Six-membered rings having the nitrogen atoms in the positions 1 and 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
- C07F9/6533—Six-membered rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Pain & Pain Management (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
내용 없음.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (12)
- 일반식(I)의 화합물, 이의 기하학적 이성체 또는 광학 대장체.상기식에서, A1은 일반식-CmH2m- (여기에서, m은 0 내지 20의 정수이다)의 2가 라디칼이고 ; A2는 일반식 -CpH2p- (여기에서, p은 2 내지 6의 정수이다)의 2가 라디칼이고 ; X는 일반식 -0- 또는 -N(R)- [여기에서, R은 수소, 탄소수 1 내지 6의 알킬 및 일반식(여기에서, a는 0 내지 3의 정수이고, Z는 탄소수 1 내지 6의 알킬 라디칼, 탄소수 1 내지 6의 알콕시라디칼, 할로겐, 하이드록시 또는 트리플루오로메틸이고, a의 각 값에 대해 Z는 동일하거나 상이할 수 있다)의 페닐 라디칼로 이루어진 그룹중에서 선택된다]의 2가 라디칼이고 ; Y는이고, 여기에서 R1은 탄소수 1 내지 6의 알킬이고, R2및 R3는 독립적으로 탄소수 1 내지 6의 알킬이거나, 또는 R1및 이들이 결합되어 있는 질소원자와 함께는 일반식[여기에서, r은 0 또는 1이고, W는 산소, CH2, 황 또는 N(R4)(여기에서, R4는 탄소수 1 내지 6의 알킬, 또는 아릴이다)이다]의 그룹을 형성하며 ; n은 3 또는 4의 정수이다.
- 제1항에 있어서, n이 3이고 X가 -O- 또는 -NH- 이며, A2가 -(CH2)2-인 화합물.
- 제2항에 있어서, Y가 일반식(여기에서, R1은 탄소수 1 내지 6의 알킬이다)의 라디칼인 화합물.
- 제3항에 있어서, 1-(4-하이드록시-3,5,10-트리옥사-9-옥소-4-포스파헥사코스-1-일)-1-메틸 피롤리디늄, P-옥사이드, 하이드록사이드, 내부염인 화합물.
- 제3항에 있어서, 1-(4-하이드록시-3,5,10-트리옥사-9-옥소-4-포스파헥사코스-1-일)-1-메틸 피롤리디늄, P-옥사이드, 하이드록사이드, 내부염인 화합물.
- 제3항에 있어서, 1-(10-아자-4-하이드록시-3,5-디옥사-9-옥소-4-포스파에이코스-1-일)-1-메틸 피롤리디늄, P-옥사이드, 하이드록사이드, 내부염인 화합물.
- 제3항에 있어서, 1-(10-아자-4-하이드록시-3,5-디옥사-9-옥소-4-포스파헥사코스-1-일)-1-메틸 피롤리디늄, P-옥사이드, 하이드록사이드, 내부염인 화합물.
- 제3항에 있어서, 1-(10-아자-4-하이드록시-3,5-디옥사-9-옥소-4-포스파펜타데크-1-일)-1-메틸 피롤리디늄, P-옥사이드, 하이드록사이드, 내부염인 화합물.
- 제2항에 있어서, 1-(4-하이드록시-3,5,10-트리옥사-9-옥소-4-포스파에이코스-1-일)-1-트리메틸 아미늄, P-옥사이드, 하이드록사이드, 내부염인 화합물.
- 활성 성분으로서 제1항에서 청구한 화합물 및 이를 위한 적당한 담체를 함유함을 특징으로 하는 약제학적 조성물.
- 소염 활성을 갖는 약제의 제조를 위한 제1항에서 청구한 화합물의 용도.
- a) 일반식(3b)의 화합물은 일반식(5)의 아민과 반응시켜, 일반식(I)의 화합물을 수득하거나, b) 일반식(5a)의 화합물을 일반식(5)의 아민과 반응시켜, 일반식(6a)의 화합물을 수득하거나, c) 일반식(4)의 화합물을 일반식(5)의 아민과 반응시켜 일반식(6)의 화합물을 수득함을 특징으로 하여, 제1항에서 청구한 화합물을 제조하는 방법상기식에서, A1, X, A2, n, R1, R2및 R3는 제1항에서 정의한 바와 같고, Hal은 염소, 브롬 또는 요오드이다.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/166,285 US4888328A (en) | 1988-03-10 | 1988-03-10 | Alkoxycarbonylalkylphospholipids and alkylaminocarbonylalkylphospholipids |
| US166285 | 1988-03-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR890014566A true KR890014566A (ko) | 1989-10-24 |
Family
ID=22602614
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019890002876A KR890014566A (ko) | 1988-03-10 | 1989-03-09 | 알콕시- 및 알킬아미노-카보닐알킬포스포리피드, 이의 제조방법 및 약제로서의 이의 용도 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4888328A (ko) |
| EP (1) | EP0332129A2 (ko) |
| JP (1) | JPH024793A (ko) |
| KR (1) | KR890014566A (ko) |
| AU (1) | AU3113489A (ko) |
| DK (1) | DK114589A (ko) |
| PT (1) | PT89966A (ko) |
| ZA (1) | ZA891761B (ko) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5030733A (en) * | 1987-07-23 | 1991-07-09 | Hoechst-Roussel Pharmaceticals Incorporated | Hydroxy-, alkoxy- and benzyloxy-substituted phospholipids |
| GB9004881D0 (en) * | 1990-03-05 | 1990-05-02 | Biocompatibles Ltd | Method of improving the ocular of synthetic polymers haemo and biocompatibility |
| EP0556216B1 (en) * | 1990-11-05 | 1997-06-04 | Biocompatibles Limited | Phosphoric acid esters and their use in the preparation of biocompatible surfaces |
| US5661138A (en) * | 1996-10-03 | 1997-08-26 | Clarion Pharmaceutical, Inc. | (o-Acyl-p-N-acylamino-phenyl)-O-phosphoethanolamines |
| CA2705463C (en) | 2007-08-10 | 2014-10-07 | Basil Rigas | Anti-inflammatory compounds and uses thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2009342C3 (de) * | 1970-02-27 | 1980-12-18 | Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V., 3400 Goettingen | Verwendung von Glycerin-alkyläther-(l)-phosphorsäure-(3)-monocholinestern |
| US4119714A (en) * | 1970-02-27 | 1978-10-10 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E. V. | Glycerin-alkylether-(1)-phosphoric acid-(3)-monocholine esters as enhancers of the natural resistance of the mammalian organism against non-carcinogenic pathogens |
| DE2009341C3 (de) * | 1970-02-27 | 1979-06-21 | Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V., 3400 Goettingen | 3-Octadecyloxy-propanol-(l)-phosphorsäure-monocholinester und Verfahren zu dessen Herstellung |
| US4163748A (en) * | 1973-09-06 | 1979-08-07 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Propane-1,3-diol phosphatides and method of preparing the same |
| US4159988A (en) * | 1974-08-06 | 1979-07-03 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Synthetic phospholipids, a process for their manufacture and their use |
| DE2619686C2 (de) * | 1976-05-04 | 1986-08-07 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen | Verwendung eines Lysolecithins zur Tumorbehandlung |
| DE2619715A1 (de) * | 1976-05-04 | 1977-11-24 | Max Planck Gesellschaft | Tumor-antigen und verfahren zu dessen herstellung |
| DD138216A1 (de) * | 1978-08-03 | 1979-10-17 | Hans Brachwitz | Verfahren zur herstellung von fluoranaloga der 1-und 2-0-alkyl-bzw.1-und 2-0-acyl-glycero-3-phosphocholine |
| GB2046092B (en) * | 1979-03-05 | 1983-11-02 | Toyama Chemical Co Ltd | Pharmaceutical composition containing a lysophospholid and a phospholipid |
| US4551532A (en) * | 1980-05-08 | 1985-11-05 | Takeda Chemical Industries, Ltd. | Ethylene glycol derivatives having anti-protozoan, anti-fungal and anti-tumor activity |
| DE3127503A1 (de) * | 1981-07-11 | 1983-02-17 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue phospholipide, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
-
1988
- 1988-03-10 US US07/166,285 patent/US4888328A/en not_active Expired - Fee Related
-
1989
- 1989-03-07 EP EP89103964A patent/EP0332129A2/en not_active Withdrawn
- 1989-03-08 ZA ZA891761A patent/ZA891761B/xx unknown
- 1989-03-09 DK DK114589A patent/DK114589A/da not_active Application Discontinuation
- 1989-03-09 AU AU31134/89A patent/AU3113489A/en not_active Abandoned
- 1989-03-09 KR KR1019890002876A patent/KR890014566A/ko not_active Application Discontinuation
- 1989-03-09 JP JP1055266A patent/JPH024793A/ja active Pending
- 1989-03-09 PT PT89966A patent/PT89966A/pt not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DK114589A (da) | 1989-09-11 |
| AU3113489A (en) | 1989-09-14 |
| EP0332129A2 (en) | 1989-09-13 |
| DK114589D0 (da) | 1989-03-09 |
| PT89966A (pt) | 1989-11-10 |
| US4888328A (en) | 1989-12-19 |
| ZA891761B (en) | 1990-04-25 |
| JPH024793A (ja) | 1990-01-09 |
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