KR890000377B1 - 아졸류의 제조방법 - Google Patents

아졸류의 제조방법 Download PDF

Info

Publication number
KR890000377B1
KR890000377B1 KR1019840001218A KR840001218A KR890000377B1 KR 890000377 B1 KR890000377 B1 KR 890000377B1 KR 1019840001218 A KR1019840001218 A KR 1019840001218A KR 840001218 A KR840001218 A KR 840001218A KR 890000377 B1 KR890000377 B1 KR 890000377B1
Authority
KR
South Korea
Prior art keywords
group
groups
phenyl
halogen
compound
Prior art date
Application number
KR1019840001218A
Other languages
English (en)
Korean (ko)
Other versions
KR850006386A (ko
Inventor
쉬튀츠 안톤
에거 헬무트
Original Assignee
산도즈 파마슈티칼스 코포레이션
게랄드 디. 샤르킨
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 산도즈 파마슈티칼스 코포레이션, 게랄드 디. 샤르킨 filed Critical 산도즈 파마슈티칼스 코포레이션
Publication of KR850006386A publication Critical patent/KR850006386A/ko
Application granted granted Critical
Publication of KR890000377B1 publication Critical patent/KR890000377B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
KR1019840001218A 1983-03-11 1984-03-10 아졸류의 제조방법 KR890000377B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH1332/83A CH655103A5 (de) 1983-03-11 1983-03-11 Azolderivate, verfahren zu ihrer herstellung und ihre verwendung.
CH1332/83 1983-03-11

Publications (2)

Publication Number Publication Date
KR850006386A KR850006386A (ko) 1985-10-05
KR890000377B1 true KR890000377B1 (ko) 1989-03-15

Family

ID=4207992

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840001218A KR890000377B1 (ko) 1983-03-11 1984-03-10 아졸류의 제조방법

Country Status (24)

Country Link
JP (1) JPS59175472A (xx)
KR (1) KR890000377B1 (xx)
AU (1) AU571494B2 (xx)
BE (1) BE899073A (xx)
CA (1) CA1242723A (xx)
CH (1) CH655103A5 (xx)
DE (1) DE3408127A1 (xx)
DK (1) DK149784A (xx)
ES (1) ES8506639A1 (xx)
FI (1) FI840968A (xx)
FR (1) FR2542315B1 (xx)
GB (1) GB2136801B (xx)
GR (1) GR81869B (xx)
HU (1) HUT36098A (xx)
IL (1) IL71203A (xx)
IT (1) IT1199085B (xx)
LU (1) LU85245A1 (xx)
NL (1) NL8400730A (xx)
NZ (1) NZ207453A (xx)
PH (1) PH24667A (xx)
PL (1) PL146072B1 (xx)
PT (1) PT78226B (xx)
SE (1) SE8401321L (xx)
ZA (1) ZA841782B (xx)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8618188D0 (en) * 1986-07-25 1986-09-03 Ici Plc Diamine compounds
DE3644616A1 (de) * 1986-12-29 1988-07-07 Lentia Gmbh Imidazolderivate, verfahren zur herstellung und deren verwendung
DE3644615A1 (de) * 1986-12-29 1988-07-07 Lentia Gmbh Imidazol- und triazolderivate zur verwendung als antimykotische mittel
US5252594A (en) * 1992-06-17 1993-10-12 Rohm And Haas Company Fungicidal (2-aryl-2-substituted)ethyl-1,2,4-triazoles
US5358939A (en) * 1992-06-25 1994-10-25 Rohm And Haas Company Fungicidal 2-aryl-2,2-disubstituted ethyl-1,2,4-triazoles
DE4412358A1 (de) * 1994-04-11 1995-10-12 Bayer Ag Cyclopropyl-ethyl-azole
GB9409882D0 (en) * 1994-05-18 1994-07-06 Sandoz Ltd Organic compounds
JP3214987B2 (ja) * 1994-09-05 2001-10-02 日本碍子株式会社 半導体装置およびその製造方法
AU2003299750A1 (en) * 2002-12-20 2004-07-22 Irm Llc Differential tumor cytotoxocity compounds and compositions
WO2004056744A1 (en) * 2002-12-23 2004-07-08 Janssen Pharmaceutica N.V. Adamantyl acetamides as hydroxysteroid dehydrogenase inhibitors
US9012494B2 (en) 2004-05-07 2015-04-21 Janssen Pharmaceutica N.V. Pyrrolidin-2-one and piperidin-2-one derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors
KR101197674B1 (ko) 2004-08-30 2012-11-07 얀센 파마슈티카 엔.브이. １１-베타 하이드록시스테로이드 탈수소효소 저해제로서의 ｎ-2 아다만타닐-２-페녹시-아세트아미드 유도체
DE602005017159D1 (de) 2004-08-30 2009-11-26 Janssen Pharmaceutica Nv Oxysteroid-dehydrogenase-inhibitoren
MY141198A (en) 2004-08-30 2010-03-31 Janssen Pharmaceutica Nv Tricyclic adamantylamide derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors
TW200626155A (en) 2004-09-20 2006-08-01 Xenon Pharmaceuticals Inc Heterocyclic derivatives and their use as therapeutic agents
AU2005329423A1 (en) 2004-09-20 2006-09-28 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
TW200626154A (en) 2004-09-20 2006-08-01 Xenon Pharmaceuticals Inc Heterocyclic derivatives and their use as therapeutic agents
WO2006034279A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as therapeutic agents
BRPI0515478A (pt) 2004-09-20 2008-07-22 Xenon Pharmaceuticals Inc derivados heterocìclicos e seu uso como mediadores de estearoil-coa-desaturase
CN101083982A (zh) 2004-09-20 2007-12-05 泽农医药公司 用于治疗硬脂酰CoA去饱和酶介导的疾病的杂环衍生物
CN101084207A (zh) 2004-09-20 2007-12-05 泽农医药公司 杂环衍生物及其作为硬脂酰CoA去饱和酶抑制剂的用途
BRPI0611187A2 (pt) 2005-06-03 2010-08-24 Xenon Pharmaceuticals Inc derivados aminotiazàis como inibidores da estearoil-coa desaturase humana
CN104530038A (zh) * 2014-12-10 2015-04-22 沈阳药科大学 酰胺咪唑类衍生物及其用途
CN112142673B (zh) * 2020-09-18 2023-06-30 聊城大学 芳基烯烃唑类衍生物及其制备方法和用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU557755A3 (ru) * 1968-08-19 1977-05-05 Янссен Фармасьютика Н.В. (Фирма) Способ получени производных имидазола
CA1189857A (en) * 1981-03-27 1985-07-02 Janssen Pharmaceutica Naamloze Vennootschap Antimicrobial triazole derivatives
AU8314482A (en) * 1981-05-19 1982-11-25 Imperial Chemical Industries Plc 3-triazolyl(imidazolyl)-2,2 bis phenyl-propionamides
EP0117462A3 (en) * 1983-02-28 1986-08-20 American Cyanamid Company N-(2-4-(1h-imidazol-1-yl)alkyl)arylamides

Also Published As

Publication number Publication date
CA1242723A (en) 1988-10-04
NL8400730A (nl) 1984-10-01
PL146072B1 (en) 1988-12-31
ZA841782B (en) 1985-10-30
KR850006386A (ko) 1985-10-05
DK149784D0 (da) 1984-02-29
JPS59175472A (ja) 1984-10-04
IT8447817A0 (it) 1984-03-08
SE8401321D0 (sv) 1984-03-09
FR2542315B1 (fr) 1986-02-07
DE3408127A1 (de) 1984-09-13
IL71203A (en) 1988-10-31
BE899073A (fr) 1984-09-05
FI840968A (fi) 1984-09-12
PT78226B (en) 1986-07-15
SE8401321L (sv) 1984-09-12
ES530461A0 (es) 1985-07-16
ES8506639A1 (es) 1985-07-16
PT78226A (en) 1984-04-01
IT1199085B (it) 1988-12-30
GB2136801B (en) 1987-03-04
GB8405900D0 (en) 1984-04-11
DK149784A (da) 1984-09-12
NZ207453A (en) 1987-09-30
IL71203A0 (en) 1984-06-29
GR81869B (xx) 1984-12-12
FR2542315A1 (fr) 1984-09-14
LU85245A1 (fr) 1984-11-14
PL246600A1 (en) 1985-03-12
GB2136801A (en) 1984-09-26
PH24667A (en) 1990-09-07
AU571494B2 (en) 1988-04-21
FI840968A0 (fi) 1984-03-09
AU2547584A (en) 1984-09-13
CH655103A5 (de) 1986-03-27
HUT36098A (en) 1985-08-28

Similar Documents

Publication Publication Date Title
KR890000377B1 (ko) 아졸류의 제조방법
US4898954A (en) Process for the preparation of oxiranes
HU187611B (en) Process for production of substituaded amino-acetofenon derivates
US4514412A (en) Substituted imidazole derivatives and their use as anti-thrombosis agents
US4177350A (en) Imidazole ethyl oxyalkoxy derivatives and thio analogues thereof
US4124767A (en) Imidazolyl-oxime ethers having anti-mycotic and bactericidal activity
CA1131233A (en) Acylated 1-azolyl-2-hydroxy-butane derivatives, processes for their preparation and their use as fungicides
US4394380A (en) 2-(2-Alkoxyalkyl)-1,2,4-triazole compounds and their use as fungicides
US4210656A (en) Imidazolyl vinyl ethers and process for preparing same
IE48820B1 (en) Imidazolyl vinyl ethers having fungicidal and bactericidal activity
JPS5817454B2 (ja) アルキル化ヒドロキシルアミン及びその製法
DD283603A5 (de) Verfahren zur herstellung von substituierten hydroxylaminen
NO165104B (no) Analogifremgangsmaate til fremstilling av terapeutisk aktive 1, 1-disubstituerte cyklopropanderivater.
JPS6026111B2 (ja) 新規な１−アゾリル−４−ヒドロキシ−ブタン誘導体，その製造方法およびそれを活性成分として含有する殺菌剤組成物
US4574155A (en) Process for preparing 2-hydrazino-1,3-diazacycloalk-2-ene hydrohalides
US4273776A (en) Antibacterial and antifungal derivatives of 3-(1H-imidazol-1-yl)-2-propen-1-ones
US5387599A (en) Triazoles, their production and use
IL65369A (en) Imidazole and triazole derivatives of gamma-butyrolactone and their use as fungicides
US4737508A (en) 1-aryl-1-(1H-azol-1-ylalkyl)-1,3-dihydroisobenzofurans, related derivatives and pharmaceutical compositions thereof useful as antifungals
US4159380A (en) Imidazolylethoxy derivatives of pyrazolo[3,4-b]pyridine-5-methanols
NO138025B (no) Analogifremgangsm}te til fremstilling av antimykotisk virksomme 1-etyl-imidazoler
US4039677A (en) Novel 1-phenethylimidazoles
US4376788A (en) Basic ethers of 4-hydroxy-benzophenones acting as beta-blocking agents
JPS61271280A (ja) 新規アゾ−ル誘導体、その製造方法と用途
US4461774A (en) Antifungal imidazolylcarboxylic acids and their derivatives

Legal Events

Date Code Title Description
N231 Notification of change of applicant
A201 Request for examination
E902 Notification of reason for refusal
G160 Decision to publish patent application
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
LAPS Lapse due to unpaid annual fee