KR870001373B1 - 항생물질 BMG 162-aF2의 제조방법 - Google Patents

항생물질 BMG 162-aF2의 제조방법 Download PDF

Info

Publication number
KR870001373B1
KR870001373B1 KR1019810003293A KR810003293A KR870001373B1 KR 870001373 B1 KR870001373 B1 KR 870001373B1 KR 1019810003293 A KR1019810003293 A KR 1019810003293A KR 810003293 A KR810003293 A KR 810003293A KR 870001373 B1 KR870001373 B1 KR 870001373B1
Authority
KR
South Korea
Prior art keywords
bmg
medium
culture
agar
growth
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
KR1019810003293A
Other languages
English (en)
Korean (ko)
Other versions
KR830007834A (ko
Inventor
하마오 우메자와
도미오 다께우찌
히로시 나가나와
히로노부 이이누마
세쓰고 구니모도
Original Assignee
자이단 호오진 비세이부쓰 가가꾸 겡뀨우가이
이찌가와 도꾸지
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 자이단 호오진 비세이부쓰 가가꾸 겡뀨우가이, 이찌가와 도꾸지 filed Critical 자이단 호오진 비세이부쓰 가가꾸 겡뀨우가이
Publication of KR830007834A publication Critical patent/KR830007834A/ko
Application granted granted Critical
Publication of KR870001373B1 publication Critical patent/KR870001373B1/ko
Expired legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/07—Bacillus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/832—Bacillus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1019810003293A 1980-09-08 1981-09-04 항생물질 BMG 162-aF2의 제조방법 Expired KR870001373B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP80/123585 1980-09-08
JP55123585A JPS5748957A (en) 1980-09-08 1980-09-08 Novel antibiotic bmg 162-af2, its preparation and carcinostatic agent comprising it as active ingredient

Publications (2)

Publication Number Publication Date
KR830007834A KR830007834A (ko) 1983-11-07
KR870001373B1 true KR870001373B1 (ko) 1987-07-24

Family

ID=14864227

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019810003293A Expired KR870001373B1 (ko) 1980-09-08 1981-09-04 항생물질 BMG 162-aF2의 제조방법

Country Status (18)

Country Link
US (2) US4416899A (enExample)
JP (1) JPS5748957A (enExample)
KR (1) KR870001373B1 (enExample)
AT (1) AT376239B (enExample)
AU (1) AU523222B2 (enExample)
BE (1) BE890229A (enExample)
CA (1) CA1175763A (enExample)
CH (1) CH655498B (enExample)
CS (1) CS226036B2 (enExample)
DE (1) DE3134353C2 (enExample)
DK (1) DK157890C (enExample)
ES (1) ES505256A0 (enExample)
FR (1) FR2489819A1 (enExample)
GB (1) GB2084999B (enExample)
HU (1) HU188077B (enExample)
IT (1) IT1209896B (enExample)
NL (1) NL8104069A (enExample)
SE (1) SE450836B (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57192347A (en) * 1981-05-18 1982-11-26 Microbial Chem Res Found N-(4-(3-aminopropyl)aminobutyl)-2,2-dihydroxyethanamide and its synthesis
JPS57185254A (en) * 1981-05-11 1982-11-15 Microbial Chem Res Found Novel carcinostatic substances and their preparation
JPS5862152A (ja) * 1981-10-08 1983-04-13 Microbial Chem Res Found Ｎ−〔４−（３−アミノプロピル）アミノブチル〕−２−（ω−グアニジノ脂肪酸アミド）−２−ヒドロキシエタンアミドおよびその誘導体ならびにその製造法
JPS5942356A (ja) * 1982-09-02 1984-03-08 Microbial Chem Res Found スパガリン関連化合物およびその製造法
JPS60185758A (ja) * 1984-03-02 1985-09-21 Microbial Chem Res Found フエニレン基を有するスパガリン関連化合物およびその製造法
US4851446A (en) * 1984-11-13 1989-07-25 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Immunosuppressing method
JPS61134312A (ja) * 1984-12-06 1986-06-21 Microbial Chem Res Found 移植免疫抑制剤並びに抗アレルギ−剤
JPS61165322A (ja) * 1985-01-14 1986-07-26 Microbial Chem Res Found スパガリン類の注射用凍結乾燥製剤
ES2039213T3 (es) * 1986-04-04 1993-09-16 Microbial Chemistry Research Foundation Procedimiento para producir nuevos compuestos relacionados con espergualina.
JP2873340B2 (ja) * 1988-04-29 1999-03-24 武田薬品工業株式会社 抗生物質ｔａｎ―１０５７，その製造法および用途
JPH0776204B2 (ja) * 1988-07-01 1995-08-16 寳酒造株式会社 スパガリン類の精製法
JPH0263181U (enExample) * 1988-10-27 1990-05-11
US4990536A (en) * 1989-04-03 1991-02-05 Nippon Kayaku Kabushiki Kaisha Immunopotentiator and spergualin-related compound therefor
US5162581A (en) * 1989-05-29 1992-11-10 Takaru Shuzo Co., Ltd. Crystalline deoxyspergualin, process for its preparation and suppository containing the same

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2998438A (en) * 1958-03-31 1961-08-29 Merck & Co Inc Eulicin and process for production
US3617448A (en) * 1967-10-03 1971-11-02 Research Corp Antibiotic and methods of producing and using it
US3743580A (en) * 1970-04-28 1973-07-03 Microbial Chem Res Found Antibiotic,negamycin,and processes for the preparation thereof
US4163796A (en) * 1977-12-14 1979-08-07 The Dow Chemical Company Stabilized aqueous amide antimicrobial composition
US4328229A (en) * 1978-03-29 1982-05-04 Taiho Pharmaceutical Company Limited Anti-cancer composition for delivering 5-fluorouracil to cancer tissues
US4226808A (en) * 1979-08-17 1980-10-07 Schering Corporation 1-Aryl-2-dihalogenodeuterioalkanoylamido-1,3-propanediol antibacterial agents

Also Published As

Publication number Publication date
GB2084999A (en) 1982-04-21
KR830007834A (ko) 1983-11-07
CS226036B2 (en) 1984-03-19
SE8105079L (sv) 1982-03-09
AU7489281A (en) 1982-03-18
JPS6316380B2 (enExample) 1988-04-08
US4474880A (en) 1984-10-02
IT1209896B (it) 1989-08-30
US4416899A (en) 1983-11-22
DK157890C (da) 1990-07-23
NL8104069A (nl) 1982-04-01
FR2489819A1 (fr) 1982-03-12
DE3134353A1 (de) 1982-04-22
IT8149237A0 (it) 1981-09-04
DK394281A (da) 1982-03-09
ES8302090A1 (es) 1983-01-01
BE890229A (fr) 1982-01-04
AT376239B (de) 1984-10-25
CH655498B (enExample) 1986-04-30
JPS5748957A (en) 1982-03-20
GB2084999B (en) 1984-06-13
ATA386081A (de) 1984-03-15
DE3134353C2 (de) 1986-03-13
ES505256A0 (es) 1983-01-01
DK157890B (da) 1990-02-26
FR2489819B1 (enExample) 1985-02-15
SE450836B (sv) 1987-08-03
AU523222B2 (en) 1982-07-15
CA1175763A (en) 1984-10-09
HU188077B (en) 1986-03-28

Similar Documents

Publication Publication Date Title
EP0055069B1 (en) Derivatives of actaplanin
EP0063456B1 (en) Pseudo-aminosugars, their production and use
EP0055070B1 (en) Antibiotic a-4696 factors b1,b2,b3,c1a,c3 and e1
EP0182315B1 (en) Novel antibiotic nk84-0218 pharmaceutical compositions containing it and process for the production of the same
KR870001373B1 (ko) 항생물질 BMG 162-aF2의 제조방법
DE2905649A1 (de) Neue aminozucker-derivate, ihre herstellung und verwendung als amylasehemmende mittel
KR920001448B1 (ko) Bbm-2478 항생제 착화합물
US4546079A (en) Streptomyces species and process for producing antibiotic
US4595698A (en) Physiologically active substance, arphamenine and production thereof
US4271067A (en) Glycopeptide
US3824305A (en) Antibiotic a-287 and process for production thereof
AU597340B2 (en) Efomycin G, its preparation and its use as a yield promoter in animals
US3912811A (en) Antibiotic pholipomycin and its preparation
US5073369A (en) Efomycins as performance promoters in animals
EP0053025A2 (en) Antibiotic and its preparation from a streptomyces microorganism
US4950605A (en) FR-900493 substance, a process for its production and a pharmaceutical composition containing the same
US4661352A (en) WS 7739 substances, their preparation and pharmaceutical composition containing the same
KR830002817B1 (ko) 생물학적으로 활성인 fr-900156물질의 제조방법
US4298599A (en) Novel antibiotic BN-235 substance, and process for the production thereof
EP0024206A2 (en) Antitumor substance, composition comprising it and process for preparing said substance
JPH0623165B2 (ja) 新規抗生物質ジエタシン類およびその製造法
JPS5951527B2 (ja) コクシジウム症の予防治療剤
JPH01290673A (ja) 新規物質ｋ３５４３ｒ１、その使用および製造

Legal Events

Date Code Title Description
PA0109 Patent application

St.27 status event code: A-0-1-A10-A12-nap-PA0109

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PG1605 Publication of application before grant of patent

St.27 status event code: A-2-2-Q10-Q13-nap-PG1605

PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U11-oth-PR1002

Fee payment year number: 1

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 5

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 6

PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 19930725

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 19930725