KR880002184B1 - Feed additive composition - Google Patents

Abstract

A fodder-aid composition for ruminants is presented. Thus, pellets were made from a mixt. contg. 25 wt.% DL-methionine, 25 wt.% stearic acid, and 50 wt.% CaCO3. As a result of an elution test, 17% of methionine was eluted in an artificial 1st stomach and 84% was eluted in an artificial 4th stomach.

Description

Feed additive composition

The present invention relates to a feed additive composition for ruminants. In particular, the present invention relates to a feed additive composition characterized by protecting at least one substance effective on a ruminant, almost invariably passing through the first position of the ruminant and eluting in an organ below the fourth position.

Ruminants co-exist with various microorganisms on the first stomach and, by their action, digest and use cellulose-like components that are not originally available to higher animals. The presence and function of the first stomach is of great significance for ruminants. Recently, however, the physiological and / or nutritional studies of ruminants point out the existence of the first place as one of the factors limiting the productivity of ruminants. As a result, studies have been conducted to more efficiently use effective substances by passing one or more substances effective to ruminants which do not want to be decomposed in the first stomach almost invariably through the first stomach and by decomposing and absorbing in the organs below the fourth stomach. There is also a desire to develop a technology that passes the first place from the livestock industry seeking efficient management, and some technologies have already been submitted, but none are believed to be sufficient. For example, German Patent No. 2212568 discloses a biologically effective coating with an aliphatic monocarboxylic acid or ricinoleic acid having 14 to 22 carbon atoms or with a coating of an acid mixture or a salt of the acid or acid mixture. Represents a substance.

On the other hand, Japanese Patent Publication No. 1057/1981 discloses a biologically active substance coated with a matrix composed of a mixture of saturated linear or branched substituted or unsubstituted aliphatic monocarboxylic acids or salts having at least 14 carbon atoms. .

In addition, Japanese Patent Application Laid-Open No. 154956/1981 discloses a coated biologically active particle material containing a salt of an aliphatic monocarboxylic acid having 14 to 22 carbon atoms or a mixture of several kinds thereof. Japanese Patent Laid-Open No. 175449/1983 also contains chitosan and one or more substances selected from linear or branched saturated or unsaturated monocarboxylic acids having 14 to 22 carbon atoms, cured vegetable fats and cured animal fats. It shows a biologically active substance coated with a protective substance.

In addition, German Federal Patent No. 2212568 and Japanese Patent Publication No. 1057/1981 expect that the collapse of the coating material is performed below the small intestine, so that the time used for digestion and absorption is limited, and digestion absorption is sufficiently performed. Has no drawbacks. In addition, Japanese Patent Laid-Open Publication Nos. 154956/1981 and 175449/1983 use a coating material which disintegrates in the fourth stomach and elutes one or more substances effective for ruminants in order to overcome the above-mentioned drawbacks. Elution in the stomach is not sufficient, and the effect cannot be said to be stable. That is, there is no satisfactory feed additive yet to pass through the first stomach and elute at the fourth stomach or less.

It is an object of the present invention to reduce the loss of one or more substances (eg, amino acids, proteins, vitamins, enzymes, carbohydrates, animal drugs, hormones, etc.) effective for ruminants in the first stomach to the fourth and lower A feed additive composition that is effective for ruminants to reach them in the fourth stomach for digestion and / or absorption in the digestive tract and which is not desirable to disintegrate in the first stomach may be protected to enhance the utilization of the active substance. To provide.

In the present invention, the acidic lower than hydrochloric acid based on the total weight of the feed additive composition is 20% by weight or more of non-aqueous salt of acid, which is acceptable to ruminants and saturated or unsaturated monocarboxylic acid having 14 or more carbon atoms, melting point 40 ℃ or more The excellent feed additive composition can be obtained by granulating one or more substances effective for ruminants with at least 10% by weight of one or more substances selected from animal fats and oils, vegetable fats of 40 ° C. or higher and waxes of 40 ° C. or higher.

Animals targeted by the feed additive composition of the present invention are ruminants, and representative examples thereof include beef cattle, dairy cows, calves, sheep and goats.

As used herein, the term "one or more substances effective for ruminants" refers to nutrients, feeds, and drugs that are not digested in the first stomach and are desired to be effectively absorbed into the body of the ruminant in the fourth and lower digestive tracts. Examples of such substances include amino acids, amino acid derivatives, proteins, vitamins, enzymes, carbohydrates, livestock drugs, hormones, and the like. Representative examples thereof include methionine, lysine, threonine, leucine, isoleucine, phenylalanine, valine and glycine as amino acids; As amino acid derivatives N-acylamino acids, such as calcium salts of N-stearoyl methionine, N-oleoylmethionine, N-hydroxyethylmethionine, lysine hydrochloride, methionine hydroxy analogs and sodium glutamate; Feather protein, fish meal, casein, corn protein and potato protein as proteins; As vitamin A vitamin A _I , vitamin A palmitate, vitamin A acetate, β-carotene, vitamin D ₂ , vitamin D ₃ , vitamin E, sodium sulfite in menadione, vitamin B group (thiamine, thiamine hydrochloride, riboflavin, nicotinic acid, nicotinic acid Amides, calcium pantothenate, pyridoxine hydrochloride, choline chloride, cyanocobalamin, biotin, folic acid and p-aminobenzoic acid; as enzymes proteases, amylases, mixed enzymes and lipases; starch, glucose and sucrose as carbohydrates; for livestock As drugs, antibiotics (e.g. tetracycline, aminoglycosides, macrolides, polypeptides, polysaccharides and polyethers), insect repellents (e.g. negphones) and insect repellents (e.g. piperazine salts) As hormones are estrogen hormones (eg estrogen, stilbestrol and hexestrol) and thyroid hormones (eg tyrotropin and high estrogen).

Usually these active substances are used alone, but a mixture of two or more kinds can also be used.

As mentioned above, the present invention may also use non-aqueous salts of acids that are less acidic than hydrochloric acid and are acceptable to ruminants. Examples of such non-aqueous salts include calcium carbonate, tertiary calcium phosphate, secondary calcium phosphate, tertiary magnesium phosphate, zinc phosphate, aluminum phosphate, calcium silicate, calcium pyrophosphate, magnesium carbonate, lead carbonate, and cobalt carbonate. Usually these are used alone but mixtures of two or more may be used.

In the present invention, the non-aqueous salt is used in more than 20% by weight based on the total weight of the feed additive composition. Less than 20% by weight makes the active substance or substances difficult to elute in the fourth stomach. In the case of increasing these extremes, the effective amount becomes less, and sufficient effect is not obtained by the practice of the present invention.

Meanwhile, the content of one or more substances selected from straight or branched saturated or unsaturated monocarboxylic acids having 14 or more carbon atoms and salts thereof, animal fats having a melting point of 40 ° C or higher, vegetable fats having a melting point of 40 ° C or higher, and waxes having a melting point of 40 ° C or higher Is at least 10% by weight based on the total weight of the feed additive composition. If the content is less than 10% by weight, the stability of the substance effective on the ruminant in the first stomach is lowered to obtain a sufficient effect. In addition, if the content is excessively large, the content of the effective substance is lowered and the problem of difficulty in dissolution in the fourth stomach appears, and thus, sufficient effects cannot be obtained.

Useful methods for the granulation of the feed additive composition of the present invention include a rolled granulation method, an extrusion granulation method, a compression granulation method such as a tableting method, a melt granulation method, a spray granulation method, a fluid granulation method, a pulverized granulation method, and a stirred granulation method. . By using one of these granulation methods, the feed additive composition of the present invention can be prepared in pellet, particle or tablet form. In some cases, binders and the like may be mixed.

Feed additive composition of the present invention is usually used by adding directly to the dead site, but may be added and mixed in advance, such as when preparing a compound feed.

As described above, the feed additive composition of the present invention passes through the first stomach of the ruminant, has excellent properties of eluting from the fourth stomach or lower organ, and the calcium carbonate contained therein is effective as its own calcium source. It is extremely useful.

[Examples 1 to 4 and Comparative Example 1]

After stearic acid and the non-aqueous salt of the composition shown in Table 1 were mixed closely in a ribbon mixer DL-methionine, pellets having a diameter of 2 mm and a length of 3 mm were prepared by a pelletizer. The resulting pellet-type feed additive composition was used for the dissolution test of DL-methionine under artificial first gastric juice and artificial fourth gastric juice. 0.1 N hydrochloric acid was used as the artificial first gastric juice. In the dissolution test, 5 g of the pellet prepared above was immersed in a Erlenmeyer flask containing 100 ml of artificial first gastric fluid or artificial fourth gastric fluid, maintained at 39 ° C. in a vibrator, and then vibrated from the pellets with DL-methionine. The amount was measured by iodine titration. The vibration time was 10 hours for the artificial first gastric juice and 3 hours for the artificial fourth gastric juice.

The composition of an Example and a comparative example and the result of the dissolution test in an Example and a comparative example are shown in Table 1. In these examples, "parts" and "%" are by weight.

[Examples 5 and 6]

Nicotinic acid amide containing pellets were prepared in the same manner as in Examples 1 to 4. The amount of nicotinic acid eluted in artificial first gastric and fourth gastric juice was measured by measuring the respective N content according to the Kjeldahl method. The composition and the results are shown in Table 2.

TABLE 1

* Expressed as% of eluted DL-methionine in the total amount of DL-methionine

** Grade 3 Calcium Phosphate

*** Grade 2 Calcium Phosphate

TABLE 2

* Expressed as% of nicotinic acid amide eluted in the total amount of nicotinic acid amide

[Examples 5 to 8 and Comparative Examples 2 and 3]

DL-methionine, 54 ° C. hardened oil, and calcium carbonate were mixed in a ribbon mixer in the ratio shown in Table 1, and pellets having a diameter of 2 mm and a length of 3 mm were prepared using a pelletizer.

The dissolution test of DL-methionine was conducted under artificial first gastric juice and artificial fourth gastric juice by using the obtained pellet-type feed additive composition. 0.1 mol sodium phosphate buffer was used as artificial first gastric juice and 0.1 N hydrochloric acid was used as artificial fourth gastric juice. Each dissolution test was carried out in the following manner. That is, 5 g of the prepared pellet was immersed in 100 ml of the artificial first gastric or fourth gastric liquid placed in an Erlenmeyer flask. It was then maintained at 39 ° C. in a vibrator. After vibrating for a predetermined time, the amount of DL-methionine eluted from the pellet into the liquid was measured by iodine titration. The first gastric juice was vibrated for 10 hours and the fourth artificial gastric juice was vibrated for 3 hours.

The composition and dissolution test results of Examples and Comparative Examples are summarized in Table 3.

Example 9

Pellets were prepared in the same manner as in Examples 1-4 using 25% DL-methionine, 25% stearic acid and 50% calcium carbonate. The pellet was tested for dissolution. The amount of eluted methionine was 17% in artificial first gastric juice and 84% in artificial fourth gastric juice.

EXAMPLES 10 AND 11

Pellets containing nicotinic acid amide were prepared in the same manner as in Examples 5-9. The dissolution test was carried out with pellets. The amount of nicotinic acid amide eluted was determined by measuring the N content in the artificial first and fourth gastric juices according to the Kjeldahl method.

The composition and the results are shown in Table 4.

TABLE 3

* Expressed as% of eluted DL-methionine in the total amount of DL-methionine.

TABLE 4

* Expressed as% of nicotinic acid amide eluted in the total amount of nicotinic acid amide.

Claims (2)

A feed addition comprising at least one substance that is effective for ruminants and that can almost pass through the first stomach of the ruminant is a composition wherein the acidity is lower than hydrochloric acid and acceptable to ruminants based on the total weight of the feed addition composition. 1 or more selected from linear or branched, saturated or unsaturated monocarboxylic acids having at least 20% by weight of non-aqueous salt of acid and 14 or more carbon atoms, animal fat having a melting point of 40 ° C, vegetable fat of 40 ° C or higher, and wax of 40 ° C or higher. Feed additive composition, characterized in that composed of more than 10% by weight of the total material on the paper and granulated. The feed additive composition according to claim 1, wherein the non-aqueous salt is calcium carbonate.