KR890009373A - 외용 피부용 조성물 - Google Patents

외용 피부용 조성물 Download PDF

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Publication number
KR890009373A
KR890009373A KR1019880016386A KR880016386A KR890009373A KR 890009373 A KR890009373 A KR 890009373A KR 1019880016386 A KR1019880016386 A KR 1019880016386A KR 880016386 A KR880016386 A KR 880016386A KR 890009373 A KR890009373 A KR 890009373A
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KR
South Korea
Prior art keywords
composition
external skin
acid
methacrylate
acrylate
Prior art date
Application number
KR1019880016386A
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English (en)
Inventor
사까이 야스유끼
이시꾸라 도요아끼
간바야시 가즈오
Original Assignee
무라다 가쓰
소와 덴꼬 가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 무라다 가쓰, 소와 덴꼬 가부시끼가이샤 filed Critical 무라다 가쓰
Publication of KR890009373A publication Critical patent/KR890009373A/ko

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

내용 없음

Description

외용 피부용 조성물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. (ⅰ)α,β-불포화 카르복실산 또는 그의 무수물 0.5-11.0중량%, (ⅱ)비닐 모노머 0.1-28.0중량%, (ⅲ)아크릴산 또는 메타크릴산의 히드록시 C2-C4알킬에스테르 1.0-5.5중량% 및 (ⅳ)아크릴산 또는 메타크릴산의 C4-C18알킬 에스테르의 균형으로 이루어지고 유리전이 온도가 -15℃~-70℃인 아크릴 또는 메타크릴 공중합체에 케토프로펜을 5-35중량%로 함유하고 지지체 상에 약물 공급층이 형성됨을 특징으로 하는 외용 피부용 조성물.
  2. 제1항에 있어서, 상기 성분(ⅰ)이 아크릴산, 메타크릴산, 이타콘산, 말레산, 푸마르산, 및 무수 말레산중에서 선택된 한가지 이상의 화합물인 것이 특징인 외용 피부용 조성물.
  3. 제1항에 있어서, 상기 성분(ⅱ)이 비닐 아세테이트, 비닐 프로피오네이트, 아크릴로니트릴, 스티렌, 비닐 베르사테이트, 및 비닐 클로라이드중에서 선택된 한가지 이상의 화합물인 것이 특징인 외용 피부용 조성물.
  4. 제1항에 있어서, 상기 성분(ⅲ)이 2-히드로시에틸아크릴레이트, 2-히드록시에틸 메타크릴레이트, 히드록시프로필 아크릴레이트, 및 히드록시프로필 메타크릴레이트중에서 선택된 적어도 하나의 화합물인 것이 특징인 외용 피부용 조성물.
  5. 제1항에 있어서, 상기 성분(ⅳ)이 n-부틸 아크릴레이트, n-부틸 메타크릴레이트, 이소프로필 아크릴레이트, 이소프로필 메타크릴레이트, 2-에틸헥실 아크릴레이트. n-헥실 메타크릴레이트, 및 라우릴 메타크릴레이트중에서 선택된 적어도 하나의 화합물인 것이 특징인 외용 피부용 조성물.
  6. 제1항에 있어서, 상기 공중합체가 (ⅰ)α,β-불포화 카르복실산 또는 그의 무수물 2.0-8.0중량%, (ⅱ)비닐 모노머 1.0-15.0중량%, (ⅲ)아크릴산 또는 메타크릴산의 히드록시 C2-C4알킬에스테르1.5-4.0중량%, 및 (ⅳ)아크릴산 또는 메타크릴산의 C4-C18알킬에스테르의 균형으로 이루어짐을 특징으로 하는 외용 피부용 조성물.
  7. 제1항에 있어서, 상기 공중합체의 유리전이 온도가 -25℃~-40℃인 것이 특징인 외용 피부용 조성물.
  8. 제1항에 있어서, 상기 지지체가 약물 불침투성이며 두께가 5-40㎛인 유연한 플라스틱 필름인 것이 특징인 외용 피부용 조성물.
  9. 제1항에 있어서, 상기 조성물이 지지체상의 두께 5-500㎛인 약물 공급층의 형태로 된 것이 특징인 외용 피부용 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880016386A 1987-12-09 1988-12-09 외용 피부용 조성물 KR890009373A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP31267587 1987-12-09
JP62-312675 1987-12-09

Publications (1)

Publication Number Publication Date
KR890009373A true KR890009373A (ko) 1989-08-01

Family

ID=18032068

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880016386A KR890009373A (ko) 1987-12-09 1988-12-09 외용 피부용 조성물

Country Status (3)

Country Link
US (1) US4938964A (ko)
EP (1) EP0319988A1 (ko)
KR (1) KR890009373A (ko)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
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JP2883107B2 (ja) * 1989-07-10 1999-04-19 塩野義製薬株式会社 紫外線吸収皮膚保護剤組成物
US5298258A (en) * 1989-12-28 1994-03-29 Nitto Denko Corporation Acrylic oily gel bioadhesive material and acrylic oily gel preparation
DE69010317T3 (de) * 1989-12-28 2000-10-12 Nitto Denko Corp Acrylgel und seine Herstellung.
GB2273044B (en) * 1992-12-02 1997-04-09 Pacific Chem Co Ltd Medicinal patches for percutaneous administration
JPH09503997A (ja) * 1993-07-08 1997-04-22 シグナス，インコーポレイテッド モノリシックなマトリックス経皮送達システム
CA2117546A1 (en) * 1993-08-27 1995-02-28 Takateru Muraoka Medical adhesive sheet
US5635203A (en) * 1994-09-29 1997-06-03 Alza Corporation Transdermal device having decreased delamination
JP3782834B2 (ja) * 1994-10-26 2006-06-07 株式会社トクホン 鎮痛抗炎症貼付剤
SE9502244D0 (sv) * 1995-06-20 1995-06-20 Bioglan Ab A composition and a process for the preparation thereof
AUPO379596A0 (en) * 1996-11-22 1996-12-19 Soltec Research Pty Ltd Percutaneous delivery system
DE19830649C2 (de) * 1998-07-09 2003-04-10 Lohmann Therapie Syst Lts Topisches Pflaster mit nichtsteroidalen Antirheumatika mit Säuregruppe
DE69936190T2 (de) * 1998-10-27 2008-01-24 Suntory Ltd. Verwendung von itakonsäure zur regulierung des glykolytischen stoffwechsels
DE10032537A1 (de) * 2000-07-05 2002-01-31 Labtec Gmbh Dermales System, enthaltend 2-(3-Benzophenyl)Propionsäure
US8481591B2 (en) 2010-11-01 2013-07-09 Stiefel Research Australia Pty. Ltd. Polymeric topical compositions

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JPS5781409A (en) * 1980-11-10 1982-05-21 Toko Yakuhin Kogyo Kk External plaster
JPS5829706A (ja) * 1981-08-14 1983-02-22 Toko Yakuhin Kogyo Kk 消炎鎮痛外用剤
JPS5839616A (ja) * 1981-09-01 1983-03-08 Hisamitsu Pharmaceut Co Inc 消炎鎮痛軟膏剤
JPS5838212A (ja) * 1981-09-01 1983-03-05 Daikyo Yakuhin Kogyo Kk 貼付剤およびその製造方法
JPS58103311A (ja) * 1981-09-01 1983-06-20 Hisamitsu Pharmaceut Co Inc 消炎鎮痛クリーム剤
JPS5984817A (ja) * 1982-11-08 1984-05-16 Sekisui Chem Co Ltd 薬剤徐放性製剤
JPS59172418A (ja) * 1983-03-22 1984-09-29 Nitto Electric Ind Co Ltd 複合製剤の製法
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JPS6059207A (ja) * 1983-09-07 1985-04-05 三菱重工業株式会社 組立式起伏装置
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Also Published As

Publication number Publication date
US4938964A (en) 1990-07-03
EP0319988A1 (en) 1989-06-14

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