KR880000094B1 - 뉴클레오시드 유도체의 제조방법 - Google Patents

뉴클레오시드 유도체의 제조방법 Download PDF

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Publication number
KR880000094B1
KR880000094B1 KR1019840007754A KR840007754A KR880000094B1 KR 880000094 B1 KR880000094 B1 KR 880000094B1 KR 1019840007754 A KR1019840007754 A KR 1019840007754A KR 840007754 A KR840007754 A KR 840007754A KR 880000094 B1 KR880000094 B1 KR 880000094B1
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KR
South Korea
Prior art keywords
nucleoside
new
corticosteroid
formula
adenine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
KR1019840007754A
Other languages
English (en)
Korean (ko)
Other versions
KR860004919A (ko
Inventor
홍청일
이기홍
김지한
Original Assignee
보령제약 주식회사
김승호
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 보령제약 주식회사, 김승호 filed Critical 보령제약 주식회사
Priority to KR1019840007754A priority Critical patent/KR880000094B1/ko
Priority to KR1019850006039A priority patent/KR880000093B1/ko
Priority to ES549558A priority patent/ES8701192A1/es
Priority to ES549587A priority patent/ES8706163A1/es
Priority to GB08530114A priority patent/GB2168353B/en
Priority to FR8518130A priority patent/FR2574411B1/fr
Priority to FR8518129A priority patent/FR2574412B1/fr
Priority to GB08530115A priority patent/GB2168350B/en
Priority to DE19853543347 priority patent/DE3543347A1/de
Priority to JP60275853A priority patent/JPS61263996A/ja
Priority to JP60275852A priority patent/JPS61197591A/ja
Priority to DE3543346A priority patent/DE3543346C2/de
Publication of KR860004919A publication Critical patent/KR860004919A/ko
Priority to ES557428A priority patent/ES8802363A1/es
Application granted granted Critical
Publication of KR880000094B1 publication Critical patent/KR880000094B1/ko
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/12—Triazine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14—Pyrrolo-pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
KR1019840007754A 1984-12-07 1984-12-07 뉴클레오시드 유도체의 제조방법 Expired KR880000094B1 (ko)

Priority Applications (13)

Application Number Priority Date Filing Date Title
KR1019840007754A KR880000094B1 (ko) 1984-12-07 1984-12-07 뉴클레오시드 유도체의 제조방법
KR1019850006039A KR880000093B1 (ko) 1984-12-07 1985-08-22 뉴클레오시드 유도체의 제조방법
ES549558A ES8701192A1 (es) 1984-12-07 1985-12-04 Procedimiento para la preparacion de nucleosidos
ES549587A ES8706163A1 (es) 1984-12-07 1985-12-05 Procedimiento para la fabricacion de nuevos derivados nu- cleosidos
FR8518130A FR2574411B1 (fr) 1984-12-07 1985-12-06 Nouveaux derives de nucleosides, utiles notamment comme medicaments anticancereux, et leur procede de fabrication
FR8518129A FR2574412B1 (fr) 1984-12-07 1985-12-06 Procede de fabrication de derives de nucleosides utiles notamment comme agents anticancereux
GB08530114A GB2168353B (en) 1984-12-07 1985-12-06 Process for preparing nucleoside derivatives
GB08530115A GB2168350B (en) 1984-12-07 1985-12-06 Nucleoside derivatives
DE19853543347 DE3543347A1 (de) 1984-12-07 1985-12-07 Verfahren zur herstellung von nucleosidderivaten
JP60275853A JPS61263996A (ja) 1984-12-07 1985-12-07 新規ヌクレオシド誘導体およびその製造法
JP60275852A JPS61197591A (ja) 1984-12-07 1985-12-07 ヌクレオシド誘導体の製造方法
DE3543346A DE3543346C2 (de) 1984-12-07 1985-12-07 Verfahren zur Herstellung von Nucleosidkonjugaten
ES557428A ES8802363A1 (es) 1984-12-07 1987-02-27 Procedimiento para la fabricacion de derivados nucleosidos

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019840007754A KR880000094B1 (ko) 1984-12-07 1984-12-07 뉴클레오시드 유도체의 제조방법

Publications (2)

Publication Number Publication Date
KR860004919A KR860004919A (ko) 1986-07-16
KR880000094B1 true KR880000094B1 (ko) 1988-02-23

Family

ID=19236525

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840007754A Expired KR880000094B1 (ko) 1984-12-07 1984-12-07 뉴클레오시드 유도체의 제조방법

Country Status (6)

Country Link
JP (2) JPS61197591A (enrdf_load_stackoverflow)
KR (1) KR880000094B1 (enrdf_load_stackoverflow)
DE (1) DE3543347A1 (enrdf_load_stackoverflow)
ES (1) ES8701192A1 (enrdf_load_stackoverflow)
FR (1) FR2574412B1 (enrdf_load_stackoverflow)
GB (1) GB2168353B (enrdf_load_stackoverflow)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6599887B2 (en) 1988-07-07 2003-07-29 Chimerix, Inc. Methods of treating viral infections using antiviral liponucleotides
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
AP1727A (en) 2000-05-26 2007-03-06 Idenix Cayman Ltd Methods and compositions for treating flaviviruses and pestiviruses.
NZ537662A (en) 2002-06-28 2007-10-26 Idenix Cayman Ltd 2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
JP2006519753A (ja) 2002-11-15 2006-08-31 イデニクス（ケイマン）リミテツド ２’−分枝ヌクレオシドおよびフラビウイルス科ウイルス突然変異
KR20050109918A (ko) 2002-12-12 2005-11-22 이데닉스 (케이만) 리미티드 2'-분지형 뉴클레오시드의 제조 방법
ITFI20040173A1 (it) * 2004-08-03 2004-11-03 Protera S R L Profarmaci attivati da dna polimerasi dipendenti da rna
GB0505781D0 (en) * 2005-03-21 2005-04-27 Univ Cardiff Chemical compounds
TWI464402B (zh) * 2011-01-12 2014-12-11 Univ Kaohsiung Medical 將核酸接上小分子的方法
EP2712868A1 (en) * 2012-09-28 2014-04-02 B. Braun Melsungen AG 5-Fluoruoracil Derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4283394A (en) * 1979-08-06 1981-08-11 Research Corporation Cytotoxic nucleoside-corticosteroid phosphodiesters

Also Published As

Publication number Publication date
ES8701192A1 (es) 1986-12-01
GB2168353B (en) 1988-06-22
KR860004919A (ko) 1986-07-16
GB2168353A (en) 1986-06-18
DE3543347A1 (de) 1986-06-12
GB8530114D0 (en) 1986-01-15
JPS6338360B2 (enrdf_load_stackoverflow) 1988-07-29
FR2574412A1 (fr) 1986-06-13
FR2574412B1 (fr) 1989-06-09
JPH0129800B2 (enrdf_load_stackoverflow) 1989-06-14
DE3543347C2 (enrdf_load_stackoverflow) 1989-11-09
JPS61263996A (ja) 1986-11-21
JPS61197591A (ja) 1986-09-01
ES549558A0 (es) 1986-12-01

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