KR890000765B1 - 아로일이미다졸론 및 그의 제조방법 - Google Patents

아로일이미다졸론 및 그의 제조방법 Download PDF

Info

Publication number
KR890000765B1
KR890000765B1 KR8200933A KR820000933A KR890000765B1 KR 890000765 B1 KR890000765 B1 KR 890000765B1 KR 8200933 A KR8200933 A KR 8200933A KR 820000933 A KR820000933 A KR 820000933A KR 890000765 B1 KR890000765 B1 KR 890000765B1
Authority
KR
South Korea
Prior art keywords
hydrogen
pyridyl
dihydro
methyl
ethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
KR8200933A
Other languages
English (en)
Korean (ko)
Other versions
KR830009046A (ko
Inventor
리차드 시. 데이지
프랭크 피. 팔로폴리
리차드 에이. 쉔틀러
제이.마아틴 그리사
Original Assignee
조세프 지. 템플, 제이 알.
메렐 다우 파마슈티칼스 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 조세프 지. 템플, 제이 알., 메렐 다우 파마슈티칼스 인코포레이티드 filed Critical 조세프 지. 템플, 제이 알.
Publication of KR830009046A publication Critical patent/KR830009046A/ko
Application granted granted Critical
Publication of KR890000765B1 publication Critical patent/KR890000765B1/ko
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/70—One oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Optical Fibers, Optical Fiber Cores, And Optical Fiber Bundles (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Luminescent Compositions (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
KR8200933A 1981-03-05 1982-03-04 아로일이미다졸론 및 그의 제조방법 Expired KR890000765B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US24088981A 1981-03-05 1981-03-05
US240889 1981-03-05
US06/314,312 US4405628A (en) 1981-03-05 1981-10-23 4-Pyridylimidazolones and method of use
US314312 1981-10-23

Publications (2)

Publication Number Publication Date
KR830009046A KR830009046A (ko) 1983-12-17
KR890000765B1 true KR890000765B1 (ko) 1989-04-05

Family

ID=26933806

Family Applications (1)

Application Number Title Priority Date Filing Date
KR8200933A Expired KR890000765B1 (ko) 1981-03-05 1982-03-04 아로일이미다졸론 및 그의 제조방법

Country Status (18)

Country Link
US (1) US4405628A (https=)
EP (1) EP0059948B1 (https=)
KR (1) KR890000765B1 (https=)
AT (1) ATE16489T1 (https=)
AU (1) AU557590B2 (https=)
CA (1) CA1190550A (https=)
DE (1) DE3267352D1 (https=)
DK (1) DK168627B1 (https=)
ES (2) ES8305352A1 (https=)
GB (1) GB2096600B (https=)
GR (1) GR76518B (https=)
HK (1) HK61686A (https=)
IE (1) IE52387B1 (https=)
IL (1) IL65137A (https=)
MY (1) MY8600700A (https=)
NO (1) NO157175C (https=)
NZ (1) NZ199885A (https=)
PH (1) PH18345A (https=)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4367236A (en) * 1981-11-04 1983-01-04 Merrell Dow Pharmaceuticals Inc. Method for the treatment of cardiac failure with alkanoylimidazol-2-one derivatives
US4552880A (en) * 1983-02-15 1985-11-12 Merrell Dow Pharmaceuticals Inc. Aroylimidazolones
US4532250A (en) * 1983-11-23 1985-07-30 American Hospital Supply Corporation 5-Heteroarylimidazol-2-ones having cardiotonic activity
US4556665A (en) * 1984-07-09 1985-12-03 Schering A.G. Cardiotonic 1,3-dihydro-4-[[(imidazol-1-yl)aryl]carbonyl]imidazol-2-ones
US4803278A (en) * 1984-07-30 1989-02-07 Merrell Dow Pharmaceuticals, Inc. Preparation of 1,3-dihydro-4-pyridoyl-2H-imidazol-2-ones
IL75902A (en) * 1984-07-30 1988-10-31 Merrell Dow Pharma Preparation of 1,3-dihydro-4-pyridoyl-2h-imidazol-2-ones
US4999365A (en) * 1987-03-20 1991-03-12 Merrell Dow Pharmaceuticals Inc. Method of reducing reperfusion injury with imidazol-2-thiones
ZA881807B (en) * 1987-03-20 1988-09-05 Merrell Dow Pharmaceuticals Inc. Method for reducing reperfusion injury with imidazol-2-thiones
ZA887662B (en) * 1987-10-19 1989-06-28 Merrell Dow Pharma Method for reducing reperfusion injury with imidazol-2-thione-carboxamides
AU8212491A (en) * 1990-06-29 1992-01-23 Upjohn Company, The Substituted 1-(alkoxyphenyl)piperazines with cns and antihypertensive activity
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
EP2527360B1 (en) 2007-06-04 2015-10-28 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EP2810951B1 (en) 2008-06-04 2017-03-15 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP3241839B1 (en) 2008-07-16 2019-09-04 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
ES2664873T3 (es) 2011-03-01 2018-04-23 Synergy Pharmaceuticals Inc. Proceso de preparación de agonistas de guanilato ciclasa C
US9545446B2 (en) 2013-02-25 2017-01-17 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
CA2905435A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
CA2905438A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
SI3004138T1 (sl) 2013-06-05 2024-07-31 Bausch Health Ireland Limited Ultra čisti agonisti gvanilat ciklaze C, postopek za njihovo pripravo in uporabo
KR102456567B1 (ko) 2013-08-09 2022-10-19 알데릭스, 인코포레이티드 인산염 수송을 억제하기 위한 화합물 및 방법
WO2020237096A1 (en) 2019-05-21 2020-11-26 Ardelyx, Inc. Combination for lowering serum phosphate in a patient

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2441933A (en) * 1945-07-30 1948-05-18 Hoffmann La Roche Substituted imidazolones and process of making them
US3538104A (en) * 1969-02-28 1970-11-03 Geigy Chem Corp Pyridyl-2-imidazolones
NZ193935A (en) * 1979-06-18 1985-05-31 Richardson Merrell Inc 4-aroyl-imidazol-2-one derivatives;pharmaceutical compositions
ZA803332B (en) * 1979-06-18 1981-01-28 Richardson Merrell Inc Novel 4-aroylimidazol-2-ones
PH18106A (en) * 1981-02-18 1985-03-21 Merrell Dow Pharma Novel-4-aroylimidazol-2-ones

Also Published As

Publication number Publication date
ATE16489T1 (de) 1985-11-15
IL65137A0 (en) 1982-05-31
IE820491L (en) 1982-09-05
GR76518B (https=) 1984-08-10
IE52387B1 (en) 1987-10-14
ES510087A0 (es) 1983-04-16
DK168627B1 (da) 1994-05-09
NZ199885A (en) 1985-04-30
MY8600700A (en) 1986-12-31
DK95482A (da) 1982-09-06
GB2096600A (en) 1982-10-20
NO157175C (no) 1988-02-03
CA1190550A (en) 1985-07-16
ES519254A0 (es) 1984-03-01
IL65137A (en) 1987-02-27
EP0059948B1 (en) 1985-11-13
ES8402827A1 (es) 1984-03-01
AU8103782A (en) 1982-09-09
AU557590B2 (en) 1986-12-24
ES8305352A1 (es) 1983-04-16
PH18345A (en) 1985-06-05
KR830009046A (ko) 1983-12-17
NO157175B (no) 1987-10-26
HK61686A (en) 1986-08-29
DE3267352D1 (en) 1985-12-19
EP0059948A1 (en) 1982-09-15
US4405628A (en) 1983-09-20
NO820686L (no) 1982-09-06
GB2096600B (en) 1985-06-05

Similar Documents

Publication Publication Date Title
KR890000765B1 (ko) 아로일이미다졸론 및 그의 제조방법
KR880002708B1 (ko) 4-아로일이미다졸리딘-2-온의 제조방법
KR900003879B1 (ko) 5-아릴-2,4-디알킬-3h-1,2,4-트리아졸-3-티온 및 이의 제조방법
KR890005203B1 (ko) 티아졸론 유도체 및 이의 제조방법
US4367236A (en) Method for the treatment of cardiac failure with alkanoylimidazol-2-one derivatives
US4552880A (en) Aroylimidazolones
KR890001151B1 (ko) 이미다졸 카복실산 유도체의 제조방법
US4447619A (en) 4-Alkanoylimidazol-2-ones
EP0495226B1 (en) 3-Aryl-5-alkylthio-4H-1,2,4-triazoles for treatment of hyperreflexia due to spinal trauma
JPH0233032B2 (https=)
JPH0733382B2 (ja) ５−複素環−２，４−ジアルキル−３ｈ−１，２，４−トリアゾ−ル−３−チオン類及びそれらの抗抑鬱剤としての用途
JPS62106086A (ja) ５―ナフチル―２，４―ジアルキル―３ｈ―１，２，４―トリアゾール―３―チオン類及びその製法

Legal Events

Date Code Title Description
PA0109 Patent application

St.27 status event code: A-0-1-A10-A12-nap-PA0109

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PG1605 Publication of application before grant of patent

St.27 status event code: A-2-2-Q10-Q13-nap-PG1605

PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U11-oth-PR1002

Fee payment year number: 1

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 5

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 6

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 7

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 8

PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 19970406

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 19970406

PN2301 Change of applicant

St.27 status event code: A-5-5-R10-R13-asn-PN2301

St.27 status event code: A-5-5-R10-R11-asn-PN2301