KR880005120A - 불안해소제 및 우울증 치료제로서의 가교된 비사이클릭 이미드 - Google Patents
불안해소제 및 우울증 치료제로서의 가교된 비사이클릭 이미드 Download PDFInfo
- Publication number
- KR880005120A KR880005120A KR870011634A KR870011634A KR880005120A KR 880005120 A KR880005120 A KR 880005120A KR 870011634 A KR870011634 A KR 870011634A KR 870011634 A KR870011634 A KR 870011634A KR 880005120 A KR880005120 A KR 880005120A
- Authority
- KR
- South Korea
- Prior art keywords
- compound
- crosslinked bicyclic
- anxiolytics
- antidepressants
- crosslinked
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (10)
- 다음 일반식 (I)의 가교 결합된 비사이클릭 이미드 화합물 및 그의 약제학적으로 허용되는 산-부가염.[일반식 I]상기식에서 R1및 R2는 각각 H 또는 CH3이고 : R3는 H 또는 F이며 : (a) X는 CH2· CH2CH2또는CH2CH2CH2이고 : Y는 CH2·CH(CH3)· CH(CH3)2· C(CH2)4또는 CH2CH2이거나 : (b) X는 CH=CH· CH2CH(CH3) 또는 CH2C(CH3)2이고: Y는 CH2이다.
- 제1항에 있어서, R3가 H이고 : X가 CH2·CH2CH2또는 CH2CH2CH2이며 : X가 CH2·C(CH2)2·C(CH2)4또는 CH2CH2인 화합물.
- 제2항에 있어서, X가 CH1CH 인 화합물.
- 제3항에 있어서, R1및 R2가 각각 H이고 Y가 CH2인 화합물.
- 제3항에 있어서, R1이 CH3이고 R2가 H이며 Y가 C(CH3)2인 화합물.
- 제5항에 있어서, 3-(4-[4-(2-피리미디닐)-1-피페라지닐]부틸)-1,8,8-트리메틸-3-아자비사이클로[3,2,1]옥탄-2,4-디온의 우회전성 이성체인 화합물.
- 제1항에 있어서, R1이 CH3이고 R2가 H이며, R3가 F이고, X가 CH2CH2이며 Y가 C(CH3)2인 화합물.
- 제1항에 있어서, R3가H이고 : X가 CH=CH· CH2CH(CHx) 또는 CH2C(CH3)2이며 : Y가 CH2인화합물.
- 제8항에 있어서, R1및 R2가 각각 H이고 X가 CH2CH(CH3)인 화합물.
- 약제학적으로 허용되는 담체 및 제1항에 따르는 가교된 비사이클릭 아미드 화합물로 이루어진 약제학적 조성물.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
USPCT/US86/02224 | 1986-10-21 | ||
US02224 | 1986-10-21 | ||
PCT/US1986/002224 WO1988003024A1 (en) | 1986-10-21 | 1986-10-21 | Bridged bicyclic imides as anxiolytics and antidepressants |
Publications (2)
Publication Number | Publication Date |
---|---|
KR880005120A true KR880005120A (ko) | 1988-06-28 |
KR900000565B1 KR900000565B1 (ko) | 1990-01-31 |
Family
ID=22195680
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019870011634A KR900000565B1 (ko) | 1986-10-21 | 1987-10-20 | 불안해소제 및 우울증 치료제로서의 가교된 비사이클릭 이미드 |
Country Status (26)
Country | Link |
---|---|
EP (1) | EP0268369B1 (ko) |
JP (1) | JPS63112581A (ko) |
KR (1) | KR900000565B1 (ko) |
CN (1) | CN1015987B (ko) |
AT (1) | ATE66222T1 (ko) |
AU (1) | AU579963B2 (ko) |
DD (1) | DD263531A5 (ko) |
DE (1) | DE3772158D1 (ko) |
DK (1) | DK547487A (ko) |
EG (1) | EG18718A (ko) |
ES (1) | ES2031517T3 (ko) |
FI (1) | FI90775C (ko) |
GR (1) | GR3002483T3 (ko) |
HU (1) | HU198203B (ko) |
IE (1) | IE60378B1 (ko) |
IL (1) | IL84206A (ko) |
MX (1) | MX8898A (ko) |
MY (1) | MY101833A (ko) |
NO (1) | NO882715L (ko) |
NZ (1) | NZ222229A (ko) |
PH (1) | PH23806A (ko) |
PL (1) | PL149172B1 (ko) |
PT (1) | PT85944B (ko) |
WO (1) | WO1988003024A1 (ko) |
YU (1) | YU45461B (ko) |
ZA (1) | ZA877863B (ko) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4748240A (en) * | 1987-04-03 | 1988-05-31 | American Home Products Corporation | Psychotropic bicyclic imides |
US4810789A (en) * | 1987-08-28 | 1989-03-07 | Bristol-Myers Company | Process for buspirone hydrochloride polymorphic crystalline form conversion |
WO1990002552A1 (en) * | 1988-09-16 | 1990-03-22 | Pfizer Inc. | Antipsychotic 4-[4-(3-benzisothiazolyl)-1-piperazinyl]butyl bridged bicyclic imides |
SU1825501A3 (ru) * | 1990-10-29 | 1995-12-10 | И.В. Комиссаров | Dl-3-[(4-[4- (2-пиридил)-1- пиперазинил]бутил)] -1,8,8-триметил -3-азабицикло[3,2,1] октан-2,4-диона дигидрохлорид, проявляющий противотревожную, нейролептическую и противорвотную активность |
CN101906107B (zh) * | 2010-08-02 | 2012-12-26 | 南京林业大学 | 一种由α-蒎烯合成樟脑酸酐的方法 |
EP3610890A1 (en) | 2012-11-14 | 2020-02-19 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4006233A (en) * | 1974-10-04 | 1977-02-01 | Merck & Co., Inc. | N-(pyrimidinyl)-tricyclo[3(or 4).2.2.02,4(or 5) ]-non (or dec)ene-dicarboximides |
US4173646A (en) * | 1974-10-04 | 1979-11-06 | Merck & Co., Inc. | Tricyclicdicarboximides |
US4182763A (en) * | 1978-05-22 | 1980-01-08 | Mead Johnson & Company | Buspirone anti-anxiety method |
US4524206A (en) * | 1983-09-12 | 1985-06-18 | Mead Johnson & Company | 1-Heteroaryl-4-(2,5-pyrrolidinedion-1-yl)alkyl)piperazine derivatives |
US4562255A (en) * | 1984-03-30 | 1985-12-31 | American Home Products Corporation | Substituted bi-alicyclic imides |
JPS61238784A (ja) * | 1985-04-17 | 1986-10-24 | Sumitomo Seiyaku Kk | コハク酸イミド誘導体及びその酸付加塩 |
DE3529872A1 (de) * | 1985-08-21 | 1987-02-26 | Kali Chemie Pharma Gmbh | Neue tetraoxoverbindungen |
-
1986
- 1986-10-19 DD DD86308077A patent/DD263531A5/de not_active IP Right Cessation
- 1986-10-21 HU HU865457A patent/HU198203B/hu not_active IP Right Cessation
- 1986-10-21 WO PCT/US1986/002224 patent/WO1988003024A1/en active IP Right Grant
- 1986-10-21 MX MX889887A patent/MX8898A/es unknown
-
1987
- 1987-01-21 IE IE283587A patent/IE60378B1/en not_active IP Right Cessation
- 1987-09-01 MY MYPI87001503A patent/MY101833A/en unknown
- 1987-10-13 DE DE8787309018T patent/DE3772158D1/de not_active Expired - Fee Related
- 1987-10-13 ES ES198787309018T patent/ES2031517T3/es not_active Expired - Lifetime
- 1987-10-13 EP EP87309018A patent/EP0268369B1/en not_active Expired - Lifetime
- 1987-10-13 AT AT87309018T patent/ATE66222T1/de not_active IP Right Cessation
- 1987-10-19 IL IL84206A patent/IL84206A/xx not_active IP Right Cessation
- 1987-10-19 PT PT85944A patent/PT85944B/pt unknown
- 1987-10-19 YU YU1920/87A patent/YU45461B/xx unknown
- 1987-10-19 PH PH35953A patent/PH23806A/en unknown
- 1987-10-19 EG EG60187A patent/EG18718A/xx active
- 1987-10-19 PL PL1987268296A patent/PL149172B1/pl unknown
- 1987-10-20 DK DK547487A patent/DK547487A/da not_active Application Discontinuation
- 1987-10-20 CN CN87107107A patent/CN1015987B/zh not_active Expired
- 1987-10-20 ZA ZA877863A patent/ZA877863B/xx unknown
- 1987-10-20 NZ NZ222229A patent/NZ222229A/xx unknown
- 1987-10-20 KR KR1019870011634A patent/KR900000565B1/ko not_active IP Right Cessation
- 1987-10-20 AU AU79946/87A patent/AU579963B2/en not_active Ceased
- 1987-10-21 JP JP62266153A patent/JPS63112581A/ja active Granted
-
1988
- 1988-06-20 FI FI882942A patent/FI90775C/fi not_active IP Right Cessation
- 1988-06-20 NO NO88882715A patent/NO882715L/no unknown
-
1991
- 1991-08-16 GR GR91401123T patent/GR3002483T3/el unknown
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