ES8802363A1 - Procedimiento para la fabricacion de derivados nucleosidos - Google Patents

Procedimiento para la fabricacion de derivados nucleosidos

Info

Publication number
ES8802363A1
ES8802363A1 ES557428A ES557428A ES8802363A1 ES 8802363 A1 ES8802363 A1 ES 8802363A1 ES 557428 A ES557428 A ES 557428A ES 557428 A ES557428 A ES 557428A ES 8802363 A1 ES8802363 A1 ES 8802363A1
Authority
ES
Spain
Prior art keywords
nucleoside derivatives
unsaturated
saturated
alkyl group
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES557428A
Other languages
English (en)
Other versions
ES557428A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boryung Pharmaceutical Co Ltd
Original Assignee
Boryung Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1019840007754A external-priority patent/KR880000094B1/ko
Application filed by Boryung Pharmaceutical Co Ltd filed Critical Boryung Pharmaceutical Co Ltd
Publication of ES8802363A1 publication Critical patent/ES8802363A1/es
Publication of ES557428A0 publication Critical patent/ES557428A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/12—Triazine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14—Pyrrolo-pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Abstract

LOS DERIVADOS NUCLEOSIDOS (I), DONDE NO EXCLUSIVAMENTE A Y C SON HIDROXI, B ADENINA O CITOSINA, W ALQUILO SATURADO O NO C8-20 Y W'' ALQUILO SATURADO O NO C7-19; SE OBTIENEN POR CONDENSACION DE FOSFOLIPIDOS (II) JUNTO CON: A) MORFOLINA EQUIMOLAR O EN EXCESO, PARA DAR MORFOLIDATO DE FOSFOLIPIDO O B) DIFENILPIROFOSFATO EQUIMOLAR O EN EXCESO, PARA DAR EL P1-GLICERO-5''-P2-DIFENILPIROFOSFATO, A TEMPERATURA ENTRE LA AMBIENTE Y LA DE REFLUJO, DURANTE 1 A 4 HORAS Y LUEGO HACIENDO REACCIONAR EL PRODUCTO DE A) O B) CON UN NUCLEOTIDO EQUIMOLAR (III). SON AGENTES ANTICANCEROSOS Y ANTIVIRICOS, QUE PENETRAN EN LA CELULA POR SU LIPOFILIA, DENTRO DE LA CUAL SE SEPARAN EN FOSFOLIPIDO Y NUCLEOTIDO.
ES557428A 1984-12-07 1987-02-27 Procedimiento para la fabricacion de derivados nucleosidos Expired ES8802363A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1019840007754A KR880000094B1 (ko) 1984-12-07 1984-12-07 뉴클레오시드 유도체의 제조방법
KR1019850006039A KR880000093B1 (ko) 1984-12-07 1985-08-22 뉴클레오시드 유도체의 제조방법

Publications (2)

Publication Number Publication Date
ES8802363A1 true ES8802363A1 (es) 1988-06-01
ES557428A0 ES557428A0 (es) 1988-06-01

Family

ID=26627420

Family Applications (2)

Application Number Title Priority Date Filing Date
ES549587A Expired ES8706163A1 (es) 1984-12-07 1985-12-05 Procedimiento para la fabricacion de nuevos derivados nu- cleosidos
ES557428A Expired ES8802363A1 (es) 1984-12-07 1987-02-27 Procedimiento para la fabricacion de derivados nucleosidos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES549587A Expired ES8706163A1 (es) 1984-12-07 1985-12-05 Procedimiento para la fabricacion de nuevos derivados nu- cleosidos

Country Status (5)

Country Link
KR (1) KR880000093B1 (es)
DE (1) DE3543346C2 (es)
ES (2) ES8706163A1 (es)
FR (1) FR2574411B1 (es)
GB (1) GB2168350B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5223263A (en) 1988-07-07 1993-06-29 Vical, Inc. Liponucleotide-containing liposomes
US6252060B1 (en) 1988-07-07 2001-06-26 Nexstar Pharmaceuticals, Inc. Antiviral liponucleosides: treatment of hepatitis B
US6599887B2 (en) 1988-07-07 2003-07-29 Chimerix, Inc. Methods of treating viral infections using antiviral liponucleotides
US5817638A (en) * 1988-07-07 1998-10-06 Nexstar Pharmaceuticals, Inc. Antiviral liponucleosides: treatment of hepatitis B
EP0355016B1 (de) * 1988-08-17 1994-02-09 Clarion Pharmaceuticals, Inc. Verfahren zur Herstellung neuer Cytidin-5'-diphosphat-alkanole und -glycerole
CA2083961A1 (en) * 1990-05-29 1991-11-30 Henk Van Den Bosch Synthesis of glycerol di- and triphosphate derivatives
DE4111730A1 (de) * 1991-04-10 1992-10-15 Knoll Ag Neue cytarabin-derivate, ihre herstellung und verwendung
US5580571A (en) * 1991-10-15 1996-12-03 Hostetler; Karl Y. Nucleoside analogues
US5879700A (en) * 1991-10-15 1999-03-09 Hostetler; Karl Y. Nucleoside analogue phosphates for topical use
US6015573A (en) * 1993-05-12 2000-01-18 Hostetler; Karl Y. Nucleoside phosphate therapy for viral infection
WO1994026273A1 (en) * 1993-05-12 1994-11-24 Hostetler Karl Y Acyclovir derivatives for topical use
US5654286A (en) * 1993-05-12 1997-08-05 Hostetler; Karl Y. Nucleotides for topical treatment of psoriasis, and methods for using same
KR0125779B1 (ko) * 1993-12-04 1997-12-19 김승호 뉴클레오시드 화합물 및 이의 제조방법
DE4400310A1 (de) * 1994-01-07 1995-07-13 Max Delbrueck Centrum Neue Nukleosid-Lipid-Addukte, ihre Herstellung und ihre pharmazeutische Verwendung
RU2183213C2 (ru) * 1996-11-05 2002-06-10 ЗАО "Производственно-коммерческая ассоциация АЗТ" Модифицированные нуклеозид-5'-трифосфаты как антивирусные агенты
AU2003217863B9 (en) * 2002-02-28 2009-10-29 Biota Scientific Management Pty Ltd Nucleotide mimics and their prodrugs
US7772197B2 (en) * 2002-09-24 2010-08-10 1,3,5-Triazines for Treatment of Viral Diseases 1,3,5-triazines for treatment of viral diseases
EP2712868A1 (en) * 2012-09-28 2014-04-02 B. Braun Melsungen AG 5-Fluoruoracil Derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3476770D1 (en) * 1983-04-11 1989-03-23 Meito Sangyo Kk Production of primary or secondary alcohol derivatives of phospholipids by the enzymatic technique

Also Published As

Publication number Publication date
GB2168350A (en) 1986-06-18
FR2574411A1 (fr) 1986-06-13
DE3543346C2 (de) 1993-11-11
ES557428A0 (es) 1988-06-01
GB8530115D0 (en) 1986-01-15
ES549587A0 (es) 1987-06-01
GB2168350B (en) 1988-03-02
DE3543346A1 (de) 1986-06-12
FR2574411B1 (fr) 1988-10-07
KR880000093B1 (ko) 1988-02-23
ES8706163A1 (es) 1987-06-01
KR860005574A (ko) 1986-07-23

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20020506