KR890001984A - 바이사이클릭 아미노 카복실산의 제조방법, 이 방법에서의 중간체, 및 이의 용도 - Google Patents

바이사이클릭 아미노 카복실산의 제조방법, 이 방법에서의 중간체, 및 이의 용도 Download PDF

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KR890001984A
KR890001984A KR1019880008172A KR880008172A KR890001984A KR 890001984 A KR890001984 A KR 890001984A KR 1019880008172 A KR1019880008172 A KR 1019880008172A KR 880008172 A KR880008172 A KR 880008172A KR 890001984 A KR890001984 A KR 890001984A
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South Korea
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formula
compound
protecting group
aralkyl
alkyl
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KR1019880008172A
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KR960012363B1 (ko
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우르바흐 한스외르그
헨닝 라이너
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하인리히 벡커,베른하르트 베크
훽스트 아크티엔게젤샤프트
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)

Abstract

내용 없음

Description

바이사이클릭 아미노 카복실산의 제조방법, 이 방법에서의 중간체, 및 이의 용도
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (7)

  1. 일반식(Ⅱ)의 화합물을 라디칼 폐환시킴을 특징으로 하여, 일반식(Ⅰ)의 화합물을 제조하는 방법.
    상기식에서, n은 1, 2 또는 3이고 R은 (C1-C14)-아실을 나타내며, R1은(C1-C6)-알킬, (C3-C7)-사이클로알킬, (C7-C11)-아르알킬 또는 다른 카복실 보호그룹을 나타내고 Hal은 염소, 브롬 또는 요오드를 나타내며, 브릿지 헤드(bridge head) 탄소원자 3a 및 (5+n)a에서의 수소원자의 배위는 바람직하게는 시스이다.
  2. 제1항에 있어서, R이 (C1-C6)-알카노일, (C6-C10)-아릴-(C1-C4)-알카노일, (C6-C10)-아로일, (C1-C6)-알콕시카보닐 또는 (C7-C11)-아르알킬옥시카보닐을 나타내는 일반식(Ⅱ)의 화합물을 폐환 시킴을 특징으로 하는 방법.
  3. 제1항에 있어서, R이 팹티드 화학분야에서 통상적인 우레탄 형태의 아민 보호그룹을 나타내는 일반식(Ⅱ)의 조성물을 폐환시킴을 특징으로 하는 방법.
  4. 제1항 내지 3항중 어느 한 항에 있어서, R1이(C1-4)-알킬 또는 (C7-C11)-아르알킬을 나타내는 일반식(Ⅱ)의 화합물을 폐환시킴을 특징으로 하는 방법.
  5. 제1항 내지 3항중 어느 한 항에 있어서, R1이 펩티드 화학분야에서 통상적인 카복실 보호그룹을 나타내는 일반식(Ⅱ)의 화합물을 폐환시킴을 특징으로 하는 방법.
  6. 하기 일반식(Ⅱa)의 화합물.
    상기식에서, n은 1, 2 또는 3이고, X는 하이드륵실, 염소, 브롬 또는 요오드를 나타내며, R은 수소 또는 (C1-C14)-아실을 나타내고, R1은 (C1-C6)-알킬, (C3-C7)-사이클로알킬, (C7-C11)-아르아킬 또는 다른 카복실 보호그룹을 나타낸다.
  7. ACE 억제제 합성시의, 제 6항에서 청구된 일반식(Ⅱa)외 화합물의 용도.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880008172A 1987-07-03 1988-07-01 비사이클릭 아미노 카복실산의 제조방법 및 이 방법에서의 중간체 KR960012363B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP3722007.1 1987-07-03
DE19873722007 DE3722007A1 (de) 1987-07-03 1987-07-03 Verfahren zur herstellung bicyclischer aminocarbonsaeuren, zwischenprodukte dieses verfahrens und deren verwendung

Publications (2)

Publication Number Publication Date
KR890001984A true KR890001984A (ko) 1989-04-07
KR960012363B1 KR960012363B1 (ko) 1996-09-20

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KR1019880008172A KR960012363B1 (ko) 1987-07-03 1988-07-01 비사이클릭 아미노 카복실산의 제조방법 및 이 방법에서의 중간체

Country Status (18)

Country Link
US (1) US5011940A (ko)
EP (1) EP0297620B1 (ko)
JP (1) JP2564614B2 (ko)
KR (1) KR960012363B1 (ko)
AT (1) ATE114642T1 (ko)
AU (1) AU617328B2 (ko)
CA (1) CA1332422C (ko)
DE (2) DE3722007A1 (ko)
DK (1) DK170373B1 (ko)
ES (1) ES2065899T3 (ko)
FI (1) FI92691C (ko)
HU (1) HU203533B (ko)
IE (1) IE66150B1 (ko)
IL (1) IL86943A0 (ko)
NO (1) NO173864C (ko)
NZ (1) NZ225253A (ko)
PT (1) PT87904B (ko)
ZA (1) ZA884727B (ko)

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US20060159742A1 (en) * 2004-11-05 2006-07-20 King Pharmaceutical Research & Development, Inc. Stabilized individually coated ramipril particles, compositions and methods

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Also Published As

Publication number Publication date
PT87904B (pt) 1995-03-01
ZA884727B (en) 1989-03-29
NO173864B (no) 1993-11-08
IE882019L (en) 1989-01-03
CA1332422C (en) 1994-10-11
KR960012363B1 (ko) 1996-09-20
ES2065899T3 (es) 1995-03-01
FI92691C (fi) 1994-12-27
ATE114642T1 (de) 1994-12-15
JP2564614B2 (ja) 1996-12-18
EP0297620A2 (de) 1989-01-04
NO882957L (no) 1989-01-04
AU1860288A (en) 1989-01-05
EP0297620A3 (de) 1991-06-05
NZ225253A (en) 1990-12-21
DK367488A (da) 1989-01-04
PT87904A (pt) 1989-06-30
EP0297620B1 (de) 1994-11-30
DK170373B1 (da) 1995-08-14
HUT50120A (en) 1989-12-28
FI883141A (fi) 1989-01-04
NO173864C (no) 1994-02-16
JPS6434960A (en) 1989-02-06
IL86943A0 (en) 1988-12-30
IE66150B1 (en) 1995-12-13
DK367488D0 (da) 1988-07-01
FI883141A0 (fi) 1988-06-30
NO882957D0 (no) 1988-07-01
DE3722007A1 (de) 1989-01-12
DE3852219D1 (de) 1995-01-12
US5011940A (en) 1991-04-30
FI92691B (fi) 1994-09-15
HU203533B (en) 1991-08-28
AU617328B2 (en) 1991-11-28

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