KR880006198A - 2,6-디아미노-3- 할로벤질피리딘, 이의 제조방법 및 이의 약제학적 용도 - Google Patents

2,6-디아미노-3- 할로벤질피리딘, 이의 제조방법 및 이의 약제학적 용도 Download PDF

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Publication number
KR880006198A
KR880006198A KR870012410A KR870012410A KR880006198A KR 880006198 A KR880006198 A KR 880006198A KR 870012410 A KR870012410 A KR 870012410A KR 870012410 A KR870012410 A KR 870012410A KR 880006198 A KR880006198 A KR 880006198A
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KR
South Korea
Prior art keywords
acid addition
physiologically acceptable
acceptable acid
formula
compound
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Application number
KR870012410A
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English (en)
Inventor
에미크 페터
엥겔 위르겐
쉐플러 게르하르트
하인리히 바이숴 카알
닉켈 베른트
Original Assignee
게르하르트 노바크, 후베르트 보프
아스타 파르마 아크티엔게젤샤프트
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Application filed by 게르하르트 노바크, 후베르트 보프, 아스타 파르마 아크티엔게젤샤프트 filed Critical 게르하르트 노바크, 후베르트 보프
Publication of KR880006198A publication Critical patent/KR880006198A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

2,6-디아미노-3-할로벤질피리딘, 이의 제조방법 및 이의 약제학적 용도
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (6)

  1. 다음 일반식(I)의 2,6-디아미노-3-할로벤질피리딘 및 생리학적으로 허용가능하는 이의 산부가염.
    상기식에서, R1은 불소이고, R2는 수소 또는 염소이다.
  2. 2,6-디아미노피리딘을 다음 일반식(Ⅱ)의 아릴알킬할라이드와 반응시키거나, 알칼리알콜레이트의 존재하에서 다음 일반식(Ⅲ)의 아릴알킬아민과 반응시킴을 특징으로하여 다음 일반식(I)의 2,6-디아미노-3-할로벤질피리딘 및 생리학적으로 허용가능한 이의 산부가염을 제조하는 방법.
    상기식에서, R1은 불소이고, R2는 수소 또는 염소이며, R3는 C1-C4알킬이고, X는 할로겐이다.
  3. 활성 성분으로서 일반식(I)의 화합물 또는 생리학적으로 허용가능한 이의 산부가염을 통상적인 불활성 물질 및/또는 담체물질과의 혼합물로 함유하는 약제학적 제제.
  4. 일반식(I)의 화합물 또는 생리학적으로 허용가능한 이의 산부가염을 통상적인 약제학적 불활성물질 및/또는 담체물질을 사용하여 통상적인 약제학적 투여형태로 제조함을 특징으로 하여 제3항에 따르는 약제학적 제제를 제조하는 방법.
  5. 인체의 통증 및 발열상태를 치료하기 위한 일반식 (I)의 화합물 및 생리학적으로 허용가능한 이의 산부가염의 용도.
  6. 인체의 통증 및 발열상태를 치료하는 약제를 제조하기 위한 일반식(I)의 화합물 또는 생리학적으로 허용 가능한 이의 산부가염의 용도.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR870012410A 1986-11-06 1987-11-05 2,6-디아미노-3- 할로벤질피리딘, 이의 제조방법 및 이의 약제학적 용도 KR880006198A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19863637829 DE3637829A1 (de) 1986-11-06 1986-11-06 Neue 2,6-diamino-3-halogenobenzylpyridine und verfahren zu ihrer herstellung sowie ihre verwendung in pharmazeutika
DEP3637829.1 1986-11-06

Publications (1)

Publication Number Publication Date
KR880006198A true KR880006198A (ko) 1988-07-22

Family

ID=6313302

Family Applications (1)

Application Number Title Priority Date Filing Date
KR870012410A KR880006198A (ko) 1986-11-06 1987-11-05 2,6-디아미노-3- 할로벤질피리딘, 이의 제조방법 및 이의 약제학적 용도

Country Status (16)

Country Link
US (1) US4851420A (ko)
EP (1) EP0266711A1 (ko)
JP (1) JPS63132875A (ko)
KR (1) KR880006198A (ko)
CN (1) CN87106966A (ko)
AU (1) AU596708B2 (ko)
DD (2) DD276280A5 (ko)
DE (1) DE3637829A1 (ko)
DK (1) DK581487A (ko)
FI (1) FI874875A (ko)
HU (1) HU197882B (ko)
IL (1) IL84366A0 (ko)
NO (1) NO874617L (ko)
PL (1) PL149462B1 (ko)
PT (1) PT86085B (ko)
ZA (1) ZA878324B (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6943034B1 (en) * 1991-11-22 2005-09-13 Affymetrix, Inc. Combinatorial strategies for polymer synthesis
CN102285887A (zh) * 2011-06-28 2011-12-21 中国科学技术大学 一种制备硝基取代的二苯甲烷及其衍生物的方法
CN111683660A (zh) * 2018-02-05 2020-09-18 斯特拉斯堡大学 用于治疗疼痛的化合物和组合物
JP2022543460A (ja) 2019-08-06 2022-10-12 ドメイン・セラピューティクス 神経ペプチドｆｆ受容体アンタゴニストとしての５－ヘテロアリール－ピリジン－２－アミン化合物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3954782A (en) * 1972-06-22 1976-05-04 Cassella Farbwerke Mainkur Aktiengesellschaft 2,6-Hydrazino-3-pyridine carboxyamides
DE2514558A1 (de) * 1974-04-12 1975-10-23 Sandoz Ag Neue organische verbindungen und verfahren zu deren herstellung

Also Published As

Publication number Publication date
FI874875A (fi) 1988-05-07
US4851420A (en) 1989-07-25
FI874875A0 (fi) 1987-11-04
PL268592A1 (en) 1988-10-13
AU8082687A (en) 1988-05-12
PT86085B (pt) 1990-11-20
JPS63132875A (ja) 1988-06-04
DE3637829A1 (de) 1988-05-11
PT86085A (de) 1987-12-01
HUT45502A (en) 1988-07-28
NO874617L (no) 1988-05-09
HU197882B (en) 1989-06-28
EP0266711A1 (de) 1988-05-11
DK581487D0 (da) 1987-11-05
NO874617D0 (no) 1987-11-05
AU596708B2 (en) 1990-05-10
CN87106966A (zh) 1988-08-31
DK581487A (da) 1988-05-07
IL84366A0 (en) 1988-04-29
DD270903A5 (de) 1989-08-16
DD276280A5 (de) 1990-02-21
PL149462B1 (en) 1990-02-28
ZA878324B (en) 1988-05-03

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