NL8500157A - FEED ADDITIVE. - Google Patents

Description

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Feed additive el.

The invention relates to a feed additive for ruminants. These are in particular a feed additive 5 which protects one or more substances important to a ruminant in such a way that they pass the gelding almost unchanged in order to be able to dissolve in the abomasum and subsequent channel.

A ruminant allows a number of different microorganisms to live in symbiosis in its rumen and uses their action to digest and consume components such as cellulose, which cannot be consumed by higher animals by themselves. The existence and function of the rumen are extremely important to the ruminant. Physiological and / or nutricological research on ruminants has shown that the existence of rumens is one of the causes of the limited productivity of ruminants in recent years. As a result, it is now being investigated on a large scale whether one or more substances of interest to a ruminant, the consumption of which is undesirable in the rumen, can be passed virtually unchanged through the rumen and into the abomasum and the subsequent digestive tract. can disintegrate and absorb, so that the important substances can be used more efficiently. There is also still a need to develop a technique to improve animal husbandry which allows the virtually unchanged passage of such important substances through the rumen. Some techniques have already been proposed. However, none of these techniques seem to be fully effective. For example, German Patent 22 12 568 describes a biologically effective granular material, which is coated with an aliphatic monocarboxylic acid of 14-22 carbon atoms or ricinoleic acid or with coating films of such an acid mixture or a salt of such an acid or acid mixture.

On the other hand, Japanese Patent Publication 1057/1981 discloses a biologically active substance, which is coated with a matrix formed from a saturated straight or branched, unsubstituted or substituted aliphatic monocarboxylic acid with at least 14 carbon atoms or 8,500,157 MW. 2 - a salt thereof, or a mixture of the saturated acid or its salt and an unsaturated straight or branched chain unsubstituted or substituted aliphatic monocarboxylic acid with at least 14 carbon atoms or a salt thereof.

Japanese patent 154956/1981 discloses a biologically active granular material comprising coating films comprising an aliphatic monocarboxylic acid with 14-22 carbon atoms or a mixture of salts of some aliphatic monocarboxylic acids with 14-22 carbon contain atoms. Reference may also be made to Japanese Patent Application No. 175449/1983, which discloses a biologically active substance enclosed by protective film coatings comprising one or more straight or branched chain monocarboxylic acids, hydrogenated or unsaturated, fats and / or hydrogenated animal fats and / or chitosan.

The methods of German patent 22 12 568 and the

Japanese patent publication 1057/1981, however, have the drawback that the time available for digestion and absorption is insufficient for sufficient digestion and absorption, because they mainly aim to cause the degradation of the coatings in the small intestine and the subsequent digestive tract. In Japanese Patent Laid-Open Nos. 154956/1981 and 175449/1983, to overcome the above drawbacks, coatings are used which disintegrate in order to dissolve one or more substances of importance to ruminants in the abomasum. However, the effect of these methods is not constant, since the degradation of the coatings in the abomasum is not sufficient. Thus, there is not yet a satisfactory feed additive that can be passed through the rumen unchanged and dissolved in the abomasum and subsequent digestive tract.

The invention now relates to a feed additive which can protect one or more substances important to ruminants, for example amino acids, proteins, vitamins, enzymes, carbohydrates, medicines, hormones, etc. against consumption in the rumen such that they can protect the abomasum ranges for digestion and / or absorption in the abomasum and subsequent digestive 8500157 ------———— ^ - 3 -! channel with the least possible loss in the rumen, thereby improving the useful effect of such substances.

According to the invention, such a feed additive can now be obtained by granulating one or more ruminant substances with a water-insoluble salt of an acid which is less acidic than hydrochloric acid and which is acceptable to the ruminant in an amount of at least / wt%, based on the total weight of the feed additive and at least one straight or branched monocarboxylic acid, whether or not saturated, with at least 14 carbon atoms or a salt thereof, an animal fat with a melting point of at least 40 ° C, a vegetable fat with a melting point of at least 40 ° C and / or a wax with a melting point of at least 40 ° C, in a total amount of at least 10% by weight, based on the total weight of the feed additive.

The feed additive of the invention can be administered to ruminants, including as good examples fat pastures, dairy cattle, calves, sheep, goats, etc.

The term "at least one ruminant substance" or "one or more ruminant substances" means nutrients and / or drugs which are readily effective in the abomasum and subsequent digestive tract as such in the body of the ruminant. want to absorb ruminant without being subjected to consumption in the rumen. Examples of such substances are amino acids, amino acid derivatives, proteins, vitamins, enzymes, carbohydrates, medicines, hormones, etc. Representative examples are: amino acids such as methionine, lysine, threonine, leucine, isoleucine, phenylalanine, valine and glycine, amino acid derivatives such as N-acylamino acids, for example N-stearo-ylmethionine, N-oleolylmethionine, the calcium salt of N-hydroxyme-30-methylhydionine, lys , methionine hydroxy analogues and sodium glutamate, proteins such as feather meal, fish meal, casein, corn protein and potato protein, vitamins such as vitamin, vitamin A palmitate, vitamin A acetate, ^ 0-carotene, vitamin D £, vitamin D ^, vitamin E, menadione sodium bisulfite , a group of vitamins B (aneurine, aneurine hydrochloride, riboflavin, nicotinic acid, nicotinic acid - 85 0 0 1 5 7 - 4 - amide, calcium pantothenate, pyridoxine hydrochloride, choline chloride, cyanobalamin, biotin, folinic acid and p-aminobenzoic acid), enzymes such as protease preparation, amylsase preparation, mixed enzyme preparation and lipase preparation, carbohydrates such as starch, glucose and sucrose, 5 medicines such as antibiotics tics, such as tetracyclines, aminoglycosides, macrolides, polypeptides, polysaccharides and polyethers, such as Negphone and antiparasitics, such as piperazine salts and hormones such as estrogen, stilboestrol and hexoestrol and thyroid hormones, such as tyrotropin and goit.

Usually such important substances are used alone. However, they can also use two or more such important substances in combination as a mixture. As already stated, the invention uses a water-insoluble salt of an acid which is less acidic than hydrochloric acid and which is acceptable for a ruminant animal. Examples of such a water-insoluble salt are calcium carbonate, tertiary calcium phosphate, secondary calcium phosphate, tertiary magnesium phosphate, zinc phosphate, aluminum phosphate, calcium silicate, calcium pyrophosphate, magnesium carbonate, lead carbonate, cobalt carbonate, etc. Usually they are used separately. However, a mixture of two or more such exemplary water-insoluble salts can also be used.

In the present invention, the water-insoluble salt is used in an amount of at least 20% by weight, based on the total weight of the feed additive. Amounts less than 25% by weight make the major substance or substances more soluble in the abomasum. However, the salt must not be present in an unusually high concentration, because such a high concentration makes the content of important substance or substances too low to obtain sufficient effect.

On the other hand, the content of at least one straight or branched, saturated or unsaturated monocarboxylic acid with at least 14 carbon atoms or a salt thereof, is animal fat with a melting point of at least 40 ° C, vegetable fat with a melting point of at least 40 ° C or wax with a melting point of at least 40 ° C, at least 10% by weight, based on the total weight of the feed additive. If its content is less than 8500157 ....... -s - 5 - than 10% by weight, the stability of the ruminant material or substances is impaired in such a way that no significant effect occurs. However, if this content were to rise excessively, the content of the major substance or substances would correspondingly decrease and its dissolution in the abomasum would be difficult. The substance or substances could then no longer give any significant effect.

To granulate the feed additive of the invention, use can be made of compaction granulation, such as roll granulation, extrusion granulation and tabletting, melt granulation, spray granulation, flow granulation, grinding granulation and stirring granulation.

In any of these granulation methods, the feed additive of the invention may be formed into pellets, granules or tablets. In some cases, a binder can also be included.

The feed additive of the invention can generally be applied by adding it directly to the feed. However, it can be added beforehand and mixed, for example in the preparation of special feeds.

As already stated, the feed additive of the invention is of great importance from an industrial point of view, since it has such excellent properties that the loss in ruminant rumen is small and the digestion and / or absorption takes place in the abomasum and subsequent alimentary tract and when the water-insoluble salt of the acid, which is less acidic than hydrochloric acid and is acceptable to the ruminant, is calcium carbonate, the calcium carbonate is also an effective calcium source.

Examples I-IV and comparative example 1.

After intimately mixing DL-methionine, stearic acid and a water-insoluble salt, in the respective amounts given in Table A, in a tire mixer, men were 2 mm wide and 3 mm long using pieces of equipment for the production of press pieces. Using the thus obtained pellet-like feed additive, leaching tests of DL-methionine were carried out in an artificial ruminal juice and an artificial abomasal juice. A 0.1 M sodium phosphate buffer was used as the artificial ruminal juice 8 P Π 0 1 5 7 Λ - 6 -. 0.1 N hydrochloric acid was used as an artificial abomasal juice. Each of the leaching tests was performed as follows. 5 g of pellets prepared above were immersed in 100 ml of artificial ruminal or abomasal juice in an Erlenmeyer flask. The whole was then kept in a shaker at 39 ° C. After shaking for a predetermined period, the amount of DL-methionine leached from the pellets into the corresponding juice was measured by iodometric titration. The shaking time was adjusted to 10 hours with artificial ruminal juice and 3 hours with artificial abomasal juice.

The compositions of the examples and of the comparison, the example and the results of the leaching tests in the examples and the comparative example are summarized in table Δ. By these examples and subsequent examples, parts and percent refers to parts by weight and percentages by weight.

15 Examples V and VI.

Nicotinic acid amide-containing pellets were prepared in the same manner as in Examples I-IV. The amounts of leached nicotinic acid amide in the artificial ruminal and abomasal juice were measured by measuring the respective N content according to the Kjeldahl method. Compositions and results are given in Table B.

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Examples VII-X plus comparative examples 2 and 3.

After intimately mixing DL-methionine, 54 ° C hydrogenated oil and calcium carbonate in the amounts specified in Table C respectively in a belt mixer, pellets 5 mm wide and 3 mm long were prepared using a pelletizer . Using the thus obtained pellet-like feed additive, leaching tests on DL-methionine were carried out in an artificial ruminal juice and an artificial abomasal juice. A 0.1 M sodium phosphate buffer was used as the artificial ruminal juice. 0.1 N hydrochloric acid was used as an artificial abomasal juice. Each of the leaching tests was performed as follows. 5 g of pellets prepared above were immersed in 100 ml of artificial ruminal or abomasal juice in an Erlenmeyer flask. The whole was then kept in a shaker at 39 ° C. After shaking for a predetermined period, the amount of DL-methionine leached from the pellets into the corresponding juice was measured by iodometric titration. The shaking time was adjusted to 10 hours with artificial ruminal juice and 3 hours with artificial abomasal juice.

The compositions of the examples and of the comparative examples and the results of the leaching tests in the examples and the comparative examples are summarized in Table C.

Example XI.

Using 25 wt% DL-methionine, 25 wt% stearic acid and 50 wt% calcium carbonate, pellets were prepared in the same manner as in Examples I-IV. A leaching test was carried out on the pellets. The amount of leached methionine was 17% with artificial ruminal juice and 84% with artificial abomasal juice.

Examples XII and XIII.

Nicotinic acid amide-containing pellets were prepared in the same manner as in Examples VII-XI. A leaching test was carried out on the pellets. The amounts of leached nicotinic acid amide were determined by measuring the N content in the artificial ruminal and abomasal juice by the Kjeldahl method. Composition and 35 results are given in Table D.

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Claims (2)

Feed additive containing at least one substance important to a ruminant and able to pass through the ruminant rumen almost unchanged, characterized in that the preparation is furthermore a water-insoluble salt of an acid which is less acidic than hydrochloric acid 5 and the ruminant is acceptable, contains in an amount of at least 20% by weight, based on the total weight of the feed additive, and contains at least one straight or branched monocarboxylic acid, whether or not saturated, with at least 14 carbon atoms or a salt thereof, an animal fat with a melting point of at least 40 ° C, a plant-like nice fat with a melting point of at least 40 ° C and / or a wax with a melting point of at least 40 ° C contains an amount of at least 10% by weight, based on the total weight of the feed additive while the preparation is granulated. 2. Feed additive according to claim 1, characterized in that the water-insoluble salt is calcium carbonate. 8500157