KR880010776A - 림포킨 및 이중-가닥 rna의 상승 작용화 조성물 - Google Patents

림포킨 및 이중-가닥 rna의 상승 작용화 조성물 Download PDF

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KR880010776A
KR880010776A KR1019880002204A KR880002204A KR880010776A KR 880010776 A KR880010776 A KR 880010776A KR 1019880002204 A KR1019880002204 A KR 1019880002204A KR 880002204 A KR880002204 A KR 880002204A KR 880010776 A KR880010776 A KR 880010776A
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dsrna
interleukin
lymphokine
therapeutic composition
human
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KR1019880002204A
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KR960008009B1 (ko
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에이.카터 윌리암
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헴 리서어치 인코오포레이티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

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  • Health & Medical Sciences (AREA)
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Abstract

내용 없음

Description

림포킨 및 이중-가닥 RNA의 상승 작용화 조성물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제 1도는 재결합된 인터류킨-2(rIL-2) 및 림포칸 활성 킬러(LAK)세포로 하는 현재 종양 치료법을 나타낸 도식도, 제 2도는 여러 가지의 IL-2 투여량과 독성 및 투여한 재독성을 비교한 개괄적인 임상데이타를 나타낸 막대그래프, 제 3A도 및 제 3B도는 IL-2의 투여량을 다르게 했을때의 세포독소와 dsRNA를 일정하게 투여했을 때의 세포독소를 비교한 막대 그래프.

Claims (11)

  1. 종양 또는 바이러스 감염된 또는 면역 조절 기능을 잃은 세포의 숫자를 줄이기 위하여 dsRNA, 림포킨 및, 선택적으로 사이클로옥시지나제 활성제를 억제하는 물질을 이루어진 결합체를 사람에게 투여하는 것을 포함하는 사람을 치료하는 방법.
  2. 제 1항에 있어서, 상기 dsRNA는 잘못 짝지은 dsRNA이며, 바람직하게는 rIn. (C12U)n의 일반식을 가지는 것을 특징하는 방법.
  3. 제 2항에 있어서, 상기 림포킨은 인터페론 또는 인터류킨인 것을 특징으로 하는 방법.
  4. 상기 항 중 어느 한 항에 있어서, 사이클로옥시지나제를 억제하는 물질을 또한 프로스타글라딘 방출 및 생성된 NK 세포 감소 조절응답을 폐기하는 것을 특징으로 하는 방법.
  5. 상기 항 중 어느 한 항에 있어서, 인체 중의 NK 및 LAK세포의 농도는 독성을 증가시킴이 없이 향상 된 항종양, 항바이러스 또는 면역조절 응답을 가져오는 것을 특징으로 하는 방법.
  6. 제 3항에 있어서, 잘못 짝지은 dsRNA는 환자의 체액을 기준하여 0.01-1,000ug/ml의 농도의 함량으로 투여되며, 인터류킨-2는 환자의 체중을 기준하여 약 102-106IL-2/kg의 농도의 당량으로 투여되는 것을 특징으로 하는 방법.
  7. dsRNA 및 림포킨을 상대 농도로 도시 또는 연속적으로 투여하여 광잉의 dsRNA 또는 인터류킨에 있어서의 독성을 증가시킴이 없이 기관내에 NK 및 LAK 세포의 향상된 수준을 가져오는 것을 특징으로 하는 치료 조성물.
  8. 제7항에 있어서, 사클로옥시지나제 활성제를 억제하는 물질을 또한 포함하는 것을 특징으로 하는 치료 조성물.
  9. 제8항에 있어서, 상기 억제제는 NK 세포 감소 조절 메카니즘을 억제하는 것을 특징으로 하는 치료 조성물.
  10. 상기 항 중 어느 한 항에 있어서, 상기 dsRNA는 잘못 짝지은 dsRNA이며, 바람직하게는 rIn.(C12U)n의식을 가지는 것을 특징으로 하는 치료 조성물.
  11. 상기 항중 어느 한 항에 있어서, 상기 림포킨은 인터페론(바람직하게는 알파 인터페론), 또는 인터류킨(바람직하게는 인터류킨 2) 인 것을 특징으로 하는 치료 조성물.
    ※참고사항:최초출원 내용에 의하여 공개하는 것임.
KR1019880002204A 1987-03-03 1988-03-02 인터류킨 및 이중-가닥 rna를 포함하는 상승작용화 조성물 KR960008009B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2136887A 1987-03-03 1987-03-03
US21,368 1987-03-03
US021368 1987-03-03

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KR880010776A true KR880010776A (ko) 1988-10-24
KR960008009B1 KR960008009B1 (ko) 1996-06-19

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KR1019880002204A KR960008009B1 (ko) 1987-03-03 1988-03-02 인터류킨 및 이중-가닥 rna를 포함하는 상승작용화 조성물

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EP (1) EP0281380B1 (ko)
JP (1) JPH0713024B2 (ko)
KR (1) KR960008009B1 (ko)
CN (1) CN1054509C (ko)
AT (1) ATE130760T1 (ko)
AU (2) AU1256588A (ko)
CA (1) CA1336810C (ko)
DE (1) DE3854726T2 (ko)
DK (1) DK113188A (ko)
ES (1) ES2082749T3 (ko)
FI (1) FI880961A (ko)
IE (1) IE75895B1 (ko)
IL (1) IL85603A (ko)
NO (1) NO880946L (ko)
NZ (1) NZ223720A (ko)
PH (1) PH24467A (ko)
PT (1) PT86879B (ko)
RU (1) RU1836103C (ko)
ZA (1) ZA881512B (ko)

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ZA881639B (en) * 1987-03-23 1989-02-22 Hem Res Inc Treatment of human viral infection by dsrna combined with viral inhibitors
DK0405315T3 (da) * 1989-06-30 1995-09-25 American Cyanamid Co Anvendelse af et fagocyt-aktiverende stof: LPS eller IL-2 til fremstilling af et lægemiddel til behandling af Staphylococcus aureus-infektioner hos køer
FR2766715B1 (fr) * 1997-08-04 2001-02-16 Scras Produit comprenant au moins de l'arn double brin en association avec au moins un agent anti-viral pour une utilisation therapeutique simultanee, separee ou etalee dans le temps, dans le traitement d'une maladie virale
FR2768344B1 (fr) * 1997-08-26 2001-02-16 Scras Produit comprenant au moins un arn double brin en association avec au moins un agent anti-viral pour une utilisation therapeutique dans le traitement d'une maladie virale
FR2768345B1 (fr) * 1997-09-17 2001-05-04 Scras Produit comprenant au moins un arn double brin en association avec au moins un agent anti-viral pour une utilisation therapeutique dans le traitement d'une maladie virale, notamment d'une hepatite virale
TW589189B (en) * 1997-08-04 2004-06-01 Scras Kit containing at least one double-stranded RNA combined with at least one anti-viral agent for therapeutic use in the treatment of a viral disease, notably of viral hepatitis
US6506559B1 (en) 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
AUPP249298A0 (en) 1998-03-20 1998-04-23 Ag-Gene Australia Limited Synthetic genes and genetic constructs comprising same I
BRPI9908967B1 (pt) 1998-03-20 2017-05-30 Benitec Australia Ltd processos para reprimir, retardar ou de outro modo reduzir a expressão de um gene alvo em uma célula de planta
CA2361201A1 (en) 1999-01-28 2000-08-03 Medical College Of Georgia Research Institute, Inc. Composition and method for in vivo and in vitro attenuation of gene expression using double stranded rna
US6423885B1 (en) 1999-08-13 2002-07-23 Commonwealth Scientific And Industrial Research Organization (Csiro) Methods for obtaining modified phenotypes in plant cells
US20020132257A1 (en) 2001-01-31 2002-09-19 Tony Giordano Use of post-transcriptional gene silencing for identifying nucleic acid sequences that modulate the function of a cell
WO2006054129A1 (en) * 2004-11-19 2006-05-26 Institut Gustave Roussy Improved treatment of cancer by double-stranded rna
EP2116602A1 (en) 2008-05-07 2009-11-11 Institut Gustave Roussy Combination products for treating cancer
US20130195919A1 (en) 2010-03-05 2013-08-01 President And Fellows Of Harvard College Induced dendritic cell compositions and uses thereof
CN106794246B (zh) 2014-08-08 2021-10-15 OncoQuest制药有限公司 肿瘤抗原特异性抗体和tlr3刺激以增强检查点干扰癌症疗法的性能
CA3213217A1 (en) 2021-04-28 2022-11-03 Raphael Darteil Strong potentiation of tlr3 agonists effects using fxr agonists as a combined treatment

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EP0113162B1 (en) * 1982-09-16 1989-07-19 Hem Research, Inc. Anti-proliferative action of dsnras on tumor cells
CA1326450C (en) * 1985-08-26 1994-01-25 William A. Carter Modulation of aids virus-related events by double stranded rnas (dsrnas)

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CN1054509C (zh) 2000-07-19
NO880946D0 (no) 1988-03-03
DE3854726D1 (de) 1996-01-11
DK113188D0 (da) 1988-03-02
EP0281380B1 (en) 1995-11-29
EP0281380A3 (en) 1989-09-27
PH24467A (en) 1990-07-18
CN1032296A (zh) 1989-04-12
IL85603A0 (en) 1988-08-31
PT86879B (pt) 1992-05-29
IL85603A (en) 1993-05-13
RU1836103C (ru) 1993-08-23
AU1256588A (en) 1988-09-01
PT86879A (pt) 1988-04-01
KR960008009B1 (ko) 1996-06-19
DE3854726T2 (de) 1996-07-25
FI880961A (fi) 1988-09-04
NZ223720A (en) 1991-07-26
EP0281380A2 (en) 1988-09-07
ES2082749T3 (es) 1996-04-01
CA1336810C (en) 1995-08-29
DK113188A (da) 1988-09-04
IE75895B1 (en) 1997-09-24
AU1618992A (en) 1992-08-06
ATE130760T1 (de) 1995-12-15
JPS63295514A (ja) 1988-12-01
IE880588L (en) 1988-09-03
ZA881512B (en) 1988-11-30
FI880961A0 (fi) 1988-03-02
NO880946L (no) 1988-09-05
JPH0713024B2 (ja) 1995-02-15

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