KR890002226A - 핵산 유도체의 제법 및 제제법 - Google Patents
핵산 유도체의 제법 및 제제법 Download PDFInfo
- Publication number
- KR890002226A KR890002226A KR1019880008258A KR880008258A KR890002226A KR 890002226 A KR890002226 A KR 890002226A KR 1019880008258 A KR1019880008258 A KR 1019880008258A KR 880008258 A KR880008258 A KR 880008258A KR 890002226 A KR890002226 A KR 890002226A
- Authority
- KR
- South Korea
- Prior art keywords
- nucleic acid
- producing
- stranded nucleic
- preparation
- double
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (5)
- RNA를 모체로 하고 전체의 분자 사이즈 분포가 침강 정수치로 4S-13S의 범위내에 있는 2중쇄 핵산 유도체으 제조법에 있어서, 아닐링전에 각가 2중쇄 핵사폴리머를 사이주화하는 것을 특징으로 하는 핵산 유도체의 제법.
- RNA를 모체로 하고 전체의 분자 사이즈 분포에서의 최대 분포의 분자가 염기수로서 50-10,000 범위내에 있는 2중쇄 핵산 유도체의 제조법에 있어서, 아닐링전에 각각의 핵산 폴리머를 사이즈화하는 것을 특징으로 하는 핵산 유도체의 제법.
- 제1항 또는 제2항에 있어서, 사이즈화 한후 아닐링하기 전에 1중쇄 핵산 폴리머를 구성하는 핵산을 황화하기 위하여 아릴 알콜을 첨가하여 처리하는 것을 특징으로 하는 1중쇄 핵산 코폴리머의 제법.
- 제1항 또는 제2항에 있어서, 사이즈화 한후 아닐링하기 전에 1중쇄 핵산 폴리머를 아온 교환 수지에 의하여 처리하고, 그 분자사이즈 분포를 일정범위내로 집합시켜 사이즈 한정하는 것을 특징으로 하는 방법.
- 핵산 유도체를 주성분으로 하는 주사제의 제조방법에 있어서, 이온 교환수지를 사용하여 처리하는 것을 특징으로하는 파이로젠의 제거방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP?62-167434 | 1987-07-03 | ||
| JP16743487 | 1987-07-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR890002226A true KR890002226A (ko) | 1989-04-10 |
Family
ID=15849635
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019880008258A KR890002226A (ko) | 1987-07-03 | 1988-07-02 | 핵산 유도체의 제법 및 제제법 |
Country Status (19)
| Country | Link |
|---|---|
| KR (1) | KR890002226A (ko) |
| CN (1) | CN1024556C (ko) |
| AT (1) | AT397658B (ko) |
| AU (1) | AU1864488A (ko) |
| CH (1) | CH676123A5 (ko) |
| DE (1) | DE3822406A1 (ko) |
| DK (1) | DK369088A (ko) |
| ES (1) | ES2007252A6 (ko) |
| FI (1) | FI883163A (ko) |
| FR (1) | FR2617403B1 (ko) |
| GB (1) | GB2207138B (ko) |
| HU (1) | HU202250B (ko) |
| IL (1) | IL86884A0 (ko) |
| IT (1) | IT1224504B (ko) |
| NL (1) | NL8801664A (ko) |
| NO (1) | NO882922L (ko) |
| PT (1) | PT87903B (ko) |
| SE (1) | SE8802480L (ko) |
| ZA (1) | ZA884698B (ko) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4963532A (en) * | 1987-11-25 | 1990-10-16 | Hem Research, Inc. | dsRNA-based prevention of viral escape |
| KR100644172B1 (ko) | 1998-05-25 | 2006-11-10 | 니뽄 신야쿠 가부시키가이샤 | 핵산 함유 복합체 제제의 제조 방법 |
| DE60021354T2 (de) * | 1999-02-15 | 2006-04-27 | Nippon Shinyaku Co., Ltd. | Polynukleotide mit gekürzter kette und verfahren zu ihrer herstellung |
| US9816095B2 (en) | 2012-12-06 | 2017-11-14 | Kyowa Hakko Bio Co., Ltd. | Double-stranded ribonucleic acid for adjuvants |
| CN117517551A (zh) * | 2023-11-03 | 2024-02-06 | 成都迈科康生物科技有限公司 | 一种采用高效液相色谱法检测聚肌胞含量的方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ194880A (en) * | 1979-09-17 | 1983-07-15 | Merck & Co Inc | Interferon-inducing composition containing modified polyriboinosinic-polyribocytidylic acid |
-
1988
- 1988-06-27 IL IL86884A patent/IL86884A0/xx unknown
- 1988-06-27 GB GB8815262A patent/GB2207138B/en not_active Expired - Fee Related
- 1988-06-29 AT AT0169988A patent/AT397658B/de not_active IP Right Cessation
- 1988-06-29 CH CH2467/88A patent/CH676123A5/fr not_active IP Right Cessation
- 1988-06-29 CN CN88104080A patent/CN1024556C/zh not_active Expired - Fee Related
- 1988-06-30 ZA ZA884698A patent/ZA884698B/xx unknown
- 1988-06-30 NL NL8801664A patent/NL8801664A/nl not_active Application Discontinuation
- 1988-06-30 NO NO88882922A patent/NO882922L/no unknown
- 1988-07-01 HU HU883461A patent/HU202250B/hu not_active IP Right Cessation
- 1988-07-01 SE SE8802480A patent/SE8802480L/xx not_active Application Discontinuation
- 1988-07-01 ES ES8802078A patent/ES2007252A6/es not_active Expired
- 1988-07-01 IT IT8848147A patent/IT1224504B/it active
- 1988-07-01 PT PT87903A patent/PT87903B/pt not_active IP Right Cessation
- 1988-07-01 DE DE3822406A patent/DE3822406A1/de not_active Withdrawn
- 1988-07-01 FR FR8808938A patent/FR2617403B1/fr not_active Expired - Fee Related
- 1988-07-01 FI FI883163A patent/FI883163A/fi not_active IP Right Cessation
- 1988-07-01 DK DK369088A patent/DK369088A/da not_active Application Discontinuation
- 1988-07-01 AU AU18644/88A patent/AU1864488A/en not_active Abandoned
- 1988-07-02 KR KR1019880008258A patent/KR890002226A/ko not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| GB8815262D0 (en) | 1988-08-03 |
| NO882922L (no) | 1989-01-04 |
| PT87903B (pt) | 1995-03-01 |
| DK369088D0 (da) | 1988-07-01 |
| AU1864488A (en) | 1989-04-27 |
| FI883163A (fi) | 1989-01-04 |
| PT87903A (pt) | 1989-06-30 |
| NO882922D0 (no) | 1988-06-30 |
| GB2207138A (en) | 1989-01-25 |
| ZA884698B (en) | 1989-03-29 |
| FR2617403B1 (fr) | 1993-05-07 |
| FR2617403A1 (fr) | 1989-01-06 |
| IT1224504B (it) | 1990-10-04 |
| GB2207138B (en) | 1992-02-05 |
| ES2007252A6 (es) | 1989-06-01 |
| HU202250B (en) | 1991-02-28 |
| ATA169988A (de) | 1993-10-15 |
| DK369088A (da) | 1989-01-04 |
| CN1024556C (zh) | 1994-05-18 |
| FI883163A0 (fi) | 1988-07-01 |
| HUT48272A (en) | 1989-05-29 |
| IT8848147A0 (it) | 1988-07-01 |
| DE3822406A1 (de) | 1989-01-12 |
| SE8802480D0 (sv) | 1988-07-01 |
| SE8802480L (sv) | 1989-01-04 |
| AT397658B (de) | 1994-06-27 |
| CN1030424A (zh) | 1989-01-18 |
| IL86884A0 (en) | 1988-11-30 |
| NL8801664A (nl) | 1989-02-01 |
| CH676123A5 (ko) | 1990-12-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |