KR880007530A - 방사성프로필 2-요오도스피로페리돌 및 그의 제조방법 - Google Patents
방사성프로필 2-요오도스피로페리돌 및 그의 제조방법 Download PDFInfo
- Publication number
- KR880007530A KR880007530A KR870014963A KR870014963A KR880007530A KR 880007530 A KR880007530 A KR 880007530A KR 870014963 A KR870014963 A KR 870014963A KR 870014963 A KR870014963 A KR 870014963A KR 880007530 A KR880007530 A KR 880007530A
- Authority
- KR
- South Korea
- Prior art keywords
- iodospiroperidol
- radiopropyl
- propyl
- atom
- general formula
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title 1
- 229910052740 iodine Inorganic materials 0.000 claims 4
- 230000002285 radioactive effect Effects 0.000 claims 4
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims 3
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 3
- 125000004429 atom Chemical group 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 150000002496 iodine Chemical class 0.000 claims 1
- 239000011630 iodine Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229910001511 metal iodide Inorganic materials 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- PVWOIHVRPOBWPI-UHFFFAOYSA-N n-propyl iodide Chemical compound CCCI PVWOIHVRPOBWPI-UHFFFAOYSA-N 0.000 claims 1
- DKGZKTPJOSAWFA-UHFFFAOYSA-N spiperone Chemical compound C1=CC(F)=CC=C1C(=O)CCCN1CCC2(C(NCN2C=2C=CC=CC=2)=O)CC1 DKGZKTPJOSAWFA-UHFFFAOYSA-N 0.000 claims 1
- 229950001675 spiperone Drugs 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
내용 없음.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (4)
- 하기 일반식(Ⅰ)의 방사성프로필 2-요오도스피로페리돌(상기식중, I*는 방사성 요오드 원자이다.
- 제1항에 있어서, I*가 I-123, I-125, I-131 및 I-132로 구성된 요오드 이성질체의 군에서 선택된 원자인 화합물.
- 하기 일반식(Ⅱ)의 2-요오도스피로페리돌을 염기 존재하에 1-요오도프로판과 반응시킴을 특징으로 하는 하기 일반식(Ⅰ)의 프로필 2-요오도스피로페리돌의 제조방법.(상기 식중, I*는 방사성 요오드 원자이다.)
- 하기 일반식(Ⅲ)의 프로필 2-할로게노스피로페리돌을 방사성 요오드화 금속과 교환 반응시킴을 특징으로 하는 하기 일반식(Ⅰ)의 방사성 프로필 2-요오드스피로페리돌의 제조방법.(상기 식중, I*는 방사성 요오드 원자이고, X는 할로겐원자이다.)※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61314256A JPH085882B2 (ja) | 1986-12-26 | 1986-12-26 | 新規なヨ−ドスピロペリド−ル誘導体およびその製造法 |
| JP314256/1986 | 1986-12-26 | ||
| JP?61-314256 | 1986-12-26 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR880007530A true KR880007530A (ko) | 1988-08-27 |
| KR950008315B1 KR950008315B1 (ko) | 1995-07-27 |
Family
ID=18051160
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019870014963A KR950008315B1 (ko) | 1986-12-26 | 1987-12-26 | 방사성 프로필2-요오도스피로페리돌 및 그의 제조방법 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4945162A (ko) |
| EP (1) | EP0275666B1 (ko) |
| JP (1) | JPH085882B2 (ko) |
| KR (1) | KR950008315B1 (ko) |
| AU (1) | AU597447B2 (ko) |
| CA (1) | CA1287357C (ko) |
| DE (1) | DE3764356D1 (ko) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL106692A (en) * | 1993-08-13 | 1997-04-15 | Israel Atomic Energy Comm | AZIDOALKYL DERIVATIVES AND THEIR USE FOR THE PREPARATION OF 99mTc COMPLEXES FOR IMAGING |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3155669A (en) * | 1962-06-22 | 1964-11-03 | Res Lab Dr C Janssen N V | 2, 4, 8-triaza-spiro (4, 5) dec-2-enes |
| AT253507B (de) * | 1963-06-20 | 1967-04-10 | Janssen Pharmaceutica Nv | Verfahren zur Herstellung von neuen Triazaspiro-(4,5)-decanen und ihren Säureadditionssalzen |
| US3238216A (en) * | 1963-06-20 | 1966-03-01 | Res Lab Dr C Janssen N V | Substituted 1, 3, 8-triaza-spiro (4, 5) decanes |
| JPS5755714B2 (ko) * | 1972-03-18 | 1982-11-25 | ||
| JPS4914476A (ko) * | 1972-06-07 | 1974-02-07 | ||
| JPS5760335B2 (ko) * | 1972-06-14 | 1982-12-18 | Sumitomo Chemical Co | |
| JPS5053845A (ko) * | 1973-09-12 | 1975-05-13 | ||
| JPS5995288A (ja) * | 1982-11-22 | 1984-06-01 | Sumitomo Chem Co Ltd | 新規な放射性ヨ−ドスピロペリド−ルおよびその製造法 |
| US4656280A (en) * | 1984-03-07 | 1987-04-07 | E. I. Du Pont De Nemours And Company | Radioiodinated dopamine receptor ligand |
| WO1985005359A1 (en) * | 1984-05-22 | 1985-12-05 | Sumitomo Chemical Company, Limited | Novel radioactive iodospiroperidol and process for its preparation |
| JPS6248684A (ja) * | 1985-08-26 | 1987-03-03 | Sumitomo Chem Co Ltd | 新規なヨ−ドブチロフエノン誘導体およびその製造法 |
-
1986
- 1986-12-26 JP JP61314256A patent/JPH085882B2/ja not_active Expired - Fee Related
-
1987
- 1987-12-01 AU AU81979/87A patent/AU597447B2/en not_active Ceased
- 1987-12-04 US US07/128,821 patent/US4945162A/en not_active Expired - Lifetime
- 1987-12-08 CA CA000553781A patent/CA1287357C/en not_active Expired - Fee Related
- 1987-12-15 DE DE8787311018T patent/DE3764356D1/de not_active Expired - Fee Related
- 1987-12-15 EP EP87311018A patent/EP0275666B1/en not_active Expired - Lifetime
- 1987-12-26 KR KR1019870014963A patent/KR950008315B1/ko not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU8197987A (en) | 1988-06-30 |
| EP0275666B1 (en) | 1990-08-16 |
| CA1287357C (en) | 1991-08-06 |
| EP0275666A1 (en) | 1988-07-27 |
| JPS63165384A (ja) | 1988-07-08 |
| JPH085882B2 (ja) | 1996-01-24 |
| US4945162A (en) | 1990-07-31 |
| KR950008315B1 (ko) | 1995-07-27 |
| DE3764356D1 (de) | 1990-09-20 |
| AU597447B2 (en) | 1990-05-31 |
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| FPAY | Annual fee payment |
Payment date: 20040723 Year of fee payment: 10 |
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