KR890012541A - 안정화된 마크롤리드 조성물 - Google Patents

안정화된 마크롤리드 조성물 Download PDF

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Publication number
KR890012541A
KR890012541A KR1019890001931A KR890001931A KR890012541A KR 890012541 A KR890012541 A KR 890012541A KR 1019890001931 A KR1019890001931 A KR 1019890001931A KR 890001931 A KR890001931 A KR 890001931A KR 890012541 A KR890012541 A KR 890012541A
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South Korea
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compound
formula
composition
antioxidant
derivative
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KR1019890001931A
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KR960011234B1 (ko
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토마스 이스트릭 데이비드
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알퐁스 아르.노에
아메리칸 사이아나미드 캄파니
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Agronomy & Crop Science (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Communicable Diseases (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Cosmetics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)

Abstract

내용 없음.

Description

안정화된 마크롤리드 조성물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 하기 구조식(I)의 화합물 또는 그의 유도체와 항산화제로 구성되는 안정화된 조성물.
    상기 식중, R1은 메틸, 에틸 또는 이소프로필기이고, R2는 수소 원자 또는 메틸기이다.
  2. 제1항에 있어서, 구조식(I)의 화합물 중 R1이 이소프로필기이고, R2가 수소 원자인 것을 특징으로 하는 조성물.
  3. 제1항에 있어서, 황산화제가 C1-12알킬 몰식자산염, 벤질 히드록시벤조에이트 또는 C1-16알킬 히드록시 벤조에이트 또는 그의 염, 부틸화 히드록시아니솔, 부틸화 히드록시톨루엔, 퀴논 또는 그의 염, 노르디히드로과이어레트산, 또는 α-코토페롤인 것을 특징으로 하는 조성물.
  4. 제1항에 있어서, 항산화제가 부틸화 히드록시톨루엔인 것을 특징으로 하는 조성물.
  5. 제1항에 있어서, 항상화제를 구조식(I)의 화합물 또는 그의 유도체의 0.005 내지 1중량%로 함유하는 것을 특징으로 하는 조성물.
  6. 제1항에 있어서, 살충제로서 사용하기에 적당한 형태이며, 1종 이상의 담체 또는 부형제를 함유하는 것을 특징으로 하는 조성물.
  7. 구조식(I)의 화합물 또는 그의 유도체와 항산화제를 혼합하는 것으로 되는 제1항에 의한 조성물의 제조 방법.
  8. 제7항에 있어서, 상기 화합물 및 항산화제가 용액으로부터 공침전되는 것을 특징으로 하는 방법.
  9. 제1항에 의한 조성물을 해충 또는 그 소재지에 투여하는 것으로 되는 곤충, 진드기 또는 선충류 해충의 방제법.
  10. 구조식(I)의 화합물 또는 그의 유도체를 항상화제와 접촉시키는 것으로 되는 상기 화합물의 안정화 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890001931A 1988-02-18 1989-02-18 안정화된 마크롤리드 조성물 KR960011234B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8803836 1988-02-18
GB888803836A GB8803836D0 (en) 1988-02-18 1988-02-18 Compositions
GB8803836 1988-02-18

Publications (2)

Publication Number Publication Date
KR890012541A true KR890012541A (ko) 1989-09-18
KR960011234B1 KR960011234B1 (ko) 1996-08-21

Family

ID=10631977

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890001931A KR960011234B1 (ko) 1988-02-18 1989-02-18 안정화된 마크롤리드 조성물

Country Status (18)

Country Link
EP (1) EP0329460B1 (ko)
JP (1) JP2843591B2 (ko)
KR (1) KR960011234B1 (ko)
AT (1) ATE76291T1 (ko)
AU (1) AU625746B2 (ko)
BR (1) BR8900688A (ko)
CA (1) CA1323835C (ko)
DD (1) DD297821A5 (ko)
DE (1) DE68901543D1 (ko)
DK (1) DK175300B1 (ko)
ES (1) ES2031351T3 (ko)
GB (1) GB8803836D0 (ko)
GR (1) GR3004648T3 (ko)
HU (1) HU203189B (ko)
IE (1) IE61053B1 (ko)
NZ (1) NZ228038A (ko)
PT (1) PT89760B (ko)
ZA (1) ZA891248B (ko)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0432494B1 (en) * 1989-12-15 1997-02-05 American Cyanamid Company Pour-on formulations effective for the control of internal and external parasites of homothermic animals
US6514951B1 (en) 1989-12-15 2003-02-04 American Cyanamid Company Pour-on formulations effective for the control of internal and external parasites of homothermic animals
US5346698A (en) * 1991-01-15 1994-09-13 Mycogen Corporation Synergistic pesticidal compositions
JP2540394B2 (ja) * 1991-05-28 1996-10-02 ニチアス株式会社 エルボカバ―の製造方法および製造装置
ES2086022T3 (es) * 1991-07-23 1996-06-16 American Cyanamid Co Composiciones estables para administracion parenteral y su uso.
RO115102B1 (ro) * 1993-05-10 1999-11-30 Merck & Co Inc Formulari topice pe baza de avermectina si procedee de preparare a acestora
US5602107A (en) * 1993-05-10 1997-02-11 Merck & Co., Inc. Pour-on formulations consisting of gylcols, glycerides and avermectin compounds
PL174488B1 (pl) * 1993-05-10 1998-08-31 Merck & Co Inc Preparat do zwalczania pasożytów zwierząt oraz sposób wytwarzania preparatu do zwalczania pasożytów zwierząt
GB9826882D0 (en) 1998-12-07 1999-01-27 Novartis Ag Organic compounds
DK1197215T3 (da) * 2000-10-10 2006-07-10 Wyeth Corp Anthelmintiske sammensætninger
BG64140B1 (bg) * 2000-12-21 2004-02-27 "Биовет" Ад Състав за растителна защита с инсектицидно и акарицидно действие
ATE385795T1 (de) 2002-07-30 2008-03-15 Wyeth Corp Parenterale formulierungen mit einem rapamycin hydroxyester
US20080125480A1 (en) * 2004-12-30 2008-05-29 Cheminova A/S Oil-In-Water Formulation Of Avermectins
EP1962819A1 (en) * 2005-12-20 2008-09-03 Wyeth Control of cci-779 dosage form stability through control of drug substance impurities
FR2906467B1 (fr) * 2006-09-28 2012-11-09 Galderma Sa Utilisation de composes de la famille des milbemycines pour le traitement de desordres dermatologiques chez l'homme
JP2024523472A (ja) 2021-06-25 2024-06-28 インターベット インターナショナル ベー． フェー． 口当たりの良い動物用組成物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH408284A (de) * 1958-06-26 1966-02-28 Philips Nv Verfahren zum Stabilisieren kristallinischer Verbindungen gegen Oxydation
NZ197796A (en) * 1980-08-04 1984-11-09 Merck & Co Inc Stabilised aqueous formulations containing ivermectin
JPS5920285A (ja) * 1982-07-23 1984-02-01 Sankyo Co Ltd ミルベマイシンｄの５−二塩基酸エステル誘導体及びその塩
AU2314184A (en) * 1983-01-10 1984-07-12 Robert Young & Company Limited Endoparasiticidal composition containing levamisole
NZ210505A (en) * 1983-12-22 1988-06-30 Merck & Co Inc Parasiticidal compositions containing avermectin or milbemycin derivatives
GB2166436B (en) * 1984-09-14 1989-05-24 Glaxo Group Ltd Antibiotic compounds and their preparation

Also Published As

Publication number Publication date
NZ228038A (en) 1991-07-26
CA1323835C (en) 1993-11-02
ZA891248B (en) 1989-10-25
ATE76291T1 (de) 1992-06-15
GR3004648T3 (ko) 1993-04-28
JP2843591B2 (ja) 1999-01-06
HU203189B (en) 1991-06-28
IE890510L (en) 1989-08-18
JPH023690A (ja) 1990-01-09
EP0329460A3 (en) 1989-10-18
AU3006589A (en) 1989-08-24
KR960011234B1 (ko) 1996-08-21
IE61053B1 (en) 1994-09-21
HUT50629A (en) 1990-03-28
PT89760B (pt) 1994-03-31
DK175300B1 (da) 2004-08-16
PT89760A (pt) 1989-10-04
DE68901543D1 (de) 1992-06-25
DD297821A5 (de) 1992-01-23
ES2031351T3 (es) 1992-12-01
EP0329460B1 (en) 1992-05-20
AU625746B2 (en) 1992-07-16
DK75689D0 (da) 1989-02-17
BR8900688A (pt) 1989-10-10
GB8803836D0 (en) 1988-03-16
EP0329460A2 (en) 1989-08-23
DK75689A (da) 1989-08-19

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